Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis

BMC Medicine

Volumn 11, Issue 1, 2013, Pages

  Benedict, Ralph H B ^a   Weinstock Guttmam, Bianca ^a   Marr, Karen ^a   Valnarov, Vesela ^a   Kennedy, Cheryl ^a   Carl, Ellen ^a   Brooks, Christina ^a   Hojnacki, David ^a   Zivadinov, Robert ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

CCSVI; Cognition; Multiple sclerosis

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BECK DEPRESSION INVENTORY; BECK DEPRESSION INVENTORY FAST SCREEN; CHRONIC CEREBROSPINAL VENOUS INSUFFICIENCY; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DECISION MAKING; DEPRESSION; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; DOPPLER ECHOGRAPHY; EDUCATION; FEMALE; GENDER; HEMODYNAMICS; HUMAN; HYPOTHESIS; LEARNING; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PREDICTOR VARIABLE; RECALL;

ADULT; AGED; CEREBROVASCULAR CIRCULATION; CHRONIC DISEASE; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; SINGLE-BLIND METHOD; SPINAL CORD; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; VENOUS INSUFFICIENCY;

EID: 84880182242     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-11-167     Document Type: Article

References (51)

1. Hauser SL, Oksenberg JR, Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron 2006, 52:61-76. 10.1016/j.neuron.2006.09.011, 17015227.
2. Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu Rev Neurosci 2008, 31:247-269. 10.1146/annurev.neuro.30.051606.094313, 18558855.
3. Rao SM, Leo GJ, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 1991, 41:685-691. 10.1212/WNL.41.5.685, 2027484.
4. Benedict RHB, Cookfair D, Gavett R, Gunther M, Munschauer F, Garg N, Weinstock-Guttman B. Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). J Int Neuropsychol Soc 2006, 12:549-558.
5. Patti F, Amato M, Trojano M, Bastianello S, Tola M, Goretti B, Caniatti L, Di Monte E, Ferrazza P, Brescia Morra V, Lo Fermo S, Picconi O, Luccichenti G, COGIMUS Study Group Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study. Mult Scler 2009, 15:779-788. 10.1177/1352458509105544, 19542262, COGIMUS Study Group.
6. Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler 2007, 13:1004-1010. 10.1177/1352458507077943, 17623735.
7. Houtchens MK, Benedict RHB, Killiany R, Sharma J, Jaisani Z, Singh B, Weinstock-Guttman B, Guttmann CRG, Bakshi R. Thalamic atrophy and cognition in multiple sclerosis. Neurology 2007, 69:113-123.
8. Roosendaal SD, Bendfeldt K, Vrenken H, Polman CH, Borgwardt S, Radue EW, Kappos L, Pelletier D, Hauser SL, Matthews PM, Barkhof F, Geurts JJ. Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability. Mult Scler 2011, 17:1098-1106. 10.1177/1352458511404916, 21586487.
9. Fisher E, Lee JC, Nakamura K, Rudick RA. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann Neurol 2008, 64:255-265. 10.1002/ana.21436, 18661561.
10. Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, Salvi F. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2009, 80:392-399. 2647682, 19060024.
11. Khan O, Filippi M, Freedman MS, Barkhof F, Dore-Duffy P, Lassmann H, Trapp B, Bar-Or A, Zak I, Siegel MJ, Lisak R. Chronic cerebrospinal venous insufficiency and multiple sclerosis. Ann Neurol 2010, 67:286-290. 10.1002/ana.22001, 20373339.
12. Zivadinov R, Ramanathan M, Dolic K, Marr K, Karmon Y, Siddiqui AH, Benedict RH, Weinstock-Guttman B. Chronic cerebrospinal venous insufficiency in multiple sclerosis: diagnostic, pathogenetic, clinical and treatment perspectives. Expert Rev Neurother 2011, 11:1277-1294. 10.1586/ern.11.117, 21864074.
13. Rudick RA. Multiple sclerosis: is multiple sclerosis caused by venous insufficiency?. Nat Rev Neurol 2010, 6:472-474. 10.1038/nrneurol.2010.117, 20811464.
14. Zamboni P, Menegatti E, Galeotti R, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, Salvi F. The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J Neurol Sci 2009, 282:21-27. 10.1016/j.jns.2008.11.027, 19144359.
15. Zivadinov R. Funding CCSVI research is/was a waste of valuable time, money and intellectual energy. No. Mult Scler 2013, 19:858-860.
16. Baracchini C, Perini P, Causin F, Calabrese M, Rinaldi F, Gallo P. Progressive multiple sclerosis is not associated with chronic cerebrospinal venous insufficiency. Neurology 2011, 77:844-850. 10.1212/WNL.0b013e31822c6208, 21849656.
17. Batista S, Teter B, Sequeira K, Josyula S, Hoogs M, Ramanathan M, Benedict RH, Weinstock-Guttman B. Cognitive impairment is associated with reduced bone mass in multiple sclerosis. Mult Scler 2012, 18:1459-1465. 10.1177/1352458512440206, 22419674.
18. Doepp F, Paul F, Valdueza JM, Schmierer K, Schreiber SJ. No cerebrocervical venous congestion in patients with multiple sclerosis. Ann Neurol 2010, 68:173-183.
19. Baracchini C, Perini P, Calabrese M, Causin F, Rinaldi F, Gallo P. No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol 2011, 69:90-99. 10.1002/ana.22228, 21280079.
20. Centonze D, Floris R, Stefanini M, Rossi S, Fabiano S, Castelli M, Marziali S, Spinelli A, Motta C, Garaci FG, Bernardi G, Simonetti G. Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity. Ann Neurol 2011, 70:51-58.
21. Tsivgoulis G, Mantatzis M, Bogiatzi C, Vadikolias K, Voumvourakis K, Prassopoulos P, Piperidou C, Heliopoulos I. Extracranial venous hemodynamics in multiple sclerosis: a case-control study. Neurology 2011, 77:1241-1245. 10.1212/WNL.0b013e318230a149, 21849653.
22. Mayer CA, Pfeilschifter W, Lorenz MW, Nedelmann M, Bechmann I, Steinmetz H, Ziemann U. The perfect crime? CCSVI not leaving a trace in MS. J Neurol Neurosurg Psychiatry 2011, 82:436-440. 10.1136/jnnp.2010.231613, 3061048, 21296899.
23. Zivadinov R, Marr K, Cutter G, Ramanathan M, Benedict RH, Kennedy C, Elfadil M, Yeh AE, Reuther J, Brooks C, Hunt K, Andrews M, Carl E, Dwyer MG, Hojnacki D, Weinstock-Guttman B. Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS. Neurology 2011, 77:138-144. 10.1212/WNL.0b013e318212a901, 21490322.
24. Weinstock-Guttman B, Ramanathan M, Marr K, Hojnack D, Benedict RH, Morgan C, Yeh EA, Carl E, Kennedy C, Reuther J, Brooks C, Hunt K, Elfadil M, Andrews M, Zivadinov R. Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis. BMC Neurol 2012, 12:26. 10.1186/1471-2377-12-26, 3462121, 22587224.
25. Dolic K, Marr K, Valnarov V, Dwyer MG, Carl E, Hagemeier J, Kennedy C, Brooks C, Kilanowski C, Hunt K, Hojnacki D, Weinstock-Guttman B, Zivadinov R. Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis. Funct Neurol 2011, 26:205-214.
26. Bastianello S, Romani A, Viselner G, Tibaldi EC, Giugni E, Altieri M, Cecconi P, Mendozzi L, Farina M, Mariani D, Galassi A, Quattrini C, Mancini M, Bresciamorra V, Lagace A, McDonald S, Bono G, Bergamaschi R. Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study. BMC Neurol 2011, 11:132. 10.1186/1471-2377-11-132, 3221625, 22029656.
27. Zivadinov R, Cutter G, Marr K, Ramanathan M, Benedict RH, Bergsland N, Morgan C, Carl E, Hojnacki D, Yeh EA, Willis L, Cherneva M, Kennedy C, Dwyer MG, Weinstock-Guttman B. No association between conventional brain MR imaging and chronic cerebrospinal venous insufficiency in multiple sclerosis. AJNR Am J Neuroradiol 2012, 33:1913-1917. 10.3174/ajnr.A3112, 22576891.
28. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Ann Neurol 1983, 13:227-231. 10.1002/ana.410130302, 6847134.
29. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. [see comment]. Neurology 1996, 46:907-911. 10.1212/WNL.46.4.907, 8780061.
30. Beck AT, Steer RA, Brown GK. BDI-Fast Screen for Medical Patients: Manual 2000, San Antonio, TX: Psychological Corporation.
31. Benedict RHB, Fishman I, McClellan MM, Bakshi R, Weinstock-Guttman B. Validity of the beck depression inventory - fast screen in multiple sclerosis. Mult Scler 2003, 9:393-396. 10.1191/1352458503ms902oa, 12926845.
32. Benedict RHB, Fischer JS, Archibald CJ, Arnett PA, Beatty WW, Bobholz J, Chelune G, Fisk JD, Langdon DW, Caruso LS, Foley F, LaRocca NG, Vowels L, Weinstein A, DeLuca J, Rao SM, Munschauer F. Minimal neuropsychological assessment of MS patients: a consensus approach. Clin Neuropsychol 2002, 16:381-397. 10.1076/clin.16.3.381.13859, 12607150.
33. Parmenter BA, Testa SM, Schretlen DJ, Weinstock-Guttman B, Benedict RHB. The utility of regression-based norms in interpreting the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). J Int Neuropsychol Soc 2010, 16:6-16. 10.1017/S1355617709990750, 19796441.
34. Benedict RHB. Effects of using same- versus alternate-form memory tests during short-interval repeated assessments in multiple sclerosis. J Int Neuropsychol Soc 2005, 11:727-736.
35. Benedict R, Ramasamy D, Munschauer FE, Weinstock-Guttman B, Zivadinov R. Memory impairment in multiple sclerosis: correlation with deep gray matter and mesial temporal atrophy. Mult Scler 2008, 14:S252.
36. Tekok-Kilic A, Benedict RHB, Weinstock-Guttman B, Dwyer MG, Carone D, Srinivasaraghavan B, Yella V, Abdelrahman N, Munschauer F, Bakshi R, Zivadinov R. Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis. NeuroImage 2007, 36:1294-1300. 10.1016/j.neuroimage.2007.04.017, 17524670.
37. Smith A. Symbol Digit Modalities Test: Manual 1982, Los Angeles: Western Psychological Services.
38. Gronwall D. Paced auditory serial addition task: A measure of recovery from concussion. Percept Mot Skills 1977, 44:367-373. 10.2466/pms.1977.44.2.367, 866038.
39. Delis DC, Kramer JH, Kaplan E, Ober BA. Califorina Verbal Learning Test 2000, San Antonio, TX: The Psychological Corporation, 2.
40. Benedict RHB, Schretlen D, Groninger L, Dobraski M, Shpritz B. Revision of the Brief Visuospatial Memory Test: studies of normal performance, reliability, and validity. Psychol Assess 1996, 8:145-153.
41. Benton AL, Hamsher KS. Multilingual Aphasia Examination 1989, Iowa City: IA: AJA Associates.
42. Benton AL, Sivan AB, Hamsher K, Varney NR, Spreen O. Contributions to Neuropsychological Assessment 1994, New York: Oxford University Press, 2.
43. Delis DC, Kaplan E, Kramer JH. Delis-Kaplan Executive Function System 2001, San Antonio, TX: The Psychological Corporation.
44. Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojanacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, Zivadinov R. The severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis is related to altered cerebrospinal fluid dynamics. Funct Neurol 2009, 24:133-138.
45. Batista S, Zivadinov R, Hoogs M, Bergsland N, Heininen-Brown M, Dwyer MG, Weinstock-Guttman B, Benedict RH. Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis. J Neurol 2012, 259:139-146. 10.1007/s00415-011-6147-1, 21720932.
46. Eshaghi A, Riyahi-Alam S, Roostaei T, Haeri G, Aghsaei A, Aidi MR, Pouretemad HR, Zarei M, Farhang S, Saeedi R, Nazeri A, Ganjgahi H, Etesam F, Azimi AR, Benedict RH, Sahraian MA. Validity and reliability of a Persian translation of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). Clin Neuropsychol 2012, 26:975-984. 10.1080/13854046.2012.694912, 22681459.
47. Parmenter BA, Zivadinov R, Kerenyi L, Gavett R, Weinstock-Guttman B, Dwyer M, Garg N, Munschauer F, Benedict RHB. Validity of the Wisconsin card sorting and Delis-Kaplan executive function system (DKEFS) sorting tests in multiple sclerosis. J Clin Exp Neuropsychol 2007, 29:215-223. 10.1080/13803390600672163, 17365256.
48. Zivadinov R, Galeotti R, Hojnacki D, Menegatti E, Dwyer MG, Schirda C, Malagoni AM, Marr K, Kennedy C, Bartolomei I, Magnano C, Salvi F, Weinstock-Guttman B, Zamboni P. Value of MR venography for detection of internal jugular vein anomalies in multiple sclerosis: a pilot longitudinal study. AJNR Am J Neuroradiol 2011, 32:938-946. 10.3174/ajnr.A2386, 21474626.
49. Hojnacki D, Zamboni P, Lopez-Soriano A, Galleotti R, Menegatti E, Weinstock-Guttman B, Schirda C, Magnano C, Malagoni AM, Kennedy C, Bartolomei I, Salvi F, Zivadinov R. Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls. Int Angiol 2010, 29:127-139.
50. Benedict RH, Zivadinov R. Risk factors for and management of cognitive dysfunction in multiple sclerosis. Nat Rev Neurol 2011, 7:332-342. 10.1038/nrneurol.2011.61, 21556031.
51. Filippi M, Rocca MA, Benedict RH, DeLuca J, Geurts JJ, Rombouts SA, Ron M, Comi G. The contribution of MRI in assessing cognitive impairment in multiple sclerosis. Neurology 2010, 75:2121-2128. 10.1212/WNL.0b013e318200d768, 3385423, 21135387.