Reducing clostridium difficile incidence, colectomies, and mortality in the hospital setting: A successful multidisciplinary approach

Joint Commission Journal on Quality and Patient Safety

Volumn 39, Issue 7, 2013, Pages 298-305

  Mermel, Leonard A ^a,b   Jefferson, Julie ^b,c   Blanchard, Kerry ^b   Parenteau, Stephen ^b   Mathis, Benjamin ^a,d   Chapin, Kimberle ^a,e   Machan, Jason T ^a,b,f  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c BROWN UNIVERSITY   (United States)

^d Miami Dade Medical Examiner Department   (United States)

^e Lifespan   (United States)

^f UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

ADDICTION; ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTION; COLON RESECTION; CROSS INFECTION; DISEASE TRANSMISSION; FECES; HEALTH CARE QUALITY; HOSPITAL SERVICE; HUMAN; INCIDENCE; INFECTION CONTROL; MICROBIOLOGY; MORTALITY; ORGANIZATION AND MANAGEMENT; POLYMERASE CHAIN REACTION; STATISTICS; TERTIARY HEALTH CARE; UNITED STATES;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COLECTOMY; CROSS INFECTION; FECES; HOSPITAL MORTALITY; HOUSEKEEPING, HOSPITAL; HUMANS; INCIDENCE; INFECTION CONTROL; POLYMERASE CHAIN REACTION; QUALITY OF HEALTH CARE; RHODE ISLAND; SUBSTANCE-RELATED DISORDERS; TERTIARY CARE CENTERS;

EID: 84880516737     PISSN: 15537250     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1553-7250(13)39042-4     Document Type: Article

References (23)

1. US Agency for Healthcare Research and Quality, Healthcare Cost and Utilization Project (HCUP). Clostridium difficile infections (CDI) in hospital stays, 2009. Statistical Brief 124. Lucado J, Gould C, Elixhauser A. Jan 2012. Accessed May 30, 2013. http://www.hcup-us.ahrq.gov/reports/statbriefs /sb124.pdf.
2. Dubberke ER, et al. Short- and long-term attributable costs of Clostridium difficile-associated disease in nonsurgical inpatients. Clin Infect Dis. 2008 Feb 15;46(4): 497-504.
3. Cohen SH, et al.; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31(5): 431-455.
4. Dellit TH, et al.; Infectious Diseases Society of America; Society for Healthcare Epidemiology of America. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007 Jan 15;44(2): 159-177.
5. McDonald LC, et al.; Ad Hoc Clostridium difficile Surveillance Working Group. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol. 2007;28(2): 140-145.
6. Chapin KC, et al. Comparison of five assays for detection of Clostridium difficile toxin. J Mol Diagn. 2011;13(4): 395-400.
7. Chapin K. Discrepancies in testing recommendations for Clostridium difficile infection: Updated review favors amplification test systems. Expert Rev Mol Diagn. 2012;12(3): 223-226.
8. Neal MD, et al. Diverting loop ileostomy and colonic lavage: An alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease. Ann Surg. 2011;254(3): 423-429.
9. Kelly CR, de Leon L, Jasutkar N. Fecal microbiota transplantation for relapsing Clostridium difficile infection in 26 patients: Methodology and results. J Clin Gastroenterol. 2012;46(2): 145-149.
10. Kassakian SZ, et al. Impact of chlorhexidine bathing on hospital-acquired infections in general medical patients. Infect Control Hosp Epidemiol. 2011; 32(3): 238-243.
11. Rupp ME, et al. Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections. Infect Control Hosp Epidemiol. 2012;33(11): 1094-1100.
12. Huber PJ. The behavior of maximum likelihood estimates under nonstandard conditions. In Le Cam LM, Neyman J, editors. Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, vol 1: Statistics. Berkeley, CA: University of California Press, 1967. 221-233.
13. White H. A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity. Econometrica. 1980;48(4): 817-838.
14. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics.1979;6(2): 65-70.
15. Oake N, et al. The effect of hospital-acquired Clostridium difficile infection on in-hospital mortality. Arch Intern Med. 2010 Nov 8;170(20): 1804-1810.
16. O'Brien JA, et al. The emerging infectious challenge of Clostridium difficile- associated disease in Massachusetts hospitals: Clinical and economic consequences. Infect Control Hosp Epidemiol. 2007;28(11): 1219-1227.
17. McGlone SM, et al. The economic burden of Clostridium difficile. Clin Microbiol Infect. 2012;18(3): 282-289.
18. Centers for Disease Control and Prevention. Healthcare-associated Infections (HAIs). (Updated: Mar 6 2012.) Accessed May 30, 2013. http://www.cdc.gov/hai/organisms/cdiff/Cdiff-shd.html.
19. Centers for Disease Control and Prevention. Vital signs: Preventing Clostridium difficile infections. MMWR Morb Mortal Wkly Rep. 2012 Mar 9;61(9): 157-162.
20. Loo VG, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005 Dec 8;353(23): 2442-2449.
21. Fowler S, et al. Successful use of feedback to improve antibiotic prescribing and reduce Clostridium difficile infection: A controlled interrupted time series. J Antimicrob Chemother. 2007;59(5): 990-995.
22. Muto CA, et al. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach. Clin Infect Dis. 2007 Nov 15;45(10): 1266-1273.
23. Power M, et al. Reducing Clostridium difficile infection in acute care by using an improvement collaborative. BMJ. 2010 Jul 21;341:c3359.