Anti-antimicrobial peptides: Folding-mediated host defense antagonists

Journal of Biological Chemistry

Volumn 288, Issue 28, 2013, Pages 20162-20172

  Ryan, Lloyd ^a,b   Lamarre, Baptiste ^a   Diu, Ting ^a,c   Ravi, Jascindra ^a   Judge, Peter J ^d   Temple, Adam ^e   Carr, Matthew ^e   Cerasoli, Eleonora ^a   Su, Bo ^c   Jenkinson, Howard F ^c   Martyna, Glenn ^f   Crain, Jason ^e   Watts, Anthony ^d   Ryadnov, Maxim G ^a,e  

^a NATIONAL PHYSICAL LABORATORY   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f IBM T J WATSON RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL PEPTIDE; ANTIMICROBIAL RESISTANCES; BACTERIAL CULTURES; INNATE IMMUNES; MEMBRANE-BOUND; MOLECULAR DYNAMICS SIMULATIONS; MULTICELLULAR ORGANISMS; SOLID-STATE NMR SPECTROSCOPY;

BIOASSAY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

MICROORGANISMS;

BOVINE MYELOID ANTIMICROBIAL PEPTIDE 27; BOVINE MYELOID ANTIMICROBIAL PEPTIDE 27 ANTAGONIST; CECROPIN B; CECROPIN B ANTAGONIST; OLIGOMER; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; BIOASSAY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HOST RESISTANCE; HYDROPHOBICITY; MICROCOCCUS LUTEUS; MICROSCOPY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FOLDING; PSEUDOMONAS AERUGINOSA; SOLID STATE; STAPHYLOCOCCUS AUREUS;

ANTIMICROBIAL PEPTIDES; MEMBRANE BIOPHYSICS; MICROSCOPY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN DESIGN; PROTEIN FOLDING;

ANTIMICROBIAL CATIONIC PEPTIDES; CATHELICIDINS; CECROPINS; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMOLYSIS; HUMANS; MAGAININS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84880067486     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.459560     Document Type: Article

References (38)

1. Rose, A., and Meier, I. (2004) Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins. Cell Mol. Life Sci. 61, 1996-2009 (Pubitemid 39149890)
2. Boucrot, E., Pick, A., Çamdere, G., Liska, N., Evergren, E., McMahon, H. T., and Kozlov, M. M. (2012) Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains. Cell 149, 124-136
3. Lin, R. C., and Scheller, R. H. (2000) Mechanisms of synaptic vesicle exocytosis. Annu. Rev. Cell Dev. Biol. 16, 19-49 (Pubitemid 32037499)
4. De Matteis, M. A., and Morrow, J. S. (2000) Spectrin tethers and mesh in the biosynthetic pathway. J. Cell Sci. 113, 2331-2343 (Pubitemid 30599339)
5. Knodler, L. A., Ibarra, J. A., Pérez-Rueda, E., Yip, C. K., and Steele-Mortimer, O. (2011) Coiled-coil domains enhance the membrane association of Salmonella type III effectors. Cell Microbiol. 13, 1497-1517
6. Naider, F., and Anglister, J. (2009) Peptides in the treatment of AIDS. Curr. Opin. Struct. Biol. 19, 473-482
7. Fjell, C. D., Hiss, J. A., Hancock, R. E., and Schneider, G. (2012) Designing antimicrobial peptides: form follows function. Nat. Rev. Drug Discov. 11, 37-51
8. Grigoryan, G., and Keating, A. E. (2008) Structural specificity in coiled-coil interactions. Curr. Opin. Struct. Biol. 18, 477-483
9. Lupas, A. N., and Gruber, M. (2005) The structure of α-helical coiled coils. Adv. Protein Chem. 70, 37-78
10. Peschel, A., and Sahl, H. G. (2006) The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat. Rev. Microbiol. 4, 529-536 (Pubitemid 43905612)
11. Rozzelle, J. E., Jr., Tropsha, A., and Erickson, B. W. (1994) Rational design of a three-heptad coiled-coil protein and comparison by molecular dynamics simulation with the GCN4 coiled coil: presence of interior threecenter hydrogen bonds. Protein Sci. 3, 345-355 (Pubitemid 24086365)
12. Senes, A., Engel, D. E., and DeGrado, W. F. (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr. Opin. Struct. Biol. 14, 465-479 (Pubitemid 39094354)
13. Kim, S., Jeon, T. J., Oberai, A., Yang, D., Schmidt, J. J., and Bowie, J. U. (2005) Transmembrane glycine zippers: physiological and pathological roles in membrane proteins. Proc. Natl. Acad. Sci. U.S.A. 102, 14278-14283 (Pubitemid 41429689)
14. Simmaco, M., Kreil, G., and Barra, D. (2009) Bombinins, antimicrobial peptides from Bombina species. Biochim. Biophys. Acta 1788, 1551-1555
15. MacKenzie, K. R., Prestegard, J. H., and Engelman, D. M. (1997) A transmembrane helix dimer: structure and implications. Science 276, 131-133 (Pubitemid 27161261)
16. Glukhov, E., Stark, M., Burrows, L. L., and Deber, C. M. (2005) Basis for selectivity of cationic antimicrobial peptides for bacterial versus mammalian membranes. J. Biol. Chem. 280, 33960-33967 (Pubitemid 41443116)
17. Mygind, P. H., Fischer, R. L., Schnorr, K. M., Hansen, M. T., Sönksen, C. P., Ludvigsen, S., Raventós, D., Buskov, S., Christensen, B., De Maria, L., Taboureau, O., Yaver, D., Elvig-Jørgensen, S. G., Sørensen, M. V., Christensen, B. E., Kjaerulff, S., Frimodt-Moller, N., Lehrer, R. I., Zasloff, M., and Kristensen, H. H. (2005) Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437, 975-980 (Pubitemid 41486973)
18. Gourley, D. G., Schüttelkopf, A. W., Leonard, G. A., Luba, J., Hardy, L. W., Beverley, S. M., and Hunter, W. N. (2001) Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. Nat. Struct. Biol. 8, 521-525 (Pubitemid 32525011)
19. Veit, G., Kobbe, B., Keene, D. R., Paulsson, M., Koch, M., and Wagener, R. (2006) Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain. J. Biol. Chem. 281, 3494-3504 (Pubitemid 43845965)
20. Zanetti, M. (2004) Cathelicidins, multifunctional peptides of the innate immunity. J. Leukoc. Biol. 75, 39-48
21. Boman, H. G. (2003) Antibacterial peptides: basis facts and emerging concepts. J. Intern. Med. 254, 197-215
22. Yang, S. T., Jeon, J. H., Kim, Y., Shin, S. Y., Hahm, K. S., and Kim, J. I. (2006) Possible role of a PXXP central hinge in the antibacterial activity and membrane interaction of PMAP-23, a member of cathelicidin family. Biochemistry 45, 1775-1784 (Pubitemid 43222121)
23. Yoder, N. C., and Kumar, K. (2006) Selective protein-protein interactions driven by a phenylalanine interface. J. Am. Chem. Soc. 128, 188-191 (Pubitemid 43100870)
24. Tripet, B., Wagschal, K., Lavigne, P., Mant, C. T., and Hodges, R. S. (2000) Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled coil: 20 amino acid substitutions in position "d." J. Mol. Biol. 300, 377-402
25. Ryadnov, M. G., Bella, A., Timson, S., and Woolfson, D. N. (2009) Modular design of peptide fibrillar nano- to microstructures. J. Am. Chem. Soc. 131, 13240-13241
26. Morrisett, J. D., Jackson, R. L., and Gotto, A. M., Jr. (1977) Lipid-protein interactions in the plasma lipoproteins. Biochim. Biophys. Acta 472, 93-133
27. Oh, D., Shin, S. Y., Lee, S., Kang, J. H., Kim, S. D., Ryu, P. D., Hahm, K. S., and Kim, Y. (2000) Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8): magainin 2(1-12) and its analogues, on their antibiotic activities and structures. Biochemistry 39, 11855-11864
28. Sharma, A. K., Zhou, G. P., Kupferman, J., Surks, H. K., Christensen, E. N., Chou, J. J., Mendelsohn, M. E., and Rigby, A. C. (2008) Probing the interaction between the coiled-coil leucine zipper of cGMP-dependent protein kinase Iα and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J. Biol. Chem. 283, 32860-32869
29. De Crescenzo, G., Litowski, J. R., Hodges, R. S., and O'Connor-McCourt, M. D. (2003) Real-time monitoring of the interactions of two-stranded de novo designed coiled-coils: effect of chain length on the kinetic and thermodynamic constants of binding. Biochemistry 42, 1754-1763 (Pubitemid 36205984)
30. Ryadnov, M. G., Ceyhan, B., Niemeyer, C. M., and Woolfson, D. N. (2003) "Belt and braces": a peptide-based linker system of de novo design. J. Am. Chem. Soc. 125, 9388-9394 (Pubitemid 36936058)
31. Cerasoli, E., Ravi, J., Gregor, C., Hussain, R., Siligardi, G., Martyna, G., Crain, J., and Ryadnov, M. G. (2012) Membrane mediated regulation in free peptides of HIV-1 gp41: minimal modulation of the hemifusion phase. Phys. Chem. Chem. Phys. 14, 1277-1285
32. Hicks, M. R., Kowałski, J., and Rodger, A. (2010) LD spectroscopy of natural and synthetic biomaterials. Chem. Soc. Rev. 39, 3380-3393
33. Bulheller, B. M., Rodger, A., Hicks, M. R., Dafforn, T. R., Serpell, L. C., Marshall, K. E., Bromley, E. H., King, P. J., Channon, K. J., Woolfson, D. N., and Hirst, J. D. (2009) Flow linear dichroism of some prototypical proteins. J. Am. Chem. Soc. 131, 13305-13314
34. Gazit, E., Lee, W. J., Brey, P. T., and Shai, Y. (1994) Mode of action of the antibacterial cecropin B2: a spectrofluorometric study. Biochemistry 33, 10681-10692 (Pubitemid 24292290)
35. Bonev, B. B., Chan, W. C., Bycroft, B. W., Roberts, G. C., and Watts, A. (2000) Interaction of the lantibiotic nisin with mixed lipid bilayers: a 31P and 2H NMR study. Biochemistry 39, 11425-11433
36. Isono, F., Katayama, T., Inukai, M., and Haneishi, T. (1989) Mureidomycins A-D, novel peptidylnucleoside antibiotics with spheroplast forming activity. III. Biological properties. J. Antibiot. 42, 674-679 (Pubitemid 19142318)
37. Yeung, A. T., Gellatly, S. L., and Hancock, R. E. (2011) Multifunctional cationic host defence peptides and their clinical applications. Cell Mol. Life Sci. 68, 2161-2176
38. Afacan, N. J., Yeung, A. T., Pena, O. M., and Hancock, R. E. (2012) Therapeutic potential of host defense peptide in antibiotic-resistant infections. Curr. Pharm. Des. 18, 807-819