A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma

Carcinogenesis

Volumn 34, Issue 7, 2013, Pages 1529-1535

  Plantinga, Theo S ^a   Costantini, Irene ^a   Heinhuis, Bas ^a   Huijbers, Angelique ^a   Semango, George ^a   Kusters, Benno ^a,b   Netea, Mihai G ^a   Hermus, Ad R M M ^a   Smit, Jan W A ^a   Dinarello, Charles A ^a   Joosten, Leo A B ^a   Netea Maier, Romana T ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 32; INTERLEUKIN 32 BETA; INTERLEUKIN 32 GAMMA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; RADIOACTIVE IODINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOMA CELL; CELL STIMULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EPITHELIUM CELL; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GERM LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; THYROID CARCINOMA; THYROIDECTOMY; TUMOR REGRESSION;

ADULT; ALLELES; CASE-CONTROL STUDIES; EPITHELIAL CELLS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKINS; IODINE RADIOISOTOPES; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; THYROID NEOPLASMS; THYROIDECTOMY;

EID: 84880298347     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt092     Document Type: Article

References (31)

1. Cunha, L.L. et al. (2012) Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma. Clin. Endocrinol. (Oxf), 77, 918-925.
2. Wei, Q. et al. (2012) Density of tumor associated macrophage correlates with lymph node metastasis in papillary thyroid carcinoma. Thyroid, 22, 905-910.
3. Jemal, A. et al. (2006) Cancer statistics, 2006. CA. Cancer J. Clin., 56, 106-130.
4. Kondo, T. et al. (2006) Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat. Rev. Cancer, 6, 292-306.
5. Roger, P.P. et al. (2010) Signal transduction in the human thyrocyte and its perversion in thyroid tumors. Mol. Cell. Endocrinol., 321, 3-19.
6. Fugazzola, L. et al. (2011) Papillary thyroid carcinoma and inflammation. Front. Endocrinol. (Lausanne)., 2, 88.
7. Liotti, F. et al. (2012) Inflammation in thyroid oncogenesis. Am. J. Cancer Res., 2, 286-297.
8. Heinhuis, B. et al. (2010) IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2. Ann. Rheum. Dis., 69, 1866-1872.
9. Joosten, L.A. et al. (2006) IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A., 103, 3298-3303.
10. Calabrese, F. et al. (2008) IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 178,894-901.
11. Marcondes, A.M. et al. (2008) Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc. Natl. Acad. Sci. U.S.A., 105, 2865-2870.
12. Seo, E.H. et al. (2008) Detection of expressed IL-32 in human stomach cancer using ELISA and immunostaining. J. Microbiol. Biotechnol., 18, 1606-1612.
13. Nishida, A. et al. (2009) Interleukin-32 expression in the pancreas. J. Biol. Chem., 284, 17868-17876.
14. Sorrentino, C. et al. (2009) Expression of IL-32 in human lung cancer is related to the histotype and metastatic phenotype. Am. J. Respir. Crit. Care Med., 180, 769-779.
15. Heinhuis, B. et al. (2011) Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann. Rheum. Dis., 70, 660-667.
16. Hong, J. et al. (2010) Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta. Cytokine,49, 171-176.
17. Netea, M.G. et al. (2005) IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A.,102, 16309-16314.
18. Jung, M.Y. et al. (2011) IL-32gamma induces the maturation of dendritic cells with Th1-and Th17-polarizing ability through enhanced IL-12 and IL-6 production. J. Immunol., 186, 6848-6859.
19. Oh, J.H. et al. (2011) IL-32γ inhibits cancer cell growth through inactivation of NF-?B and STAT3 signals. Oncogene, 30, 3345-3359.
20. Arcaroli, J.J. et al. (2011) Association between IL-32 genotypes and outcome in infection-associated acute lung injury. Crit. Care, 15, R138.
21. Sobin, L.H. (2002) UICC TNM Classification of Malignant Tumours. Wiley-Liss, Hoboken, NJ.
22. Meyer, N. et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J. Allergy Clin. Immunol., 125, 858-865.
23. Netea, M.G. et al. (2006) Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism. PLoS Med., 3, e277.
24. Heinhuis, B. et al. (2011) Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A., 108, 4962-4967.
25. Li, W. et al. (2010) IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J. Immunol., 185, 5056-5065.
26. Nicola, J.P. et al. (2009) Functional toll-like receptor 4 conferring lipopolysaccharide responsiveness is expressed in thyroid cells. Endocrinology, 150, 500-508.
27. Ajjan, R.A. et al. (1998) Regulation and tissue distribution of the human sodium iodide symporter gene. Clin. Endocrinol. (Oxf), 49, 517-523.
28. Ajjan, R.A. et al. (1998) The sodium iodide symporter gene and its regulation by cytokines found in autoimmunity. J. Endocrinol., 158, 351-358.
29. Arturi, F. et al. (1998) Iodide symporter gene expression in human thyroid tumors. J. Clin. Endocrinol. Metab., 83, 2493-2496.
30. Ferretti, E. et al. (2008) Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors. J. Clin. Endocrinol. Metab., 93, 4080-4087.
31. Riesco-Eizaguirre, G. et al. (2006) The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I- targeting to the membrane. Endocr. Relat. Cancer, 13, 257-269.