Chronic kidney disease causes disruption of gastric and small intestinal epithelial tight junction

American Journal of Nephrology

Volumn 38, Issue 2, 2013, Pages 99-103

  Vaziri, Nosratola D ^a   Yuan, Jun ^a   Nazertehrani, Sohrab ^a   Ni, Zhenmin ^a   Liu, Shuman ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

End stage renal disease; Enterocolitis; Gastritis; Inflammation; Malnutrition; Uremia

Indexed keywords

CLAUDIN 1; CREATININE; MALONALDEHYDE; OCCLUDIN; PROTEIN ZO1; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME BLOOD LEVEL; ILEUM; MALE; NEPHRECTOMY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RAT; SMALL INTESTINE; STOMACH; STOMACH EPITHELIUM; TIGHT JUNCTION; JEJUNUM; SMALL INTESTINE MUCOSA; UREA BLOOD LEVEL; UREMIA;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CLAUDIN-1; EPITHELIAL CELLS; INFLAMMATION; INTESTINE, SMALL; KIDNEY FAILURE, CHRONIC; MALE; OCCLUDIN; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84880436588     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000353764     Document Type: Article

References (22)

1. Cachofeiro V, Goicochea M, de Vinuesa SG, Oubina P, Lahera V, Luno J: Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl 2008; 111:S4-S9.
2. Stenvinkel P: Inflammation in end-stage renal disease: the hidden enemy. Nephrology (Carlton) 2006; 11: 36-41.
3. Ruiz S, Pergola PE, Zager RA, Vaziri ND: Targeting Nrf2 activation to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int 2013; 83: 1029-1041.
4. Vaziri ND: CKD impairs barrier function and alters microbial flora of the intestine - a major link to inflammation and uremic toxicity. Curr Opin Nephrol Hypertens 2012; 21: 587-592.
5. Magnusson M, Magnusson KE, Sundqvist T, et al: Increased intestinal permeability to differently sized polyethylene glycols in uremic rats: effects of low- and high protein diets. Nephron 1990; 56: 306-311.
6. Magnusson M, Magnusson KE, Sundqvist T, et al: Impaired intestinal barrier function measured by differently sized polyethylene glycols in patients with chronic renal failure. Gut 1991; 32: 754-759.
7. de Almeida Duarte JB, de Aguilar-Nascimento JE, Nascimento M, et al: Bacterial translocation in experimental uremia. Urol Res 2004; 32: 266-270.
8. Vaziri ND, Dure-Smith B, Miller R, et al: Pathology of gastrointestinal tract in chronic hemodialysis patients: an autopsy study of 78 cases. Am J Gastroenterol 1985; 80: 608-611.
9. Feroze U, Kalantar-Zadeh K, Sterling KA, Molnar MZ, Noori N, Benner D, Shah V, Dwivedi R, Becker K, Kovesdy CP, Raj DS: Examining associations of circulating endotoxin with nutritional status, inflammation, and mortality in hemodialysis patients. J Ren Nutr 2012; 22: 317-326.
10. Goncalves S, Pecoits-Filho R, Perreto S, et al: Associations between renal function, volume status and endotoxaemia in chronic kidney disease patients. Nephrol Dial Transplant 2006; 21: 2788-2794.
11. Szeto CC, Kwan BC, Chow KM, et al: Endotoxemia is related to systemic inflammation and atherosclerosis in peritoneal dialysis patients. Clin J Am Soc Nephrol 2008; 3: 431-436.
12. Vaziri ND, Yuan J, Rahimi A, Ni Z, Said H, Subramanian VS: Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation. Nephrol Dial Transplant 2012; 27: 2686-2693.
13. Vaziri ND, Yuan J, Norris K: Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease. Am J Nephrol 2013; 37: 1-6.
14. Vaziri ND, Ni Z, Oveisi F, et al: Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats. Hypertension 2000; 36: 957-964.
15. Turner JR: Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009; 9: 799-809.
16. Nusrat A, Turner JR, Madara JL: Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 2000; 279:G851-G857.
17. Vaziri ND, Goshtasbi N, Yuan J, Jellbauer S, Moradi H, Raffatellu M, Kalantar-Zadeh K: Uremic human plasma degrades intestinal epithelial barrier structure and function. Am J Nephrology 2012; 36: 438-443.
18. Lee YT: Urea concentration in intestinal fluids in normal and uremic dogs. J Surg Oncol 1971; 3: 163-168.
19. Bourke E, Milne MD, Stokes GS: Caecal pH and ammonia in experimental uraemia. Gut 1966; 7: 558-561.
20. Swales JD, Tange JD, Evans DJ: Intestinal ammonia in uraemia: the effect of a urease inhibitor, acetohydroxamic acid. Clin Sci 1972; 42: 105-112.
21. Vaziri ND, Wong J, Pahl MV, Piceno YM, Yuan J, De Santis TZ, Ni Z, Nguyen TH, Andersen GL: Chronic kidney disease alters the composition of intestinal microbial flora. Kidney Int 2013; 83: 308-315.
22. Vaziri ND, Yuan J, Khazaeli M, Masuda Y, Ichii H, Liu S: Oral activated charcoal adsorbent (AST-120) ameliorates CKD-induced intestinal epithelial barrier disruption and systemic inflammation. Am J Nephrol 2013; 37: 518-525.