Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues

Biochemistry

Volumn 52, Issue 26, 2013, Pages 4474-4481

  Sevrioukova, Irina F ^a   Poulos, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION PROCESS; CYTOCHROME P450-3A4; HYDROPHOBIC INTERACTIONS; LIGAND BINDING MODE; LIGAND INTERACTIONS; POLAR INTERACTIONS; STERIC HINDRANCES; STRUCTURE/ACTIVITY RELATIONSHIP;

BINDING ENERGY; BINDING SITES;

LIGANDS;

CYTOCHROME P450 3A4; LIGAND; RITONAVIR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; LIGAND BINDING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP3A; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; PROTEIN BINDING; RITONAVIR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880150381     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4005396     Document Type: Article

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