Noninferiority of a task-shifting hiv care and treatment model using peer counselors and nurses among ugandan women initiated on ART: Evidence from a randomized trial

Journal of Acquired Immune Deficiency Syndromes

Volumn 63, Issue 4, 2013, Pages

  Kiweewa, Flavia M ^a,b   Wabwire, Deo ^a   Nakibuuka, Jessica ^a   Mubiru, Mike ^a   Bagenda, Danstan ^a,b   Musoke, Phillippa ^a,c   Fowler, Mary G ^a,d   Antelman, Gretchen ^e  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b MAKERERE UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Uganda)

^c MAKERERE UNIVERSITY   (Uganda)

^d DEPARTMENT OF PATHOLOGY   (United States)

^e Department of Medicine   (United States)

Author keywords

Adherence; Antiretroviral therapy; HIV; Intervention; Nurses; Peers; Task shifting

Indexed keywords

VIRUS RNA;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; NURSE; OUTCOME ASSESSMENT; PATIENT COUNSELING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UGANDA; VIRUS DETECTION; VIRUS LOAD;

EID: 84880199761     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3182987ce6     Document Type: Article

References (40)

1. UNAIDS. Available at:http://www.unaids.org/documents/20101123- GlobalReport-em.pdf; 2010 Contract No.:Document Number. Accessed November 23, 2010.
2. Sewankambo NK, Gray RH, Ahmad S, et al. Mortality associated with HIV infection in rural Rakai District, Uganda. AIDS. 2000;14:2391-2400.
3. Hladik W, Musinguzi J, Kirungi W, et al. The estimated burden of HIV/AIDS in Uganda, 2005-2010. AIDS. 2008;22:503-510.
4. Lima VD, Harrigan R, Bangsberg DR, et al. The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time. J Acquir Immune Defic Syndr. 2009;50:529-536.
5. Kaiser R, Bunnell R, Hightower A, et al. Factors associated with HIV infection in married or cohabitating couples in Kenya:results from a nationally representative study. PLoS One. 2011;6:e17842.
6. Wood E, Hogg RS, Yip B, et al. The impact of adherence on CD4 cell count responses among HIV-infected patients. J Acquir Immune Defic Syndr. 2004;35:261-268.
7. Nachega JB, Hislop M, Dowdy DW, et al. Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes. Ann Intern Med. 2007;146:564-573.
8. Paterson DL, Swindells S, Mohr J, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133:21-30.
9. Bangsberg DR. Less than 95% adherence to nonnucleoside reverse-transcriptase inhibitor therapy can lead to viral suppression. Clin Infect Dis. 2006;43:939-941.
10. Shuter J, Sarlo JA, Kanmaz TJ, et al. HIV-infected patients receiving lopinavir/ritonavir-based antiretroviral therapy achieve high rates of virologic suppression despite adherence rates less than 95%. J Acquir Immune Defic Syndr. 2007;45:4-8.
11. Martin M, Del Cacho E, Codina C, et al. Relationship between adherence level, type of the antiretroviral regimen, and plasma HIV type 1 RNA viral load: A prospective cohort study. AIDS Res Hum Retroviruses. 2008; 24:1263-1268.
12. Harrigan PR, Hogg RS, Dong WW, et al. Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. J Infect Dis. 2005;191:339-347.
13. Tuldra A, Fumaz CR, Ferrer MJ, et al. Prospective randomized two-Arm controlled study to determine the efficacy of a specific intervention to improve long-term adherence to highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2000;25:221-228.
14. Richard N, Juntilla M, Abraha A, et al. High prevalence of antiretroviral resistance in treated Ugandans infected with non-ubtype B human immunodeficiency virus type
15. AIDS Res Hum Retroviruses. 2004;20:355-364.
16. Boden D, Hurley A, Zhang L, et al. HIV-1 drug resistance in newly infected individuals. JAMA. 1999;282:1135-1141.
17. Friedland GH, Williams A. Attaining higher goals in HIV treatment:The central importance of adherence. AIDS. 1999;13(suppl 1):S61-72.
18. Simoni JM, Frick PA, Pantalone DW, et al. Antiretroviral adherence interventions: A review of current literature and ongoing studies. Top HIV Med. 2003;11:185-198.
19. Stevens W, Kaye S, Corrah T. Antiretroviral therapy in Africa. BMJ. 2004;328:280-282.
20. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type
21. Rakai Project Study Group. N Engl J Med. 2000;342:921-929.
22. Laniece I, Ciss M, Desclaux A, et al. Adherence to HAART and its principal determinants in a cohort of Senegalese adults. AIDS. 2003;17 (suppl 3):S103-108.
23. Nemes MI, Carvalho HB, Souza MF. Antiretroviral therapy adherence in Brazil. AIDS. 2004;18(suppl 3):S15-20.
24. Weiser S, Wolfe W, Bangsberg D, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34:281-288.
25. Callaghan M, Ford N, Schneider H. A systematic review of task-hifting for HIV treatment and care in Africa. Hum Resour Health. 2010;8:8.
26. Mdege ND, Chindove S, Ali S. The effectiveness and cost implications of task-hifting in the delivery of antiretroviral therapy to HIVinfected patients: A systematic review. Health Policy Plan. 2012;28:223-236.
27. Sanne I, Orrell C, Fox MP, et al. Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-A): A randomised non-inferiority trial. Lancet. 2010;376:33-40.
28. Selke HM, Kimaiyo S, Sidle JE, et al. Task-hifting of antiretroviral delivery from health care workers to persons living with HIV/AIDS:clinical outcomes of a community-based program in Kenya. J Acquir Immune Defic Syndr. 2010;55:483-490.
29. Chang LW, Alamo S, Guma S, et al. Two-year virologic outcomes of an alternative AIDS care model:evaluation of a peer health worker and nurse-taffed community-based program in Uganda. J Acquir Immune Defic Syndr. 2009;50:276-282.
30. Chang LW, Kagaayi J, Nakigozi G, et al. Responding to the human resource crisis:peer health workers, mobile phones, and HIV care in Rakai, Uganda. AIDS Patient Care STDS. 2008;22:173-174.
31. Chang LW, Kagaayi J, Nakigozi G, et al. Effect of peer health workers on AIDS care in Rakai, Uganda: A cluster-randomized trial. PLoS One. 2010;5:e10923.
32. Chow SC, Jun S, Wang H. Sample Size Calculations in Clinical Research. 2nd ed. New York, NY:Chapman & Hall/CRC; 2008.
33. Harries AD, Zachariah R, Lawn SD, et al. Strategies to improve patient retention on antiretroviral therapy in sub-aharan Africa. Trop Med Int Health. 2010;15(suppl 1):70-75.
34. Torpey KE, Kabaso ME, Mutale LN, et al. Adherence support workers: A way to address human resource constraints in antiretroviral treatment programs in the public health setting in Zambia. PLoS One. 2008;3:e2204.
35. Shumbusho F, van Griensven J, Lowrance D, et al. Task shifting for scale-up of HIV care:evaluation of nurse-centered antiretroviral treatment at rural health centers in Rwanda. PLoS Med. 2009;6:e1000163.
36. van Griensven J, De Naeyer L, Uwera J, et al. Success with antiretroviral treatment for children in Kigali, Rwanda:experience with health center/- nurse-based care. BMC Pediatr. 2008;8:39.
37. Fairall L, Bachmann MO, Lombard C, et al. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): A pragmatic, parallel, cluster-randomised trial. Lancet. 2012;380:889-898.
38. Fairall LR, Bachmann MO, Zwarenstein MF, et al. Streamlining tasks and roles to expand treatment and care for HIV:randomised controlled trial protocol. Trials. 2008;9:21.
39. Torgerson DJ, Torgerson CJ. Designing Randomised Trials in Health, Education and the Social Sciences:An Introduction. New York, NY:Palgrave MacMillan; 2008.
40. Jaffar S, Amuron B, Foster S, et al. Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: A cluster-randomised equivalence trial. Lancet. 2009; 374:2080-2089.