IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-κB Activation

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Wong, Leo Lap Yan ^a   Lam, Ian Pak Yan ^a   Wong, Tracy Yuk Nar ^a   Lai, Wai Lung ^a   Liu, Heong Fai ^a   Yeung, Lam Lung ^b   Ching, Yick Pang ^a,c,d  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c THE UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

2,29 DIHYDROXY 1,19 DINAPHTHYLDISUIFIDE; ANTINEOPLASTIC AGENT; BROXURIDINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IPA 3; P21 ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CANCER; LIVER CARCINOGENESIS; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; TUMOR VOLUME; TUMOR XENOGRAFT;

EID: 84880410408     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068843     Document Type: Article

References (28)

1. Parkin DM, Bray F, Ferlay J, Pisani P, (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108.
2. Tang ZY, (2001) Hepatocellular carcinoma-cause, treatment and metastasis. World J Gastroenterol 7: 445-454.
3. Sherman M, (2005) Hepatocellular carcinoma: epidemiology, risk factors, and screening Semin Liver Dis. 25: 143-154.
4. Ching YP, Leong VY, Lee MF, Xu HT, Jin DY, et al. (2007) P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res 67: 3601-3608.
5. Molli PR, Li DQ, Murray BW, Rayala SK, Kumar R, (2009) PAK signaling in oncogenesis. Oncogene 28: 2545-2555.
6. King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, et al. (2000) p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem 275: 41201-41209.
7. Zenke FT, King CC, Bohl BP, Bokoch GM, (1999) Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem 274: 32565-32573.
8. Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, et al. (2008) An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 15: 322-331.
9. Viaud J, Peterson JR, (2009) An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther 8: 2559-2565.
10. Takahashi K, Suzuki K, (2009) Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex. Cell Signal 21: 695-703.
11. Kalin S, Amstutz B, Gastaldelli M, Wolfrum N, Boucke K, et al. (2010) Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35. J Virol 84: 5336-5350.
12. Hu L, Lau SH, Tzang CH, Wen JM, Wang W, et al. (2004) Association of Vimentin overexpression and hepatocellular carcinoma metastasis. Oncogene 23: 298-302.
13. Li Y, Tang ZY, Ye SL, Liu YK, Chen J, et al. (2001) Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97. World J Gastroenterol 7: 630-636.
14. Mak GW, Chan MM, Leong VY, Lee JM, Yau TO, et al. (2011) Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis. Cancer Res 71: 2949-2958.
15. Lai WL, Hung WY, Wong LL, Yuan Z, Leong VY, et al. (2012) The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2. Hepatology 56: 1770-1781.
16. Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K, (2003) JNK phosphorylates paxillin and regulates cell migration. Nature 424: 219-223.
17. Fan S, Gao M, Meng Q, Laterra JJ, Symons MH, et al. (2005) Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene 24: 1749-1766.
18. Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, et al. (2000) Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem 275: 19693-19699.
19. Zhou L, Yan C, Gieling RG, Kida Y, Garner W, et al. (2009) Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1. BMC Immunol 10: 1-15.
20. Yeh CB, Hsieh MJ, Hsieh YH, Chien MH, Chiou HL, et al. (2012) Antimetastatic Effects of Norcantharidin on Hepatocellular Carcinoma by Transcriptional Inhibition of MMP-9 through Modulation of NF-kB Activity. PLoS ONE 7(2): e31055 doi: 10.1371/journal.pone.0031055.
21. Koga H, Sakisaka S, Ohishi M, Kawaguchi T, Taniguchi E, et al. (1999) Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Hepatology 29: 688-696.
22. Kichina JV, Goc A, Al-Husein B, Somanath PR, Kandel ES, (2010) PAK1 as a therapeutic target. Expert Opin Ther Targets 14: 703-725.
23. Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, et al. (2000) p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20: 453-461.
24. Maeda S, (2010) NF-kappaB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis. Gastroenterol Res Pract 2010: 367694.
25. Wu R, Abramson AL, Symons MH, Steinberg BM, (2010) Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. Int. J. Cancer 127: 2230-2237.
26. Dummler B, Ohshiro K, Kumar R, Field J, (2009) Pak protein kinases and theirrole in cancer. Cancer Metastasis Rev 28: 51-63.
27. Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, et al. (2007) 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. Mol Pharmacol 72: 1124-1131.
28. Koh CG, Tan EJ, Manser E, Lim L, (2002) The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr Biol 12: 317-321.