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Volumn 260, Issue 7, 2013, Pages 1701-1708

CYP46A1 T/C polymorphism associated with the APOEε4 allele increases the risk of Alzheimer's disease

Author keywords

Alzheimer's disease (AD); Apolipoprotein E (APOE); Cholesterol 24S hydroxylase gene (CYP46A1); Meta analysis; Polymorphism

Indexed keywords

APOLIPOPROTEIN E4; CHOLESTEROL 24S HYDROXYLASE; OXYGENASE; UNCLASSIFIED DRUG;

EID: 84880272606     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-012-6690-4     Document Type: Review
Times cited : (15)

References (44)
  • 1
    • 0034509668 scopus 로고    scopus 로고
    • Genetic factors in the genesis of Alzheimer's disease
    • 11193785 10.1111/j.1749-6632.2000.tb05552.x 1:CAS:528: DC%2BD3MXntVaqtw%3D%3D
    • St George-Hyslop PH (2000) Genetic factors in the genesis of Alzheimer's disease. Ann NY Acad Sci 924:1-7
    • (2000) Ann NY Acad Sci , vol.924 , pp. 1-7
    • St George-Hyslop, P.H.1
  • 2
    • 66249141948 scopus 로고    scopus 로고
    • Alzheimer's disease genetics current status and future perspectives
    • 19501718 10.1016/S0074-7742(09)00409-7 1:CAS:528:DC%2BD1MXht1Wis7bE
    • Bertram L (2009) Alzheimer's disease genetics current status and future perspectives. Int Rev Neurobiol 84:167-184
    • (2009) Int Rev Neurobiol , vol.84 , pp. 167-184
    • Bertram, L.1
  • 3
    • 79957604912 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: New evidences for an old hypothesis?
    • 21371880 10.1016/j.gde.2011.02.002 1:CAS:528:DC%2BC3MXmvVantbc%3D (Epub 1 Mar 2011)
    • Lambert JC, Amouyel P (2011) Genetics of Alzheimer's disease: new evidences for an old hypothesis? Curr Opin Genet Dev 21:295-301 (Epub 1 Mar 2011)
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 295-301
    • Lambert, J.C.1    Amouyel, P.2
  • 4
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    • 19734903 10.1038/ng.439 1:CAS:528:DC%2BD1MXhtV2gsb%2FK (Epub 6 Sept 2009)
    • Lambert JC, Heath S, Even G et al (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41:1094-1099 (Epub 6 Sept 2009)
    • (2009) Nat Genet , vol.41 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3
  • 5
    • 75149138378 scopus 로고    scopus 로고
    • The pursuit of susceptibility genes for Alzheimer's disease: Progress and prospects
    • 20080314 10.1016/j.tig.2009.12.004 1:CAS:528:DC%2BC3cXhtlWktro%3D (Epub 18 Jan 2010)
    • Sleegers K, Lambert JC, Bertram L et al (2010) The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. Trends Genet 26:84-93 (Epub 18 Jan 2010)
    • (2010) Trends Genet , vol.26 , pp. 84-93
    • Sleegers, K.1    Lambert, J.C.2    Bertram, L.3
  • 6
    • 77952307991 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic loci associated with Alzheimer disease
    • 20460622 10.1001/jama.2010.574 1:CAS:528:DC%2BC3cXmtVOksro%3D
    • Seshadri S, Fitzpatrick AL, Ikram MA et al (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303:1832-1840
    • (2010) JAMA , vol.303 , pp. 1832-1840
    • Seshadri, S.1    Fitzpatrick, A.L.2    Ikram, M.A.3
  • 7
    • 70450219539 scopus 로고    scopus 로고
    • Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
    • 20050287 10.1111/j.1471-4159.2009.06408.x 1:CAS:528:DC%2BD1MXhsFGqtrvJ
    • Martins IJ, Berger T, Sharman MJ et al (2009) Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. J Neurochem 111:1275-1308
    • (2009) J Neurochem , vol.111 , pp. 1275-1308
    • Martins, I.J.1    Berger, T.2    Sharman, M.J.3
  • 8
    • 55749114033 scopus 로고    scopus 로고
    • Interaction between Alzheimer's Abeta (25-35) peptide and phospholipid bilayers: The role of cholesterol
    • 18706389 10.1016/j.bbamem.2008.07.014 (Epub 28 Jul 2008)
    • D'Errico G, Vitiello G, Ortona O et al (2008) Interaction between Alzheimer's Abeta (25-35) peptide and phospholipid bilayers: the role of cholesterol. Biochim Biophys Acta 1778:2710-2716 (Epub 28 Jul 2008)
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 2710-2716
    • D'Errico, G.1    Vitiello, G.2    Ortona, O.3
  • 9
    • 74749108240 scopus 로고    scopus 로고
    • Interaction of a beta-sheet breaker peptide with lipid membranes
    • 20063331 10.1002/psc.1207 1:CAS:528:DC%2BC3cXkvFKnsg%3D%3D
    • Vitiello G, Grimaldi M, Ramunno A et al (2010) Interaction of a beta-sheet breaker peptide with lipid membranes. J Pept Sci 16:115-122
    • (2010) J Pept Sci , vol.16 , pp. 115-122
    • Vitiello, G.1    Grimaldi, M.2    Ramunno, A.3
  • 10
    • 0031848338 scopus 로고    scopus 로고
    • Cholesterol homeostasis in human brain: Turnover of 24S- hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
    • 9717719 1:CAS:528:DyaK1cXlsVansbk%3D
    • Bjorkhem I, Lutjohann D, Diczfalusy U et al (1998) Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res 39:1594-1600
    • (1998) J Lipid Res , vol.39 , pp. 1594-1600
    • Bjorkhem, I.1    Lutjohann, D.2    Diczfalusy, U.3
  • 11
    • 0037227538 scopus 로고    scopus 로고
    • Increased brain β-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    • 12533085 10.1001/archneur.60.1.29
    • Papassotiropoulos A, Streffer JR, Tsolaki M et al (2003) Increased brain β-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism. Arch Neurol 60:29-35
    • (2003) Arch Neurol , vol.60 , pp. 29-35
    • Papassotiropoulos, A.1    Streffer, J.R.2    Tsolaki, M.3
  • 12
    • 2542523048 scopus 로고    scopus 로고
    • Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer disease: From risk factors to disease modulators
    • 15165699 10.1016/j.neurobiolaging.2003.08.004 1:CAS:528: DC%2BD2cXksVGgtrk%3D
    • Borroni B, Archetti S, Agosti C et al (2004) Intronic CYP46 polymorphism along with ApoE genotype in sporadic Alzheimer disease: from risk factors to disease modulators. Neurobiol Aging 25:747-751
    • (2004) Neurobiol Aging , vol.25 , pp. 747-751
    • Borroni, B.1    Archetti, S.2    Agosti, C.3
  • 13
    • 33645975169 scopus 로고    scopus 로고
    • Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease
    • 10.1016/j.neurobiolaging.2005.03.029 (Epub 1 Aug 2005)
    • Tedde A, Rotondi M, Cellini E et al (2006) Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease. Neurobiol Aging 27:773.e1-773.e3 (Epub 1 Aug 2005)
    • (2006) Neurobiol Aging , vol.27
    • Tedde, A.1    Rotondi, M.2    Cellini, E.3
  • 15
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • 17192785 10.1038/ng1934 1:CAS:528:DC%2BD28XhtlGktLjM
    • Bertram L, McQueen MB, Mullin K et al (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39:17-23
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3
  • 16
    • 70350778518 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: A two-year follow up study
    • 19212968 10.1002/gps.2196
    • Fu BY, Ma SL, Tang NL et al (2009) Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study. Int J Geriatr Psychiatry 24:921-926
    • (2009) Int J Geriatr Psychiatry , vol.24 , pp. 921-926
    • Fu, B.Y.1    Ma, S.L.2    Tang, N.L.3
  • 17
    • 33645943730 scopus 로고    scopus 로고
    • An intronic cholesterol 24S-hydroxylase polymorphism associated with Alzheimer disease
    • 1:CAS:528:DC%2BD2sXitlemsLs%3D
    • He XM, Zhang ZX, Zhang JW et al (2006) An intronic cholesterol 24S-hydroxylase polymorphism associated with Alzheimer disease. Chin J Neurol 39:44-47
    • (2006) Chin J Neurol , vol.39 , pp. 44-47
    • He, X.M.1    Zhang, Z.X.2    Zhang, J.W.3
  • 18
    • 34249790890 scopus 로고    scopus 로고
    • Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease
    • 17550732 1:CAS:528:DC%2BD1cXmsFWitr8%3D
    • Wang F, Jia JP (2007) Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease. Zhonghua Yi Xue Za Zhi 87:614-618
    • (2007) Zhonghua Yi Xue Za Zhi , vol.87 , pp. 614-618
    • Wang, F.1    Jia, J.P.2
  • 19
    • 78650458614 scopus 로고    scopus 로고
    • CYP46A1 functional promoter haplotypes decipher genetic susceptibility to Alzheimer's disease
    • 20693622 1:CAS:528:DC%2BC3cXhtlOhtrrJ
    • Li Y, Chu LW, Wang B et al (2010) CYP46A1 functional promoter haplotypes decipher genetic susceptibility to Alzheimer's disease. J Alzheimers Dis 21:1311-1323
    • (2010) J Alzheimers Dis , vol.21 , pp. 1311-1323
    • Li, Y.1    Chu, L.W.2    Wang, B.3
  • 20
    • 63449091937 scopus 로고    scopus 로고
    • CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism
    • 19286353 10.1016/j.eurpsy.2008.12.005 (Epub 16 Mar 2009)
    • Kölsch H, Lütjohann D, Jessen F et al (2009) CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. Eur Psychiatry 24:183-190 (Epub 16 Mar 2009)
    • (2009) Eur Psychiatry , vol.24 , pp. 183-190
    • Kölsch, H.1    Lütjohann, D.2    Jessen, F.3
  • 21
    • 35348837212 scopus 로고    scopus 로고
    • Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: Effects of gender, CYP46, and ApoE polymorphisms
    • 17901546 10.1007/s12031-007-0040-5 1:CAS:528:DC%2BD2sXhtFemu7zE
    • Vega GL, Weiner MF (2007) Plasma 24S hydroxycholesterol response to statins in Alzheimer's disease patients: effects of gender, CYP46, and ApoE polymorphisms. J Mol Neurosci 33:51-55
    • (2007) J Mol Neurosci , vol.33 , pp. 51-55
    • Vega, G.L.1    Weiner, M.F.2
  • 22
    • 28444470503 scopus 로고    scopus 로고
    • Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
    • 16157450 10.1016/j.neulet.2005.08.048 1:CAS:528:DC%2BD2MXht1OksrjE (Epub 12 Sep 2005)
    • Shibata N, Kawarai T, Lee JH et al (2006) Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. Neurosci Lett 391:142-146 (Epub 12 Sep 2005)
    • (2006) Neurosci Lett , vol.391 , pp. 142-146
    • Shibata, N.1    Kawarai, T.2    Lee, J.H.3
  • 23
    • 33644556838 scopus 로고    scopus 로고
    • Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary
    • 16484661 10.1136/jnnp.2005.071928 1:STN:280:DC%2BD28%2FpslGiug%3D%3D
    • Helisalmi S, Vepsäläinen S, Koivisto AM et al (2006) Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary. J Neurol Neurosurg Psychiatry 77:421-422
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 421-422
    • Helisalmi, S.1    Vepsäläinen, S.2    Koivisto, A.M.3
  • 24
    • 0037008389 scopus 로고    scopus 로고
    • Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease
    • 12123847 10.1016/S0304-3940(02)00443-3 1:CAS:528:DC%2BD38Xlt12mtLc%3D
    • Desai P, DeKosky ST, Kamboh MI (2002) Genetic variation in the cholesterol 24-hydroxylase (CYP46) gene and the risk of Alzheimer's disease. Neurosci Lett 328:9-12
    • (2002) Neurosci Lett , vol.328 , pp. 9-12
    • Desai, P.1    Dekosky, S.T.2    Kamboh, M.I.3
  • 25
    • 0036384169 scopus 로고    scopus 로고
    • Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    • 12232784 10.1038/sj.mp.4001109
    • Kölsch H, Lütjohann D, Ludwig M (2002) Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Mol Psychiatry 7:899-902
    • (2002) Mol Psychiatry , vol.7 , pp. 899-902
    • Kölsch, H.1    Lütjohann, D.2    Ludwig, M.3
  • 26
    • 3042701772 scopus 로고    scopus 로고
    • APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease
    • 15106838 10.1097/00001756-200401190-00019 1:CAS:528:DC%2BD2cXjsFSrsb8%3D
    • Chalmers KA, Culpan D, Kehoe PG et al (2004) APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease. Neuroreport 15:95-98
    • (2004) Neuroreport , vol.15 , pp. 95-98
    • Chalmers, K.A.1    Culpan, D.2    Kehoe, P.G.3
  • 27
    • 5644280069 scopus 로고    scopus 로고
    • Genetic association of CYP46 and risk for Alzheimer's disease
    • 15286456 10.1159/000080025 1:CAS:528:DC%2BD2cXotVCitrc%3D (Epub 29 Jul 2004)
    • Combarros O, Infante J, Llorca J, Berciano J (2004) Genetic association of CYP46 and risk for Alzheimer's disease. Dement Geriatr Cogn Disord 18:257-260 (Epub 29 Jul 2004)
    • (2004) Dement Geriatr Cogn Disord , vol.18 , pp. 257-260
    • Combarros, O.1    Infante, J.2    Llorca, J.3    Berciano, J.4
  • 28
    • 4344576749 scopus 로고    scopus 로고
    • Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease
    • 15331159 10.1016/j.neulet.2004.06.011 1:CAS:528:DC%2BD2cXntFWqtrc%3D
    • Ingelsson M, Jesneck J, Irizarry MC, Hyman BT, Rebeck GW (2004) Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease. Neurosci Lett 367:228-231
    • (2004) Neurosci Lett , vol.367 , pp. 228-231
    • Ingelsson, M.1    Jesneck, J.2    Irizarry, M.C.3    Hyman, B.T.4    Rebeck, G.W.5
  • 29
    • 2942740962 scopus 로고    scopus 로고
    • Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease
    • 15034781 10.1007/s00439-004-1107-9 1:CAS:528:DC%2BD2cXjt1Gmurw%3D (Epub 18 Mar 2004)
    • Johansson A, Katzov H, Zetterberg H et al (2004) Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease. Hum Genet 114:581-587 (Epub 18 Mar 2004)
    • (2004) Hum Genet , vol.114 , pp. 581-587
    • Johansson, A.1    Katzov, H.2    Zetterberg, H.3
  • 30
    • 2542422805 scopus 로고    scopus 로고
    • Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population
    • 15172102 10.1016/j.neulet.2004.03.066 1:CAS:528:DC%2BD2cXksVCit70%3D
    • Kabbara A, Payet N, Cottel D (2004) Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. Neurosci Lett 363:139-143
    • (2004) Neurosci Lett , vol.363 , pp. 139-143
    • Kabbara, A.1    Payet, N.2    Cottel, D.3
  • 31
    • 4644359813 scopus 로고    scopus 로고
    • Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese
    • 15450677 10.1016/j.neulet.2004.07.020 1:CAS:528:DC%2BD2cXnvV2ks7o%3D
    • Wang B, Zhang C, Zheng W et al (2004) Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer's disease in Chinese. Neurosci Lett 369:104-107
    • (2004) Neurosci Lett , vol.369 , pp. 104-107
    • Wang, B.1    Zhang, C.2    Zheng, W.3
  • 32
    • 20344399373 scopus 로고    scopus 로고
    • CYP46: A risk factor for Alzheimer's disease or a coincidence?
    • 15936520 10.1016/j.neulet.2005.03.049 1:CAS:528:DC%2BD2MXltVemsL8%3D (Epub 21 Apr 2005)
    • Golanska E, Hulas-Bigoszewska K, Wojcik I et al (2005) CYP46: a risk factor for Alzheimer's disease or a coincidence? Neurosci Lett 383:105-108 (Epub 21 Apr 2005)
    • (2005) Neurosci Lett , vol.383 , pp. 105-108
    • Golanska, E.1    Hulas-Bigoszewska, K.2    Wojcik, I.3
  • 33
    • 27644511599 scopus 로고    scopus 로고
    • CYP46 T/C polymorphism is not associated with Alzheimer's dementia in a population from Hungary
    • 16258842 10.1007/s11064-005-5979-4
    • Juhász A, Rimanóczy A, Boda K et al (2005) CYP46 T/C polymorphism is not associated with Alzheimer's dementia in a population from Hungary. Neurochem Res 30:943-948
    • (2005) Neurochem Res , vol.30 , pp. 943-948
    • Juhász, A.1    Rimanóczy, A.2    Boda, K.3
  • 34
    • 30844460819 scopus 로고    scopus 로고
    • Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease
    • 16340204 10.1159/000090215 (Epub 9 Dec 2005)
    • Fernández Del Pozo V, Alvarez Alvarez M, Fernández Martínez M et al (2005) Polymorphism in the cholesterol 24S-hydroxylase gene (CYP46A1) associated with the APOEpsilon3 allele increases the risk of Alzheimer's disease and of mild cognitive impairment progressing to Alzheimer's disease. Dement Geriatr Cogn Disord 21:81-87 (Epub 9 Dec 2005)
    • (2005) Dement Geriatr Cogn Disord , vol.21 , pp. 81-87
    • Fernández Del Pozo, V.1    Alvarez Alvarez, M.2    Fernández Martínez, M.3
  • 35
    • 33750922698 scopus 로고    scopus 로고
    • Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients
    • 16960449 10.1159/000095723 1:CAS:528:DC%2BD28XhtFymtL3F (Epub 8 Sept 2006)
    • Li Y, Chu LW, Chen YQ et al (2006) Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients. Dement Geriatr Cogn Disord 22:399-404 (Epub 8 Sept 2006)
    • (2006) Dement Geriatr Cogn Disord , vol.22 , pp. 399-404
    • Li, Y.1    Chu, L.W.2    Chen, Y.Q.3
  • 36
    • 33645655021 scopus 로고    scopus 로고
    • Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population
    • 16734927 10.1017/S1041610205003108
    • Ma SL, Tang NL, Lam LC, Chiu HF (2006) Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population. Int Psychogeriatr 18:37-45
    • (2006) Int Psychogeriatr , vol.18 , pp. 37-45
    • Ma, S.L.1    Tang, N.L.2    Lam, L.C.3    Chiu, H.F.4
  • 37
    • 34147158749 scopus 로고    scopus 로고
    • Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese
    • 17335784 10.1016/j.brainres.2007.02.005 1:CAS:528:DC%2BD2sXksVOqtLY%3D (Epub 8 Feb 2007)
    • Wang F, Jia J (2007) Polymorphisms of cholesterol metabolism genes CYP46 and ABCA1 and the risk of sporadic Alzheimer's disease in Chinese. Brain Res 1147:34-38 (Epub 8 Feb 2007)
    • (2007) Brain Res , vol.1147 , pp. 34-38
    • Wang, F.1    Jia, J.2
  • 38
    • 67849104137 scopus 로고    scopus 로고
    • Earlier onset of Alzheimer's disease: Risk polymorphisms within PRNP, PRND, CYP46, and APOE genes
    • 19363267 1:CAS:528:DC%2BD1MXmvVOhsr4%3D
    • Golanska E, Hulas-Bigoszewska K, Sieruta M et al (2009) Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes. J Alzheimers Dis 17:359-368
    • (2009) J Alzheimers Dis , vol.17 , pp. 359-368
    • Golanska, E.1    Hulas-Bigoszewska, K.2    Sieruta, M.3
  • 39
    • 79953272286 scopus 로고    scopus 로고
    • A pilot study of gene/gene and gene/environment interactions in Alzheimer disease
    • 20682755 10.3121/cmr.2010.894 1:CAS:528:DC%2BC3MXmtV2js74%3D (Epub 3 Aug 2010)
    • Ghebranious N, Mukesh B, Giampietro PF et al (2011) A pilot study of gene/gene and gene/environment interactions in Alzheimer disease. Clin Med Res 9:17-25 (Epub 3 Aug 2010)
    • (2011) Clin Med Res , vol.9 , pp. 17-25
    • Ghebranious, N.1    Mukesh, B.2    Giampietro, P.F.3
  • 41
    • 84855525518 scopus 로고    scopus 로고
    • Genetics of late-onset Alzheimer's disease: Update from the alzgene database and analysis of shared pathways
    • 832379 (Epub 10 Dec 2011)
    • Olgiati P, Politis AM, Papadimitriou GN, De Ronchi D, Serretti A (2011) Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways. Int J Alzheimers Dis 832379 (Epub 10 Dec 2011)
    • (2011) Int J Alzheimers Dis
    • Olgiati, P.1    Politis, A.M.2    Papadimitriou, G.N.3    De Ronchi, D.4    Serretti, A.5
  • 42
    • 12744273863 scopus 로고    scopus 로고
    • Midlife cardiovascular risk factors and risk of dementia in late life
    • 15668425 10.1212/01.WNL.0000149519.47454.F2 1:STN:280: DC%2BD2M%2FktFSmsA%3D%3D
    • Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K (2005) Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 64:277-281
    • (2005) Neurology , vol.64 , pp. 277-281
    • Whitmer, R.A.1    Sidney, S.2    Selby, J.3    Johnston, S.C.4    Yaffe, K.5
  • 43
    • 37249065259 scopus 로고    scopus 로고
    • Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease
    • 17854420 1:CAS:528:DC%2BD1cXisFGjsbc%3D (Epub 14 Sept 2007)
    • Llorca J, Rodríguez-Rodríguez E, Dierssen-Sotos T et al (2008) Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease. Acta Neurol Scand 117:1-14 (Epub 14 Sept 2007)
    • (2008) Acta Neurol Scand , vol.117 , pp. 1-14
    • Llorca, J.1    Rodríguez-Rodríguez, E.2    Dierssen-Sotos, T.3
  • 44
    • 0035083555 scopus 로고    scopus 로고
    • Cholesterol metabolism in the brain
    • 11264981 10.1097/00041433-200104000-00003 1:CAS:528:DC%2BD3MXislWgsbo%3D
    • Dietschy JM, Turley SD (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12:105-112
    • (2001) Curr Opin Lipidol , vol.12 , pp. 105-112
    • Dietschy, J.M.1    Turley, S.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.