Expression of catalytically active matrix metalloproteinase-1 in dermal fibroblasts induces collagen fragmentation and functional alterations that resemble aged human skin

Aging Cell

Volumn 12, Issue 4, 2013, Pages 661-671

  Xia, Wei ^a   Hammerberg, Craig ^a   Li, Yong ^a   He, Tianyuan ^a   Quan, Taihao ^a   Voorhees, John J ^a   Fisher, Gary J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Aging; Extracellular matrix; Matrix metalloproteinase; Molecular biology of aging

Indexed keywords

2 [N (4 METHOXYSULFONYL)(3 PYRIDINYLMETHYL)AMINO] 3 METHYLBUTYROHYDROXAMIC ACID; COLLAGEN FIBRIL; F ACTIN; INTERSTITIAL COLLAGENASE; MUTANT PROTEIN; PROCOLLAGEN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; ACTIN; COLLAGEN TYPE 1; HYDROXAMIC ACID; MMP1 PROTEIN, HUMAN; PYRAZINE DERIVATIVE; SULFONAMIDE;

ACTIN FILAMENT; ADULT; AGED; ARTICLE; CELL FUNCTION; CELL STRUCTURE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; CYTOPLASM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SKIN FIBROBLAST; SKIN FUNCTION; TEMPERATURE DEPENDENCE; ADENOVIRIDAE; BIOLOGICAL MODEL; CELL CULTURE; CELL SHAPE; CYTOLOGY; DERMIS; ENZYMOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM; TEMPERATURE; TIME; VERY ELDERLY; YOUNG ADULT;

ACTINS; ADENOVIRIDAE; ADULT; AGED, 80 AND OVER; CELL SHAPE; CELLS, CULTURED; COLLAGEN TYPE I; DERMIS; ENZYME ACTIVATION; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 1; MODELS, BIOLOGICAL; PYRAZINES; RNA, SMALL INTERFERING; SKIN AGING; SULFONAMIDES; TEMPERATURE; TIME FACTORS; TRANSFECTION; YOUNG ADULT;

EID: 84880514510     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12089     Document Type: Article

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