Additional histopathologic examination of the lungs from a 3-month inhalation toxicity study with multiwall carbon nanotubes in rats

Toxicological Sciences

Volumn 134, Issue 1, 2013, Pages 103-110

  Treumann, Silke ^a   Ma Hock, Lan ^a   Gröters, Sibylle ^a   Landsiedel, Robert ^a   van Ravenzwaay, Bennard ^a  

^a BASF SE   (Germany)

Author keywords

90 day inhalation study; Asbestos; Fibrosis; Lung; MWCNT; Pleura

Indexed keywords

COLLAGEN; MULTI WALLED NANOTUBE; AEROSOL; AIR POLLUTANT; CARBON NANOTUBE; LIPOPROTEIN; RETICULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ELECTRON MICROSCOPY; FEMALE; FIBER; HISTOPATHOLOGY; INHALATION; LUNG ALVEOLUS WALL; LUNG PARENCHYMA; LUNG TOXICITY; LYMPH NODE; MALE; NONHUMAN; RAT; AEROSOL; AIR POLLUTANT; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; ECHOGRAPHY; EXPOSURE; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG GRANULOMA; METABOLISM; NEUTROPHIL CHEMOTAXIS; ORGAN SIZE; PARTICLE SIZE; PATHOLOGY; PRACTICE GUIDELINE; PROCEDURES; TISSUE DISTRIBUTION; TOXICITY; TOXICITY TESTING; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AEROSOLS; AIR POLLUTANTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANULOMA, RESPIRATORY TRACT; GUIDELINES AS TOPIC; INHALATION EXPOSURE; LIPOPROTEINS; LUNG; MACROPHAGES, ALVEOLAR; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOTUBES, CARBON; NEUTROPHIL INFILTRATION; ORGAN SIZE; PARTICLE SIZE; RATS; RETICULIN; TISSUE DISTRIBUTION; TOXICITY TESTS, SUBCHRONIC;

EID: 84880301988     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kft089     Document Type: Article

References (22)

1. Bernstein, D. M., Chevalier, J., and Smith, P. (2005a). Comparison of Calidria chrysotile asbestos to pure tremolite: Final results of the inhalation biopersistence and histopathology examination following short-term exposure. Inhal. Toxicol. 17, 427-449.
2. Bernstein, D. M., Rogers, R., and Smith, P. (2005b). The biopersistence of Canadian chrysotile asbestos following inhalation: Final results through 1 year after cessation of exposure. Inhal. Toxicol. 17, 1-14.
3. Bernstein, D. M., and Hoskins, J. A. (2006). The health effects of chrysotile: Current perspective based upon recent data. Regul. Toxicol. Pharmacol. 45, 252-264.
4. Bernstein, D. M., Rogers, R., Smith, P., and Chevalier, J. (2006). The toxicological response of Brazilian chrysotile asbestos: A multidose subchronic 90-day inhalation toxicology study with 92-day recovery to assess cellular and pathological response. Inhal. Toxicol. 18, 313-332.
5. Davis, J. M., and Cowie, H. A. (1990). The relationship between fibrosis and cancer in experimental animals exposed to asbestos and other fibers. Environ. Health Perspect. 88, 305-309.
6. Dungworth, D. L., Ernst, H., Nolte, T., and Mohr, U. (1992). Nonneoplastic lesions in the lungs. In Pathobiology of the Aging Rat (U. Mohr, C. C. Capen, D. L. Dungworth, R. A. Griesemer, N. Ito, and V. S. Turusov, Eds.), Vol. I, pp. 143-160. ILSI Press, Washington, DC.
7. Ma-Hock, L., Gamer, A. O., Landsiedel, R., Leibold, E., Frechen, T., Sens, B., Linsenbuehler, M., and van Ravenzwaay, B. (2007). Generation and characterization of test atmospheres with nanomaterials. Inhal. Toxicol. 19, 833-848.
8. Ma-Hock, L., Treumann, S., Strauss, V., Brill, S., Luizi, F., Mertler, M., Wiench, K., Gamer, A. O., van Ravenzwaay, B., and Landsiedel, R. (2009). Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol. Sci. 112, 468-481.
9. Manke, A., Wang, L., and Rojanasakul, Y. (2013). Pulmonary toxicity and fibrogenic response of carbon nanotubes. Toxicol. Mech. Methods 23, 196-206.
10. Mitchell, L. A., Gao, J., Wal, R. V., Gigliotti, A., Burchiel, S. W., and McDonald, J. D. (2007). Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol. Sci. 100, 203-214.
11. Muller, J., Huaux, F., Moreau, N., Misson, P., Heilier, J. F., Delos, M., Arras, M., Fonseca, A., Nagy, J. B., and Lison, D. (2005). Respiratory toxicity of multi-wall carbon nanotubes. Toxicol. Appl. Pharmacol. 207, 221-231.
12. Mutlu, G. M., Budinger, G. R., Green, A. A., Urich, D., Soberanes, S., Chiarella, S. E., Alheid, G. F., McCrimmon, D. R., Szleifer, I., and Hersam, M. C. (2010). Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett. 10, 1664-1670.
13. OECD (1981). OECD Guidelines for Testing of Chemicals, Section 4: Health Effects, No. 413, Sub-Chronic Inhalation Toxicity: 90-day Study. Organisation for Economic Cooperation and Development, Paris.
14. Pauluhn, J. (2010). Multi-walled carbon nanotubes (Baytubes): Approach for derivation of occupational exposure limit. Regul. Toxicol. Pharmacol. 57, 78-89.
15. Pierce, J. S., McKinley, M. A., Paustenbach, D. J., and Finley, B. L. (2008). An evaluation of reported no-effect chrysotile asbestos exposures for lung cancer and mesothelioma. Crit. Rev. Toxicol. 38, 191-214.
16. Porter, D. W., Hubbs, A. F., Mercer, R. R., Wu, N., Wolfarth, M. G., Sriram, K., Leonard, S., Battelli, L., Schwegler-Berry, D., Friend, S., et al. (2010). Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269, 136-147.
17. Shvedova, A. A., Kisin, E. R., Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. I., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., et al. (2005). Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 289, L698-L708.
18. Titford, M. (2009). Progress in the development of microscopical techniques for diagnostic pathology. J. Histotech. 32, 9-19.
19. Tran, C. L., Hankin, S. M., Ross, B., Aitken, R. J., Jones, A. D., Donaldson, K., Stone, V., and Trantra, R. (2008). An Outline Scoping Study to Determine Whether High Aspect Ratio Nanoparticles (harn) Should Raise the Same Concerns as Do Asbestos Fibres. Report on project CB0406. Available at: http://www.iom-support.co.uk/Portals/3/SN_Content/Documents/HARN.pdf. Accessed March 2011.
20. Vlasova, I. I., Vakhrusheva, T. V., Sokolov, A. V., Kostevich, V. A., Gusev, A. A., Gusev, S. A., Melnikova, V. I., and Lobach, A. S. (2012). PEGylated single-walled carbon nanotubes activate neutrophils to increase production of hypochlorous acid, the oxidant capable of degrading nanotubes. Toxicol. Appl. Pharmacol. 264, 131-142.
21. Warheit, D. B. (2009). Long-term inhalation toxicity studies with multiwalled carbon nanotubes: Closing the gaps or initiating the debate? Toxicol. Sci. 112, 273-275.
22. Yarborough, C. M. (2007). The risk of mesothelioma from exposure to chrysotile asbestos. Curr. Opin. Pulm. Med. 13, 334-338.