Dynamic equilibria between monomeric and oligomeric misfolded states of the mammalian prion protein measured by 19F NMR

Journal of the American Chemical Society

Volumn 135, Issue 28, 2013, Pages 10533-10541

  Larda, Sacha Thierry ^a   Simonetti, Karen ^b   Al Abdul Wahid, M Sameer ^a   Sharpe, Simon ^b,c   Prosser, R Scott ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CRITICAL STEPS; DYNAMIC EQUILIBRIA; MAMMALIAN PRION PROTEINS; MISFOLDED PROTEINS; MOLECULAR MECHANISM; RATE-LIMITING STEPS; SURROUNDING FORMATIONS; THERMODYNAMIC DRIVING FORCES;

AGGREGATES; MAMMALS; NEURODEGENERATIVE DISEASES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS;

PROTEINS;

BETA OCTAMER; OCTAMER TRANSCRIPTION FACTOR; PRION PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; FLUORINE NUCLEAR MAGNETIC RESONANCE; PRION DISEASE; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; THERMODYNAMICS;

ANIMALS; FLUORINE; HUMANS; KINETICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; THERMODYNAMICS;

EID: 84880371944     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja404584s     Document Type: Article

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