A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates

Proteomics

Volumn 6, Issue 7, 2006, Pages 2112-2120

  Thomas, Daniel A ^a   Francis, Peter ^b   Smith, Carla ^b   Ratcliffe, Steven ^b   Ede, Nicholas J ^c   Kay, Corinne ^d   Wayne, Gareth ^b   Martin, Steve L ^b   Moore, Keith ^b   Amour, Augustin ^b   Hooper, Nigel M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c Mimotopes Pty Ltd   (Australia)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Calpain; Fluorescence resonance energy transfer; Matrix metalloprotease; Peptide library; Protease

Indexed keywords

ARGININE; CALPAIN; CALPAIN I; CALPAIN II; COLLAGENASE 3; GLUTAMINE; GLYCINE; LEUCINE; LYSINE; MACROPHAGE ELASTASE; PEPSIN A; PEPTIDE LIBRARY; PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; ENZYME SUBSTRATE; FEASIBILITY STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAPID ENDOPEPTIDASE PROFILING LIBRARY; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

CALPAIN; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROLYSIS; MATRIX METALLOPROTEINASES; PEPTIDE HYDROLASES; PEPTIDE LIBRARY; PROTEIN SUBUNITS; PROTEOMICS; SUBSTRATE SPECIFICITY;

EID: 33645697317     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200500153     Document Type: Article

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