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Volumn 32, Issue 28, 2013, Pages 3371-3380

LMTK3 is implicated in endocrine resistance via multiple signaling pathways

Author keywords

Breast cancer; Endocrine resistance; Estrogen receptor; HSPB8; LMTK3; Oncogene

Indexed keywords

ENZYME; ESTROGEN RECEPTOR ALPHA; HEAT SHOCK PROTEIN 22; LEMUR TYROSINE LINASE 3; PROTEIN TYROSINE KINASE; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 84880268260     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.343     Document Type: Article
Times cited : (38)

References (47)
  • 1
    • 84880255354 scopus 로고    scopus 로고
    • CRUK. http://cancerhelp.cancerresearchuk.org/type/breast-cancer/2012.
    • (2012)
  • 2
    • 33751530274 scopus 로고    scopus 로고
    • Steroid receptors and their role in the biology and control of breast cancer growth
    • Cordera F, Jordan VC. Steroid receptors and their role in the biology and control of breast cancer growth. Semin Oncol 2006; 33: 631-641.
    • (2006) Semin Oncol , vol.33 , pp. 631-641
    • Cordera, F.1    Jordan, V.C.2
  • 3
    • 33644816667 scopus 로고    scopus 로고
    • Breast cancer (non-metastatic)
    • Dixon JM, Rodger A, Stebbing J. Breast cancer (non-metastatic). Clin Evid 2005; 13: 2226-2257.
    • (2005) Clin Evid , vol.13 , pp. 2226-2257
    • Dixon, J.M.1    Rodger, A.2    Stebbing, J.3
  • 5
    • 33846552983 scopus 로고    scopus 로고
    • Role of CYP2D6 testing in selection of endocrine therapy for breast cancer
    • Stebbing J, Stearns V, Davidson NE. Role of CYP2D6 testing in selection of endocrine therapy for breast cancer. Pharmacogenomics 2007; 8: 1-3.
    • (2007) Pharmacogenomics , vol.8 , pp. 1-3
    • Stebbing, J.1    Stearns, V.2    Davidson, N.E.3
  • 6
    • 33645213375 scopus 로고    scopus 로고
    • Models of hormone resistance in vitro and in vivo
    • Schafer JM, Jordan VC. Models of hormone resistance in vitro and in vivo. Methods Mol Med 2006; 120: 453-464.
    • (2006) Methods Mol Med , vol.120 , pp. 453-464
    • Schafer, J.M.1    Jordan, V.C.2
  • 7
    • 0036488531 scopus 로고    scopus 로고
    • Endocrine-responsive breast cancer and strategies for combating resistance
    • Ali S, Coombes RC. Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer 2002; 2: 101-112.
    • (2002) Nat Rev Cancer , vol.2 , pp. 101-112
    • Ali, S.1    Coombes, R.C.2
  • 10
    • 79958093406 scopus 로고    scopus 로고
    • Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer
    • Giamas G, Filipovic A, Jacob J, Messier W, Zhang H, Yang D et al. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nat Med 2011; 17: 715-719.
    • (2011) Nat Med , vol.17 , pp. 715-719
    • Giamas, G.1    Filipovic, A.2    Jacob, J.3    Messier, W.4    Zhang, H.5    Yang, D.6
  • 11
    • 79952128110 scopus 로고    scopus 로고
    • Highthroughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy
    • Gonzalez-Malerva L, Park J, Zou L, Hu Y, Moradpour Z, Pearlberg J et al. Highthroughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci USA. 2011; 108: 2058-2063.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2058-2063
    • Gonzalez-Malerva, L.1    Park, J.2    Zou, L.3    Hu, Y.4    Moradpour, Z.5    Pearlberg, J.6
  • 12
    • 77950867220 scopus 로고    scopus 로고
    • Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients
    • Chanplakorn N, Chanplakorn P, Suzuki T, Ono K, Chan MS, Miki Y et al. Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. Breast Cancer Res Treat 120: 639-648.
    • Breast Cancer Res Treat , vol.120 , pp. 639-648
    • Chanplakorn, N.1    Chanplakorn, P.2    Suzuki, T.3    Ono, K.4    Chan, M.S.5    Miki, Y.6
  • 13
    • 48049084757 scopus 로고    scopus 로고
    • Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer
    • Chow LW, Yip AY, Loo WT, Lam CK, Toi M. Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer. J Steroid Biochem Mol Biol 2008; 111: 13-17.
    • (2008) J Steroid Biochem Mol Biol , vol.111 , pp. 13-17
    • Chow, L.W.1    Yip, A.Y.2    Loo, W.T.3    Lam, C.K.4    Toi, M.5
  • 14
    • 84863011201 scopus 로고    scopus 로고
    • Genomic analysis of circulating cell-free DNA infers breast cancer dormancy
    • Shaw JA, Page K, Blighe K, Hava N, Guttery D, Ward B et al. Genomic analysis of circulating cell-free DNA infers breast cancer dormancy. Genome Res 2012; 22: 220-231.
    • (2012) Genome Res , vol.22 , pp. 220-231
    • Shaw, J.A.1    Page, K.2    Blighe, K.3    Hava, N.4    Guttery, D.5    Ward, B.6
  • 15
    • 0018083331 scopus 로고
    • Isolation of two human tumor epithelial cell lines from solid breast carcinomas
    • Lasfargues EY, Coutinho WG, Redfield ES. Isolation of two human tumor epithelial cell lines from solid breast carcinomas. J Natl Cancer Inst 1978; 61: 967-978.
    • (1978) J Natl Cancer Inst , vol.61 , pp. 967-978
    • Lasfargues, E.Y.1    Coutinho, W.G.2    Redfield, E.S.3
  • 16
    • 70350507985 scopus 로고    scopus 로고
    • Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase
    • Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell 2009; 16: 413-424.
    • (2009) Cancer Cell , vol.16 , pp. 413-424
    • Zhang, Q.1    Gu, J.2    Li, L.3    Liu, J.4    Luo, B.5    Cheung, H.W.6
  • 17
    • 76349095348 scopus 로고    scopus 로고
    • Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer
    • Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, Desmedt C et al. Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med 2010; 16: 214-218.
    • (2010) Nat Med , vol.16 , pp. 214-218
    • Li, Y.1    Zou, L.2    Li, Q.3    Haibe-Kains, B.4    Tian, R.5    Desmedt, C.6
  • 18
    • 84866144576 scopus 로고    scopus 로고
    • Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA
    • epub ahead of print 08 November 2011
    • Paroni G, Fratelli M, Gardini G, Bassano C, Flora M, Zanetti A et al. Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA. Oncogene 2011, epub ahead of print 08 November 2011.
    • (2011) Oncogene
    • Paroni, G.1    Fratelli, M.2    Gardini, G.3    Bassano, C.4    Flora, M.5    Zanetti, A.6
  • 19
    • 33746043754 scopus 로고    scopus 로고
    • Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells
    • Harrington WR, Sengupta S, Katzenellenbogen BS. Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. Endocrinology 2006; 147: 3843-3850.
    • (2006) Endocrinology , vol.147 , pp. 3843-3850
    • Harrington, W.R.1    Sengupta, S.2    Katzenellenbogen, B.S.3
  • 20
    • 43449106199 scopus 로고    scopus 로고
    • Ets-2 and p160 proteins collaborate to regulate c-Myc in endocrine resistant breast cancer
    • Al-azawi D, Ilroy MM, Kelly G, Redmond AM, Bane FT, Cocchiglia S et al. Ets-2 and p160 proteins collaborate to regulate c-Myc in endocrine resistant breast cancer. Oncogene 2008; 27: 3021-3031.
    • (2008) Oncogene , vol.27 , pp. 3021-3031
    • Al-Azawi, D.1    Ilroy, M.M.2    Kelly, G.3    Redmond, A.M.4    Bane, F.T.5    Cocchiglia, S.6
  • 21
    • 79953311521 scopus 로고    scopus 로고
    • A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance
    • Miller TW, Balko JM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M et al. A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance. Clin Cancer Res 17: 2024-2034.
    • Clin Cancer Res , vol.17 , pp. 2024-2034
    • Miller, T.W.1    Balko, J.M.2    Ghazoui, Z.3    Dunbier, A.4    Anderson, H.5    Dowsett, M.6
  • 22
    • 79959570695 scopus 로고    scopus 로고
    • Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer
    • Guo S, RR Gonzalez-Perez. Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer. PLoS One 2011; 6: e21467.
    • (2011) PLoS One , vol.6
    • Guo, S.1    Gonzalez-Perez, R.R.2
  • 23
    • 48549103124 scopus 로고    scopus 로고
    • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    • Rizzo P, Miao H, D0Souza G, Osipo C, Song LL, Yun J et al. Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 2008; 68: 5226-5235.
    • (2008) Cancer Res , vol.68 , pp. 5226-5235
    • Rizzo, P.1    Miao, H.2    D'Souza, G.3    Osipo, C.4    Song, L.L.5    Yun, J.6
  • 25
    • 24344474845 scopus 로고    scopus 로고
    • Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors
    • Tomura H, Mogi C, Sato K, Okajima F. Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors. Cell Signal 2005; 17: 1466-1476.
    • (2005) Cell Signal , vol.17 , pp. 1466-1476
    • Tomura, H.1    Mogi, C.2    Sato, K.3    Okajima, F.4
  • 26
    • 0033772419 scopus 로고    scopus 로고
    • Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
    • Xu Y, Zhu K, Hong G, Wu W, Baudhuin LM, Xiao Y et al. Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1. Nat Cell Biol 2000; 2: 261-267.
    • (2000) Nat Cell Biol , vol.2 , pp. 261-267
    • Xu, Y.1    Zhu, K.2    Hong, G.3    Wu, W.4    Baudhuin, L.M.5    Xiao, Y.6
  • 27
    • 79960044081 scopus 로고    scopus 로고
    • Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
    • Stone JC. Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells. Genes Cancer 2011; 2: 320-334.
    • (2011) Genes Cancer , vol.2 , pp. 320-334
    • Stone, J.C.1
  • 29
    • 79960370365 scopus 로고    scopus 로고
    • PANcreatic-DERived factor: Novel hormone PANDERing to glucose regulation
    • Wilson CG, Robert-Cooperman CE, Burkhardt BR. PANcreatic-DERived factor: novel hormone PANDERing to glucose regulation. FEBS Lett 2011; 585: 2137-2143.
    • (2011) FEBS Lett , vol.585 , pp. 2137-2143
    • Wilson, C.G.1    Robert-Cooperman, C.E.2    Burkhardt, B.R.3
  • 30
    • 78951471142 scopus 로고    scopus 로고
    • Role of FGD1, a Cdc42 guanine nucleotide exchange factor, in epidermal growth factor-stimulated c-Jun NH2- terminal kinase activation and cell migration
    • Oshima T, Fujino T, Ando K, Hayakawa M. Role of FGD1, a Cdc42 guanine nucleotide exchange factor, in epidermal growth factor-stimulated c-Jun NH2- terminal kinase activation and cell migration. Biol Pharm Bull 2011; 34: 54-60.
    • (2011) Biol Pharm Bull , vol.34 , pp. 54-60
    • Oshima, T.1    Fujino, T.2    Ando, K.3    Hayakawa, M.4
  • 32
    • 46249090608 scopus 로고    scopus 로고
    • Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer
    • Noetzel E, Veeck J, Niederacher D, Galm O, Horn F, Hartmann A et al. Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer. BMC Cancer 2008; 8: 154.
    • (2008) BMC Cancer , vol.8 , pp. 154
    • Noetzel, E.1    Veeck, J.2    Niederacher, D.3    Galm, O.4    Horn, F.5    Hartmann, A.6
  • 34
    • 78650675585 scopus 로고    scopus 로고
    • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    • Fedele CG, Ooms LM, Ho M, Vieusseux J, O0Toole SA, Millar EK et al. Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci USA. 2010; 107: 22231-22236.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22231-22236
    • Fedele, C.G.1    Ooms, L.M.2    Ho, M.3    Vieusseux, J.4    O'Toole, S.A.5    Millar, E.K.6
  • 35
    • 78650877960 scopus 로고    scopus 로고
    • SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells
    • Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol 2011; 25: 72-82.
    • (2011) Mol Endocrinol , vol.25 , pp. 72-82
    • Wang, Y.1    Zhou, D.2    Phung, S.3    Masri, S.4    Smith, D.5    Chen, S.6
  • 37
    • 40749110728 scopus 로고    scopus 로고
    • Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptorpositive breast cancer cells
    • Sun X, Fontaine JM, Bartl I, Behnam B, Welsh MJ, Benndorf R. Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptorpositive breast cancer cells. Cell Stress Chaperones 2007; 12: 307-319.
    • (2007) Cell Stress Chaperones , vol.12 , pp. 307-319
    • Sun, X.1    Fontaine, J.M.2    Bartl, I.3    Behnam, B.4    Welsh, M.J.5    Benndorf, R.6
  • 39
    • 80052170422 scopus 로고    scopus 로고
    • Killing the second messenger: Targeting loss of cell cycle control in endocrine-resistant breast cancer
    • Lange CA, Yee D. Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer. Endocr Relat Cancer 2011; 18: C19-C24.
    • (2011) Endocr Relat Cancer , vol.18
    • Lange, C.A.1    Yee, D.2
  • 41
    • 69249137029 scopus 로고    scopus 로고
    • Biological determinants of endocrine resistance in breast cancer
    • Musgrove EA, Sutherland RL. Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 2009; 9: 631-643.
    • (2009) Nat Rev Cancer , vol.9 , pp. 631-643
    • Musgrove, E.A.1    Sutherland, R.L.2
  • 42
    • 79551576468 scopus 로고    scopus 로고
    • Mechanisms of endocrine resistance in breast cancer
    • Osborne CK, Schiff R. Mechanisms of endocrine resistance in breast cancer. Ann Rev Med 2011; 62: 233-247.
    • (2011) Ann Rev Med , vol.62 , pp. 233-247
    • Osborne, C.K.1    Schiff, R.2
  • 43
    • 67650828089 scopus 로고    scopus 로고
    • Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells
    • Hu DG, Mackenzie PI. Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells. Mol Pharmacol 2009; 76: 425-439.
    • (2009) Mol Pharmacol , vol.76 , pp. 425-439
    • Hu, D.G.1    MacKenzie, P.I.2
  • 45
    • 33645730357 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors
    • Creighton CJ, Hilger AM, Murthy S, Rae JM, Chinnaiyan AM, El-Ashry D. Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors. Cancer Res 2006; 66: 3903-3911.
    • (2006) Cancer Res , vol.66 , pp. 3903-3911
    • Creighton, C.J.1    Hilger, A.M.2    Murthy, S.3    Rae, J.M.4    Chinnaiyan, A.M.5    El-Ashry, D.6
  • 46
    • 33846207899 scopus 로고    scopus 로고
    • Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant
    • Fan M, Yan PS, Hartman-Frey C, Chen L, Paik H, Oyer SL et al. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res 2006; 66: 11954-11966.
    • (2006) Cancer Res , vol.66 , pp. 11954-11966
    • Fan, M.1    Yan, P.S.2    Hartman-Frey, C.3    Chen, L.4    Paik, H.5    Oyer, S.L.6


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