Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion

Journal of Physiology

Volumn 550, Issue 1, 2003, Pages 27-33

  Dodson, Paul D ^b   Billups, Brian ^b   Rusznák, Zoltán ^a   Szǔcs, Géza ^a   Barker, Matthew C ^b   Forsythe, Ian D ^b  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DENDROTOXIN; PROTEIN SUBUNIT; TITYUS TOXIN; VOLTAGE GATED POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.2;

AFTERDISCHARGE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MEMBRANE POTENTIAL; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE ENDING; NERVE FIBER; NERVE FIBER MEMBRANE POTENTIAL; NONHUMAN; PERIKARYON; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SYNAPTIC MEMBRANE; VOLTAGE CLAMP; ACTION POTENTIAL; AMPLITUDE MODULATION; BRAIN STEM; COCHLEAR NUCLEUS; DEPOLARIZATION; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; IMMUNOHISTOCHEMISTRY; SYNAPTIC POTENTIAL; SYNAPTIC TERMINAL HYPEREXCITABILITY;

ACTION POTENTIALS; ANIMALS; AXONS; BRAIN STEM; DELAYED RECTIFIER POTASSIUM CHANNELS; ELECTRIC CONDUCTIVITY; KV1.1 POTASSIUM CHANNEL; KV1.2 POTASSIUM CHANNEL; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PRESYNAPTIC TERMINALS; RATS; RATS, INBRED STRAINS; RATS, WISTAR;

EID: 0037930230     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.046250     Document Type: Article

References (30)

1. Anderson AJ & Harvey AL (1988). Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. Br J Pharmacol 93, 215-221.
2. Barrett EF & Barrett JN (1982). Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol 323, 117-144.
3. Billups B, Wong AY & Forsythe ID (2002). Detecting synaptic connections in the medial nucleus of the trapezoid body using calcium imaging. Pflugers Arch 444, 663-669.
4. + conductances with complementary functions in postsynaptic integration at a central auditory synapse. J Neurosci 15, 8011-8022.
5. Brew HM, Hallows JL & Tempel BL (2003). Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1. J Physiol 548, 1-20.
6. + channels. Ann N Y Acad Sci 868, 233-285.
7. Cunningham MO & Jones RS (2001). Dendrotoxin sensitive potassium channels modulate GABA but not glutamate release in the rat entorhinal cortex in vitro. Neuroscience 107, 395-404.
8. Dodson PD, Barker MC & Forsythe ID (2002). Two heteromeric Kv1 potassium channels differentially regulate action potential firing. J Neurosci 22, 6953-6961.
9. Elezgarai I, Diez J, Puente N, Azkue JJ, Benitez R, Bilbao A, Knopfel T, Donate-Oliver F & Grandes P (2003). Subcellular localization of the voltage-dependent potassium channel Kv3.1b in postnatal and adult rat medial nucleus of the trapezoid body. Neuroscience 118, 889-898.
10. Fitzakerley JL, Star KV, Rinn JL & Elmquist BJ (2000). Expression of Shal potassium channel subunits in the adult and developing cochlear nucleus of the mouse. Hear Res 147, 31-45.
11. Forsythe ID (1994). Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro. J Physiol 479, 381-387.
12. Geiger JR & Jonas P (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K(+) channels in hippocampal mossy fiber boutons. Neuron 28, 927-939.
13. Hopkins WF (1998). Toxin and subunit specificity of blocking affinity of three peptide toxins for heteromultimeric, voltage-gated potassium channels expressed in Xenopus oocytes. J Pharmacol Exp Ther 285, 1051-1060.
14. Jackson M, Konnerth A & Augustine G (1991). Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals. Proc Natl Acad Sci U S A 88, 380-384.
15. Lambe EK & Aghajanian GK (2001). The Role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. J Neurosci 21, 9955-9963.
16. Manganas LN, Wang Q, Scannevin RH, Antonucci DE, Rhodes KJ & Trimmer JS (2001). Identification of a trafficking determinant localized to the Kv1 potassium channel pore. Proc Natl Acad Sci USA 98, 14055-14059.
17. + channels. Neuron 24, 1037-1047.
18. + channel complexes. J Neurosci 17, 8246-8258.
19. Robertson B, Owen D, Stow J, Butler C & Newland C (1996). Novel effects of dendrotoxin homologues on subtypes of mammalian Kv1 potassium channels expressed in Xenopus oocytes. FEBS Lett 383, 26-30.
20. + channels designed for high-frequency repetitive firing. Trends Neurosci 24, 517-526.
21. Rusznak Z, Forsythe ID, Brew HM & Stanfield PR (1997). Membrane currents influencing action potential latency in granule neurons of the rat cochlear nucleus. Eur J Neurosci 9, 2348-2358.
22. + channel Kv1 subtypes in synaptic membranes from bovine brain. Biochemistry 36, 8195-8201.
23. Smart SL, Lopantsev V, Zhang CL, Robbins CA, Wang H, Chiu SY, Schwartzkroin PA, Messing A & Tempel BL (1998). Deletion of the K(V 1.1 potassium channel causes epilepsy in mice. Neuron 20, 809-819.
24. Southan AP & Robertson B (1998). Patch-clamp recordings from cerebellar basket cell bodies and their presynaptic terminals reveal an asymmetric distribution of voltage-gated potassium channels. J Neurosci 18, 948-955.
25. Southan AP & Robertson B (2000). Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and Purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals. J Neurosci 20, 114-122.
26. 2+ concentration rises in rat cerebellar basket cell axons. J Physiol 520, 65-78.
27. Trussell LO (1999). Synaptic mechanisms for coding timing in auditory neurons. Annu Rev Physiol 61, 477-496.
28. Wang H, Kunkel DD, Schwartzkroin PA & Tempel BL (1994). Localization of Kv1.1 and Kv1.2, 2 K-channel proteins, to synaptic terminals, somata, and dendrites in the mouse-brain. J Neurosci 14, 4588-4599.
29. Zhang C-L, Messing A & Chiu SY (1999). Specific alteration of spontaneous GABAergic inhibition in cerebellar Purkinje cells in mice lacking the potassium channel Kv1.1. J Neurosci 19, 2852-2864.
30. Zhou L, Zhang CL, Messing A & Chiu SY (1998). Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: role of potassium channels under the myelin sheath in young nerves. J Neurosci 18, 7200-7215.