메뉴 건너뛰기




Volumn 27, Issue 3, 2013, Pages 76-84

Everolimus immunosuppression in de novo heart transplant recipients: What does the evidence tell us now?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETABOLITE; AZATHIOPRINE; CALCINEURIN INHIBITOR; CREATININE; CYCLOSPORIN; EVEROLIMUS; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; STEROID; TACROLIMUS;

EID: 84880131323     PISSN: 0955470X     EISSN: 15579816     Source Type: Journal    
DOI: 10.1016/j.trre.2013.03.002     Document Type: Review
Times cited : (28)

References (82)
  • 1
    • 77955928444 scopus 로고    scopus 로고
    • Everolimus: efficacy and safety in cardiac transplantation
    • Schaffer S.A., Ross H.J. Everolimus: efficacy and safety in cardiac transplantation. Expert Opin Drug Saf 2010, 9:843-854.
    • (2010) Expert Opin Drug Saf , vol.9 , pp. 843-854
    • Schaffer, S.A.1    Ross, H.J.2
  • 2
    • 77954363497 scopus 로고    scopus 로고
    • Clinical recommendations for the use of everolimus in heart transplantation
    • Manito N., Delgado J.F., Crespo-Leiro M.G., et al. Clinical recommendations for the use of everolimus in heart transplantation. Transplant Rev (Orlando) 2010, 24:129-142.
    • (2010) Transplant Rev (Orlando) , vol.24 , pp. 129-142
    • Manito, N.1    Delgado, J.F.2    Crespo-Leiro, M.G.3
  • 3
    • 84876930437 scopus 로고    scopus 로고
    • Everolimus versus mycophenolate mofetil in heart transplantation: a randomised, multicentre trial
    • [Epub ahead of print]
    • Eisen H, Kobashigawa J, Starling RC, et al. Everolimus versus mycophenolate mofetil in heart transplantation: a randomised, multicentre trial. Am J Transplant 2013. [Epub ahead of print]. http://dx.doi.org/10.1111/ajt.12181.
    • (2013) Am J Transplant
    • Eisen, H.1    Kobashigawa, J.2    Starling, R.C.3
  • 4
    • 84875946224 scopus 로고    scopus 로고
    • Efficacy and safety of low-dose cyclosporine with everolimus and steroids in de novo heart transplant patients: a multicentre, randomized trial
    • Zuckermann A., Wang S.S., Ross H., et al. Efficacy and safety of low-dose cyclosporine with everolimus and steroids in de novo heart transplant patients: a multicentre, randomized trial. J Transplant. 2011, 2011:535983.
    • (2011) J Transplant. , vol.2011 , pp. 535983
    • Zuckermann, A.1    Wang, S.S.2    Ross, H.3
  • 5
    • 67651008877 scopus 로고    scopus 로고
    • 2411 Study Investigators: everolimus with reduced cyclosporine versus MMF with standard cyclosporine in de novo heart transplant recipients
    • Lehmkuhl H.B., Arizon J., Viganò M., et al. 2411 Study Investigators: everolimus with reduced cyclosporine versus MMF with standard cyclosporine in de novo heart transplant recipients. Transplantation 2009, 88:115-122.
    • (2009) Transplantation , vol.88 , pp. 115-122
    • Lehmkuhl, H.B.1    Arizon, J.2    Viganò, M.3
  • 6
    • 77955506095 scopus 로고    scopus 로고
    • Can cyclosporine blood level be reduced to half after heart transplantation?
    • Wang S.S., Chou N.K., Chi N.H., et al. Can cyclosporine blood level be reduced to half after heart transplantation?. Transplant Proc 2010, 42:930-933.
    • (2010) Transplant Proc , vol.42 , pp. 930-933
    • Wang, S.S.1    Chou, N.K.2    Chi, N.H.3
  • 7
    • 77950952997 scopus 로고    scopus 로고
    • Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial
    • Gullestad L., Iversen M., Mortensen S.A., et al. Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial. Transplantation 2010, 89:864-872.
    • (2010) Transplantation , vol.89 , pp. 864-872
    • Gullestad, L.1    Iversen, M.2    Mortensen, S.A.3
  • 8
    • 76649119471 scopus 로고    scopus 로고
    • Cyclosporine lowering with everolimus or mycophenolate to preserve renal function in heart recipients: a randomized study
    • Potena L., Bianchi I.G., Magnani G., et al. Cyclosporine lowering with everolimus or mycophenolate to preserve renal function in heart recipients: a randomized study. Transplantation 2010, 89:263-265.
    • (2010) Transplantation , vol.89 , pp. 263-265
    • Potena, L.1    Bianchi, I.G.2    Magnani, G.3
  • 9
    • 80054122390 scopus 로고    scopus 로고
    • Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: practical clinical management questions
    • Epailly E., Albanell J., Andreassen A., et al. Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: practical clinical management questions. Clin Transplant 2011, 25:E475-E486.
    • (2011) Clin Transplant , vol.25
    • Epailly, E.1    Albanell, J.2    Andreassen, A.3
  • 10
    • 38949126946 scopus 로고    scopus 로고
    • Cyclosporine reduction in the presence of everolimus: 3-month data from a Canadian pilot study of maintenance cardiac allograft recipients
    • CADENCE Study Group
    • Ross H., Pflugfelder P., Haddad H., et al. Cyclosporine reduction in the presence of everolimus: 3-month data from a Canadian pilot study of maintenance cardiac allograft recipients. J Heart Lung Transplant 2008, 27:197-202. CADENCE Study Group.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 197-202
    • Ross, H.1    Pflugfelder, P.2    Haddad, H.3
  • 11
    • 77952545939 scopus 로고    scopus 로고
    • Benefit of early conversion from CNI-based to everolimus-based immunosuppression in heart transplantation
    • Gude E., Gullestad L., Arora S., et al. Benefit of early conversion from CNI-based to everolimus-based immunosuppression in heart transplantation. J Heart Lung Transplant 2010, 29:641-647.
    • (2010) J Heart Lung Transplant , vol.29 , pp. 641-647
    • Gude, E.1    Gullestad, L.2    Arora, S.3
  • 12
    • 65549163804 scopus 로고    scopus 로고
    • Does everolimus associated with a low dose of cyclosporine in long-term cardiac transplant recipients improve renal function? Initial experience
    • Boffini M., Sansone F., Patanè F., et al. Does everolimus associated with a low dose of cyclosporine in long-term cardiac transplant recipients improve renal function? Initial experience. Transplant Proc 2009, 41:1349-1352.
    • (2009) Transplant Proc , vol.41 , pp. 1349-1352
    • Boffini, M.1    Sansone, F.2    Patanè, F.3
  • 13
    • 79959452569 scopus 로고    scopus 로고
    • Everolimus plus dosage reduction of cyclosporine in cardiac transplant recipients with chronic kidney disease: a two-year follow-up study
    • Fuchs U., Zittermann A., Hakim-Meibodi K., et al. Everolimus plus dosage reduction of cyclosporine in cardiac transplant recipients with chronic kidney disease: a two-year follow-up study. Transplant Proc 2011, 43:1839-1846.
    • (2011) Transplant Proc , vol.43 , pp. 1839-1846
    • Fuchs, U.1    Zittermann, A.2    Hakim-Meibodi, K.3
  • 14
    • 33646404334 scopus 로고    scopus 로고
    • Everolimus and reduced cyclosporine trough levels in maintenance heart transplant recipients
    • Schweiger M., Wasler A., Prenner G., et al. Everolimus and reduced cyclosporine trough levels in maintenance heart transplant recipients. Transpl Immunol 2006, 16:46-51.
    • (2006) Transpl Immunol , vol.16 , pp. 46-51
    • Schweiger, M.1    Wasler, A.2    Prenner, G.3
  • 15
    • 34548686826 scopus 로고    scopus 로고
    • MTOR inhibitors: do they help preserve renal function?
    • Moro J., Almenar L., Martínez-Dolz L., et al. mTOR inhibitors: do they help preserve renal function?. Transplant Proc 2007, 39:2135-2137.
    • (2007) Transplant Proc , vol.39 , pp. 2135-2137
    • Moro, J.1    Almenar, L.2    Martínez-Dolz, L.3
  • 16
    • 82155196444 scopus 로고    scopus 로고
    • Renal function in children with heart transplantation after switching to CNI-free immunosuppression with everolimus
    • Behnke-Hall K., Bauer J., Thul J., et al. Renal function in children with heart transplantation after switching to CNI-free immunosuppression with everolimus. Pediatr Transplant 2011, 15:784-789.
    • (2011) Pediatr Transplant , vol.15 , pp. 784-789
    • Behnke-Hall, K.1    Bauer, J.2    Thul, J.3
  • 17
    • 55749100122 scopus 로고    scopus 로고
    • Preliminary experience with conversion from calcineurin inhibitors to everolimus in cardiac transplantation maintenance therapy
    • Sánchez-Brotons J.A., Sobrino-Márquez J.M., Lage-Gallé E., et al. Preliminary experience with conversion from calcineurin inhibitors to everolimus in cardiac transplantation maintenance therapy. Transplant Proc 2008, 40:3046-3048.
    • (2008) Transplant Proc , vol.40 , pp. 3046-3048
    • Sánchez-Brotons, J.A.1    Sobrino-Márquez, J.M.2    Lage-Gallé, E.3
  • 18
    • 65649125950 scopus 로고    scopus 로고
    • Progression of renal dysfunction in cardiac transplantation after the introduction of everolimus in the immunosuppressive regime
    • Moro López J.A., Almenar L., Martínez-Dolz L., et al. Progression of renal dysfunction in cardiac transplantation after the introduction of everolimus in the immunosuppressive regime. Transplantation 2009, 87:538-541.
    • (2009) Transplantation , vol.87 , pp. 538-541
    • Moro López, J.A.1    Almenar, L.2    Martínez-Dolz, L.3
  • 19
    • 79959447991 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free immunosuppression using everolimus (Certican) after heart transplantation: 2years' follow-up from the University Hospital Münster
    • Stypmann J., Engelen M.A., Eckernkemper S., et al. Calcineurin inhibitor-free immunosuppression using everolimus (Certican) after heart transplantation: 2years' follow-up from the University Hospital Münster. Transplant Proc 2011, 43:1847-1852.
    • (2011) Transplant Proc , vol.43 , pp. 1847-1852
    • Stypmann, J.1    Engelen, M.A.2    Eckernkemper, S.3
  • 20
    • 33847375217 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free immunosuppression using everolimus (Certican) in maintenance heart transplant recipients: 6months' follow-up
    • Rothenburger M., Teerling E., Bruch C., et al. Calcineurin inhibitor-free immunosuppression using everolimus (Certican) in maintenance heart transplant recipients: 6months' follow-up. J Heart Lung Transplant 2007, 26:250-257.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 250-257
    • Rothenburger, M.1    Teerling, E.2    Bruch, C.3
  • 21
    • 84894890490 scopus 로고    scopus 로고
    • Study design and preliminary results of the Italian Everolimus Registry CERTIC
    • Parisi F., Branzi A., Fiocchi R., et al. Study design and preliminary results of the Italian Everolimus Registry CERTIC. J Heart Lung Transplant 2012, 31(Suppl.):S223-S224.
    • (2012) J Heart Lung Transplant , vol.31 , Issue.SUPPL.
    • Parisi, F.1    Branzi, A.2    Fiocchi, R.3
  • 22
    • 84867057600 scopus 로고    scopus 로고
    • Virtual histology assessment of cardiac allograft vasculopathy following introduction of everolimus - results of a multicenter trial
    • Arora S., Erikstad I., Ueland T., et al. Virtual histology assessment of cardiac allograft vasculopathy following introduction of everolimus - results of a multicenter trial. Am J Transplant 2012, 12:2700-2709.
    • (2012) Am J Transplant , vol.12 , pp. 2700-2709
    • Arora, S.1    Erikstad, I.2    Ueland, T.3
  • 23
    • 77954509263 scopus 로고    scopus 로고
    • Effect of everolimus on skin cancers in calcineurin inhibitor-treated heart transplant recipients
    • Euvrard S., Boissonnat P., Roussoulières A., et al. Effect of everolimus on skin cancers in calcineurin inhibitor-treated heart transplant recipients. Transpl Int 2010, 23:855-857.
    • (2010) Transpl Int , vol.23 , pp. 855-857
    • Euvrard, S.1    Boissonnat, P.2    Roussoulières, A.3
  • 24
    • 15044351065 scopus 로고    scopus 로고
    • Clinical experience with Certican (everolimus) in de novo heart transplant patients at the Deutsches Herzzentrum Berlin
    • [discussion S210]
    • Lehmkuhl H., Hetzer R. Clinical experience with Certican (everolimus) in de novo heart transplant patients at the Deutsches Herzzentrum Berlin. J Heart Lung Transplant 2005, 24(4 Suppl):S201. [discussion S210].
    • (2005) J Heart Lung Transplant , vol.24 , Issue.4 SUPPL.
    • Lehmkuhl, H.1    Hetzer, R.2
  • 25
    • 34347233810 scopus 로고    scopus 로고
    • Observational study with everolimus (Certican) in combination with low-dose cyclosporine in de novo heart transplant recipients
    • Lehmkuhl H.B., Mai D., Dandel M., et al. Observational study with everolimus (Certican) in combination with low-dose cyclosporine in de novo heart transplant recipients. J Heart Lung Transplant 2007, 26:700-704.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 700-704
    • Lehmkuhl, H.B.1    Mai, D.2    Dandel, M.3
  • 26
    • 77955493955 scopus 로고    scopus 로고
    • The survival of heart transplant recipients using cyclosporine and everolimus is not inferior to that using cyclosporine and mycophenolate
    • Wang S.S., Chou N.K., Chi N.H., et al. The survival of heart transplant recipients using cyclosporine and everolimus is not inferior to that using cyclosporine and mycophenolate. Transplant Proc 2010, 42:938-939.
    • (2010) Transplant Proc , vol.42 , pp. 938-939
    • Wang, S.S.1    Chou, N.K.2    Chi, N.H.3
  • 27
    • 53149101690 scopus 로고    scopus 로고
    • Heart transplantation under cyclosporine or tacrolimus combined with mycophenolate mofetil or everolimus
    • Wang S.S., Chou N.K., Chi N.H., et al. Heart transplantation under cyclosporine or tacrolimus combined with mycophenolate mofetil or everolimus. Transplant Proc 2008, 40:2607-2608.
    • (2008) Transplant Proc , vol.40 , pp. 2607-2608
    • Wang, S.S.1    Chou, N.K.2    Chi, N.H.3
  • 28
    • 53149128006 scopus 로고    scopus 로고
    • Induction immunosuppression with basiliximab in heart transplantation
    • Chou N.K., Wang S.S., Chen Y.S., et al. Induction immunosuppression with basiliximab in heart transplantation. Transplant Proc 2008, 40:2623-2625.
    • (2008) Transplant Proc , vol.40 , pp. 2623-2625
    • Chou, N.K.1    Wang, S.S.2    Chen, Y.S.3
  • 29
    • 84860748127 scopus 로고    scopus 로고
    • Clinical experience of tacrolimus with everolimus in heart transplantation
    • Wang S.S., Chou N.K., Chi N.H., et al. Clinical experience of tacrolimus with everolimus in heart transplantation. Transplant Proc 2012, 44:907-909.
    • (2012) Transplant Proc , vol.44 , pp. 907-909
    • Wang, S.S.1    Chou, N.K.2    Chi, N.H.3
  • 30
    • 19244366021 scopus 로고    scopus 로고
    • Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
    • RAD B253 Study Group
    • Eisen H.J., Tuzcu E.M., Dorent R., et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med 2003, 349:847-858. RAD B253 Study Group.
    • (2003) N Engl J Med , vol.349 , pp. 847-858
    • Eisen, H.J.1    Tuzcu, E.M.2    Dorent, R.3
  • 31
    • 3943072739 scopus 로고    scopus 로고
    • Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: a three-year Phase II, randomized, multicenter, open-label study
    • Nashan B., Curtis J., Ponticelli C., et al. Everolimus and reduced-exposure cyclosporine in de novo renal-transplant recipients: a three-year Phase II, randomized, multicenter, open-label study. Transplantation 2004, 78:1332-1340.
    • (2004) Transplantation , vol.78 , pp. 1332-1340
    • Nashan, B.1    Curtis, J.2    Ponticelli, C.3
  • 32
    • 10044246181 scopus 로고    scopus 로고
    • Therapeutic drug monitoring for everolimus in heart transplant recipients based on exposure-effect modeling
    • Starling R.C., Hare J.M., Hauptman P., et al. Therapeutic drug monitoring for everolimus in heart transplant recipients based on exposure-effect modeling. Am J Transplant 2004, 4:2126-2131.
    • (2004) Am J Transplant , vol.4 , pp. 2126-2131
    • Starling, R.C.1    Hare, J.M.2    Hauptman, P.3
  • 33
    • 53049096567 scopus 로고    scopus 로고
    • Avoidance of calcineurin inhibitors with use of proliferation signal inhibitors in de novo heart transplantation with renal failure
    • Gonzalez-Vilchez F., de Prada J.A., Exposito V., et al. Avoidance of calcineurin inhibitors with use of proliferation signal inhibitors in de novo heart transplantation with renal failure. J Heart Lung Transplant 2008, 27:1135-1141.
    • (2008) J Heart Lung Transplant , vol.27 , pp. 1135-1141
    • Gonzalez-Vilchez, F.1    de Prada, J.A.2    Exposito, V.3
  • 34
    • 0034466751 scopus 로고    scopus 로고
    • What is the optimal prophylaxis for treatment of cardiac allograft vasculopathy?
    • Kobashigawa J. What is the optimal prophylaxis for treatment of cardiac allograft vasculopathy?. Curr Control Trials Cardiovasc Med 2000, 1:166-171.
    • (2000) Curr Control Trials Cardiovasc Med , vol.1 , pp. 166-171
    • Kobashigawa, J.1
  • 35
    • 79953310537 scopus 로고    scopus 로고
    • Cardiac allograft vasculopathy: current knowledge and future direction
    • Colvin-Adams M., Agnihotri A. Cardiac allograft vasculopathy: current knowledge and future direction. Clin Transplant 2011, 25:175-184.
    • (2011) Clin Transplant , vol.25 , pp. 175-184
    • Colvin-Adams, M.1    Agnihotri, A.2
  • 36
    • 23744498894 scopus 로고    scopus 로고
    • Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report - 2005
    • Taylor D.O., Edwards L.B., Boucek M.M., et al. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult heart transplant report - 2005. J Heart Lung Transplant 2005, 24:945-955.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 945-955
    • Taylor, D.O.1    Edwards, L.B.2    Boucek, M.M.3
  • 37
    • 0742322206 scopus 로고    scopus 로고
    • Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation
    • Azzola A., Havryk A., Chhajed P., et al. Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation. Transplantation 2004, 77:275-280.
    • (2004) Transplantation , vol.77 , pp. 275-280
    • Azzola, A.1    Havryk, A.2    Chhajed, P.3
  • 38
    • 34948819132 scopus 로고    scopus 로고
    • Prognostic impact of microvasculopathy on survival after heart transplantation: evidence from 9713 endomyocardial biopsies
    • Hiemann N.E., Wellnhofer E., Knosalla C., et al. Prognostic impact of microvasculopathy on survival after heart transplantation: evidence from 9713 endomyocardial biopsies. Circulation 2007, 116:1274-1282.
    • (2007) Circulation , vol.116 , pp. 1274-1282
    • Hiemann, N.E.1    Wellnhofer, E.2    Knosalla, C.3
  • 39
    • 0026328030 scopus 로고
    • Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts
    • Akselband Y., Harding M.W., Nelson P.A. Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts. Transplant Proc 1991, 23:2833-2836.
    • (1991) Transplant Proc , vol.23 , pp. 2833-2836
    • Akselband, Y.1    Harding, M.W.2    Nelson, P.A.3
  • 40
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
    • Humar R., Kiefer F.N., Berns H., et al. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 2002, 16:771-780.
    • (2002) FASEB J , vol.16 , pp. 771-780
    • Humar, R.1    Kiefer, F.N.2    Berns, H.3
  • 41
    • 0033057120 scopus 로고    scopus 로고
    • SDZ RAD inhibits cold ischemia-induced vascular remodeling
    • Schuurman H.-J., Pally C., Weckbecker G., et al. SDZ RAD inhibits cold ischemia-induced vascular remodeling. Transplant Proc 1999, 31:1024-1025.
    • (1999) Transplant Proc , vol.31 , pp. 1024-1025
    • Schuurman, H.-J.1    Pally, C.2    Weckbecker, G.3
  • 42
    • 0242268930 scopus 로고    scopus 로고
    • Differential effect of cyclosporine A and SDZ RAD on neointima formation of carotid artery allografts in apolipoprotein E-deficient mice
    • Matsumoto Y., Hof A., Baumlin Y., et al. Differential effect of cyclosporine A and SDZ RAD on neointima formation of carotid artery allografts in apolipoprotein E-deficient mice. Transplantation 2003, 76:1166-1170.
    • (2003) Transplantation , vol.76 , pp. 1166-1170
    • Matsumoto, Y.1    Hof, A.2    Baumlin, Y.3
  • 43
    • 79960040877 scopus 로고    scopus 로고
    • Twelve-month clinical outcomes of everolimus-eluting stent as compared to paclitaxel- and sirolimus-eluting stent in patients undergoing percutaneous coronary interventions. A meta-analysis of randomized clinical trials
    • Cassese S., Piccolo R., Galasso G., et al. Twelve-month clinical outcomes of everolimus-eluting stent as compared to paclitaxel- and sirolimus-eluting stent in patients undergoing percutaneous coronary interventions. A meta-analysis of randomized clinical trials. Int J Cardiol 2011, 150:84-89.
    • (2011) Int J Cardiol , vol.150 , pp. 84-89
    • Cassese, S.1    Piccolo, R.2    Galasso, G.3
  • 44
    • 84857619444 scopus 로고    scopus 로고
    • Long-term comparison of everolimus- and sirolimus-eluting stents in patients with acute coronary syndromes
    • Kalesan B., Stefanini G.G., Räber L., et al. Long-term comparison of everolimus- and sirolimus-eluting stents in patients with acute coronary syndromes. JACC Cardiovasc Interv 2012, 5:145-154.
    • (2012) JACC Cardiovasc Interv , vol.5 , pp. 145-154
    • Kalesan, B.1    Stefanini, G.G.2    Räber, L.3
  • 45
    • 79956142994 scopus 로고    scopus 로고
    • Long-term comparison of everolimus-eluting and sirolimus-eluting stents for coronary revascularization
    • Räber L., Jüni P., Nüesch E., et al. Long-term comparison of everolimus-eluting and sirolimus-eluting stents for coronary revascularization. J Am Coll Cardiol 2011, 57:2143-2151.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 2143-2151
    • Räber, L.1    Jüni, P.2    Nüesch, E.3
  • 46
    • 80855139679 scopus 로고    scopus 로고
    • Everolimus prevents endomyocardial remodeling after heart transplantation
    • Hiemann N.E., Wellnhofer E., Lehmkuhl H.B., et al. Everolimus prevents endomyocardial remodeling after heart transplantation. Transplantation 2011, 92:1165-1172.
    • (2011) Transplantation , vol.92 , pp. 1165-1172
    • Hiemann, N.E.1    Wellnhofer, E.2    Lehmkuhl, H.B.3
  • 47
    • 20944441873 scopus 로고    scopus 로고
    • Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years
    • Kobashigawa J.A., Tobis J.M., Starling R.C., et al. Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years. J Am Coll Cardiol 2005, 45:1532-1537.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1532-1537
    • Kobashigawa, J.A.1    Tobis, J.M.2    Starling, R.C.3
  • 48
    • 34249279808 scopus 로고    scopus 로고
    • RAD B253 Study Group: prevention of acute rejection and allograft vasculopathy by everolimus in cardiac transplants recipients: a 24-month analysis
    • Viganò M., Tuzcu M., Benza R., et al. RAD B253 Study Group: prevention of acute rejection and allograft vasculopathy by everolimus in cardiac transplants recipients: a 24-month analysis. J Heart Lung Transplant 2007, 26:584-592.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 584-592
    • Viganò, M.1    Tuzcu, M.2    Benza, R.3
  • 49
    • 37849054599 scopus 로고    scopus 로고
    • Intravascular ultrasound correlates with coronary flow reserve and predicts the survival in angiographically normal cardiac transplant recipients
    • Lee C.M., Wu Y.W., Jui H.Y., et al. Intravascular ultrasound correlates with coronary flow reserve and predicts the survival in angiographically normal cardiac transplant recipients. Cardiology 2008, 109:93-98.
    • (2008) Cardiology , vol.109 , pp. 93-98
    • Lee, C.M.1    Wu, Y.W.2    Jui, H.Y.3
  • 50
    • 0038164872 scopus 로고    scopus 로고
    • First-year intravascular ultrasound results as a surrogate marker for outcomes after heart transplantation
    • Kobashigawa J.A. First-year intravascular ultrasound results as a surrogate marker for outcomes after heart transplantation. J Heart Lung Transplant 2003, 22:711-714.
    • (2003) J Heart Lung Transplant , vol.22 , pp. 711-714
    • Kobashigawa, J.A.1
  • 51
    • 20944441984 scopus 로고    scopus 로고
    • Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac transplantation
    • Tuzcu E.M., Kapadia S.R., Sachar R., et al. Intravascular ultrasound evidence of angiographically silent progression in coronary atherosclerosis predicts long-term morbidity and mortality after cardiac transplantation. J Am Coll Cardiol 2005, 45:1538-1542.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1538-1542
    • Tuzcu, E.M.1    Kapadia, S.R.2    Sachar, R.3
  • 52
    • 33750377251 scopus 로고    scopus 로고
    • The impact of proliferation signal inhibitors on the healthcare burden of major adverse cardiac events following heart transplantation
    • Eisen H., Yang X. The impact of proliferation signal inhibitors on the healthcare burden of major adverse cardiac events following heart transplantation. Transplantation 2006, 82(8S):S13-S18.
    • (2006) Transplantation , vol.82 , Issue.8 S
    • Eisen, H.1    Yang, X.2
  • 53
    • 79960305705 scopus 로고    scopus 로고
    • Effect of everolimus introduction on cardiac allograft vasculopathy-results of a randomized, multicenter trial
    • Arora S., Ueland T., Wennerblom B., et al. Effect of everolimus introduction on cardiac allograft vasculopathy-results of a randomized, multicenter trial. Transplantation 2011, 92:235-243.
    • (2011) Transplantation , vol.92 , pp. 235-243
    • Arora, S.1    Ueland, T.2    Wennerblom, B.3
  • 54
    • 79954489163 scopus 로고    scopus 로고
    • Factors associated with the development of cytomegalovirus infection following solid organ transplantation
    • da Cunha-Bang C., Sørensen S.S., Iversen M., et al. Factors associated with the development of cytomegalovirus infection following solid organ transplantation. Scand J Infect Dis 2011, 43:360-365.
    • (2011) Scand J Infect Dis , vol.43 , pp. 360-365
    • da Cunha-Bang, C.1    Sørensen, S.S.2    Iversen, M.3
  • 55
    • 79953864833 scopus 로고    scopus 로고
    • Update and review: state-of-the-art management of cytomegalovirus infection and disease following thoracic organ transplantation
    • Snydman D.R., Limaye A.P., Potena L., Zamora M.R. Update and review: state-of-the-art management of cytomegalovirus infection and disease following thoracic organ transplantation. Transplant Proc 2011, 43(3 Suppl):S1-S17.
    • (2011) Transplant Proc , vol.43 , Issue.3 SUPPL.
    • Snydman, D.R.1    Limaye, A.P.2    Potena, L.3    Zamora, M.R.4
  • 56
    • 34347386490 scopus 로고    scopus 로고
    • Cytomegalovirus-associated allograft rejection in heart transplant patients
    • Potena L., Valantine H.A. Cytomegalovirus-associated allograft rejection in heart transplant patients. Curr Opin Infect Dis 2007, 20:425-431.
    • (2007) Curr Opin Infect Dis , vol.20 , pp. 425-431
    • Potena, L.1    Valantine, H.A.2
  • 57
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials
    • Webster A.C., Lee V.W., Chapman J.R., et al. Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials. Transplantation 2006, 81:1234-1248.
    • (2006) Transplantation , vol.81 , pp. 1234-1248
    • Webster, A.C.1    Lee, V.W.2    Chapman, J.R.3
  • 58
    • 84857194014 scopus 로고    scopus 로고
    • Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: pooled analysis of three clinical trials
    • Brennan D.C., Legendre C., Patel D., et al. Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: pooled analysis of three clinical trials. Am J Transplant 2011, 11:2453-2462.
    • (2011) Am J Transplant , vol.11 , pp. 2453-2462
    • Brennan, D.C.1    Legendre, C.2    Patel, D.3
  • 59
    • 84875942737 scopus 로고    scopus 로고
    • Everolimus is associated with a reduced incidence of cytomegalovirus infection following de novo cardiac transplantation
    • Kobashigawa J., Ross H., Bara C., et al. Everolimus is associated with a reduced incidence of cytomegalovirus infection following de novo cardiac transplantation. Transpl Infect Dis 2013, 15:150-162.
    • (2013) Transpl Infect Dis , vol.15 , pp. 150-162
    • Kobashigawa, J.1    Ross, H.2    Bara, C.3
  • 60
    • 77149153725 scopus 로고    scopus 로고
    • RAD A2411 Study Investigators: lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: a randomized, multicenter study
    • Viganò M., Dengler T., Mattei M.F., et al. RAD A2411 Study Investigators: lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: a randomized, multicenter study. Transpl Infect Dis 2010, 12:23-30.
    • (2010) Transpl Infect Dis , vol.12 , pp. 23-30
    • Viganò, M.1    Dengler, T.2    Mattei, M.F.3
  • 61
    • 37349084974 scopus 로고    scopus 로고
    • A lower incidence of cytomegalovirus infection in de novo heart transplant recipients randomized to everolimus
    • Hill J.A., Hummel M., Starling R.C., et al. A lower incidence of cytomegalovirus infection in de novo heart transplant recipients randomized to everolimus. Transplantation 2007, 84:1436-1442.
    • (2007) Transplantation , vol.84 , pp. 1436-1442
    • Hill, J.A.1    Hummel, M.2    Starling, R.C.3
  • 62
    • 84861818332 scopus 로고    scopus 로고
    • CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages
    • Poglitsch M., Weichhart T., Hecking M., et al. CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Am J Transplant 2012, 12:1458-1468.
    • (2012) Am J Transplant , vol.12 , pp. 1458-1468
    • Poglitsch, M.1    Weichhart, T.2    Hecking, M.3
  • 63
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T-cell differentiation
    • Araki K., Turner A.P., Shaffer V.O., et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009, 460:108-112.
    • (2009) Nature , vol.460 , pp. 108-112
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3
  • 64
    • 77951678634 scopus 로고    scopus 로고
    • The role of mTOR in memory CD8 T-cell differentiation
    • Araki K., Youngblood B., Ahmed R. The role of mTOR in memory CD8 T-cell differentiation. Immunol Rev 2010, 235:234-243.
    • (2010) Immunol Rev , vol.235 , pp. 234-243
    • Araki, K.1    Youngblood, B.2    Ahmed, R.3
  • 65
    • 84856872316 scopus 로고    scopus 로고
    • Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: the significance of baseline glomerular filtration rate
    • Arora S., Gude E., Sigurdardottir V., et al. Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: the significance of baseline glomerular filtration rate. J Heart Lung Transplant 2012, 31:259-265.
    • (2012) J Heart Lung Transplant , vol.31 , pp. 259-265
    • Arora, S.1    Gude, E.2    Sigurdardottir, V.3
  • 66
    • 80051798081 scopus 로고    scopus 로고
    • Conversion of long-term kidney transplant recipients from calcineurin inhibitor therapy to everolimus: a randomized, multicenter, 24-month study
    • ASCERTAIN Investigators
    • Holdaas H., Rostaing L., Serón D., et al. Conversion of long-term kidney transplant recipients from calcineurin inhibitor therapy to everolimus: a randomized, multicenter, 24-month study. Transplantation 2011, 92:410-418. ASCERTAIN Investigators.
    • (2011) Transplantation , vol.92 , pp. 410-418
    • Holdaas, H.1    Rostaing, L.2    Serón, D.3
  • 67
    • 27644436740 scopus 로고    scopus 로고
    • Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
    • Kauffman H.M., Cherikh W.S., Cheng Y., Hanto D.W., Kahan B.D. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 2005, 80:883-889.
    • (2005) Transplantation , vol.80 , pp. 883-889
    • Kauffman, H.M.1    Cherikh, W.S.2    Cheng, Y.3    Hanto, D.W.4    Kahan, B.D.5
  • 68
    • 84880274717 scopus 로고    scopus 로고
    • The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
    • [Epub ahead of print]
    • Sully K., Akinduro O., Philpott M.P., et al. The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. Oncogene 2012, [Epub ahead of print]. 10.1038/onc.2012.338.
    • (2012) Oncogene
    • Sully, K.1    Akinduro, O.2    Philpott, M.P.3
  • 69
    • 38949125143 scopus 로고    scopus 로고
    • Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation
    • Zuckermann A., Manito N., Epailly E., et al. Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation. J Lung Heart Transplant 2008, 27:141-149.
    • (2008) J Lung Heart Transplant , vol.27 , pp. 141-149
    • Zuckermann, A.1    Manito, N.2    Epailly, E.3
  • 70
    • 79959830895 scopus 로고    scopus 로고
    • Surgical wound complications after heart transplantation
    • Zuckermann A., Barten M.J. Surgical wound complications after heart transplantation. Transplant Int 2011, 24:627-636.
    • (2011) Transplant Int , vol.24 , pp. 627-636
    • Zuckermann, A.1    Barten, M.J.2
  • 71
    • 80755144030 scopus 로고    scopus 로고
    • Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials
    • Pengel L.H., Liu L.Q., Morris P.J. Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials. Transplant Int 2011, 24:1216-1230.
    • (2011) Transplant Int , vol.24 , pp. 1216-1230
    • Pengel, L.H.1    Liu, L.Q.2    Morris, P.J.3
  • 72
    • 80052397126 scopus 로고    scopus 로고
    • Impact of de novo everolimus-based immunosuppression on incisional complications in heart transplantation
    • Zuckermann A., Arizon J.M., Dong G., et al. Impact of de novo everolimus-based immunosuppression on incisional complications in heart transplantation. Transplantation 2011, 92:594-600.
    • (2011) Transplantation , vol.92 , pp. 594-600
    • Zuckermann, A.1    Arizon, J.M.2    Dong, G.3
  • 73
    • 67651039979 scopus 로고    scopus 로고
    • RAD A2420 Study Group: incidence of delayed graft function and wound healing complications after deceased-donor kidney transplantation is not affected by de novo everolimus
    • Albano L., Berthoux F., Moal M.C., et al. RAD A2420 Study Group: incidence of delayed graft function and wound healing complications after deceased-donor kidney transplantation is not affected by de novo everolimus. Transplantation 2009, 88:69-76.
    • (2009) Transplantation , vol.88 , pp. 69-76
    • Albano, L.1    Berthoux, F.2    Moal, M.C.3
  • 74
    • 84894884271 scopus 로고    scopus 로고
    • Early vs delayed everolimus in de novo heart transplant recipients
    • Potena L., Rinaldi M., Maiello C., et al. Early vs delayed everolimus in de novo heart transplant recipients. J Heart Lung Transplant 2011, 30(4 Supp):S35.
    • (2011) J Heart Lung Transplant , vol.30 , Issue.4 SUPPL.
    • Potena, L.1    Rinaldi, M.2    Maiello, C.3
  • 75
    • 0036828707 scopus 로고    scopus 로고
    • Predictors of pericardial effusion after orthotopic heart transplantation
    • Quin J.A., Tauriainen M.P., Huber L.M., et al. Predictors of pericardial effusion after orthotopic heart transplantation. J Thorac Cardiovasc Surg 2002, 124:979-983.
    • (2002) J Thorac Cardiovasc Surg , vol.124 , pp. 979-983
    • Quin, J.A.1    Tauriainen, M.P.2    Huber, L.M.3
  • 76
    • 0028217832 scopus 로고
    • Pericardial effusions after cardiac transplantation
    • Hauptman P.J., Couper G.S., Aranki S.F., et al. Pericardial effusions after cardiac transplantation. J Am Coll Cardiol 1994, 23:1625-1629.
    • (1994) J Am Coll Cardiol , vol.23 , pp. 1625-1629
    • Hauptman, P.J.1    Couper, G.S.2    Aranki, S.F.3
  • 77
    • 34250167157 scopus 로고    scopus 로고
    • Clinical course and predictors of pericardial effusion following cardiac transplantation
    • Al-Dadah A.S., Guthrie T.J., Pasque M.K., et al. Clinical course and predictors of pericardial effusion following cardiac transplantation. Transplant Proc 2007, 39:1589-1592.
    • (2007) Transplant Proc , vol.39 , pp. 1589-1592
    • Al-Dadah, A.S.1    Guthrie, T.J.2    Pasque, M.K.3
  • 78
    • 0029159919 scopus 로고
    • Significance of pericardial effusion after heart transplantation
    • Ciliberto G.R., Anjos M.C., Gronda E., et al. Significance of pericardial effusion after heart transplantation. Am J Cardiol 1995, 76:297-300.
    • (1995) Am J Cardiol , vol.76 , pp. 297-300
    • Ciliberto, G.R.1    Anjos, M.C.2    Gronda, E.3
  • 79
    • 78650832714 scopus 로고    scopus 로고
    • Two-year outcomes in thoracic transplant recipients after conversion to everolimus with reduced calcineurin inhibitor within a multicenter, open-label, randomized trial
    • Gullestad L., Mortensen S.A., Eiskjær H., et al. Two-year outcomes in thoracic transplant recipients after conversion to everolimus with reduced calcineurin inhibitor within a multicenter, open-label, randomized trial. Transplantation 2010, 90:1581-1589.
    • (2010) Transplantation , vol.90 , pp. 1581-1589
    • Gullestad, L.1    Mortensen, S.A.2    Eiskjær, H.3
  • 80
    • 33745393847 scopus 로고    scopus 로고
    • Study Investigators: tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report
    • Kobashigawa J.A., Miller L.W., Russell S.D., et al. Study Investigators: tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am J Transplant 2006, 6:1377-1386.
    • (2006) Am J Transplant , vol.6 , pp. 1377-1386
    • Kobashigawa, J.A.1    Miller, L.W.2    Russell, S.D.3
  • 81
    • 58749088941 scopus 로고    scopus 로고
    • Influence of interactions between immunosuppressive drugs on therapeutic drug monitoring
    • Kuypers D.R. Influence of interactions between immunosuppressive drugs on therapeutic drug monitoring. Ann Transplant 2008, 13:11-18.
    • (2008) Ann Transplant , vol.13 , pp. 11-18
    • Kuypers, D.R.1
  • 82
    • 77951296433 scopus 로고    scopus 로고
    • Interaction between everolimus and tacrolimus in renal transplant recipients: a pharmacokinetic controlled trial
    • Pascual J., del Castillo D., Cabello M., et al. Interaction between everolimus and tacrolimus in renal transplant recipients: a pharmacokinetic controlled trial. Transplantation 2010, 89:994-1000.
    • (2010) Transplantation , vol.89 , pp. 994-1000
    • Pascual, J.1    del Castillo, D.2    Cabello, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.