Efficacy of AiiM, an N-acylhomoserine lactonase, against pseudomonas aeruginosa in a mouse model of acute pneumonia

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 8, 2013, Pages 3653-3658

  Migiyama, Yohei ^a,e   Kaneko, Yukihiro ^b   Yanagihara, Katsunori ^a   Morohoshi, Tomohiro ^c   Morinaga, Yoshitomo ^a   Nakamura, Shigeki ^a   Miyazaki, Taiga ^a   Hasegawa, Hiroo ^a   Izumikawa, Koichi ^a   Kakeya, Hiroshi ^a   Kohrogi, Hirotsugu ^e   Kohnob, Shigeru ^d  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UTSUNOMIYA UNIVERSITY   (Japan)

^d NAGASAKI UNIVERSITY   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AIIM PROTEIN; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; BACTERIAL ENZYME; ELASTASE; GLUCONOLACTONASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; N ACYLHOMOSERINE LACTONE; PYOCYANINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL LOAD; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CELL PROTECTION; CHROMOBACTERIUM VIOLACEUM; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE MODEL; DRUG CYTOTOXICITY; DRUG EFFICACY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PSEUDOMONAS PNEUMONIA; SURVIVAL RATE;

ANIMALS; BACTERIAL LOAD; BACTERIAL PROTEINS; BRONCHOALVEOLAR LAVAGE FLUID; CARBOXYLIC ESTER HYDROLASES; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; EPITHELIAL CELLS; HUMANS; INTERLEUKINS; LUNG; MALE; MICE; PANCREATIC ELASTASE; PEROXIDASE; PLASMIDS; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PYOCYANINE; QUORUM SENSING; SURVIVAL ANALYSIS; VIRULENCE FACTORS;

EID: 84880281765     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00456-13     Document Type: Article

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