Inflammation-dependent secretion and splicing of IL-32γ in rheumatoid arthritis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 12, 2011, Pages 4962-4967

  Heinhuis, Bas ^a   Koenders, Marije I ^a   Van De Loo, Fons A ^a   Netea, Mihai G ^a   Van Den Berg, Wim B ^a   Joosten, Leo A B ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; INTERLEUKIN 32; INTERLEUKIN 32GAMMA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM;

3T3 CELLS; ADENOVIRIDAE; ALTERNATIVE SPLICING; ANIMALS; ARTHRITIS, RHEUMATOID; CYTOKINES; FIBROBLASTS; HELA CELLS; HUMANS; INFLAMMATION; INTERLEUKINS; MICE; PROTEIN ISOFORMS; RNA SPLICE SITES; SYNOVIAL MEMBRANE;

MUS;

EID: 79953197232     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1016005108     Document Type: Article

References (28)

1. Goda C, et al. (2006) Involvement of IL-32 in activation-induced cell death in T cells. Int Immunol 18:233-240. (Pubitemid 43160136)
2. Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (2005) Interleukin-32: A cytokine and inducer of TNFα. Immunity 22:131-142.
3. Dahl CA, Schall RP, He HL, Cairns JS (1992) Identification of a novel gene expressed in activated natural killer cells and T cells. J Immunol 148:597-603.
4. Mun SH, et al. (2009) Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum 60:678-685.
5. Shioya M, et al. (2007) Epithelial overexpression of interleukin- 32α in inflammatory bowel disease. Clin Exp Immunol 149:480-486. (Pubitemid 47256156)
6. Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol 125:858-865, e10.
7. Marcondes AM, et al. (2008) Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function. Proc Natl Acad Sci USA 105:2865-2870. (Pubitemid 351723635)
8. Netea MG, et al. (2006) Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-γ-dependent mechanism. PLoS Med 3:e277.
9. Heinhuis B, et al. (2010) IL-32γ and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2. Ann Rheum Dis 69:1866-1872.
10. Bai X, et al. (2010) IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol 184:3830-3840.
11. Heinhuis B, et al. (December 27, 2010) Tumour necrosis factor α-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade. Ann Rheum Dis, 10.1136/ard.2010.139196.
12. Hong J, et al. (2010) Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFα and IL-1β. Cytokine 49:171-176.
13. Nold-Petry CA, et al. (2009) IL-32-dependent effects of IL-1β on endothelial cell functions. Proc Natl Acad Sci USA 106:3883-3888.
14. Nold MF, et al. (2008) Endogenous IL-32 controls cytokine and HIV-1 production. J Immunol 181:557-565.
15. Joosten LA, et al. (2006) IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci USA 103:3298-3303. (Pubitemid 43346464)
16. Wahl MC, Will CL, Lührmann R (2009) The spliceosome: Design principles of a dynamic RNP machine. Cell 136:701-718.
17. Montell C, Fisher EF, Caruthers MH, Berk AJ (1984) Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol Cell Biol 4:966-972. (Pubitemid 14051814)
18. Bendtsen JD, Nielsen H, von Heijne G, Brunak S (2004) Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340:783-795. (Pubitemid 38829638)
19. Choi J, et al. (2010) Paradoxical effects of constitutive human IL-32γ in transgenic mice during experimental colitis. Proc Natl Acad Sci USA 107:21082-21086.
20. Cagnard N, et al. (2005) Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes. Eur Cytokine Netw 16:289-292. (Pubitemid 350056544)
21. Kalsheker N, Swanson T (1990) Exclusion of an exon in monocyte α-1-antitrypsin mRNA after stimulation of U937 cells by interleukin-6. Biochem Biophys Res Commun 172:1116-1121.
22. Mizgerd JP, Spieker MR, Lupa MM (2002) Exon truncation by alternative splicing of murine ICAM-1. Physiol Genomics 12:47-51.
23. Kobayashi H, et al. (2010) Interleukin-32β propagates vascular inflammation and exacerbates sepsis in a mouse model. PLoS One 5:e9458.
24. Shoda H, et al. (2006) Interactions between IL-32 and tumor necrosis factor α contribute to the exacerbation of immune-inflammatory diseases. Arthritis Res Ther 8:R166.
25. Choi JD, et al. (2009) Identification of the most active interleukin-32 isoform. Immunology 126:535-542.
26. Netea MG, et al. (2005) IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1β and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci USA 102:16309-16314. (Pubitemid 41688910)
27. Alsaleh G, et al. (2010) Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 12:R135.
28. Hasegawa H, Thomas HJ, Schooley K, Born TL (2011) Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein. Cytokine 53:74-83.