The hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers

Methods in Molecular Biology

Volumn 1015, Issue , 2013, Pages 279-289

  Kim, Mee J ^a   Ahituv, Nadav ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enhancer; Hydrodynamic tail vein; Pharmacogenomics; Promoter

Indexed keywords

LUCIFERASE; NUCLEIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSAY; CONTROLLED STUDY; ENHANCER REGION; ENZYME ASSAY; GENE REGULATORY NETWORK; HYDRODYNAMICS; LIVER; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHARMACOGENOMICS; PRIORITY JOURNAL; PROMOTER REGION; TAIL;

ANIMALS; ENHANCER ELEMENTS, GENETIC; GENE TRANSFER TECHNIQUES; HEPATOCYTES; HUMANS; LIVER; MICE; PROMOTER REGIONS, GENETIC; TAIL; TRANSFECTION; VEINS;

EID: 84880365088     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-435-7_18     Document Type: Article

References (23)

1. Zhang G, Budker V, Wolff JA (1999) High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 10:1735-1737
2. Eggenhofer E et al (2009) High volume naked DNA tail-vein injection restores liver function in Fah-knock out mice. Hepatology 25: 1002-1008
3. Herweijer H, Zhang G et al (2001) Time course of gene expression after plasmid DNA gene transfer to the liver. J Gene Med 3(3):280-291
4. Herweijer H, Wolff JA (2003) Progress and prospects: Naked DNA gene transfer and therapy. Gene Ther 10:453-458
5. Herweijer H, Wolff JA (2007) Gene therapy progress and prospects: Hydrodynamic gene delivery. Gene Ther 14:99-107
6. Lewis DL et al (2002) Effi cient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 32:107-108
7. McCaffrey AP et al (2002) RNA interference in adult mice. Nature 418:38-39
8. Sen A et al (2003) Inhibition of hepatitis C virus protein expression by RNA interference. Virus Res 96:27-35
9. Song E et al (2003) RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 9:347-351
10. Zender L et al (2003) Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci USA 100: 7797-7802
11. Xu J et al (2005) Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter. Biochem Biophys Res Commun 329:538-543
12. Keng VW et al (2011) Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the sleeping beauty transposon system. Hepatology 53:781-790
13. Zhou T et al (2010) Intracellular gene transfer in rats by tail vein injection of plasmid DNA. AAPS J 12:692-698
14. Chalasani N et al (2010) Genome-wide association study identifi es variants associated with histologic features of nonalcoholic fatty liver disease. Gastroenterology 139:1567-1576
15. Zhang H et al (2010) Genome-wide association study identifi es 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet 42:755-758
16. Chen WM et al (2008) Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest 118:2620-2628
17. Schadt EE et al (2008) Mapping the genetic architecture of gene expression in human liver. PLoS Biol 6:1020-1032
18. MIRUS, TransIT ® -EE Hydrodynamic Delivery Solution Protocol. http://www. mirusbio.com/assets/cms-files/protocols/ML043.pdf . Accessed July 2011
19. Choi JH et al (2009) Identifi cation and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics 19:770-780
20. Kim MJ et al (2011) Functional characterization of liver enhancers regulating drugassociated transporters. Clin Pharmacol Ther 89:571-578
21. Simonet WS et al (1993) A far-downstream hepatocyte-specifi c control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice. J Biol Chem 268:8221-8229
22. Caliper Life Sciences, IVIS ® Lumina II. http://www.caliperls.com/ products/preclinicalimaging/ivis-luminaii.htm . Accessed July 2011
23. Promega Corporation, Dual-Luciferase ® Reporter Assay Technical Manual. http://www.promega.com/resources/protocols/technical-manuals/0/dual- luciferase-reporterassay-system-protocol/ . Accessed July 2011