A novel ex vivo culture model for inflammatory bone destruction

Journal of Dental Research

Volumn 92, Issue 8, 2013, Pages 728-734

  Sloan, A J ^a   Taylor, S Y ^a   Smith, E L ^a,c   Roberts, J L ^a   Chen, L ^b   Wei, X Q ^a   Waddington, R J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

bone; inflammation; LPS; osteoclast; periodontal disease; RANKL MCSF

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; AUTACOID; BONE SIALOPROTEIN; COLLAGEN TYPE 1; IBSP PROTEIN, MOUSE; INTERLEUKIN 23; INTERLEUKIN 6; ISOENZYME; LIPOPOLYSACCHARIDE; OSTEOCALCIN; OSTEOPONTIN; SCLEROPROTEIN; SPP1 PROTEIN, MOUSE; TARTRATE-RESISTANT ACID PHOSPHATASE; TUMOR NECROSIS FACTOR ALPHA;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BONE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; DISEASE MODEL; IMMUNOLOGY; INFLAMMATION; JAW DISEASE; MACROPHAGE; MALE; MONOCYTE; MOUSE; NEUTROPHIL; ORGAN CULTURE TECHNIQUE; OSTEOCLAST; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTITIS; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; RANKL/MCSF;

BONE; INFLAMMATION; LPS; OSTEOCLAST; PERIODONTAL DISEASE; RANKL/MCSF;

ACID PHOSPHATASE; ALVEOLAR BONE LOSS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; INFLAMMATION MEDIATORS; INTEGRIN-BINDING SIALOPROTEIN; INTERLEUKIN-23; INTERLEUKIN-6; ISOENZYMES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MANDIBULAR DISEASES; MICE; MONOCYTES; NEUTROPHILS; ORGAN CULTURE TECHNIQUES; OSTEOCALCIN; OSTEOCLASTS; OSTEOPONTIN; PERIODONTAL LIGAMENT; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880290824     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034513495240     Document Type: Article

References (30)

1. Adamopoulos IE, Tessmer M, Chao CC, Adda S, Gorman D, Petro M, et al. IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass. J Immunol. 2011 ; 187: 951-959
2. Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998 ; 160: 403-409
3. Bartold PM, Cantley MD, Haynes DR. Mechanisms and control of pathologic bone loss in periodontitis. Periodontol. 2010 ; 2000: 53 55-69
4. Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, et al. TNF-alpha and pathologic bone resorption. Keio J Med. 2005 ; 54: 127-131
5. Chen L, Wei XQ, Evans B, Jiang W, Aeschlimann D. IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappaB (RANK) expression in myeloid precursor cells. Eur J Immunol. 2008 ; 38: 2845-2854
6. Dhopatkar AA, Sloan AJ, Rock WP, Cooper PR, Smith AJ. British Orthodontic Society, Chapman Prize Winner 2003. A novel in vitro culture model to investigate the reaction of the dentine-pulp complex to orthodontic force. J Orthod. 2005 ; 32: 122-132
7. Fuller K, Owens JM, Jagger CJ, Wilson A, Moss R, Chambers TJ. Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts. J Exp Med. 1993 ; 178: 1733-1744
8. Geivelis M, Turner DW, Pederson ED, Lamberts BL. Measurements of interleukin-6 in gingival crevicular fluid from adults with destructive periodontal disease. J Periodontol. 1993 ; 64: 980-983
9. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol. 1990 ; 145: 3297-3303
10. Jin Q, Cirelli JA, Park CH, Sugai JV, Taba M, Kostenuik PJ, et al. RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis. J Periodontol. 2007 ; 78: 1300-1308
11. Kato N, Nakayama Y, Nakajima Y, Samoto H, Saito R, Yamanouchi F, et al. Regulation of bone sialoprotein (BSP) gene transcription by lipopolysaccharide. J Cell Biochem. 2006 ; 97: 368-379
12. Kim JH, Jin HM, Kim K, Song I, Youn BU, Matsuo K, et al. The mechanism of osteoclast differentiation induced by IL-1. J Immunol. 2009 ; 183: 1862-1870
13. Koide M, Suda S, Saitoh S, Ofuji Y, Suzuki T, Yoshie H, et al. In vivo administration of IL-1 beta accelerates silk ligature-induced alveolar bone resorption in rats. J Oral Pathol Med. 1995 ; 24: 420-434
14. Kong YY, Boyle WJ, Penninger JM. Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol Cell Biol. 1999 ; 77: 188-193
15. Lamster IB, Novak MJ. Host mediators in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. Crit Rev Oral Biol Med. 1992 ; 3: 31-60
16. Lerner UH. New molecules in the tumour necrosis factor ligand and receptor superfamilies with importance for physiological and pathological bone resorption. Crit Rev Oral Biol Med. 2004 ; 15: 64-81
17. Mogi M, Otogoto J, Ota N, Inagaki H, Minami M, Kojima K. Interleukin 1 beta, interleukin 6, beta 2-microglobulin, and transforming growth factor-alpha in gingival crevicular fluid from human periodontal disease. Arch Oral Biol. 1999 ; 44: 535-539
18. Nagahama SI, Cunningham ML, Lee MY, Byers MR. Normal development of dental innervation and nerve/tissue interactions in the colony-stimulating factor-1 deficient osteopetrotic mouse. Dev Dyn. 1998 ; 211: 52-59
19. Ono K, Kaneko H, Choudhary S, Pilbeam CC, Lorenzo JA, Akatsu T, et al. Biphasic effect of prostaglandin E2 on osteoclast formation in spleen cell cultures: role of the EP2 receptor. J Bone Miner Res. 2005 ; 20: 23-29
20. Owens JM, Gallagher AC, Chambers TJ. IL-10 modulates formation of osteoclasts in murine hemopoietic cultures. J Immunol. 1996 ; 157: 936-940
21. Roberts HC, Moseley R, Sloan AJ, Youde SJ, Waddington RJ. Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: consequences for bone repair during periodontal disease. Eur J Oral Sci. 2008 ; 116: 207-216
22. Roodman GD. Regulation of osteoclast differentiation. Ann NY Acad Sci. 2006 ; 1068: 100-109
23. Salvi GE, Brown CE, Fujihashi K, Kiyono H, Smith FW, Beck JD, et al. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. J Periodontal Res. 1998 ; 33: 212-225
24. Schett G. Effects of inflammatory and anti-inflammatory cytokines on the bone. Eur J Clin Invest. 2011 ; 41: 1361-1366
25. Sloan AJ, Lynch CD. Dental tissue repair: novel models for dental tissue regeneration strategies. Oper Dent J. 2012 ; 6: 214-219
26. Smith EL, Locke M, Waddington RJ, Sloan AJ. An ex vivo rodent mandible culture model for bone repair. Tissue Eng Part C Methods. 2010 ; 16: 1287-1296
27. Susilowati H, Santoso AL, Barid I, Sosroseno W. Rat periodontal fibroblast responses to bacterial lipopolysaccharide in vitro. J Microbiol Immunol Infect. 2002 ; 35: 203-206
28. Taubman MA, Kawai T. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med. 2001 ; 12: 125-135
29. Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S, Findlay DM, et al. Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med. 1995 ; 182: 1461-1468
30. Yoshitake F, Itoh S, Narita H, Ishihara K, Ebisu S. Interleukin-6 directly inhibits osteoclast differentiation by suppressing receptor activator of NF-kappaB signaling pathways. J Biol Chem. 2008 ; 283: 11535-11540 of Animals in Research