Chronic Cadmium Treatment Promotes Oxidative Stress and Endothelial Damage in Isolated Rat Aorta

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Almenara, Camila C P ^a   Broseghini Filho, Gilson B ^a   Vescovi, Marcus V A ^a   Angeli, Jhuli K ^a   Faria, Thaís de O ^a   Stefanon, Ivanita ^a   Vassallo, Dalton V ^a,b   Padilha, Alessandra S ^a  

^a FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^b Escola Superior de Ciencias da Santa Casa de Misericordia de Vitoria   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; APOCYNIN; CADMIUM CHLORIDE; CATALASE; DRINKING WATER; ENALAPRIL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LOSARTAN; N(G) NITROARGININE METHYL ESTER; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL PRESSURE; ARTICLE; BIOAVAILABILITY; BLOOD VESSEL REACTIVITY; BODY WEIGHT; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ISOLATED ORGAN; MALE; NONHUMAN; OXIDATIVE STRESS; PLETHYSMOGRAPHY; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE; TRACE METAL BLOOD LEVEL;

ACETOPHENONES; ACETYLCHOLINE; ANIMALS; AORTA; BLOOD PRESSURE; BODY WEIGHT; CADMIUM; CATALASE; DENSITOMETRY; ENALAPRIL; ENDOTHELIUM, VASCULAR; LOSARTAN; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; OXIDATIVE STRESS; PHENYLEPHRINE; RATS; SUPEROXIDE DISMUTASE; SYSTOLE;

EID: 84880067816     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068418     Document Type: Article

References (37)

1. World Health Organization. (1992) Cadmium. Environmental Health Criteria 134. WHO International Programme on Chemical Safety (IPCS), Geneva, Switzerland.
2. Agency for Toxic Substances and Disease Registry (ATSDR). (2008) Toxicological Profile for Cadmium (Draft for Public Comment). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
3. Afridi HI, Kazi TG, Kazi NG, Jamali MK, Arain MB, et al. (2010) Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and non smokers hypertensive patients. J Human Hypertension 24: 34-43.
4. Sato M, Kondoh M, (2002) Recent studies on metallotionein protection against toxicity of heavy metals and oxygen free radicals. Tohoky J Exp Med 196: 9-12.
5. Satarug S, Nishijo M, Ujjin P, Vanavanitkun Y, Moore MR, (2005) Cadmium-induced nephopathy in the development of high blood pressure. Toxicol Lett 157: 57-68.
6. Zhang W, Fievez L, Cheu E, Bureau F, Rong W, et al. (2010) Anti-inflammatory effects of formoterol and ipratropium bromide against acute cadmium-induced pulmonary inflammation in rats. Eur J Pharmacol. 628(1-3): 171-178.
7. Nishijo M, Morikawa Y, Nakagawa H, Tawara K, Miura K, et al. (2006) Causes of death and renal tubular dysfunction in residents exposed to cadmium in the environment. Occup Environ Med 63 (8): 545-550.
8. Nawrot TS, Van Hecke E, Thiys L, Richart T, Kuznetsova T, et al. (2008) Cadmium related mortality and long term secular trend in the cadmium body burden of an environmental exposed population. Environ Health Perspect 116: 1620-1628.
9. Menke A, Muntner P, Silbergeld EK, Platz EA, Guallar E, (2009) Cadmium levels in urine and mortality among U.S. adults. Environ Health Perspect 117(2): 190-6.
10. Donpunha W, Konungviriyapan U, Sompamit K, Pakdeechote P, Konungviriyapan V, et al. (2011) Protective effect of ascorbic acid on cadmium-induced hypertension and vascular dysfunction in mice. Biometals 24: 105-115.
11. Prozialeck WC, Edwards JR, Nerbert DW, Woods JM, Barchowsky A, et al. (2007) The vascular system as a target of metal toxicity. Toxicol Sci 102: 207-218.
12. Yoopan N, Watcharasit P, Wongsawatkul O, Piyachaturawat P, Satayavivad J, (2008) Atenuation of eNOS expression in cadmium-induced hypertensive rats. Toxicol Lett 176: 157-161.
13. Takahashi Y, Poteser M, Masui H, Koizumi N, Wakabayashi I, (2004) Effects of cadmium in vitro on contractile and relaxant responses of isolated rat aortas. Environ Health Prev Med. 9(6): 251-6.
14. Carageorgiou H, Tzotzes V Sideris A, Zarros A Tsakiris S, (2005) Cadmium effects on brain acetylcholinesterase activity and antioxidante status of adult rats: modulation by zinc, calcium and L-cysteine co-administration. Basic Clin Pharmacol Toxicol 97: 320-324.
15. Gokalp O, Ozdem S, Donmez S, Dogan M, Demerin H, et al. (2009) Impairment of endothelium-dependent vasorelaxation in cadmium-hypertensive rats. Toxicol Ind Health 25: 447-453.
16. Mitra S, Deshmukh A, Sachdeva R, Lu J, Mehta JL, (2011) Oxidized low-density lipoprotein and atherosclerosis implications in antioxidant therapy. Am J Med Sci. 342: 135-142.
17. Harja E, Bu DX, Hudson BI, Chang JS, Shen X, et al. (2008) Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice. J Clin Invest 118: 183-194.
18. Navas-Acien A, Selvin E, Sharrett AR, Calderon-Aranda E, Silbergeld E, et al. (2004) Lead, Cadmium, Smoking, and Increased Risk of Peripheral Arterial Disease. Circulation 109: 3196-3201.
19. Vassallo DV, Simões MR, Furieri LB, Fioresi M, Fiorim J, et al. (2011) Toxic effects of mercury, lead and gadolinium on vascular reactivity. Braz J Med Biol Res 44(9): 939-946.
20. Lemos NB, Angeli JK, Faria Tde O, Ribeiro Junior RF, Vassallo DV, et al. (2012) Low mercury concentration produces vasoconstriction, decreases nitric oxide bioavailability and increases oxidative stress in rat conductance artery. PLoS One 7(11).
21. Grizzo LT, Cordellini S, (2008) Perinatal Lead exposure affects nitric oxide and cyclooxygenase pathways in aorta of weaned rats. Toxicol Sci 103(1): 207-214.
22. Martín MC, Balfagón G, Minoves N, Blanco-Rivero J, Ferrer M, (2005) Androgen deprivation increases neuronal nitric oxide metabolism and its vasodilator effect in rat mesenteric arteries. Nitric Oxide 12: 163-176.
23. Tzotzes V, Tzilalis V, Giannakakis S, Saranteas T, Papas A, et al. (2007) Effects of acute and chronic cadmium administration on the vascular reactivity of rat aorta. Biometals. 20(1): 83-91.
24. Pinheiro MC, Macchi BM, Vieira JL, Oikawa T, Amoras WW, et al. (2008) Mercury exposure and antioxidant defenses in women: a comparative study in the Amazon. Environ Res 107: 53-59.
25. Puri VN, (1999) Cadmium induced hypertension. Clin Exp Hypertens 21(1-2): 79-84.
26. Vanhoutte PM, Shimokawa H, Tang EH, Feletou M, (2009) Endothelial dysfunction and vascular disease. Acta. Physiol(Oxf) 196(2): 193-222.
27. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG, (2000) Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hidrogen peroxide. Cir Res 86: 347-354.
28. Beckman JS, Koppenol WH, (1996) Nitric oxide, superoxide and peroxynitrite: the good, the bad, and ugly. Am J Physiol. 271 (5 Pt 1): C1424-37.
29. Gaubin Y, Vaissade F, Croute F, Beau B, Soleilhavoup J, et al. (2000) Implication of free radicals and glutathione in the mechanism of cadmium-induced expression of stress proteins in the A549 human lung cell-line. Biochim Biophys Acta 1495: 4-13.
30. Tandon SK, Singh S, Prasad S, Khandekar K, Dwivedi VK, et al. (2003) Reversal of cadmium induced oxidative stress by chelanting agent, antioxidant or their combination in rat. Toxicol Lett 10 145(3): 211-7.
31. Messner B, Bernhard D, (2010) Cadmium and cardiovascular diseases: cell biology, pathophysiology, and epidemiological relevance. Biometals. 23(5): 811-22.
32. Hare JM, Stamler JS, (2005) NO/Redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest. 115 (3): 509-517.
33. White SJ, Hayes EM, Lehouse S, Jeremy JY, Horvvoets AJ, et al. (2011) Characterization of the differential response of endothelial cells exposed to normal and elevated laminar sheer stress. J Cell Physiol 226(11): 2841-2848.
34. Ferramola ML, Antón RI, Anzulovich AC, Giménez MS, (2011) Myocardical oxidative stress following sub-chronic and chronic oral cadmium exposure in rats. Environ Toxicol Pharmacol 32(1): 17-26.
35. Manca D, Ricard AC, Trottier B, Chevalier G, (1991) Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 67: 303-23.
36. Bertín G, Averbeck D, (2006) Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 88: 1549-1559.
37. Ozturk IM, Buyukakilli B, Balli E, Cimen B, Gunes S, et al. (2009) Determination of acute and chronic effects of cadmium on the cardiovascular system of rats. Toxicol Mech And Methods 19(4): 308-317.