Prolyl endopeptidase activity in bronchoalveolar lavage fluid: A novel diagnostic biomarker in a guinea pig model of invasive pulmonary aspergillosis

Medical Mycology

Volumn 51, Issue 6, 2013, Pages 592-602

  Jambunathan, Kalyani ^a   Watson, Douglas S ^a   Najvar, Laura K ^b,d   Wiederhold, Nathan P ^b,e   Kirkpatrick, William R ^b,d   Patterson, Thomas F ^b,d   Askew, David S ^c   Kodukula, Krishna ^a   Galande, Amit K ^a  

^a SRI INTERNATIONAL   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^e UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Broncheoalveolar lavage fluid; Combinatorial library; Fluorogenic probes; Invasive aspergillosis; Proteolytic enzymes

Indexed keywords

ENROFLOXACIN; FLUORESCENT DYE; PROLYL ENDOPEPTIDASE; BETA 1,3 GLUCAN; GALACTOMANNAN;

ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BACTERIAL INFECTION; COMBINATORIAL LIBRARY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; EXPERIMENTAL GUINEA PIG; GENOME; LUNG ASPERGILLOSIS; LUNG LAVAGE; MALE; NONHUMAN; PROTEIN DEGRADATION; ANIMAL EXPERIMENT; ANIMAL MODEL; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; GUINEA PIG MODEL; INTERMETHOD COMPARISON; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

CAVIA;

EID: 84880262792     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2012.761360     Document Type: Article

References (42)

1. Latge JP.Aspergillus fumigatus and aspergillosis.Clin Microbiol Rev 1999 ; 12: 310-350
2. Segal BJ.Aspergillosis.N Engl J Med 2009 ; 360: 1870-1884
3. Hospenthal DR, Kwon-Chung KJ, Bennett JE.Concentrations of airborne Aspergillus compared to the incidence of invasive aspergillosis: Lack of correlation.Med Myco 1998 ; 36: 165-168
4. Woodcock AA, Steel N, Moore CB, e t al.Fungal contamination of bedding.Allergy 2006 ; 61: 140-142 (Pubitemid 43381205)
5. Askew DS.A spergillus fumigatus: Virulence genes in a street-smart mold.Curr Opin Microbiol 2008 ; 11: 331-337
6. Wilson LS, Reyes CM, Stolpman M, e t al.The direct cost and incidence of systemic fungal infections.Value Hlth 2002 ; 5: 26-34 (Pubitemid 34160368)
7. McNeil MM, Nash SL, Hajjeh RA, e t al.Trends in mortality due to invasive mycotic diseases in the United States 1980-1997.Clin Infect Dis 2011 ; 33: 641-647
8. Denning DW.Invasive Aspergillosis.Clin Infect Dis 1998 ; 26: 781-803 ; quiz 804-805
9. Caillot D, Casasnovas O, Bernard A, e t al.Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery.J Clin Oncol 1997 ; 15: 139-147 (Pubitemid 27020567)
10. Caillot D, Mannone L, Cuisenier B, Couaillier JF.Role of early diagnosis and aggressive surgery in the management of invasive pulmonary aspergillosis in neutropenic patients.Clin Microbiol Infect 2001; 7: 54-61
11. Gangneux JP, Lavarde D, Bretagne S, Guiguen C, Gandemer V.Transient Aspergillus antiogenaemia: Think of milk.Lancet 2002; 359: 1251 (Pubitemid 34304275)
12. Ostrosky-Zeichner L.Invasive mycoses: Diagnostic challenges.Amer J Med 2012 ; 125: S14-24
13. Aquino VR, Goldani LZ, Pasqualotto AC.Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis.Mycopathologia 2007 ; 163: 191-202 (Pubitemid 46625370)
14. Klingspor L, Loeffler J.Aspergillus PCR formidable challenges and progress.Med Mycol 2009 ; 47: S241-247
15. Nierman WC, Pain A, Anderson MJ, e t al.Genomic sequencing of the pathogenic and allergenic fi lamentous fungus Aspergillus fumigatus.Nature 2005 ; 438: 1151-1156 (Pubitemid 41831684)
16. Willger Sd, Grahl N, Cramer RA Jr.A spergillus fumigatus metabolism: Clues to mechanisms of in vivo fungal growth and virulence.Med Mycol 2009 ; 47: S72-79
17. Kolattukudy PE, Lee JD, Rogers LM, e t al.Evidence for possible involvement of an elastolytic serine protease in aspergillosis.Infect Immun 1993 ; 61: 2357-2368 (Pubitemid 23159222)
18. Markaryan A, Morozova I, Yu H, Kolattukudy PE.Purifi cation and characterization of an elastinolytic metalloprotease from Aspergillus fumigatus and immunoelectron microscopic evidence of secretion of this enzyme by the fungus invading the murine lung.Infect Immun 1994 ; 62: 2149-2157 (Pubitemid 24157036)
19. McDonagh A, Fedorova ND, Crabtree J, e t al.Sub-telomere directed gene expression during the initiation of invasive aspergillosis.PLoS Pathog 2008; 4: E1000154
20. Rawlings ND, Barrett AJ, Bateman A.MEROPS: The peptidase database.Nuc Acids Res 2010 ; 38: D227-233
21. Watson DS, Jambunathan K, Askew DS, Kodukula K, Galande AK.Robust substrate profi ling method reveals striking differences in specifi cities of serum and lung fl uid proteases.Biotechniques 2011 ; 51: 95-104
22. Jambunathan K, Watson DS, Kodukula K, Galande AK.Proteolytic fi ngerprinting of complex biological samples using combinatorial libraries of fl uorogenic probes.Cur Protocol Protein Sci 2012 ; 70: 21.22.1-21.22.13
23. Kirkpatrick WR, Perea S, Coco BJ, Patterson TF.Efficacy of caspofungin alone and in combination with coriconazole in a guinea pig model of invasive aspergillosis.Antimicrob Agents Chemother 2002 ; 46: 2564-2568 (Pubitemid 34793464)
24. Vallor AC, Kirkpatrick WR, Najvar LK, e t al.Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture.Antimicrob Agents Chemother 2008 ; 52: 2593-2598 (Pubitemid 351915692)
25. Thomas DA, Francis P, Smith C, et al.A broad-spectrum fl uorescencebased peptide library for the rapid identification of protease substrates.Proteomics 2006 ; 6: 2112-2120
26. King JY, Ferrara R, Tabibiazar R, e t al.Pathway analysis of coronary atherosclerosis.Physiol Genomics 2005 ; 23: 103-118
27. Neumann u, Kubota H, Frei K, Ganu V, Leppert D.Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fl uorogenic susbtrate with increased specifi city constants for collagenases and tumor necrosis factor converting enzyme. Anal Biochem 2004; 328: 166-173 (Pubitemid 38542933)
28. Watson DS, Feng X, Askew DS, e t al.Substrate specifi city profi ling of the Aspergillus fumigatus proteolytic secretome reveals consensus motifs with the predominance of Ile/Leu and Phe/Tyr.PLoS One 2011; 6: E21001
29. Schall R, Kupfahl C, Buchheidt D, Neumaier M, Findeisen P.Systematic identification of substrates for profi ling of secreted proteases from Aspergillus species.J Microbiol Methods 2007 ; 71: 93-100 (Pubitemid 47538765)
30. Yeo SF, Wong B.Current status of nonculture methods for diagnosis of invasive fungal infections.Clin Microbiol Rev 2002 ; 15: 465-484 (Pubitemid 34761353)
31. D'Haese J, Theunissen K, Vermeulen E, e t al.Detection of galactomannan in bronchoalveolar lavage fl uid samples of patients at risk for invasive pulmonary aspergillosis-Analytical and clinical validity.J Clin Microbiol 2012 ; 50: 1258-1263
32. Tortorano AM, Esposto MC, Prigitano A, et al.Cross-reactivity of Fusarium spp. in the Aspergillus galactomannan enzyme-linked immunosorbent assay.J Clin Microbiol 2012 ; 50: 1051-1053
33. Yager P, Domingo GJ, Gerdes J.Point-of-care diagnostics for global health.Annu Rev Biomed Eng 2008 ; 10: 107-144
34. Kim HJ, Shelver Wl, Hwang EC, Xu T, Li QX.Automated fl ow fl uorescent immunoassay for part per trillion detection of the neonicotinoid insecticide thiamethoxam.Anal Chim Acta 2006, 571: 66-73 (Pubitemid 43903432)
35. Tung CH.Fluorescent peptide probes for in vivo diagnostic imaging.Biopolymers 2004 ; 76: 391-403
36. Pierce MC, Javier DJ, Richards-Kortum R.Optical contrast agents an imaging system for detection and diagnosis of cancer.International journal of cancer J Int du Cancer 2008 ; 123: 1979-1990
37. Aikawa E, Nahrendorf M, Sosnovik D, et al.Multimodality molecular imaging identifi es proteolytic and osteogenic activities in early aortic valve disease.Circulation 2007 ; 115: 377-386 (Pubitemid 46148512)
38. Edens L, Dekker P, van der Hoevan R, e t al.Extracellular prolyl endoprotease from Aspergillus niger and its use in the debittering of protein hydrolysates.J Agric Food Chem 2005 ; 53: 7950-7957 (Pubitemid 41499643)
39. Gaggar A, Rowe SM, Matthew H, Blalock JE.Proline-Glycine-Proline (PGP) and high mobility group box protein-1 (HMGB1): potential mediators of cystic fibrosis airways infl ammation.Open Respir Med J 2010 ; 4: 32-38
40. O'Reilly P, Jackson PL, Noerager B, et al.N-Alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD.Respir Res 2009; 10: 38
41. Gagger A, Jackson PL, Noerager BD, e t al.A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic infl ammation.J Immunol 2008 ; 180: 5662-5669
42. Galande AK, Hilderbrand SA, Weissleder R, Tung CH.Enzymetargeted fl uorescent imaging probes on a multiple antigenic peptide core.J Med Chem 2006 ; 49: 4715-4720 (Pubitemid 44162699)