Comprehensive profiling of peripheral immune cells and subsets in patients with intermittent allergic rhinitis compared to healthy controls and after treatment with glucocorticoids

Inflammation

Volumn 36, Issue 4, 2013, Pages 821-829

  Zhang, Huan ^a   Cardell, Lars Olaf ^b   Bjorkander, Janne ^a,c   Benson, Mikael ^a   Wang, Hui ^a,d  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c RYHOV COUNTY HOSPITAL   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

glucocorticoids; intermittent allergic rhinitis; orthogonal partial least squares discriminant analysis; peripheral blood

Indexed keywords

ANTIHISTAMINIC AGENT; FLUTICASONE; GLUCOCORTICOID; NITRIC OXIDE;

ADOLESCENT; ADULT; ARTICLE; BASOPHIL; BIRCH; BIRCH POLLEN; CELL SEPARATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; DISEASE ASSOCIATION; EOSINOPHIL; FEMALE; FLOW CYTOMETRY; HAY FEVER; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; MULTIPLE CYCLE TREATMENT; MULTIVARIATE ANALYSIS; PARTIAL LEAST SQUARES REGRESSION; PATIENT COMPLIANCE; POLLEN; TH2 CELL; TREATMENT DURATION; TREATMENT RESPONSE; VISUAL ANALOG SCALE;

ADOLESCENT; ADULT; BASOPHILS; BETULA; CASE-CONTROL STUDIES; EOSINOPHILS; FEMALE; GLUCOCORTICOIDS; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NASAL MUCOSA; RHINITIS, ALLERGIC, SEASONAL; TH2 CELLS; YOUNG ADULT;

EID: 84880322672     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-013-9608-0     Document Type: Article

References (51)

1. Braunstahl, G.J.; and P.W. Hellings. 2006. Nasobronchial interaction mechanisms in allergic airways disease. Current Opinion in Otolaryngology & Head and Neck Surgery 14: 176-182.
2. Saini, S.; D.C. Bloom, A. Bieneman, K. Vasagar, A. Togias, and J. Schroeder. 2004. Systemic effects of allergen exposure on blood basophil IL-13 secretion and FcεRIβ. The Journal of Allergy and Clinical Immunology 114: 768-774.
3. Denburg, J.A. 1998. The origins of basophils and eosinophils in allergic inflammation. The Journal of Allergy and Clinical Immunology 102: S74-S76.
4. Orhan, F.; B.E. Sekerel, G. Adalioglu, M. Pinar, and A. Tuncer. 2004. Effect of nasal triamcinolone acetonide on seasonal variations of bronchial hyperresponsiveness and bronchial inflammation in nonasthmatic children with seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology 92: 438-445.
5. Poggi, A.; P. Canevali, M. Contatore, and G. Ciprandi. 2012. Higher frequencies of CD161+ circulating T lymphocytes in allergic rhinitis patients compared to healthy donors. International Archives of Allergy and Immunology 158: 151-156.
6. Moniuszko, M.; A. Bodzenta-Lukaszyk, and M. Dabrowska. 2010. Effects of oral glucocorticoid therapy on CD4+ CD25+ CD127-and CD4+ CD25high T cell levels in asthmatic patients. Inflammation 33: 415-420.
7. Greiner, A.N.; P.W. Hellings, G. Rotiroti, and G.K. Scadding. 2011. Allergic rhinitis. The Lancet 378: 2112-2122.
8. Akdis, M.; J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, R. Crameri, S. Thunberg, G. Deniz, R. Valenta, H. Fiebig, C. Kegel, R. Disch, C.B. Schmidt-Weber, K. Blaser, and C.A. Akdis. 2004. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. The Journal of Experimental Medicine 199: 1567-1575.
9. Woodfolk, J.A. 2007. T-cell responses to allergens. The Journal of Allergy and Clinical Immunology 119: 280-294.
10. KleinJan, A.; M. Willart, L.S. van Rijt, G.J. Braunstahl, K. Leman, S. Jung, H.C. Hoogsteden, and B.N. Lambrecht. 2006. An essential role for dendritic cells in human and experimental allergic rhinitis. The Journal of Allergy and Clinical Immunology 118: 1117-1125.
11. Glück, J.; B. Rogala, E. Rogala, and E. Oles. 2007. Allergen immunotherapy in intermittent allergic rhinitis reduces the intracellular expression of IL-4 by CD8+ T cells. Vaccine 26: 77-81.
12. Benson, M.; L. Carlsson, G. Guillot, M. Jernas, M.A. Langston, M. Rudemo, and B. Andersson. 2006. A network-based analysis of allergen-challenged CD4+ T cells from patients with allergic rhinitis. Genes and Immunity 7: 514-521.
13. Cirillo, I.; F.L.M. Ricciardolo, G. Medusei, A. Signori, and G. Ciprandi. 2013. Exhaled nitric oxide may predict bronchial hyperreactivity in patients with allergic rhinitis. International Archives of Allergy and Immunology 160: 322-328.
14. Paton, J.Y. 2012. Perception of lung function, adherence to inhaled corticosteroids, and the role of peak expiratory flow feedback in paediatric asthma. Thorax 67: 1023-1024.
15. Bousquet, P.J.; C. Bachert, G.W. Canonica, T.B. Casale, J. Mullol, J.M. Klossek, T. Zuberbier, and J. Bousquet. 2010. Uncontrolled allergic rhinitis during treatment and its impact on quality of life: a cluster randomized trial. Journal of Allergy and Clinical Immunology 126: 666-668. e665.
16. Zhao, Y.; H. Wang, M. Gustafsson, A. Muraro, S. Bruhn, and M. Benson. 2012. Combined multivariate and pathway analyses show that allergen-induced gene expression changes in CD4+ T cells are reversed by glucocorticoids. PLoS One 7: e39016.
17. Whelehan, O.P.; M.E. Earll, E. Johansson, M. Toft, and L. Eriksson. 2006. Detection of ovarian cancer using chemometric analysis of proteomic profiles. Chemometrics and Intelligent Laboratory Systems 84: 82-87.
18. Vinay, P.; E. Allignet, C. Pichette, M. Watford, G. Lemieux, and A. Gougoux. 1980. Changes in renal metabolite profile and ammoniagenesis during acute and chronic metabolic acidosis in dog and rat. Kidney International 17: 312-325.
19. Cosmi, L.; F. Annunziato, M. Iwasaki, G. Galli, R. Manetti, E. Maggi, K. Nagata, and S. Romagnani. 2000. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. European Journal of Immunology 30: 2972-2979.
20. Cosmi, L.; R. De Palma, V. Santarlasci, L. Maggi, M. Capone, F. Frosali, G. Rodolico, V. Querci, G. Abbate, R. Angeli, L. Berrino, M. Fambrini, M. Caproni, F. Tonelli, E. Lazzeri, P. Parronchi, F. Liotta, E. Maggi, S. Romagnani, and F. Annunziato. 2008. Human interleukin 17-producing cells originate from a CD161 + CD4+ T cell precursor. The Journal of Experimental Medicine 205: 1903-1916.
21. Liu, W.; A.L. Putnam, Z. Xu-Yu, G.L. Szot, M.R. Lee, S. Zhu, P.A. Gottlieb, P. Kapranov, T.R. Gingeras, B. Fazekas de St Groth, C. Clayberger, D.M. Soper, S.F. Ziegler, and J.A. Bluestone. 2006. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. The Journal of Experimental Medicine 203: 1701-1711.
22. Rossi, R.L.; G. Rossetti, L. Wenandy, S. Curti, A. Ripamonti, R.J. Bonnal, R.S. Birolo, M. Moro, M.C. Crosti, P. Gruarin, S. Maglie, F. Marabita, D. Mascheroni, V. Parente, M. Comelli, E. Trabucchi, R. De Francesco, J. Geginat, S. Abrignani, and M. Pagani. 2011. Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b. Nature Immunology 12: 796-803.
23. Thysell, E.; I. Surowiec, E. Hornberg, S. Crnalic, A. Widmark, A.I. Johansson, P. Stattin, A. Bergh, T. Moritz, H. Antti, and P. Wikstrom. 2010. Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol. PLoS One 5: e14175.
24. Moazzami, A.A.; R. Andersson, and A. Kamal-Eldin. 2010. Changes in the metabolic profile of rat liver after alpha-tocopherol deficiency as revealed by metabolomics analysis. NMR in Biomedicine 24: 499-505.
25. Stone, K.D.; C. Prussin, and D.D. Metcalfe. 2010. IgE, mast cells, basophils, and eosinophils. The Journal of Allergy and Clinical Immunology 125: S73-S80.
26. Okano, M.; A. Satoskar, M. Abe, D. Harn, K. Nishizaki, Y. Takeda, T. Yoshino, F. Brombacher, and A. Satoskar. 2001. Interleukinâ€4â €ndependent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. Allergy 55: 723-731.
27. Woschnagg, C.; R. Garcia, S. Rak, and P. Venge. 2002. IL†priming of the PMAâ€nduced oxidative metabolism of human eosinophils from allergic and normal subjects during a pollen season. Clinical and Experimental Allergy 31: 555-564.
28. Ohnishi, T.; H. Kita, D. Weiler, S. Sur, J. Sedgwick, W. Calhoun, W. Busse, J. Abrams, and G. Gleich. 1993. IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction. American Journal of Respiratory and Critical Care Medicine 147: 901-907.
29. Wang, H.; R. Mobini, Y. Fang, F. Barrenäs, H. Zhang, Z. Xiang, and M. Benson. 2010. Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases ILâ€7RB, which regulates basophil apoptosis and degranulation. Clinical and Experimental Allergy 40: 1194-1202.
30. Wang, J.; Q.J. Cheng, and P. Konecny. 2003. Hemopoietic cells with features of the mast cell and basophil lineages and their potential role in allergy. Current Drug Targets. Inflammation and Allergy 2: 293-302.
31. Savage, J.H.; J.-P. Courneya, P.M. Sterba, D.W. MacGlashan, S.S. Saini, and R.A. Wood. 2012. Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy. Journal of Allergy and Clinical Immunology 130: 1123-1129. e1122.
32. Sullivan, B.M.; and R.M. Locksley. 2009. Basophils: a nonredundant contributor to host immunity. Immunity 30: 12-20.
33. Kaplan, A.P. 2001. Chemokines, chemokine receptors and allergy. International Archives of Allergy and Immunology 124: 423-431.
34. Reed, C. 1994. The importance of eosinophils in the immunology of asthma and allergic disease. Annals of Allergy 72: 376.
35. Till, S.J.; L.A. Jopling, P.A. Wachholz, R.L. Robson, S. Qin, D.P. Andrew, L. Wu, J. van Neerven, T.J. Williams, and S.R. Durham. 2001. T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4. The Journal of Immunology 166: 2303-2310.
36. Nausch, N.; C.D. Bourke, L.J. Appleby, N. Rujeni, O. Lantz, F. Trottein, N. Midzi, T. Mduluza, and F. Mutapi. 2012. Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Sci Rep 2: 472.
37. McKinney, E.F.; P.A. Lyons, E.J. Carr, J.L. Hollis, D.R.W. Jayne, L.C. Willcocks, M. Koukoulaki, A. Brazma, V. Jovanovic, and D.M. Kemeny. 2010. A CD8+ T cell transcription signature predicts prognosis in autoimmune disease. Nature Medicine 16: 586-591.
38. de Vos, G.; J.M. Milush, J. Aaron, Y. Pichardo, V.A. York, R. Nazari, D. Rosenstreich, D.F. Nixon, and A. Wiznia. 2012. Peripheral CD8+ T-cell levels are decreased in atopic wheezing children aged less than 4 years. Journal of Investigational Allergology and Clinical Immunology 22: 442-444.
39. Bousquet, J.; N. Khaltaev, A. Cruz, J. Denburg, W. Fokkens, A. Togias, T. Zuberbier, C. Baena-Cagnani, G. Canonica, and C. Van Weel. 2008. Allergic rhinitis and its impact on asthma (ARIA) 2008*. Allergy 63: 8-160.
40. Okano, M. 2009. Mechanisms and clinical implications of glucocorticosteroids in the treatment of allergic rhinitis. Clinical and Experimental Immunology 158: 164-173.
41. Rhen, T.; and J.A. Cidlowski. 2005. Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. The New England Journal of Medicine 353: 1711-1723.
42. Barnes, P.J.; and I.M. Adcock. 2009. Glucocorticoid resistance in inflammatory diseases. The Lancet 373: 1905-1917.
43. Leung, D.Y.M.; and J.W. Bloom. 2003. Update on glucocorticoid action and resistance. The Journal of Allergy and Clinical Immunology 111: 3-22.
44. Karagiannidis, C.; M. Akdis, P. Holopainen, N.J. Woolley, G. Hense, B. Rückert, P.-Y. Mantel, G. Menz, C.A. Akdis, K. Blaser, and C.B. Schmidt-Weber. 2004. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. The Journal of Allergy and Clinical Immunology 114: 1425-1433.
45. Piemonti, L.; P. Monti, P. Allavena, M. Sironi, L. Soldini, B.E. Leone, C. Socci, and V. Di Carlo. 1999. Glucocorticoids affect human dendritic cell differentiation and maturation. The Journal of Immunology 162: 6473-6481.
46. Mainali, E.S.; T. Kikuchi, and J.G. Tew. 2005. Dexamethasone inhibits maturation and alters function of monocyte-derived dendritic cells from cord blood. Pediatric Research 58: 125-131.
47. Holm, A.; W. Fokkens, T. Godthelp, P. Mulder, T. Vroom, and E. Rijntjes. 1995. Effect of 3 months' nasal steroid therapy on nasal T cells and Langerhans cells in patients suffering from allergic rhinitis. Allergy 50: 204-209.
48. Durham, S.R.; H.J. Gould, C.P. Thienes, M.R. Jacobson, K. Masuyama, S. Rak, O. Lowhagen, E. Schotman, L. Cameron, and Q.A. Hamid. 1997. Expression of ε germ-line gene transcripts and mRNA for the ε heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. European Journal of Immunology 27: 2899-2906.
49. Masuyama, K.; M. Jacobson, S. Rak, Q. Meng, R. Sudderick, A. Kay, O. Lowhagen, Q. Hamid, and S. Durham. 1994. Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis. Immunology 82: 192.
50. Erin, E.M.; A.S. Zacharasiewicz, G.C. Nicholson, A.J. Tan, L.A. Higgins, T.J. Williams, R.D. Murdoch, S.R. Durham, P.J. Barnes, and T.T. Hansel. 2005. Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge. Clinical and Experimental Allergy 35: 1608-1614.
51. Umland, S.P.; D.K. Nahrebne, S. Razac, A. Beavis, K.J. Pennline, R.W. Egan, and M.M. Billah. 1997. The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-gamma production by cultured primary CD4+ T cells. The Journal of Allergy and Clinical Immunology 100: 511-519.