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Volumn 121, Issue 19, 2013, Pages 3988-3996

Endothelial RAF1/ERK activation regulates arterial morphogenesis

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CHICKEN OVALBUMIN UPSTREAM PROMOTER TRANSCRIPTION FACTOR 2; DLL4 PROTEIN; EFNB2 PROTEIN; EPHRIN RECEPTOR B4; HES2 PROTEIN; HEY1 PROTEIN; HEY2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NETRIN; NETRIN G1; NOTCH RECEPTOR; NOTCH4 RECEPTOR; NRP1 PROTEIN; PROTEIN; RAF PROTEIN; RAF1 PROTEIN; SEMA6A PROTEIN; SEMAPHORIN; SERINE; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN C; SEMA6A PROTEIN, MOUSE;

EID: 84880492894     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-12-474601     Document Type: Article
Times cited : (60)

References (46)
  • 1
    • 5444261424 scopus 로고    scopus 로고
    • Dosage-sensitive requirement for mouse DLL4 in artery development
    • Duarte A, Hirashima M, Benedito R, et al. Dosage-sensitive requirement for mouse DLL4 in artery development. Genes Dev. 2004;18(20): 2474-2478.
    • (2004) Genes Dev , vol.18 , Issue.20 , pp. 2474-2478
    • Duarte, A.1    Hirashima, M.2    Benedito, R.3
  • 2
    • 0034212710 scopus 로고    scopus 로고
    • Notch signaling is essential for vascular morphogenesis in mice
    • Krebs LT, Xue Y, Norton CR, et al. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 2000;14(11):1343-1352.
    • (2000) Genes Dev , vol.14 , Issue.11 , pp. 1343-1352
    • Krebs, L.T.1    Xue, Y.2    Norton, C.R.3
  • 4
    • 0034195220 scopus 로고    scopus 로고
    • DLL4, a novel notch ligand expressed in arterial endothelium
    • Shutter JR, Scully S, Fan W, et al. DLL4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 2000;14(11):1313-1318.
    • (2000) Genes Dev , vol.14 , Issue.11 , pp. 1313-1318
    • Shutter, J.R.1    Scully, S.2    Fan, W.3
  • 5
    • 67049108093 scopus 로고    scopus 로고
    • DLL1-mediated notch activation regulates endothelial identity in mouse fetal arteries
    • Sörensen I, Adams RH, Gossler A. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009; 113(22):5680-5688.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5680-5688
    • Sörensen, I.1    Adams, R.H.2    Gossler, A.3
  • 6
    • 52649121738 scopus 로고    scopus 로고
    • Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos
    • Trindade A, Kumar SR, Scehnet JS, et al. Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood. 2008;112(5): 1720-1729.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1720-1729
    • Trindade, A.1    Kumar, S.R.2    Scehnet, J.S.3
  • 7
    • 33846040204 scopus 로고    scopus 로고
    • Critical role of endothelial notch1 signaling in postnatal angiogenesis
    • Takeshita K, Satoh M, Ii M, et al. Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res. 2007;100(1):70-78.
    • (2007) Circ Res , vol.100 , Issue.1 , pp. 70-78
    • Takeshita, K.1    Satoh, M.2    Ii, M.3
  • 8
    • 33847046849 scopus 로고    scopus 로고
    • DLL4 signalling through notch1 regulates formation of tip cells during angiogenesis
    • Hellström M, Phng LK, Hofmann JJ, et al. DLL4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007; 445(7129):776-780.
    • (2007) Nature , vol.445 , Issue.7129 , pp. 776-780
    • Hellström, M.1    Phng, L.K.2    Hofmann, J.J.3
  • 9
    • 33847039645 scopus 로고    scopus 로고
    • Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries
    • Siekmann AF, Lawson ND. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature. 2007;445(7129):781-784.
    • (2007) Nature , vol.445 , Issue.7129 , pp. 781-784
    • Siekmann, A.F.1    Lawson, N.D.2
  • 10
    • 33847031641 scopus 로고    scopus 로고
    • Notch ligand delta-like 1 is essential for postnatal arteriogenesis
    • Limbourg A, Ploom M, Elligsen D, et al. Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res. 2007;100(3):363-371.
    • (2007) Circ Res , vol.100 , Issue.3 , pp. 363-371
    • Limbourg, A.1    Ploom, M.2    Elligsen, D.3
  • 11
    • 8644290828 scopus 로고    scopus 로고
    • Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    • Gale NW, Dominguez MG, Noguera I, et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA. 2004;101(45):15949-15954.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.45 , pp. 15949-15954
    • Gale, N.W.1    Dominguez, M.G.2    Noguera, I.3
  • 13
    • 77951498501 scopus 로고    scopus 로고
    • Vegf receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
    • Nilsson I, Bahram F, Li X, et al. VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J. 2010; 29(8):1377-1388.
    • (2010) EMBO J , vol.29 , Issue.8 , pp. 1377-1388
    • Nilsson, I.1    Bahram, F.2    Li, X.3
  • 14
    • 84859453770 scopus 로고    scopus 로고
    • Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling
    • Benedito R, Rocha SF, Woeste M, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature. 2012;484(7392):110-114.
    • (2012) Nature , vol.484 , Issue.7392 , pp. 110-114
    • Benedito, R.1    Rocha, S.F.2    Woeste, M.3
  • 16
    • 0037080956 scopus 로고    scopus 로고
    • Regulation of Raf-1 activation and signalling by dephosphorylation
    • Dhillon AS, Meikle S, Yazici Z, Eulitz M, Kolch W. Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J. 2002;21(1-2):64-71.
    • (2002) EMBO J , vol.21 , Issue.1-2 , pp. 64-71
    • Dhillon, A.S.1    Meikle, S.2    Yazici, Z.3    Eulitz, M.4    Kolch, W.5
  • 17
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of raf by Akt (protein kinase B)
    • Zimmermann S, Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science. 1999;286(5445):1741-1744.
    • (1999) Science , vol.286 , Issue.5445 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2
  • 18
    • 0041529686 scopus 로고    scopus 로고
    • Protein kinase a blocks Raf-1 activity by stimulating 14-3-3 binding and blocking raf-1 interaction with ras
    • Dumaz N, Marais R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem. 2003;278(32):29819-29823.
    • (2003) J Biol Chem , vol.278 , Issue.32 , pp. 29819-29823
    • Dumaz, N.1    Marais, R.2
  • 19
    • 0027326410 scopus 로고
    • Protein kinase C alpha activates RAF-1 by direct phosphorylation
    • Kolch W, Heidecker G, Kochs G, et al. Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature. 1993;364(6434): 249-252.
    • (1993) Nature , vol.364 , Issue.6434 , pp. 249-252
    • Kolch, W.1    Heidecker, G.2    Kochs, G.3
  • 20
    • 30044452600 scopus 로고    scopus 로고
    • Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/ threonine phosphatase 2a holoenzymes
    • Adams DG, Coffee RL Jr, Zhang H, Pelech S, Strack S, Wadzinski BE. Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/ threonine phosphatase 2A holoenzymes. J Biol Chem. 2005;280(52):42644-42654.
    • (2005) J Biol Chem , vol.280 , Issue.52 , pp. 42644-42654
    • Adams, D.G.1    Coffee, R.L.2    Zhang, H.3    Pelech, S.4    Strack, S.5    Wadzinski, B.E.6
  • 21
    • 30744432102 scopus 로고    scopus 로고
    • Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    • Chen J, Somanath PR, Razorenova O, et al. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nat Med. 2005;11(11):1188-1196.
    • (2005) Nat Med , vol.11 , Issue.11 , pp. 1188-1196
    • Chen, J.1    Somanath, P.R.2    Razorenova, O.3
  • 22
    • 48749114949 scopus 로고    scopus 로고
    • Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing
    • Somanath PR, Chen J, Byzova TV. Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing. Angiogenesis. 2008;11(3):277-288.
    • (2008) Angiogenesis , vol.11 , Issue.3 , pp. 277-288
    • Somanath, P.R.1    Chen, J.2    Byzova, T.V.3
  • 23
    • 53249149629 scopus 로고    scopus 로고
    • Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification
    • Hong CC, Kume T, Peterson RT. Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circ Res. 2008;103(6):573-579.
    • (2008) Circ Res , vol.103 , Issue.6 , pp. 573-579
    • Hong, C.C.1    Kume, T.2    Peterson, R.T.3
  • 24
    • 77951160785 scopus 로고    scopus 로고
    • ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish
    • Ren B, Deng Y, Mukhopadhyay A, et al. ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J Clin Invest. 2010;120(4): 1217-1228.
    • (2010) J Clin Invest , vol.120 , Issue.4 , pp. 1217-1228
    • Ren, B.1    Deng, Y.2    Mukhopadhyay, A.3
  • 25
    • 61949107700 scopus 로고    scopus 로고
    • Guidance of vascular development: Lessons from the nervous system
    • Larrivée B, Freitas C, Suchting S, Brunet I, Eichmann A. Guidance of vascular development: lessons from the nervous system. Circ Res. 2009; 104(4):428-441.
    • (2009) Circ Res , vol.104 , Issue.4 , pp. 428-441
    • Larrivée, B.1    Freitas, C.2    Suchting, S.3    Brunet, I.4    Eichmann, A.5
  • 26
    • 0032577446 scopus 로고    scopus 로고
    • Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor eph-b4
    • Wang HU, Chen ZF, Anderson DJ. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998;93(5): 741-753.
    • (1998) Cell , vol.93 , Issue.5 , pp. 741-753
    • Wang, H.U.1    Chen, Z.F.2    Anderson, D.J.3
  • 27
    • 0034756449 scopus 로고    scopus 로고
    • Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
    • Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G. Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins. Mech Dev. 2001;109(1):115-119.
    • (2001) Mech Dev , vol.109 , Issue.1 , pp. 115-119
    • Herzog, Y.1    Kalcheim, C.2    Kahane, N.3    Reshef, R.4    Neufeld, G.5
  • 28
    • 77955291848 scopus 로고    scopus 로고
    • Axon guidance molecules in vascular patterning
    • Adams RH, Eichmann A. Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol. 2010;2(5):a001875.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.5 , pp. a001875
    • Adams, R.H.1    Eichmann, A.2
  • 29
    • 35148894033 scopus 로고    scopus 로고
    • Activation of the UNC5B receptor by netrin-1 inhibits sprouting angiogenesis
    • Larrivée B, Freitas C, Trombe M, et al. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev. 2007;21(19): 2433-2447.
    • (2007) Genes Dev , vol.21 , Issue.19 , pp. 2433-2447
    • Larrivée, B.1    Freitas, C.2    Trombe, M.3
  • 30
    • 84855406000 scopus 로고    scopus 로고
    • Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels
    • Meadows SM, Fletcher PJ, Moran C, et al. Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012;110(1):34-46.
    • (2012) Circ Res , vol.110 , Issue.1 , pp. 34-46
    • Meadows, S.M.1    Fletcher, P.J.2    Moran, C.3
  • 31
    • 57649221000 scopus 로고    scopus 로고
    • Ephrin-B2-induced cleavage of ephb2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
    • Lin KT, Sloniowski S, Ethell DW, Ethell IM. Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J Biol Chem. 2008;283(43): 28969-28979.
    • (2008) J Biol Chem , vol.283 , Issue.43 , pp. 28969-28979
    • Lin, K.T.1    Sloniowski, S.2    Ethell, D.W.3    Ethell, I.M.4
  • 32
    • 84874631217 scopus 로고    scopus 로고
    • Endothelial ERK signaling controls lymphatic fate specification
    • Deng Y, Atri D, Eichmann A, Simons M. Endothelial ERK signaling controls lymphatic fate specification. J Clin Invest. 2013;123(3): 1202-1215.
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 1202-1215
    • Deng, Y.1    Atri, D.2    Eichmann, A.3    Simons, M.4
  • 34
    • 84856812740 scopus 로고    scopus 로고
    • Microrna-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6a
    • Urbich C, Kaluza D, Frömel T, et al. MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. Blood. 2012;119(6):1607-1616.
    • (2012) Blood , vol.119 , Issue.6 , pp. 1607-1616
    • Urbich, C.1    Kaluza, D.2    Frömel, T.3
  • 35
    • 0038497941 scopus 로고    scopus 로고
    • Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells
    • Füller T, Korff T, Kilian A, Dandekar G, Augustin HG. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci. 2003;116(Pt 12):2461-2470.
    • (2003) J Cell Sci , vol.116 , pp. 2461-2470
    • Füller, T.1    Korff, T.2    Kilian, A.3    Dandekar, G.4    Augustin, H.G.5
  • 36
    • 33744483170 scopus 로고    scopus 로고
    • Selective regulation of arterial branching morphogenesis by synectin
    • Chittenden TW, Claes F, Lanahan AA, et al. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell. 2006;10(6): 783-795.
    • (2006) Dev Cell , vol.10 , Issue.6 , pp. 783-795
    • Chittenden, T.W.1    Claes, F.2    Lanahan, A.A.3
  • 37
    • 77952952373 scopus 로고    scopus 로고
    • Vegf receptor 2 endocytic trafficking regulates arterial morphogenesis
    • Lanahan AA, Hermans K, Claes F, et al. VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell. 2010;18(5):713-724.
    • (2010) Dev Cell , vol.18 , Issue.5 , pp. 713-724
    • Lanahan, A.A.1    Hermans, K.2    Claes, F.3
  • 38
    • 63649138023 scopus 로고    scopus 로고
    • Arterial-venous specification during development
    • Swift MR, Weinstein BM. Arterial-venous specification during development. Circ Res. 2009; 104(5):576-588.
    • (2009) Circ Res , vol.104 , Issue.5 , pp. 576-588
    • Swift, M.R.1    Weinstein, B.M.2
  • 39
    • 0037216703 scopus 로고    scopus 로고
    • Regulation of notch1 and DLL4 by vascular endothelial growth factor in arterial endothelial cells: Implications for modulating arteriogenesis and angiogenesis
    • Liu ZJ, Shirakawa T, Li Y, et al. Regulation of Notch1 and DLL4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol. 2003;23(1):14-25.
    • (2003) Mol Cell Biol , vol.23 , Issue.1 , pp. 14-25
    • Liu, Z.J.1    Shirakawa, T.2    Li, Y.3
  • 40
    • 48749117994 scopus 로고    scopus 로고
    • Foxc transcription factors directly regulate DLL4 and Hey2 expression by interacting with the vegf-notch signaling pathways in endothelial cells
    • Hayashi H, Kume T. Foxc transcription factors directly regulate DLL4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells. PLoS ONE. 2008; 3(6):e2401.
    • (2008) Plos ONE , vol.3 , Issue.6 , pp. e2401
    • Hayashi, H.1    Kume, T.2
  • 41
    • 33745646792 scopus 로고    scopus 로고
    • Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling
    • Hong CC, Peterson QP, Hong JY, Peterson RT. Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ ERK signaling. Curr Biol. 2006;16(13):1366-1372.
    • (2006) Curr Biol , vol.16 , Issue.13 , pp. 1366-1372
    • Hong, C.C.1    Peterson, Q.P.2    Hong, J.Y.3    Peterson, R.T.4
  • 42
    • 77956191631 scopus 로고    scopus 로고
    • Semaphorin signaling: Molecular switches at the midline
    • Derijck AA, Van Erp S, Pasterkamp RJ. Semaphorin signaling: molecular switches at the midline. Trends Cell Biol. 2010;20(9):568-576.
    • (2010) Trends Cell Biol , vol.20 , Issue.9 , pp. 568-576
    • Derijck, A.A.1    Van Erp, S.2    Pasterkamp, R.J.3
  • 43
    • 19944430075 scopus 로고    scopus 로고
    • Semaphorin 3e and plexin-d1 control vascular pattern independently of neuropilins
    • Gu C, Yoshida Y, Livet J, et al. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005; 307(5707):265-268.
    • (2005) Science , vol.307 , Issue.5707 , pp. 265-268
    • Gu, C.1    Yoshida, Y.2    Livet, J.3
  • 44
    • 70449428715 scopus 로고    scopus 로고
    • Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models
    • Maione F, Molla F, Meda C, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest. 2009;119(11):3356-3372.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3356-3372
    • Maione, F.1    Molla, F.2    Meda, C.3
  • 45
    • 84868626633 scopus 로고    scopus 로고
    • Semaphorin 6A regulates angiogenesis by modulating vegf signaling
    • Segarra M, Ohnuki H, Maric D, et al. Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood. 2012;120(19):4104-4115.
    • (2012) Blood , vol.120 , Issue.19 , pp. 4104-4115
    • Segarra, M.1    Ohnuki, H.2    Maric, D.3
  • 46
    • 0033082959 scopus 로고    scopus 로고
    • Roles of ephrinb ligands and ephb receptors in cardiovascular development: Demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
    • Adams RH, Wilkinson GA, Weiss C, et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999;13(3):295-306.
    • (1999) Genes Dev , vol.13 , Issue.3 , pp. 295-306
    • Adams, R.H.1    Wilkinson, G.A.2    Weiss, C.3


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