Neuroendocrine carcinoma of the stomach morphologic and immunohistochemical characteristics and prognosis

American Journal of Surgical Pathology

Volumn 37, Issue 7, 2013, Pages 949-959

  Ishida, Michihiro ^a   Sekine, Shigeki ^b   Fukagawa, Takeo ^a   Ohashi, Masaki ^a   Morita, Shinji ^a   Taniguchi, Hirokazu ^c   Katai, Hitoshi ^a   Tsuda, Hitoshi ^c   Kushima, Ryoji ^c  

^a Gastric Surgery Division   (United States)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Immunohistochemistry; Neuroendocrine carcinoma; Prognosis; Stomach

Indexed keywords

CD56 ANTIGEN; CHROMOGRANIN A; SYNAPTOPHYSIN; TUMOR MARKER;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CARCINOMA; CELL SIZE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; JAPAN; KAPLAN MEIER METHOD; MALE; METABOLISM; METASTASIS; METHODOLOGY; MIDDLE AGED; MORTALITY; PATHOLOGY; PRECANCER; PROGNOSIS; STOMACH TUMOR; SURVIVAL RATE; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD56; CARCINOMA, NEUROENDOCRINE; CELL SIZE; CHROMOGRANIN A; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; JAPAN; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE; SYNAPTOPHYSIN; TUMOR MARKERS, BIOLOGICAL;

EID: 84880292117     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31828ff59d     Document Type: Article

References (40)

1. Solcia E, Arnold R, Capella C. Neuroendocrine neoplasms of the stomach. WHO Classification of Tumours of the Digestive System. Lyon: IARC Press; 2010:64-68.
2. Kloppel G. Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer. 2011;18:S1-S16.
3. Rindi G, Luinetti O, Cornaggia M, et al. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology. 1993;104: 994-1006.
4. Rindi G, Bordi C, Rappel S, et al. Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J Surg. 1996;20:168-172.
5. Rindi G, Azzoni C, La Rosa S, et al. ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis. Gastroenterology. 1999;116: 532-542.
6. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063-3072.
7. La Rosa S, Inzani F, Vanoli A, et al. Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms. Hum Pathol. 2011;42:1373-1384.
8. Klimstra DS, Modlin IR, Coppola D, et al. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 2010;39:707-712.
9. Matsui K, Jin XM, Kitagawa M, et al. Clinicopathologic features of neuroendocrine carcinomas of the stomach: appraisal of small cell and large cell variants. Arch Pathol Lab Med. 1998;122: 1010-1017.
10. Jiang SX, Mikami T, Umezawa A, et al. Gastric large cell neuroendocrine carcinomas: a distinct clinicopathologic entity. Am J Surg Pathol. 2006;30:945-953.
11. Kubota T, Ohyama S, Hiki N, et al. Endocrine carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single institute. Gastric Cancer. 2012;15:323-330.
12. Shia J, Tang LH, Weiser MR, et al. Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol. 2008;32:719-731.
13. Capella C, La Rosa S, Uccella S, et al. Mixed endocrine-exocrine tumors of the gastrointestinal tract. Semin Diagn Pathol. 2000;17: 91-103.
14. Erickson LA, Lloyd RV. Practical markers used in the diagnosis of endocrine tumors. Adv Anat Pathol. 2004;11:175-189.
15. Rayhan N, Sano T, Qian ZR, et al. Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach. J Med Invest. 2005;52:191-202.
16. Shida T, Furuya M, Kishimoto T, et al. The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors. Mod Pathol. 2008;21:1363-1370.
17. Wang YC, Gallego-Arteche E, Iezza G, et al. Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. Endocr Relat Cancer. 2009;16:267-279.
18. Sobin LH, Gospodarowicz MK,Wittekind CTNM. Classification of Malignant Tumours. 7th ed. Oxford, UK: Wiley-Blackwell; 2009.
19. Ueyama T, Tsuneyoshi M. Poorly differentiated solid type adenocarcinomas in the stomach: a clinicopathologic study of 71 cases. J Surg Oncol. 1992;51:81-87.
20. Isobe Y, Nashimoto A, Akazawa K, et al. Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry. Gastric Cancer. 2011;14:301-316.
21. Nishikura K, Watanabe H, Iwafuchi M, et al. Carcinogenesis of gastric endocrine cell carcinoma: analysis of histopathology and p53 gene alteration. Gastric Cancer. 2003;6:203-209.
22. Maehara Y, Kabashima A, Koga T, et al. Vascular invasion and potential for tumor angiogenesis and metastasis in gastric carcinoma. Surgery. 2000;128:408-416.
23. Ikeguchi M, Katano K, Oka A, et al. Relationship between hematogenic metastasis of gastric cancer and the maximum extent of venous invasion by cancer cells in the gastric wall. Hepatogastroenterology. 1995;42:660-665.
24. Ishida M, Morita S, Saka M, et al. Metachronous liver metastasis from early gastric cancer. J Gastrointest Surg. 2012;16:837-841.
25. Maehara Y, Emi Y, Baba H, et al. Recurrences and related characteristics of gastric cancer. Br J Cancer. 1996;74:975-979.
26. Katai H, Maruyama K, Sasako M, et al. Mode of recurrence after gastric cancer surgery. Dig Surg. 1994;11:99-103.
27. Borges M, Linnoila RI, van de Velde HJ, et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature. 1997;386:852-855.
28. Ito T, Udaka N, Yazawa T, et al. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development. 2000;127:3913-3921.
29. Jiang SX, Kameya T, Asamura H, et al. hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. Mod Pathol. 2004;17:222-229.
30. Ball DW, Azzoli CG, Baylin SB, et al. Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proc Natl Acad Sci USA. 1993;90:5648-5652.
31. Shida T, Furuya M, Nikaido T, et al. Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas. Clin Cancer Res. 2005;11:450-458.
32. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998;125:2213-2221.
33. Cheng L, Chen CL, Luo P, et al. Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci. 2003;23:9961-9967.
34. Craven SE, Lim KC, Ye W, et al. Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development. 2004;131: 1165-1173.
35. Cai YC, Banner B, Glickman J, et al. Cytokeratin 7 and 20 and thyroid transcription factor 1 can help distinguish pulmonary from gastrointestinal carcinoid and pancreatic endocrine tumors. Hum Pathol. 2001;32:1087-1093.
36. Sturm N, Rossi G, Lantuejoul S, et al. Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids. Hum Pathol. 2002;33:175-182.
37. Li AF, Li AC, Hsu CY, et al. Small cell carcinomas in gastrointestinal tract: immunohistochemical and clinicopathological features. J Clin Pathol. 2010;63:620-625.
38. Lee H, Choi J, An JS, et al. The clinicopathological characteristics of gastrointestinal neuroendocrine tumors; an analysis of 65 cases. Korean J Pathol. 2007;41:149-157.
39. Agoff SN, Lamps LW, Philip AT, et al. Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol. 2000;13:238-242.
40. Namikawa T, Kobayashi M, Okabayashi T, et al. Primary gastric small cell carcinoma: report of a case and review of the literature. Med Mol Morphol. 2005;38:256-261.