In vivo lung deposition and sub-acute inhalation toxicity studies of nano-sized alendronate sodium as an antidote for inhaled toxic substances in Sprague Dawley rats

Environmental Toxicology and Pharmacology

Volumn 36, Issue 2, 2013, Pages 636-647

  Sultana, Shaheen ^a   Ali, Rashid ^b   Talegaonkar, Sushama ^a   Ahmad, Farhan Jalees ^a   Mittal, Gaurav ^b   Bhatnagar, Aseem ^b  

^a HAMDARD UNIVERSITY   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Alendronate sodium; Biodistribution; Gamma scintigraphy; Histopathology; Sub acute inhalation toxicity; Technetium 99m

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALENDRONIC ACID; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CATALASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TECHNETIUM 99M; URANIUM;

AEROSOL; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG FORMULATION; ENZYME ACTIVITY; HEMATOLOGY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; LACTATE DEHYDROGENASE BLOOD LEVEL; LUNG LAVAGE; LUNG TOXICITY; MALE; MICROSCOPY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION SICKNESS; RAT; TREATMENT OUTCOME;

ALENDRONATE SODIUM; BIODISTRIBUTION; GAMMA SCINTIGRAPHY; HISTOPATHOLOGY; SUB-ACUTE INHALATION TOXICITY; TECHNETIUM-99M;

ADMINISTRATION, INHALATION; AEROSOLS; ALENDRONATE; ANIMALS; ANTIDOTES; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; CHELATING AGENTS; DRUG ADMINISTRATION SCHEDULE; LUNG; MALE; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; TISSUE DISTRIBUTION;

EID: 84880372449     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2013.05.016     Document Type: Article

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