Lactate clearance for assessing response to resuscitation in severe sepsis

Academic Emergency Medicine

Volumn 20, Issue 8, 2013, Pages 844-847

  Jones, Alan E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; METFORMIN; OXYGEN; PYRUVATE DEHYDROGENASE;

CENTRAL VENOUS PRESSURE; CRITICALLY ILL PATIENT; DISEASE SEVERITY; ERYTHROCYTE TRANSFUSION; HEALTH CARE COST; HUMAN; INTENSIVE CARE UNIT; LACTATE CLEARANCE; MEAN ARTERIAL PRESSURE; METABOLIC PARAMETERS; MORTALITY; OXYGEN SUPPLY; PRIORITY JOURNAL; RESUSCITATION; REVIEW; SEPSIS; SEPTIC SHOCK; TREATMENT RESPONSE; URINE VOLUME;

HOSPITAL MORTALITY; HUMANS; LACTIC ACID; RESUSCITATION; SEPSIS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84880379915     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/acem.12179     Document Type: Review

References (20)

1. Jones AE, Brown MD, Trzeciak S, et al. The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med. 2008; 36: 2734-9.
2. Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008; 36: 296-327.
3. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001; 345: 1368-77.
4. Gattinoni L, Brazzi L, Pelosi P, et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med. 1995; 333: 1025-32.
5. Jones AE, Kline JA,. Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med. 2005; 33: 1888-9.
6. Jones AE, Shapiro NI, Roshon M,. Implementing early goal-directed therapy in the emergency setting: the challenges and experiences of translating research innovations into clinical reality in academic and community settings. Acad Emerg Med. 2007; 14: 1072-8.
7. Jones AE, Shapiro NI, Trzeciak S, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010; 303: 739-46.
8. Shapiro NI, Howell MD, Talmor D, et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005; 45: 524-8.
9. Mikkelsen M, Miltiades A, Gaieski D, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med. 2009; 37: 1670-7.
10. Bakker J, Gris P, Coffernils M, Kahn R, Vincent JL,. Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg. 1996; 171: 221-6.
11. Nguyen H, Rivers E, Knoblich B, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med. 2004; 32: 1637-42.
12. Arnold RC, Shapiro NI, Jones AE, et al. Multi-center study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock. 2009; 32: 36-9.
13. Jansen TC, van Bommel J, Schoonderbeek FJ, et al. Early lactate-guided therapy in intensive care unit patients a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med. 2010; 182: 752-61.
14. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL,. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest. 1991; 99: 956-62.
15. Xiao-zhi W, Chang-jun L, Fu-quan GA,. Efficacy of goal-directed therapy in the treatment of septic shock. Chin Crit Care Med. 2007; 18: 661-4.
16. Weil M, Afifi A,. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation. 1970; 41: 989-1001.
17. Nguyen HB, Loomba M, Yang J, et al. Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock. J Inflam (Lond). 2010; 7: 6.
18. Pope JV, Jones AE, Gaieski DF, Arnold RC, Trzeciak S, Shapiro NI,. Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsis. Ann Emerg Med. 2010; 55: 40-6.
19. Puskarich M, Trzeciak S, Shapiro N, et al. Concordance and prognostic value of central venous oxygen saturation and lactate clearance in emergency department patients with septic shock. Acad Emerg Med. 2012; 19: 252-8.
20. Puskarich MA, Trzeciak S, Shapiro NI, et al. Whole blood lacatate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest. 2013; 143: 1548-53.