A novel approach to the use of subgingival controlled-release chlorhexidine delivery in chronic periodontitis: A randomized clinical trial

Journal of Periodontology

Volumn 82, Issue 8, 2011, Pages 1131-1139

  Gonzales, Jose R ^a   Harnack, Lutz ^a   Schmitt Corsitto, Gabriella ^a   Boedeker, Rolf H ^a   Chakraborty, Trinad ^a   Domann, Eugen ^a   Meyle, Joerg ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Chlorhexidine; Clinical trial; Microbiology; Periodontitis; Plaque; Scaling and root planing

Indexed keywords

ACUTE PHASE PROTEIN; C REACTIVE PROTEIN; CARRIER PROTEIN; CHLORHEXIDINE; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN; TOPICAL ANTIINFECTIVE AGENT;

ANTIBIOTIC PROPHYLAXIS; ARTICLE; BLOOD; CHRONIC PERIODONTITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DOUBLE BLIND PROCEDURE; HUMAN; LONGITUDINAL STUDY; METHODOLOGY; MICROBIOLOGY; MULTIMODALITY CANCER THERAPY; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE; TREATMENT OUTCOME;

ACUTE-PHASE PROTEINS; ANTI-INFECTIVE AGENTS, LOCAL; ANTIBIOTIC PROPHYLAXIS; C-REACTIVE PROTEIN; CARRIER PROTEINS; CHLORHEXIDINE; CHRONIC PERIODONTITIS; COMBINED MODALITY THERAPY; DELAYED-ACTION PREPARATIONS; DENTAL PLAQUE; DENTAL SCALING; DOUBLE-BLIND METHOD; HUMANS; LONGITUDINAL STUDIES; MEMBRANE GLYCOPROTEINS; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; TREATMENT OUTCOME;

EID: 80051740009     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2011.100287     Document Type: Article

References (35)

1. Stabholz A, Sela MN, Friedman M, Golomb G, Soskolne A. Clinical and microbiological effects of sustained release chlorhexidine in periodontal pockets. J Clin Periodontol 1986;13:783-788. (Pubitemid 17199498)
2. Steinberg D, Friedman M, Soskolne A, Sela MN. A new degradable controlled release device for treatment of periodontal disease: in vitro release study. J Periodontol 1990;61:393-398. (Pubitemid 20286172)
3. Soskolne WA, Heasman PA, Stabholz A, et al. Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi-center study. J Periodontol 1997;68:32-38. (Pubitemid 27099499)
4. Jeffcoat MK, Bray KS, Ciancio SG, et al. Adjunctive use of a subgingival controlled-release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol 1998;69:989-997. (Pubitemid 28452907)
5. Cosyn J, Wyn I. A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis. J Periodontol 2006;77:257-264. (Pubitemid 44725079)
6. Jeffcoat MK, Palcanis KG, Weatherford TW, Reese M, Geurs NC, Flashner M. Use of a biodegradable chlorhexidine chip in the treatment of adult periodontitis: clinical and radiographic findings. J Periodontol 2000; 71:256-262. (Pubitemid 30124115)
7. Soskolne WA, Proskin HM, Stabholz A. Probing depth changes following 2 years of periodontal maintenance therapy including adjunctive controlled release of chlorhexidine. J Periodontol 2003;74:420-427. (Pubitemid 36553378)
8. Rodrigues IF, Machion L, Casati MZ, et al. Clinical evaluation of the use of locally delivered chlorhexidine in periodontal maintenance therapy. J Periodontol 2007;78:624-628.
9. Reddy MS, Jeffcoat MK, Geurs NC, et al. Efficacy of controlled-release subgingival chlorhexidine to enhance periodontal regeneration. J Periodontol 2003; 74:411-419. (Pubitemid 36553377)
10. Daneshmand N, Jorgensen MG, Nowzari H, Morrison JL, Slots J. Initial effect of controlled release chlorhexidine on subgingival microorganisms. J Periodontal Res 2002;37:375-379.
11. Meyle J, Ammoura A, Hossain H, Bödecker RH, Chakraborty T, Domann E. Sustained local delivery of chlorhexidine during initial therapy of chronic periodontitis. Perio 2005;2:117-129.
12. Mizrak T, Güncü GN, Caglayan F, Balci TA, Aktar GS, Ipek F. Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid. J Periodontol 2006;77:437-443. (Pubitemid 44740667)
13. Paolantonio M, D'Angelo M, Grassi RF, et al. Clinical and microbiologic effects of subgingival controlledrelease delivery of chlorhexidine chip in the treatment of periodontitis: a multicenter study. J Periodontol 2008;79:271-282.
14. Heumann D. CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria. J Endotoxin Res 2001;7:439-441. (Pubitemid 34048527)
15. D'Aiuto F, Ready D, Tonetti MS. Periodontal disease and C-reactive protein-associated cardiovascular risk. J Periodontal Res 2004;39:236-241. (Pubitemid 38969606)
16. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72:1221-1227. (Pubitemid 33607184)
17. O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol 1972;43:38.
18. Saxer UP, Mühlemann HR. Motivation and education (in German). SSO Schweiz Monatsschr Zahnheilkd 1975;85:905-919.
19. Houssain H, Chakraborty T, Domann E. TaqMan-PCR for testing Salmonella enterica in human stool samples (in German). Hyg Mikrobiol 2002;6:196-201.
20. Yoshida A, Kawada M, Suzuki N, et al. TaqMan realtime polymerase chain reaction assay for the correlation of Treponema denticola numbers with the severity of periodontal disease. Oral Microbiol Immunol 2004; 19:196-200. (Pubitemid 38649614)
21. Kuboniwa M, Amano A, Kimura KR, et al. Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes. Oral Microbiol Immunol 2004;19:168-176. (Pubitemid 38649610)
22. Kubar A, Saygun I, Yapar M, Ozdemir A, Slots J. Realtime PCR quantification of cytomegalovirus in aggressive periodontitis lesions using TaqMan technology. J Periodontal Res 2004;39:81-86. (Pubitemid 39090087)
23. Lyons SR, Griffen AL, Leys EJ. Quantitative real-time PCR for Porphyromonas gingivalis and total bacteria. J Clin Microbiol 2000;38:2362-2365. (Pubitemid 30414365)
24. Atlas RM, Parks LC. Handbook of Microbiological Media. Boca Raton, FL: CRC Press; 1993:276-470.
25. McGill R, Tukey JW, Larsen WA. Variations of box plots. Am Stat 1978;32:12-16.
26. Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex," a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000 2005;38:72-122. (Pubitemid 43034324)
27. Buhlin K, Gustafsson A, Pockley AG, Frostegård J, Klinge B. Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J 2003;24:2099-2107. (Pubitemid 37486529)
28. Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 1997;107:347-352. (Pubitemid 27049263)
29. Biasucci LM; CDC; AHA. CDC/AHA workshop on markers of inflammation and cardiovascular disease: application to clinical and public health practice: clinical use of inflammatory markers in patients with cardiovascular diseases: a background paper. Circulation 2004;110:e560-e567.
30. Deschner J, Singhal A, Long P, Liu CC, Piesco N, Agarwal S. Cleavage of CD14 and LBP by a protease from Prevotella intermedia. Arch Microbiol 2003;179: 430-436. (Pubitemid 36745687)
31. Ren L, Jin L, Leung WK. Local expression of lipopoly-saccharide-binding protein in human gingival tissues. J Periodontal Res 2004;39:242-248. (Pubitemid 38969607)
32. Ren L, Leung WK, Darveau RP, Jin L. The expression profile of lipopolysaccharide-binding protein, membrane-bound CD14, and toll-like receptors 2 and 4 in chronic periodontitis. J Periodontol 2005;76: 1950-1959. (Pubitemid 41748985)
33. Ren L, Leung WK, Loo TW, Jin L. Lipopolysaccharide-binding protein down-regulates the expression of interleukin-6 by human gingival fibroblast. J Periodontal Res 2005;40:407-416. (Pubitemid 41252867)
34. Schröder NW, Opitz B, Lamping N, et al. Involvement of lipopolysaccharide binding protein, CD14, and Tolllike receptors in the initiation of innate immune responses by Treponema glycolipids. J Immunol 2000; 165:2683-2693. (Pubitemid 30660718)
35. Azmak N, Atilla G, Luoto H, Sorsa T. The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid. J Periodontol 2002;73:608-615. (Pubitemid 34679074)