Structural basis for influence of viral glycans on ligand binding by influenza hemagglutinin

Biophysical Journal

Volumn 95, Issue 7, 2008, Pages

  Kasson, Peter M ^a   Pande, Vijay S ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; N ACETYLNEURAMINIC ACID; POLYSACCHARIDE;

BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; HUMAN; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; LETTER; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

BINDING SITES; CARBOHYDRATE CONFORMATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; MODELS, MOLECULAR; N-ACETYLNEURAMINIC ACID; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 55949101550     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1529/biophysj.108.141507     Document Type: Article

References (17)

1. Wilson, I. A., J. J. Skehel, and D. C. Wiley. 1981. Structure of the hemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature. 289:366-373.
2. Marinina, V. P., A. S. Gambarian, N. V. Bovin, A. B. Tuzikov, A. A. Shilov, B. V. Sinitsyn, and M. N. Matrosovich. 2003. Mol. Biol. (Mosk.). [The effect of losing glycosylation sites near the receptor-binding region on the receptor phenotype of the human influenza virus H1N1]. 37:550-555.
3. Gambaryan, A. S., V. P. Marinina, A. B. Tuzikov, N. V. Bovin, I. A. Rudneva, B. V. Sinitsyn, A. A. Shilov, and M. N. Matrosovich. 1998. Effects of host-dependent glycosylation of hemagglutinin on receptor-binding properties of H1N1 human influenza A virus grown in MDCK cells and in embryonated eggs. Virology. 247:170-177.
4. Ohuchi, M., R. Ohuchi, A. Feldmann, and H. D. Klenk. 1997. Regulation of receptor binding affinity of influenza virus hemagglutinin by its carbohydrate moiety. J. Virol. 71:8377-8384.
5. Skehel, J. J., and D. C. Wiley. 2000. Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu. Rev. Biochem. 69:531-569.
6. Yamada, S., Y. Suzuki, T. Suzuki, M. Q. Le, C. A. Nidom, Y. Sakai-Tagawa, Y. Muramoto, M. Ito, M. Kiso, T. Horimoto, K. Shinya, T. Sawada, M. Kiso, T. Usui, T. Murata, Y. Lin, A. Hay, L. F. Haire, D. J. Stevens, R. J. Russell, S. J. Gamblin, J. J. Skehel, and Y. Kawaoka. 2006. Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature. 444:378-382.
7. Shinya, K., M. Ebina, S. Yamada, M. Ono, N. Kasai, and Y. Kawaoka. 2006. Avian flu: influenza virus receptors in the human airway. Nature. 440:435-436.
8. van Riel, D., V. J. Munster, E. de Wit, G. F. Rimmelzwaan, R. A. Fouchier, A. D. Osterhaus, and T. Kuiken. 2006. H5N1 Virus attachment to lower respiratory tract. Science. 312:399.
9. van Riel, D., V. J. Munster, E. de Wit, G. F. Rimmelzwaan, R. A. Fouchier, A. D. Osterhaus, and T. Kuiken. 2007. Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. Am. J. Pathol. 171:1215-1223.
10. Sauter, N. K., J. E. Hanson, G. D. Glick, J. H. Brown, R. L. Crowther, S. Park, J. J. Skehel, and D. C. Wiley. 1992. Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and x-ray crystallography. Biochemistry. 31:9609-9621.
11. Eisen, M. B., S. Sabesan, J. J. Skehel, and D. C. Wiley. 1997. Binding of the influenza A virus to cell-surface receptors: structures of five hemagglutinin-sialyloligosaccharide complexes determined by x-ray crystallography. Virology. 232:19-31.
12. Mir-Shekari, S. Y., D. A. Ashford, D. J. Harvey, R. A. Dwek, and I. T. Schulze. 1997. The glycosylation of the influenza A virus hemagglutinin by mammalian cells. A site-specific study. J. Biol. Chem. 272:4027-4036.
13. Kuroda, K., H. Geyer, R. Geyer, W. Doerfler, and H. D. Klenk. 1990. The oligosaccharides of influenza virus hemagglutinin expressed in insect cells by a baculovirus vector. Virology. 174:418-429.
14. Hess, B., C. Kutzner, D. van der Spoel, and E. Lindahl. 2008. GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation. J. Chem. Theory Comput. 4:435-447.
15. Kirschner, K. N., A. B. Yongye, S. M. Tschampel, and J. Gonzalez-Outeiriño. 2007. GLYCAM06: a generalizable biomolecular force field. Carbohydrates. J. Comput. Chem. 29:622-655.
16. Duan, Y., C. Wu, S. Chowdhury, M. C. Lee, G. Xiong, W. Zhang, R. Yang, P. Cieplak, R. Luo, T. Lee, J. Caldwell, J. Wang, and P. Kollman. 2003. A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J. Comput. Chem. 24:1999-2012.
17. Matrosovich, M. N., A. S. Gambaryan, S. Teneberg, V. E. Piskarev, S. S. Yamnikova, D. K. Lvov, J. S. Robertson, and K. A. Karlsson. 1997. Avian influenza A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site. Virology. 233:224-234.