Carcinogenesis of gastric endocrine cell carcinoma: Analysis of histopathology and p53 gene alteration

Gastric Cancer

Volumn 6, Issue 4, 2003, Pages 203-209

  Nishikura, Ken ^a   Watanabe, Hidenobu ^a   Iwafuchi, Mitsuya ^b   Fujiwara, Takato ^a   Kojima, Kazuko ^a   Ajioka, Yoichi ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Carcinogenesis; Carcinoid tumor; Endocrine cell carcinoma; p53; Stomach

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; ASIAN; CANCER PATIENT; CARCINOID; CELL CLONE; CELL TYPE; CONTROLLED STUDY; ENDOCRINE CELL; FEMALE; GASTRIC ENDOCRINE CELL CARCINOMA; GENE SEQUENCE; GENETIC ANALYSIS; HISTOGENESIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; JAPAN; MAJOR CLINICAL STUDY; MALE; MICRODISSECTION; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; STOMACH CARCINOGENESIS; STOMACH CARCINOMA;

ADENOCARCINOMA; AGED; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; ENDOCRINE GLAND NEOPLASMS; ENTEROENDOCRINE CELLS; FEMALE; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; STOMACH NEOPLASMS;

EID: 0942276879     PISSN: 14363291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10120-003-0249-0     Document Type: Article

References (18)

1. Watanabe H, Jass JR, Sobin LH. Histological typing of oesophageal and gastric tumors. 2nd Ed. Berlin Heidelberg New York Tokyo: Springer; 1990: p 24-7.
2. Solcia E, Kloppel G, Sobin LH. Histological typing of endocrine tumors. 2nd Ed. Berlin Heidelberg New York Tokyo: Springer; 2000: p 61-4.
3. Nishikura K, Watanabe H, Iwafuchi M. PCNA index and nuclear morphometry for diagnosing higher malignancies of endocrine cell tumors in the large intestine. Acta Med Biol 1997;45:143-51.
4. Nishikura K, Watanabe H, Iwafuchi M, Ajioka Y, Hashidate H, Tanabe T, et al. Histological overview of the classification of gastric carcinoid (in Japanese with English summary). Stomach and Intestine 2000;35:1349-54.
5. Iwafuchi M, Watanabe H, Ishihara N, Noda Y, Ajioka Y. Histopathology of careinoid tumor and endocrine cell carcinoma in gastrointestinal tract (in Japanese). Clin Gastroenterol 1990;5: 1669-81.
6. Tahara E. Molecular mechanism of stomach carcinogenesis. J Cancer Res Clin Oncol 1993;119:265-72.
7. Uchino S, Noguchi M, Ochiai A, Saito T, Kobayashi M, Hirohashi S. p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer. Int J Cancer 1993;54:859-64.
8. Renault B, Broek M, Fodde R, Wijnen J, Pellegata NS, Amadori D, et al. Base transitions are the most frequent genetic changes at p53 in gastric cancer. Cancer Res 1993;53:2614-7.
9. Ohashi Y, Watanabe H, Ajioka Y, Hatakeyama K. p53 immunostaining distinguishes malignant from benign lesions of the gallbladder. Pathol Int 1995;45:58-65.
10. Nakagawa S, Watanabe H, Ajioka Y, Nishikura K, Hitomi J, Hatakeyama K. Archival analysis of p53 protein overexpression and genetic mutation in esophageal squamous cell carcinoma. Acta Med Biol 1996;44:63-9.
11. Imazeki F, Omata M, Nose H, Ohto M, Isono K. p53 gene mutations in gastric and esophageal cancers. Gastroenterology 1992; 103:892-6.
12. Soussei T, Fromentel CC, May P. Structural aspects of the p53 protein in relation to gene evolution. Oncogene 1990;5:945-52.
13. Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
14. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papilloma virus type 16 and 18 promotes degradation of p53. Cell 1990;63:1129-36.
15. Yokozaki H, Kuniyasu H, Kitadai Y, Nishimura K, Todo H, Ayhan A, et al. p53 point mutations in primary human gastric carcinomas. J Cancer Res Clin Oncol 1992:119:67-70.
16. Poremba C, Yandell DW, Huang Q, Little JB, Mellin W, Schmid KW, et al. Frequency and spectrum of p53 mutations in gastric cancer - a molecular genetic and immunohistochemical study. Virchows Arch 1995;426:447-55.
17. Vortmeyer AO, Lubensky IA, Merino MJ, Wang C, Pham T, Furth EE, et al. Concordance of genetic alterations in poorly differentiated colorectal neuroendocrine carcinomas and associated adenocarcinomas. J Natl Cancer Inst 1997;89:1448-53.
18. Itsuno M, Watanabe H, Iwafuchi M, Ito S, Yanaihara N, Sato K, et al. Multiple carcinoids and endocrine cell micronests in type A gastritis - their morphology, histogenesis, and natural history. Cancer 1989;63:881-90.