Hospital-Community Interactions Foster Coexistence between Methicillin-Resistant Strains of Staphylococcus aureus

PLoS Pathogens

Volumn 9, Issue 2, 2013, Pages

  Kouyos, Roger ^a,b   Klein, Eili ^a,c,d   Grenfell, Bryan ^a  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Center for Disease Dynamics Economics and Policy   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; CHILD; COMMUNICABLE DISEASE; COMMUNITY CARE; DISEASE MODEL; DISEASE SIMULATION; GENETIC HETEROGENEITY; HEALTH SURVEY; HOSPITAL CARE; HOSPITALIZATION; HUMAN; INFANT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MORBIDITY; MORTALITY; PRESCHOOL CHILD; PUBLIC HEALTH; SCHOOL CHILD; SPECIES COEXISTENCE;

ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; DISEASE OUTBREAKS; HOSPITALIZATION; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL INTERACTIONS; MICROBIAL SENSITIVITY TESTS; MODELS, BIOLOGICAL; SELECTION, GENETIC; SPECIES SPECIFICITY; STAPHYLOCOCCAL INFECTIONS; UNITED STATES;

EID: 84880128459     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003134     Document Type: Article

References (44)

1. Klein E, Smith DL, Laxminarayan R, (2007) Hospitalizations and deaths caused by methicillin-resistant Staphylococcus aureus, United States, 1999-2005. Emerg Infect Dis 13: 1840-1846.
2. Chambers HF, Deleo FR, (2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 7: 629-641.
3. Naimi TS, LeDell KH, Como-Sabetti K, Borchardt SM, Boxrud DJ, et al. (2003) Comparison of community-and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 290: 2976-2984.
4. Popovich K, Hota B, Rice T, Aroutcheva A, Weinstein RA, (2007) Phenotypic prediction rule for community-associated methicillin-resistant Staphylococcus aureus? J Clin Microbiol 45: 2293-2295.
5. Katayama Y, Ito T, Hiramatsu K, (2000) A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother 44: 1549-1555.
6. Lee SM, Ender M, Adhikari R, Smith JM, Berger-Bachi B, et al. (2007) Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture. Antimicrob Agents Chemother 51: 1497-1499.
7. Ender M, McCallum N, Adhikari R, Berger-Bachi B, (2004) Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus. Antimicrob Agents Chemother 48: 2295-2297.
8. Thouverez M, Muller A, Hocquet D, Talon D, Bertrand X, (2003) Relationship between molecular epidemiology and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) in a French teaching hospital. J Med Microbiol 52: 801-806.
9. Horvath A, Dobay O, Kardos S, Ghidan A, Toth A, et al. (2012) Varying fitness cost associated with resistance to fluoroquinolones governs clonal dynamic of methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 31: 2029-36.
10. Okuma K, Iwakawa K, Turnidge JD, Grubb WB, Bell JM, et al. (2002) Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. Journal of Clinical Microbiology 40: 4289-4294.
11. Diep BA, Stone GG, Basuino L, Graber CJ, Miller A, et al. (2008) The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. Journal of Infectious Diseases 197: 1523-1530.
12. D'Agata EM, Webb GF, Horn MA, Moellering RC Jr, Ruan S, (2009) Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. Clin Infect Dis 48: 274-284.
13. Popovich KJ, Weinstein RA, Hota B, (2008) Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin Infect Dis 46: 787-794.
14. Klein E, Smith DL, Laxminarayan R, (2009) Community-associated methicillin-resistant Staphylococcus aureus in outpatients, United States, 1999-2006. Emerg Infect Dis 15: 1925-1930.
15. Colijn C, Cohen T, Fraser C, Hanage W, Goldstein E, et al. (2009) What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae? J R Soc Interface 7: 905-919.
16. Lipsitch M, Colijn C, Cohen T, Hanage WP, Fraser C, (2009) No coexistence for free: neutral null models for multistrain pathogens. Epidemics 1: 2-13.
17. Robicsek A, Beaumont JL, Peterson LR, (2009) Duration of Colonization with Methicillin-Resistant Staphylococcus aureus. Clinical Infectious Diseases 48: 910-913.
18. Cooke FJ, Brown NM, (2010) Community-associated methicillin-resistant Staphylococcus aureus infections. Br Med Bull 94: 215-227.
19. Mossong J, Hens N, Jit M, Beutels P, Auranen K, et al. (2008) Social contacts and mixing patterns relevant to the spread of infectious diseases. PLoS Medicine 5: e74.
20. Polk RE, Fox C, Mahoney A, Letcavage J, MacDougall C, (2007) Measurement of adult antibacterial drug use in 130 US hospitals: comparison of defined daily dose and days of therapy. Clin Infect Dis 44: 664-670.
21. Raveh D, Levy Y, Schlesinger Y, Greenberg A, Rudensky B, et al. (2001) Longitudinal surveillance of antibiotic use in the hospital. QJM 94: 141-152.
22. Smith K, Gemmell CG, Hunter IS, (2008) The association between biocide tolerance and the presence or absence of qac genes among hospital-acquired and community-acquired MRSA isolates. J Antimicrob Chemother 61: 78-84.
23. Bootsma MC, Wassenberg MW, Trapman P, Bonten MJ, (2010) The nosocomial transmission rate of animal-associated ST398 meticillin-resistant Staphylococcus aureus. J R Soc Interface 8: 578-584.
24. Verhoef J, Beaujean D, Blok H, Baars A, Meyler A, et al. (1999) A Dutch approach to methicillin-resistant Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 18: 461-466.
25. Kouyos RD, Abel Zur Wiesch P, Bonhoeffer S, (2011) On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community. PLoS Pathog 7: e1001334.
26. Smith DL, Dushoff J, Perencevich EN, Harris AD, Levin SA, (2004) Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: resistance is a regional problem. Proc Natl Acad Sci U S A 101: 3709-3714.
27. Kluytmans J, van Belkum A, Verbrugh H, (1997) Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev 10: 505-520.
28. Klein EY, Sun L, Smith DL, Laxminarayan R, (2013) The Changing Epidemiology of Methicillin-Resistant Staphylococcus aureus in the United States. American Journal of Epidemiology In press.
29. D'Agata EM, Webb GF, Pressley J, (2010) Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Strains in the Hospital Setting. Math Model Nat Phenom 5: 76-73.
30. Cespedes C, Said-Salim B, Miller M, Lo SH, Kreiswirth BN, et al. (2005) The clonality of Staphylococcus aureus nasal carriage. J Infect Dis 191: 444-452.
31. Huang SS, Datta R, Rifas-Shiman S, Kleinman K, Placzek H, et al. (2011) Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study. Crit Care 15: R210.
32. Dall'Antonia M, Coen PG, Wilks M, Whiley A, Millar M, (2005) Competition between methicillin-sensitive and-resistant Staphylococcus aureus in the anterior nares. J Hosp Infect 61: 62-67.
33. May RM, MacArthur RH, (1972) Niche overlap as a function of environmental variability. Proc Natl Acad Sci U S A 69: 1109-1113.
34. Deleo FR, Otto M, Kreiswirth BN, Chambers HF, (2010) Community-associated meticillin-resistant Staphylococcus aureus. Lancet 375: 1557-1568.
35. Kempker RR, Farley MM, Ladson JL, Satola S, Ray SM, (2010) Association of methicillin-resistant Staphylococcus aureus (MRSA) USA300 genotype with mortality in MRSA bacteremia. J Infect 61: 372-381.
36. Kreisel KM, Stine OC, Johnson JK, Perencevich EN, Shardell MD, et al. (2011) USA300 methicillin-resistant Staphylococcus aureus bacteremia and the risk of severe sepsis: is USA300 methicillin-resistant Staphylococcus aureus associated with more severe infections? Diagn Microbiol Infect Dis 70: 285-290.
37. Lalani T, Federspiel JJ, Boucher HW, Rude TH, Bae IG, et al. (2008) Associations between the genotypes of Staphylococcus aureus bloodstream isolates and clinical characteristics and outcomes of bacteremic patients. J Clin Microbiol 46: 2890-2896.
38. Moore CL, Hingwe A, Donabedian SM, Perri MB, Davis SL, et al. (2009) Comparative evaluation of epidemiology and outcomes of methicillin-resistant Staphylococcus aureus (MRSA) USA300 infections causing community- and healthcare-associated infections. Int J Antimicrob Agents 34: 148-155.
39. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, et al. (2006) Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med 144: 309-317.
40. Bonten M, Bootsma M (2010) Nosocomial transmission: Meticillin-resistant Staphylococcus aureus (MRSA). In: Kramer A, Kretzschmar M, Krickeberg K, editors. Modern Infectious Disease Epidemiology: Concepts, Methods, Mathematical Models, and Public Health. Springer.
41. Cooper BS, Medley GF, Stone SP, Kibbler CC, Cookson BD, et al. (2004) Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophes. Proc Natl Acad Sci U S A 101: 10223-10228.
42. Diekmann O, Heesterbeek JA, Metz JA, (1990) On the definition and the computation of the basic reproduction ratio R0 in models for infectious diseases in heterogeneous populations. J Math Biol 28: 365-382.
43. Lipsky BA, Pecoraro RE, Ahroni JH, Peugeot RL, (1992) Immediate and long-term efficacy of systemic antibiotics for eradicating nasal colonization with Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 11: 43-47.
44. Lucet JC, Paoletti X, Demontpion C, Degrave M, Vanjak D, et al. (2009) Carriage of methicillin-resistant Staphylococcus aureus in home care settings: prevalence, duration, and transmission to household members. Arch Intern Med 169: 1372-1378.