[6]-Shogaol inhibits the production of proinflammatory cytokines via regulation of NF-κB and phosphorylation of JNK in HMC-1 cells

Immunopharmacology and Immunotoxicology

Volumn 35, Issue 4, 2013, Pages 462-470

  Sohn, Youngjoo ^a   Han, Na Young ^a   Lee, Min Jung ^a   Cho, Hyun Joo ^a   Jung, Hyuk Sang ^a  

^a Kyung Hee University   (South Korea)

Author keywords

6 Shogaol; Cytokines; Human mast cell; Nuclear factor B; Passive cutaneous anaphylaxis

Indexed keywords

ANTIALLERGIC AGENT; CALCIMYCIN; CYTOKINE; EVANS BLUE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; SHOGAOL; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GINGER; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MAST CELL; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PERITONEUM CELL; PERITONEUM MAST CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIMYCIN; CALCIUM IONOPHORES; CARCINOGENS; CATECHOLS; CELL LINE; CYTOKINES; HISTAMINE RELEASE; HUMANS; INFLAMMATION; MALE; MAP KINASE KINASE 4; MAST CELLS; MUTAGENS; NF-KAPPA B; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TETRADECANOYLPHORBOL ACETATE;

EID: 84880314501     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2013.782318     Document Type: Article

References (54)

1. Govindarajan VS. Ginger-chemistry, technology, and quality evaluation: part 1. Crit Rev Food Sci Nutr 1982; 17: 1-96.
2. Suekawa M, Ishige A, Yuasa K, et al. Pharmacological studies on ginger. I: pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn 1984; 7: 836-848.
3. Pan MH, Hsieh MC, Hsu PC, et al. 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Mol Nutr Food Res 2008; 52: 1467-1477.
4. Dugasani S, Pichika MR, Nadarajah VD, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol 2010; 127: 515-520.
5. Sabina EP, Rasool M, Mathew L, et al. 6-Shogaol inhibits monosodium urate crystal-induced inflammation-an in vivo and in vitro study. Food Chem Toxicol 2010; 48: 229-235.
6. Profet M. The function of allergy: immunological defense against toxins. Q Rev Biol 1991; 66: 23-62.
7. Singh B, Nadkarni JR, Vishwakarma RA, et al. The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition. J Ethnopharmacol 2012; 141: 469-473.
8. Mekori YA, Oh CK, Dastych J, et al. Characterization of a mast cell line that lacks the extracellular domain of membrane c-kit. Immunology 1997; 90: 518-525.
9. Kemp SF, Lockey RF. Anaphylaxis: a review of causes and mechanisms. J Allergy Clin Immunol 2002; 110: 341-348.
10. Kim, HM, Park, YA, Lee, EJ, Shin, TY. Inhibition of immediatetype allergic reaction by Rosa davurica Pall. in a murine model. J Ethnopharmacol 1999; 67: 53-60.
11. Shakoory B, Fitzgerald SM, Lee SA, et al. The role of human mast cell-derived cytokines in eosinophil biology. J Interferon Cytokine Res 2004; 24: 271-281.
12. Salamon P, Shoham NG, Gavrieli R, et al. Human mast cells release Interleukin-8 and induce neutrophil chemotaxis on contact with activated T cells. Allergy 2005; 60: 1316-1319.
13. Galli SJ. Mast cells and basophils. Curr Opin Hematol 2000; 7: 32-39.
14. Gordon JR, Burd PR, Galli SJ. Mast cells as a source of multifunctional cytokines. Immunol Today 1990; 11: 458-464.
15. Kim SH, Shin TY. Amomum xanthiodes inhibits mast cellmediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production. Exp Biol Med (Maywood) 2005; 230: 681-687.
16. Petersen LJ, Mosbech H, Skov PS. Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability. J Allergy Clin Immunol 1996; 97: 672-679.
17. Ennis M, Pearce FL, Weston PM. Some studies on the release of histamine from mast cells stimulated with polylysine. Br J Pharmacol 1980; 70: 329-334.
18. Tasaka K, Mio M, Okamoto M. Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann Allergy 1986; 56: 464-469.
19. Koibuchi Y, Ichikawa A, Nakagawa M, Tomita K. Binding of active components of compound 48/80 to rat peritoneal mast cells. Eur J Pharmacol 1985; 115: 171-177.
20. Ortner MJ, Chignell CF. The effect of concentration on the binding of compound 48/80 to rat mast cells: a fluorescence microscopy study. Immunopharmacology 1981; 3: 187-191.
21. Li GZ, Chai OH, Lee MS, et al. Inhibitory effects of Houttuynia cordata water extracts on anaphylactic reaction and mast cell activation. Biol Pharm Bull 2005; 28: 1864-1868.
22. Hong SH, Kim MS, Lee JY, et al. Novel findings in inhibition of mast cell-dependent immediate-type cutaneous reactions by Gahmi-Shini-San. Clin Chim Acta 2001; 309: 85-90.
23. Hachisuka H, Kusuhara M, Higuchi M, et al. Purification of rat cutaneous mast cells with Percoll density centrifugation. Arch Dermatol Res 1988; 280: 358-362.
24. Yurt RW, Leid Jr RW, Austen KF. Native heparin from rat peritoneal mast cells. J Biol Chem 1977; 252: 518-521.
25. Lee K, Sohn Y, Lee MJ, et al. Effects of Angelica acutiloba on mast cell-mediated allergic reactions in vitro and in vivo. Immunopharmacol Immunotoxicol 2011; 34: 571-577.
26. Kim EK, Kim EY, Moon PD, et al. Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells. Biosci Biotechnol Biochem 2007; 71: 2886-2892.
27. Schoonbroodt S, Legrand-Poels S, Best-Belpomme M, Piette J. Activation of the NF-kappaB transcription factor in a Tlymphocytic cell line by hypochlorous acid. Biochem J 1997; 321: 777-785.
28. Cochrane DE, Douglas WW. Calcium-induced extrusion of secretory granules (exocytosis) in mast cells exposed to 48-80 or the ionophores A-23187 and X-537A. Proc Natl Acad Sci USA 1974; 71: 408-412.
29. Chai OH, Kim EK, Lee YH, et al. Histamine release induced by dendroaspis natriuretic peptide from rat mast cells. Peptides 2001; 22: 1421-1426.
30. Galli SJ, Kalesnikoff J, Grimbaldeston MA, et al. Mast cells as ''tunable'' effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005; 23: 749-786.
31. Church MK, Levi-Schaffer F. The human mast cell. J Allergy Clin Immunol 1997; 99: 155-160.
32. Lantz CS, Boesiger J, Song CH, et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 1998; 392: 90-93.
33. Takai Y, Kishimoto A, Iwasa Y, et al. Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids. J Biol Chem 1979; 254: 3692-3695.
34. Kishimoto A, Takai Y, Mori T, et al. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem 1980; 255: 2273-2276.
35. Castagna M, Takai Y, Kaibuchi K, et al. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumorpromoting phorbol esters. J Biol Chem 1982; 257: 7847-7851.
36. Moon PD, Choi IH, Kim HM. Naringenin suppresses the production of thymic stromal lymphopoietin through the blockade of RIP2 and caspase-1 signal cascade in mast cells. Eur J Pharmacol 2011; 671: 128-132.
37. Moller A, Henz BM, Grutzkau A, et al. Comparative cytokine gene expression: regulation and release by human mast cells. Immunology 1998; 93: 289-295.
38. Pelletier C, Varin-Blank N, Rivera J, et al. Fc epsilonRI-mediated induction of TNF-alpha gene expression in the RBL-2H3 mast cell line: regulation by a novel NF-kappaB-like nuclear binding complex. J Immunol 1998; 161: 4768-4776.
39. Walsh LJ, Trinchieri G, Waldorf HA, et al. Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci USA 1991; 88: 4220-4224.
40. Mican JA, Arora N, Burd PR, Metcalfe DD. Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein. J Allergy Clin Immunol 1992; 90: 815-824.
41. Park HS, Jung KS, Hwang SC, et al. Neutrophil infiltration and release of IL-8 in airway mucosa from subjects with grain dust-induced occupational asthma. Clin Exp Allergy 1998; 28: 724-730.
42. Mukaida N. Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. Int J Hematol. 2000; 72: 391-398.
43. Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest 2001; 107: 7-11.
44. Yamashita N, Koizumi H, Murata M, et al. Nuclear factor kappa B mediates interleukin-8 production in eosinophils. Int Arch Allergy Immunol 1999; 120: 230-236.
45. Ward C, Chilvers ER, Lawson MF, et al. NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J Biol Chem 1999; 274: 4309-4318.
46. Fujihara S, Ward C, Dransfield I, et al. Inhibition of nuclear factorkappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. Eur J Immunol 2002; 32: 457-466.
47. Baeuerle PA, Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 1988; 242: 540-546.
48. Baeuerle PA, Baltimore D. NF-kappa B: ten years after. Cell. 1996; 87: 13-20.
49. Azzolina A, Guarneri P, Lampiasi N. Involvement of p38 and JNK MAPKs pathways in substance P-induced production of TNF-alpha by peritoneal mast cells. Cytokine 2002; 18: 72-80.
50. Boudreau RT, Hoskin DW, Lin TJ. Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK. J Leukoc Biol 2004; 76: 1075-1081.
51. Guma M, Kashiwakura J, Crain B, et al. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci USA 2010; 107: 22122-22127.
52. Lewi, TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998; 74: 49-139.
53. Kang OH, Choi JG, Lee JH, Kwon DY. Luteolin isolated from the flowers of Lonicera japonica suppresses inflammatory mediator release by blocking NF-kappaB and MAPKs activation pathways in HMC-1 cells. Molecules 2010; 15: 385-398.
54. Wong CK, Tsang CM, Ip WK, Lam CW. Molecular mechanisms for the release of chemokines from human leukemic mast cell line (HMC)-1 cells activated by SCF and TNF-alpha: roles of ERK, p38 MAPK, and NF-kappaB. Allergy 2006; 61: 289-297.