Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G

BMC Complementary and Alternative Medicine

Volumn 13, Issue , 2013, Pages

  Seesom, Weeranuch ^a   Jaratrungtawee, Amornmart ^a   Suksamrarn, Sunit ^a   Mekseepralard, Chantana ^a   Ratananukul, Piniti ^b   Sukhumsirichart, Wasana ^a  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b THAILAND CENTER OF EXCELLENCE IN PHYSICS   (Thailand)

Author keywords

Gamma Mangostin; Leptospira; Mangosteen; Penicillin G; Synergy; Xanthones

Indexed keywords

ANTIINFECTIVE AGENT; GARCINIA MANGOSTANA EXTRACT; PENICILLIN G; PLANT EXTRACT; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIABILITY; CONTROLLED STUDY; DRUG POTENTIATION; GARCINIA MANGOSTANA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG SYNERGISM; FRUIT; GARCINIA MANGOSTANA; HERB-DRUG INTERACTIONS; HUMANS; LEPTOSPIRA; LEPTOSPIROSIS; MICROBIAL SENSITIVITY TESTS; PENICILLIN G; PLANT EXTRACTS; XANTHONES;

EID: 84880334778     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-13-182     Document Type: Article

References (46)

1. Adler B, de la Pena Moctezuma A. Leptospira and leptospirosis. Vet Microbiol 2010, 140(3-4):287-296.
2. Ko AI, Galvao Reis M, Ribeiro Dourado CM, Johnson WD, Riley LW. Urban epidemic of severe leptospirosis in brazil. Salvador leptospirosis study group. Lancet 1999, 354(9181):820-825. 10.1016/S0140-6736(99)80012-9, 10485724.
3. Plank R, Dean D. Overview of the epidemiology, microbiology, and pathogenesis of Leptospira spp. in humans. Microbes and infection/Institut Pasteur 2000, 2(10):1265-1276. 10.1016/S1286-4579(00)01280-6, 11008116.
4. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, et al. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 2003, 3(12):757-771. 10.1016/S1473-3099(03)00830-2, 14652202.
5. Chow E, Deville J, Nally J, Lovett M, Nielsen-Saines K. Prolonged leptospira urinary shedding in a 10-year-old girl. Case reports in pediatrics 2012, 2012:169013. 3350071, 22606527.
6. Edwards CN, Nicholson GD, Hassell TA, Everard CO, Callender J. Penicillin therapy in icteric leptospirosis. AmJ Trop Med Hyg 1988, 39(4):388-390.
7. Watt G, Padre LP, Tuazon ML, Calubaquib C, Santiago E, Ranoa CP, Laughlin LW. Placebo-controlled trial of intravenous penicillin for severe and late leptospirosis. Lancet 1988, 1(8583):433-435.
8. McClain JB, Ballou WR, Harrison SM, Steinweg DL. Doxycycline therapy for leptospirosis. Ann Intern Med 1984, 100(5):696-698. 10.7326/0003-4819-100-5-696, 6712032.
9. Panaphut T, Domrongkitchaiporn S, Vibhagool A, Thinkamrop B, Susaengrat W. Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis. Clin Infect Dis 2003, 36(12):1507-1513. 10.1086/375226, 12802748.
10. Murray CK, Hospenthal DR. Determination of susceptibilities of 26 Leptospira sp. serovars to 24 antimicrobial agents by a broth microdilution technique. Antimicrob Agents Chemother 2004, 48(10):4002-4005. 10.1128/AAC.48.10.4002-4005.2004, 521904, 15388465.
11. Peres V, Nagem TJ, de Oliveira FF. Tetraoxygenated naturally occurring xanthones. Phytochemistry 2000, 55(7):683-710. 10.1016/S0031-9422(00)00303-4, 11190384.
12. Vieira LM, Kijjoa A. Naturally-occurring xanthones: recent developments. Curr Med Chem 2005, 12(21):2413-2446. 10.2174/092986705774370682, 16250871.
13. Sultanbawa MUS. Xanthonoids of tropical plants. Tetrahedron 1980, 36:1465-1506.
14. Jiang DJ, Dai Z, Li YJ. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovasc Drug Rev 2004, 22(2):91-102.
15. Chin YW, Kinghorn AD. Structural characterization, biological effects, and synthetic studies on xanthones from mangosteen (Garcinia mangostana), a popular botanical dietary supplement. Mini Rev Org Chem 2008, 5(4):355-364. 10.2174/157019308786242223, 3090081, 21562610.
16. Suksamrarn S, Komutiban O, Ratananukul P, Chimnoi N, Lartpornmatulee N, Suksamrarn A. Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2006, 54(3):301-305.
17. Suksamrarn S, Suwannapoch N, Phakhodee W, Thanuhiranlert J, Ratananukul P, Chimnoi N, Suksamrarn A. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003, 51(7):857-859.
18. Arunrattiyakorn P, Suksamrarn S, Suwannasai N, Kanzaki H. Microbial metabolism of alpha-mangostin isolated from Garcinia mangostana L. Phytochemistry 2011, 72(8):730-734. 10.1016/j.phytochem.2011.02.007, 21377704.
19. Pierce SC. A Thai Herbal 2003, 118. Scotland, UK: Findhorn Press.
20. Balasubramanian K, Rajagopalan K. Novel xanthones from Garcinia mangostana, structures of BR-xanthone-A and BR-xanthone-B. Phytochemistry 1988, 27:1552-1554.
21. Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W. Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes. Fitoterapia 2007, 78(6):401-408. 10.1016/j.fitote.2007.02.019, 17644272.
22. Chen LG, Yang LL, Wang CC. Anti-inflammatory activity of mangostins from Garcinia mangostana. Food Chem Toxicol 2008, 46(2):688-693. 10.1016/j.fct.2007.09.096, 18029076.
23. Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue Y, Ohizumi H. Gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol Pharmacol 2004, 66(3):667-674. 10.1124/mol.104.002626, 15322259.
24. Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M. Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. J Nutr 2010, 140(4):842-847. 10.3945/jn.109.120022, 20181789.
25. Matsumoto K, Akao Y, Yi H, Ohguchi K, Ito T, Tanaka T, Kobayashi E, Iinuma M, Nozawa Y. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg Med Chem 2004, 12(22):5799-5806. 10.1016/j.bmc.2004.08.034, 15498656.
26. Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci 2008, 9(3):355-370. 10.3390/ijms9030355, 2635669, 19325754.
27. Watanapokasin R, Jarinthanan F, Jerusalmi A, Suksamrarn S, Nakamura Y, Sukseree S, Uthaisang-Tanethpongtamb W, Ratananukul P, Sano T. Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: caspase-dependent apoptosis induction in vitro and in mice. Appl Biochem Biotechnol 2010, 162(4):1080-1094. 10.1007/s12010-009-8903-6, 20101528.
28. Larson RT, Lorch JM, Pridgeon JW, Becnel JJ, Clark GG, Lan Q. The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor. J Med Entomol 2010, 47(2):249-257. 10.1603/ME09160, 2855149, 20380307.
29. Vlietinck AJ, De Bruyne T, Apers S, Pieters LA. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection. Planta Med 1998, 64(2):97-109. 10.1055/s-2006-957384, 9525100.
30. Kaomongkolgit R, Jamdee K, Chaisomboon N. Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci 2009, 51(3):401-406. 10.2334/josnusd.51.401, 19776506.
31. Chomnawang MT, Surassmo S, Wongsariya K, Bunyapraphatsara N. Antibacterial activity of Thai medicinal plants against methicillin-resistant Staphylococcus aureus. Fitoterapia 2009, 80(2):102-104. 10.1016/j.fitote.2008.10.007, 19022354.
32. Sundaram BM, Gopalakrishnan C, Subramanian S, Shankaranarayanan D, Kameswaran L. Antimicrobial activities of Garcinia mangostana. Planta Med 1983, 48(1):59-60.
33. Chomnawang MT, Surassmo S, Nukoolkarn VS, Gritsanapan W. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol 2005, 101(1-3):330-333.
34. Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK, Tyers M, Brown ED, Wright GD. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat Chem Biol 2011, 7(6):348-350. 10.1038/nchembio.559, 21516114.
35. Adwan G, Mhanna M. Synergistic effects of plant extracts and antibiotics on staphylococcus aureus strains isolated from clinical specimens. Middle-East J Sci Res 2008, 3:134-139.
36. Rani Basu L, Mazumdar K, Dutta NK, Karak P, Dastidar SG. Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine. Microbiol Res 2005, 160(1):95-100. 10.1016/j.micres.2004.10.002, 15782943.
37. Chaivishangkura A, Malaikaew Y, Chaovanalikit A, Jaratrungtawee A, Panseeta P, Ratananukul P, Suksamrarn S. Prenylated xanthone composition of the Garcinia mangostana (mangosteen) fruit hull. Chromatographia 2009, 69:315-318.
38. Eloff JN. A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria. Planta medica 1998, 64(8):711-713. 10.1055/s-2006-957563, 9933989.
39. Murray CK, Hospenthal DR. Broth microdilution susceptibility testing for Leptospira spp. Antimicrob Agents Chemother 2004, 48:1548-1552. 10.1128/AAC.48.5.1548-1552.2004, 400540, 15105104.
40. American Society for Microbiology Instruction to authors. Antimicrob Agents Chemother 1995, 39:I-xiv. American Society for Microbiology.
41. Dharmaratne HR, Sakagami Y, Piyasena KG, Thevanesam V. Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies. Nat Prod Res 2012, Epub ahead of print.
42. Haake DA, Walker EM, Blanco DR, Bolin CA, Miller MN, Lovett MA. Changes in the surface of Leptospira interrogans serovar grippotyphosa during in vitro cultivation. Infect Immun 1991, 59(3):1131-1140. 258378, 1997416.
43. Brenot A, Trott D, Saint Girons I, Zuerner R. Penicillin-binding proteins in Leptospira interrogans. Antimicrob Agents Chemother 2001, 45(3):870-877. 10.1128/AAC.45.3.870-877.2001, 90386, 11181373.
44. Chang HF, Yang LL. Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. Molecules 2012, 17(7):8010-8021.
45. Sukma M, Tohda M, Suksamran S, Tantisira B. γ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression. J Ethnopharmacol 2011, 35(2):450-454.
46. Chitchumroonchokchai C, Riedl KM, Suksumrarn S, Clinton SK, Kinghorn AD, Faillab ML. Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. J Nutr 2012, 142(4):675-680. 10.3945/jn.111.156992, 3301988, 22399525.