The lung, an organ for absorption?

Respiration

Volumn 72, Issue 5, 2005, Pages 552-558

  Von Wichert, Peter ^a,b   Seifart, Carola ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b NONE   (Germany)

Author keywords

Absorption; Drug uptake; Epithelium; Liquid balance; Proteins; Resorption

Indexed keywords

ADRENALIN; ALPHA INTERFERON; ANESTHETIC GAS; ANTIBIOTIC AGENT; BETA INTERFERON; BRONCHODILATING AGENT; CALCITONIN; CORTICOSTEROID; CYCLOSPORIN; ELECTROLYTE; ENKEPHALIN; ERYTHROPOIETIN; FOLLITROPIN; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HEPARIN; INSULIN; LIPID; LUTEINIZING HORMONE; MORPHINE; PARATHYROID HORMONE; PEPTIDE; PROTEIN; PROTEINASE INHIBITOR; SOMATOSTATIN; SUGAR; THYROTROPIN; UNINDEXED DRUG; VASOPRESSIN DERIVATIVE; WATER;

ABSORPTION; ACTIVE TRANSPORT; AIRWAY; DIABETES MELLITUS; ENDOCYTOSIS; EXCRETION; FLUID BALANCE; GAS EXCHANGE; HUMAN; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; NONHUMAN; PASSIVE TRANSPORT; PINOCYTOSIS; PRIORITY JOURNAL; REVIEW; TRANSCYTOSIS;

ABSORPTION; ADMINISTRATION, INHALATION; HUMANS; LIPIDS; LUNG; MOLECULAR WEIGHT; PROTEINS; RESPIRATORY MUCOSA;

EID: 26444548960     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000087685     Document Type: Review

References (90)

1. Murray JF: The Normal Lung. Philadelphia, Saunders, 1976.
2. Fishman AP: The nonrespiratory functions of the lungs; in Fisman AP (ed): Pulmonary Diseases and Disorders, ed 2. New York, McGraw-Hill, 1988.
3. Edwards DA, Ben-Jebria A, Langer R: Recent advances in pulmonary drug delivery using large, porous inhaled particles. J Appl Physiol 1998;85:379-385.
4. Gonda I: The ascent of pulmonary drug delivery. J Pharm Sci 2000;89:940-945.
5. Agu RU, Ugwoke MI, Armand M, Kinget R, Verbeke N: The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res 2001;2:198-209.
6. Gänsslen M: Über Inhalation von Insulin. Klin Wochenschr 1925;4:71.
7. Forbes B: Human airway epithelial cell lines for in vitro drug transport and metabolism studies. Pharm Sci Technol Today 2000;3:18-27.
8. Wigley FM, Londono JH, Wood SH, Shipp JC, Waldmann RH: Insulin across respiratory mucosa by aerosol delivery. Diabetes 1971;20:552-556.
9. Köhler D, Schluter KJ, Kerp L, Matthys H: Nicht radioaktives Verfahren zur Messung der Lungenpermeabilität: Inhalation von Insulin. Atemw Lungenkrkh 1987;13:230-232.
10. Cefalu WT, Balagtas CC, Landschulz WH, Gelfand RA: Sustained efficacy and pulmonary safety of inhaled insulin during 2-years outpatient therapy (abstract). Diabetes 2000;49(suppl 1):A406.
11. Todo H, Okamoto H, Lida K, Danjo K: Effect of additives on insulin absorption from intratracheally administered dry powders in rats. Int J Pharm 2001;220:101-110.
12. Groneberg DA, Witt C, Wagner U, Chung KF, Fischer A: Fundamentals of pulmonary drug delivery. Respir Med 2003;97:382-387.
13. Fiegel J, Ehrhardt C, Schaefer UF, Lehr CM, Hanes J: Large porous particle impingement on lung epithelial monolayers - Toward improved particle characterization in the lung. Pharm Res 2003;20:788-796.
14. Yu J, Chien YW: Pulmonary drug delivery: Physiologic and mechanistic aspects. Crit Rev Ther Drug Carrier Syst 1997;14:395-453.
15. Derendorf H, Hochhaus G, Mollmann H: Evaluation of pulmonary absorption using pharmakokinetic methods. J Aerosol Med 2001;14(suppl 1):S9-S17.
16. Johnson LG, Cheng PW, Boucher RC: Albumin absorption by canine bronchial epithelium. J Appl Physiol 1989;66:2772-2777.
17. von Hayek H: Die menschliche Lunge. Berlin, Springer, 1970.
18. Meyrick B, Reid L: The alveolar wall. Br J Dis Chest 1970;64:121-140.
19. Thrall RS, Peterson LB, Braley JF, Linehan JH, Dawson CA, Moore VL: Chronic pulmonary inflammation modulates the fate of proteins administered by the respiratory tract. J Lab Clin Med 1980;95:343-350.
20. Braley JF, Peterson LB, Dawson CA, Moore VL: Effect of hypersensitivity on protein uptake across the air-blood barrier of isolated rabbit lungs. J Clin Invest 1979;63:1103-1109.
21. Tillie-Leblond I, Guery BP, Janin A, Leberre R, Just N, Pittet JF, Tonnel AB, Gosset P: Chronic bronchial allergic inflammation increases alveolar liquid clearance by TNF-alpha-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 2002;283:L1303-L1309.
22. Sefrin P, Finkenzeller A: Endobronchial drug administration in resuscitation. Med Klin 1991;86:20-23.
23. Pittet JF, Lu LN, Morris DG, Modelska K, Welch WJ, Carrey HV, Roux J, Matthay MA: Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. J Immunol 2001;166:6301-6310.
24. Sartori C, Matthay MA: Alveolar epithelial fluid transport in acute lung injury: New insights. Eur Respir J 2002;20:1299-1313.
25. Folkesson HG, Norlin A, Baines DL: Salt and water transport across the alveolar epithelium in the developing lung: Correlations between function and recent molecular biology advances. Int J Mol Med 1998;2:515-531.
26. Staub NC: Pulmonary edema. Physiol Rev 1974;54:678-811.
27. DeFouw DO: Ultrastructural features of alveolar epithelial transport. Am Rev Respir Dis 1983;127:S9-S13.
28. Saumon G, Basset G: Electrolyte and fluid transport across the mature alveolar epithelium. J Appl Physiol 1993;74:1-15.
29. Lasnier JM, Wangensteen D, Schmitz LS, Gross CR, Ingbar DH: Terbutaline stimulates alveolar fluid resorption in hyperoxic lung injury. J Appl Physiol 1996;81:1723-1729.
30. Wang Y, Folkesson HG, Jayr C, Warer LB, Matthay MA: Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and β-agonist therapy. J Appl Physiol 1999;87:1852-1860.
31. Jayr V, Garat C, Meignan M, Pittet JF, Zelter M, Matthay MA: Alveolar liquid and protein clearance in anesthetized ventilated rats. J Appl Physiol 1994;76:2636-2642.
32. Ghofrani HA, Kohstall MG, Weissmann N, Schmehl T, Schermuly R, Seeger W, Grimminger F: Alveolar epithelial barrier functions in ventilated perfused rabbit lungs. Am J Physiol Lung Cell Mol Physiol 2001;280:L896-L904.
33. 2-agonists regulate surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem 2002;277:47318-47324.
34. Danto SI, Borok Z, Zhang XL, Lopez MZ, Patel P, Crandall ED, Lubman RL: Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells. Am J Physiol 1998;275:C82-C92.
35. Johnson MD, Widdicombe JH, Allen L, Barby P, Dobbs LG: Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci USA 2002;99:1966-1971.
36. Matalon S: Mechanisms and regulation of ion transport in adult mammalian alveolar type II pneumocytes. Am J Physiol 1991;261:C727-C738.
37. Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS: Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest 1999;103:555-561.
38. Matthay MA, Folkeson HG, Clerici C: Lung epithelial fluid transport and the resolution of pulmonary edema (review). Physiol Rev 2002;82:569-600.
39. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T: Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Clin Chest Med 2000;21:477-490.
40. Dobbs LG, Gonzales R, Matthay MA, Carter EP, Allen L, Verkman AS: High water-permeable type I alveolar epithelial cells confer high water permeability between the airspace and vasculature in rat lung. Proc Natl Acad Sci USA 1998;95:2991-2996.
41. Verkman AS, Matthay MA, Song Y: Aquaporin water channels and lung physiology. Am J Physiol Lung Cell Mol Physiol 2000;278:L867-L879.
42. Sakuma T, Hida M, Nambu Y, Osanai K, Togaa H, Takahashi K, Ohya N, Inoue M, Watanabe Y: Effects of hypoxia on alveolar fluid transport capacity in rat lungs. J Appl Physiol 2002;91:1766-1774.
43. Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C: Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: Reversal by beta-adrenergic agonist treatment. Am J Respir Cell Mol Biol 2001;25:554-561.
44. Dada LA, Sznajder JI: Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure. Crit Care Med 2003;31:S248-S252.
45. Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI: Hypoxia-induced endocytosis of Na-K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC. J Clin Invest 2003;111:1057-1064.
46. Planes C, Escoubet B, Blot-Chabaud M, Friedlander G, Farman N, Clerici C : Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells. Am J Respir Cell Mol Biol 1997;17:508-518.
47. Papen M, Wodopia R, Bärtsch P, Mairbaurl H: Hypoxia-effects on Ca(i)-signaling and ion transport activity of lung alveolar epithelial cells. Cell Physiol Biochem 2002;11:187-196.
48. Wodopia R, Ko HS, Billian J, Wiesner R, Bärtsch P, Mairbaurl H: Hypoxia decreases proteins involved in epithelial electrolyte transport in A549 cells and rat lung. Am J Physiol Lung Cell Mol Physiol 2000;279:L1110-L1119.
49. Clerici C, Matthay MA: Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol 2000;88:1890-1896.
50. Laffon M, Lu LN, Modelska K, Matthay MA, Pittet JF: Alpha-adrenergic blockade restores normal fluid transport capacity of alveolar epithelium after hemorrhagic shock. Am J Physiol 1999;277:L760-L768.
51. Ouiddir A, Planes C, Fernandes I, VanHesse A, Clerici C: Hypoxia upregulates activity and expression of the glucose transporter GLUT-1 in alveolar epithelial cells. Am J Respir Cell Mol Biol 1999;21:710-718.
52. Heberlein W, Wodopia R, Bärtsch P, Mairbaurl H: Possible role of ROS as mediators of hypoxia-induced ion transport inhibition of alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000;278:L640-L648.
53. Matalon S, O'Brodovich H: Sodium channels in alveolar epithelial cells: Molecular characterization, biophysical properties and physiological significance. Annu Rev Physiol 1999;61:627-661.
54. Ware L, Golden JA, Finkbeiner WE, Matthay MA: Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med 1999;159:980-988.
55. Folkesson HG, Nitenberg G, Oliver BL, Jayr C, Albertine KH, Matthay MA: Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin. Am J Physiol Lung Cell Mol Physiol 1998;275:L478-L490.
56. Effros RM, Mason GR: Measurements of pulmonary epithelial permeability in vivo. Am Rev Respir Dis 1998;127:S59-S65.
57. Bensch KG, Dominguez E, Liebow AA: Absorption of intact protein molecules across the pulmonary air-tissue barrier. Science 1967;157:1204-1206.
58. Williams MC: Endocytosis in alveolar type II cells: Effect of charge and size of tracers. Proc Natl Acad Sci USA 1984;81:6054-6058.
59. Wright JR: Clearance and recycling of pulmonary surfactant. Am J Physiol 1990;259:L1-L12.
60. Guthmann F, Harrach-Ruprecht B, Looman AC, Stevens PA, Robenek H, Rüstow B: Interaction of lipoproteins with type II pneumocytes in vitro. Eur J Cell Biol 1997;74:197-207.
61. Witt W, Kolleck I, Rüstow B: Identification of high density lipoprotein-binding proteins, including a glycosyl phosphatidylinositol-anchored membrane dipeptidase in rat lung and type II pneumocytes. Am J Respir Cell Mol Biol 2000;22:739-746.
62. Young SL, Wright JR, Clements JA: Cellular uptake and processing of surfactant lipids and apoprotein SP-A in rat lung. J Appl Physiol 1989;66:1336-1342.
63. Ryan RM, Morris RE, Rice WR, Ciraolo G, Whitsett JA: Binding and uptake of pulmonary surfactant protein (SP-A) by pulmonary type II epithelial cells. J Histochem Cytochem 1989;37:429-440.
64. Jiang XC, D'Armiento J, Mallampalli RK, Mar J, Yan SF, Lin M: Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia. J Biol Chem 1998;273:15714-15718.
65. Hastings RH, Folkeson HG, Matthay MA: Mechanisms of alveolar protein clearance in the intact lung. Am J Physiol Lung Cell Mol Physiol 2004;286:L679-L689.
66. Tino MJ, Wright JR: Interactions of surfactant protein A with epithelial cells and phagocytes. Biochim Biophys Acta 1998;1408:241-263.
67. Hastings RH, Folkesson HG, Petersen W, Ciriales R, Matthay MA: Cellular uptake of albumin instilled into the lungs of anesthetized rabbits. Am J Physiol Lung Cell Mol Physiol 1995;269:L453-L462.
68. Folkesson HG, Matthay MA, Weström BR, Kim KJ, Karlson BW, Hastings RH: Alveolar epithelial clearance of protein. J Appl Physiol 1996;80:1431-1445.
69. Peterson BT, Griffith DE, Tate RW: Clearance of proteins from air spaces following cardiogenic edema in sheep. Exp Lung Res 1998;24:41-56.
70. Hastings RH, Grady M, Sakuma T, Matthay MA: Clearance of different-sized proteins from the alveolar space in humans and rabbits. J Appl Physiol 1992;73:1310-1316.
71. Matsukawa Y, Yamahara H, Yamashita F, Lee VH, Crandall ED, Kim KJ: Rates of protein transport across rat alveolar epithelial cell monolayers. J Drug Target 2000;7:335-342.
72. Jones AT, Gumbleton M, Duncan R: Understanding endocatotic pathways and intracellular trafficking: A prerequisite for effective design of advanced drug delivery systems. Adv Drug Deliv Rev 2003;55:1353-1357.
73. Gumbleton M, Hollins AJ, Omidi Y, Campbell L, Taylor G: Targeting caveolae for vesicular drug transport. J Control Release 2003;87:139-151.
74. Hastings RH, Wright JR, Albertine KH, Ciriales R, Matthay MA: Effect of endocytosis inhibitors on alveolar clearance of albumin, immunoglobulin G and SP-A in rabbits. Am J Physiol Lung Cell Mol Physiol 1994;266:L544-L552.
75. Auricchio A, O'Connor E, Weiner D, Gao G, Hildinger M, Wang L, Calcedo R, Wilson JM: Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins. J Clin Invest 2002;110:499-504.
76. Kobayashi S, Kondo S, Juni K: Permeability of peptides and proteins in human culture alveolar A549 cell monolayer. Pharm Res 1995;12:1115-1119.
77. Groneberg DA, Nickolaus M, Springer J, Döring F, Daniel H, Fischer A: Localization of the peptide transporter PEPT2 in the lung: Implications for pulmonary oligopeptide uptake. Am J Pathol 2001;158:707-714.
78. Hamilton KO, Yazdanian MA, Audus KL: Contributions of efflux pump activity to the delivery of pulmonary therapeutics. Curr Drug Metab 2002;3:1-12.
79. Groneberg DA, Eynott PR, Döring F, Dinh QT, Oates T, Barnes PJ, Chung KF, Daniel H, Fischer A: Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax 2002;57:55-60.
80. Groneberg DA, Fischer A, Chung KF, Daniel H: Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport. Am J Respir Cell Mol Biol 2004;30:251-260.
81. Ehrhardt C, Kneuer C, Laue M, Schaefer UF, Kim K, Lehr CM: 16HBE140-human bronchial epithelial cell layers express p-glycoprotein, lung resistance-related protein and caveolin-1. Pharm Res 2003;20:545-551.
82. Tölle A, Kolleck I, Schlame M, Wauer R, Stevens PA, Rüstow B: Effect of hyperoxia on the composition of the alveolar surfactant and the turnover of surfactant phospholipids, cholesterol, plasmalogens and vitamin E. Biochim Biophys Acta 1997;1346:198-204.
83. Newhouse MT, Corkery KJ: Aerosols for systemic delivery of macromolecules. Respir Care Clin N Am 2001;7:261-275.
84. Lipworth BJ: Pharmacokinetics of inhaled drugs. Br J Clin Pharmacol 1996;42:697-705.
85. Patton JS: Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev 1996;19:3-36.
86. Foral PA, Malesker MA, Huerta G, Hilleman DE: Nebulized opioids use in COPD. Chest 2004;125:691-694.
87. Florea BI, Cassara ML, Junginger HE, Borchard G: Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. J Control Rel 2003;87:131-138.
88. Gumbleton M: Caveolae as potential macromolecule trafficking compartments within alveolar epithelium. Adv Drug Deliv Rev 2001;49:281-300.
89. Gindorf C, Steimer A, Lehr CM, Bock U, Schmitz S, Haltner E: Markertransport über biologische Barrieren. Altex 2001;18:155-164.
90. Fuchs S, Hollins AJ, Laue M, Schaefer UF, Roemer K, Gumbleton M, Lehr CM: Differentiation of human alveolar epithelial cells in primary culture. Cell Tissue Res 2003;311:31-45.