The role of the factor v Leiden mutation in osteonecrosis of the hip

Clinical and Applied Thrombosis/Hemostasis

Volumn 19, Issue 5, 2013, Pages 499-503

  Glueck, Charles J ^a   Freiberg, Richard A ^b   Boriel, Gail ^a   Khan, Zia ^a   Brar, Amanpreet ^a   Padda, Jagjit ^a   Wang, Ping ^a  

^a JEWISH HOSPITAL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

clinical epidemiology; clinical thrombophilia; hypercoagulability; thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; CORTICOSTEROID; PROTHROMBIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE NECROSIS; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; HETEROZYGOTE; HIP DISEASE; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PATIENT REFERRAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RACE; RISK FACTOR;

CLINICAL EPIDEMIOLOGY; CLINICAL THROMBOPHILIA; HYPERCOAGULABILITY; THROMBOPHILIA;

ADULT; BLOOD COAGULATION DISORDERS, INHERITED; COHORT STUDIES; FACTOR V; HIP; HUMANS; MIDDLE AGED; MUTATION; OSTEONECROSIS; PROSPECTIVE STUDIES; PROTHROMBIN; RISK FACTORS; THROMBOPHILIA;

EID: 84880377290     PISSN: 10760296     EISSN: 19382723     Source Type: Journal    
DOI: 10.1177/1076029612449901     Document Type: Article

References (38)

1. Glueck CJ, Goldenberg N, Budhani S, et al. Thrombotic events after starting exogenous testosterone in men with previously undiagnosed familial thrombophilia. Transl Res. 2011 ; 158 (4). 225-234
2. Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P. Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res. 2001 ; (386). 19-33
3. Glueck CJ, Freiberg RA, Boppana S, Wang P. Thrombophilia, hypofibrinolysis, the eNOS T-786C polymorphism, and multifocal osteonecrosis. J Bone Joint Surg Am. 2008 ; 90 (10). 2220-2229
4. Glueck CJ, Freiberg RA, Wang P. Heritable thrombophilia-hypofibrinolysis and osteonecrosis of the femoral head. Clin Orthop Relat Res. 2008 ; 466 (5). 1034-1040
5. Pierre-Jacques H, Glueck CJ, Mont MA, Hungerford DS. Familial heterozygous protein-S deficiency in a patient who had multifocal osteonecrosis. A case report. J Bone Joint Surg Am. 1997 ; 79 (7). 1079-1084
6. Glueck CJ, Freiberg RA, Wang P. Detecting thrombophilia, hypofibrinolysis, and reduced nitric oxide production in osteonecrosis. Semin Artrhoplasty. 2007 ; 18: 184-191
7. Zalavras CG, Vartholomatos G, Dokou E, Malizos KN. Genetic background of osteonecrosis: associated with thrombophilic mutations?. Clin Orthop Relat Res. 2004 ; (422). 251-255
8. Jones JP Osteonecrosis: Etiology, Diagnosis, and Treatment. Urbaniak JR Jones JP, ed. Rosemont IL: American Academy of Orthopedic Surgeons ; 1997: 89-97.
9. Jones LC, Mont MA, Le TB, et al. Procoagulants and osteonecrosis. J Rheumatol. 2003 ; 30 (4). 783-791
10. Koo KH, Kim R, Cho SH, Song HR, Lee G, Ko GH. Angiography, scintigraphy, intraosseous pressure, and histologic findings in high-risk osteonecrotic femoral heads with negative magnetic resonance images. Clin Orthop. 1994 ; (308). 127-138
11. Korompilias AV, Ortel TL, Urbaniak JR. Coagulation abnormalities in patients with hip osteonecrosis. Orthop Clin North Am. 2004 ; 35 (3). 265 vii - 271
12. Bjorkman A, Svensson PJ, Hillarp A, Burtscher IM, Runow A, Benoni G. Factor V leiden and prothrombin gene mutation: risk factors for osteonecrosis of the femoral head in adults. Clin Orthop Relat Res. 2004 ; (425). 168-172
13. Nilsson IM, Krook H, Sternby NH, Soderberg E, Soderstrom N. Severe thrombotic disease in a young man with bone marrow and skeletal changes and with a high content of an inhibitor in the fibrinolytic system. Acta Med Scand. 1961 ; 169: 323-337
14. Balasa VV, Gruppo RA, Glueck CJ, et al. Legg-Calve-Perthes disease and thrombophilia. J Bone Joint Surg Am. 2004 ; 86-A (12). 2642-2647
15. Vosmaer A, Pereira RR, Koenderman JS, Rosendaal FR, Cannegieter SC. Coagulation abnormalities in Legg-Calve-Perthes disease. J Bone Joint Surg Am. 2010 ; 92 (1). 121-128
16. Glueck CJ, Freiberg RA, Sieve L, Wang P. Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin Orthop Relat Res. 2005 ; (435). 164-170
17. Bjorkman A, Burtscher IM, Svensson PJ, Hillarp A, Besjakov J, Benoni G. Factor V Leiden and the prothrombin 20210A gene mutation and osteonecrosis of the knee. Arch Orthop Trauma Surg. 2005 ; 125 (1). 51-55
18. Lindahl TL, Lundahl TH, Nilsson L, Andersson CA. APC-resistance is a risk factor for postoperative thromboembolism in elective replacement of the hip or knee - a prospective study. Thromb Haemost. 1999 ; 81 (1). 18-21
19. Szucs G, Ajzner E, Muszbek L, Simon T, Szepesi K, Fulesdi B. Assessment of thrombotic risk factors predisposing to thromboembolic complications in prosthetic orthopedic surgery. J Orthop Sci. 2009 ; 14 (5). 484-490
20. Wahlander K, Larson G, Lindahl TL, et al. Factor V Leiden (G1691A) and prothrombin gene G20210A mutations as potential risk factors for venous thromboembolism after total hip or total knee replacement surgery. Thromb Haemost. 2002 ; 87 (4). 580-585
21. Mont MA, Jones LC, Rajadhyaksha AD, et al. Risk factors for pulmonary emboli after total hip or knee arthroplasty. Clin Orthop Relat Res. 2004 ; (422). 154-163
22. Salvati EA, Della Valle AG, Westrich GH, et al. The John Charnley Award: heritable thrombophilia and development of thromboembolic disease after total hip arthroplasty. Clin Orthop Relat Res. 2005 ; 441: 40-55
23. Ficat P Ischemia and Necrosis of Bone. Hungerford D, ed. Baltimore: Williams and Wilkins ; 1980: 171-176.
24. Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002 ; 32 (2). 94-124
25. McKee MD, Waddell JP, Kudo PA, Schemitsch EH, Richards RR. Osteonecrosis of the femoral head in men following short-course corticosteroid therapy: a report of 15 cases. CMAJ. 2001 ; 164 (2). 205-206
26. Glueck CJ, Freiberg R, Glueck HI, et al. Hypofibrinolysis: a common, major cause of osteonecrosis. Am J Hematol. 1994 ; 45 (2). 156-166
27. Glueck CJ, Freiberg R, Glueck HI, Tracy T, Stroop D, Wang Y. Idiopathic osteonecrosis, hypofibrinolysis, high plasminogen activator inhibitor, high lipoprotein(a), and therapy with stanozolol. Am J Hematol. 1995 ; 48 (4). 213-220
28. Glueck CJ, Freiberg R, Tracy T, Stroop D, Wang P. Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis. Clin Orthop. 1997 ; (334). 43-56
29. Van Veldhuizen PJ, Neff J, Murphey MD, Bodensteiner D, Skikne BS. Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip. Am J Hematol. 1993 ; 44 (4). 243-248
30. Glueck CJ, Freiberg RA, Oghene J, Fontaine RN, Wang P. Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur. J Bone Joint Surg Am. 2007 ; 89: 2460-2468
31. Koo KH, Lee JS, Lee YJ, Kim KJ, Yoo JJ, Kim HJ. Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis. J Orthop Res. 2006 ; 24 (8). 1722-1728
32. Arlet J. Ficat P. [Diagnosis of primary femur head osteonecrosis at stage 1 (preradiologic stage)]. Rev Chir Orthop Reparatrice Appar Mot. 1968 ; 54 (7). 637-648
33. Ridker PM, Miletich JP, Hennekens CH, Buring JE. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA. 1997 ; 277 (16). 1305-1307
34. Gregg JP, Yamane AJ, Grody WW. Prevalence of the factor V-Leiden mutation in four distinct American ethnic populations. Am J Med Genet. 1997 ; 73 (3). 334-336
35. Jadaon MM. Epidemiology of activated protein C resistance and factor v leiden mutation in the mediterranean region. Mediterr J Hematol Infect Dis. 2011 ; 3 (1). e2011054
36. Couturaud F, Kearon C, Leroyer C, et al. Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost. 2006 ; 96 (6). 744-749
37. Lensen R, Rosendaal F, Vandenbroucke J, Bertina R. Factor V Leiden: the venous thrombotic risk in thrombophilic families. Br J Haematol. 2000 ; 110 (4). 939-945
38. Glueck CJ, Tracy T, Wang P. Legg-Calve-Perthes disease, venous and arterial thrombi, and the factor V Leiden mutation in a four-generation kindred. J Pediatr Orthop. 2007 ; 27 (7). 834-837