Attenuating gene expression (AGE) for vaccine development

Virulence

Volumn 4, Issue 5, 2013, Pages 384-390

  Pascual, David W ^a   Suo, Zhiyong ^b   Cao, Ling ^b   Avci, Recep ^b   Yang, Xinghong ^a  

^a University of Florida   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

Appendages; Attenuating gene expression (AGE); CFA I fimbriae; F1 capsule; Flagella; Salmonella; Vaccine

Indexed keywords

ARABINOSE; SALMONELLOSIS VACCINE; VACCINE; VIRULENCE FACTOR;

ARTICLE; ATOMIC FORCE MICROSCOPY; BACTERIAL GROWTH; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; COLONY FORMING UNIT; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; FIMBRIA; GENE DOSAGE; GENE EXPRESSION; GENE OVEREXPRESSION; INFECTION; NONHUMAN; OPTICAL DENSITY; PATHOGENESIS; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84880066467     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.24886     Document Type: Article

References (49)

1. rd. Cloning and characterization of the asd gene of Salmonella typhimurium: use in stable maintenance of recombinant plasmids in Salmonella vaccine strains. Gene 1990; 94:29-35. PMID:2227450. http://dx.doi.org/10.1016/0378-1119(90)90464-3
2. Piao HH, Tam VT, Na HS, Kim HJ, Ryu PY, Kim SY, et al. Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice. J Microbiol 2010; 48:486-95. PMID:20799091. http://dx.doi.org/10.1007/s12275-010-0023-z
3. Bacon GA, Burrows TW, Yates M. The effects of biochemical mutation on the virulence of Bacterium typhosum: the virulence of mutants. Br J Exp Pathol 1950; 31:714-24. PMID:14801354
4. Hoiseth SK, Stocker BA. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 1981; 291:238-9. PMID:7015147. http://dx.doi.org/10.1038/291238a0
5. Hone DM, Tacket CO, Harris AM, Kay B, Losonsky G, Levine MM. Evaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine. J Clin Invest 1992; 90:412-20. PMID:1644914. http://dx.doi.org/10.1172/JCI115876
6. Tacket CO, Hone DM, Losonsky GA, Guers L, Edelman R, Levine MM. Clinical acceptability and immunogenicity of CVD 908 Salmonella typhi vaccine strain. Vaccine 1992; 10:443-6. PMID:1609547. http://dx.doi.org/10.1016/0264-410X(92)90392-W
7. Robertsson JA, Lindberg AA, Hoiseth S, Stocker BA. Salmonella typhimurium infection in calves: protection and survival of virulent challenge bacteria after immunization with live or inactivated vaccines. Infect Immun 1983; 41:742-50. PMID:6347895
8. Smith BP, Reina-Guerra M, Stocker BA, Hoiseth SK, Johnson E. Aromatic-dependent Salmonella dublin as a parenteral modified live vaccine for calves. Am J Vet Res 1984; 45:2231-5. PMID:6395725
9. Jones PW, Dougan G, Hayward C, Mackensie N, Collins P, Chatfield SN. Oral vaccination of calves against experimental salmonellosis using a double aro mutant of Salmonella typhimurium. Vaccine 1991; 9:29-34. PMID:2008797. http://dx.doi.org/10.1016/0264-410X(91)90313-U
10. Alam J, Singh BR, Hansda D, Singh VP, Verma JC. Evaluation of aroA deletion mutant of Salmonella enterica subspecies enterica serovar Abortusequi for its vaccine candidate potential. Indian J Exp Biol 2009; 47:871-9. PMID:20099460
11. Trebichavsky I, Splichalova A, Rychlik I, Hojna H, Muneta Y, Mori Y, et al. Attenuated aroA Salmonella enterica serovar Typhimurium does not induce inflammatory response and early protection of gnotobiotic pigs against parental virulent LT2 strain. Vaccine 2006; 24:4285-9. PMID:16584815. http://dx.doi.org/10.1016/j.vaccine.2006.02.054
12. Barrow PA, Page K, Lovell MA. The virulence for gnotobiotic pigs of live attenuated vaccine strains of Salmonella enterica serovars Typhimurium and Enteritidis. Vaccine 2001; 19:3432-6. PMID:11348707. http://dx.doi.org/10.1016/S0264-410X(01)00065-2
13. Lumsden JS, Kennedy BW, Mallard BA, Wilkie BN. The influence of the swine major histocompatibility genes on antibody and cell-mediated immune responses to immunization with an aromatic-dependent mutant of Salmonella typhimurium. Can J Vet Res 1993; 57:14-8. PMID:8431799
14. Van Immerseel F, De Buck J, De Smet I, Mast J, Haesebrouck F, Ducatelle R. The effect of vaccination with a Salmonella enteritidis aroA mutant on early cellular responses in caecal lamina propria of newly-hatched chickens. Vaccine 2002; 20:3034-41. PMID:12126917. http://dx.doi.org/10.1016/S0264-410X(02)00227-X
15. Methner U, Barrow PA, Martin G, Meyer H. Comparative study of the protective effect against Salmonella colonisation in newly hatched SPF chickens using live, attenuated Salmonella vaccine strains, wild-type Salmonella strains or a competitive exclusion product. Int J Food Microbiol 1997; 35:223-30. PMID:9105931. http://dx.doi.org/10.1016/S0168-1605(96)01236-6
16. Cooper GL, Venables LM, Woodward MJ, Hormaeche CE. Vaccination of chickens with strain CVL30, a genetically defined Salmonella enteritidis aroA live oral vaccine candidate. Infect Immun 1994; 62:4747-54. PMID:7927750
17. Saxena M, Coloe PJ, Smooker PM. Influence of promoter, gene copy number, and preexisting immunity on humoral and cellular responses to a vectored antigen delivered by a Salmonella enterica vaccine. Clin Vaccine Immunol 2009; 16:78-87. PMID:19005022. http://dx.doi.org/10.1128/CVI.00253-08
18. Xie C, He JS, Zhang M, Xue SL, Wu Q, Ding XD, et al. Oral respiratory syncytial virus (RSV) DNA vaccine expressing RSV F protein delivered by attenuated Salmonella typhimurium. Hum Gene Ther 2007; 18:746-52. PMID:17696764. http://dx.doi.org/10.1089/hum.2007.053
19. Medina E, Guzmán CA, Staendner LH, Colombo MP, Paglia P. Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route. Eur J Immunol 1999; 29:693-9. PMID:10064087. http://dx.doi.org/10.1002/(SICI)1521-4141(199902)29:02693::AID-IMMU6933.0.CO;2-V
20. Fouts TR, Tuskan RG, Chada S, Hone DM, Lewis GK. Construction and immunogenicity of Salmonella typhimurium vaccine vectors that express HIV-1 gp120. Vaccine 1995; 13:1697-705. PMID:8719522. http://dx.doi.org/10.1016/0264-410X(95)00106-B
21. Salomonsson E, Kuoppa K, Forslund AL, Zingmark C, Golovliov I, Sjöstedt A, et al. Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of Francisella tularensis. Infect Immun 2009; 77:3424-31. PMID:19506014. http://dx.doi.org/10.1128/IAI.00196-09
22. O'Callaghan D, Maskell D, Liew FY, Easmon CS, Dougan G. Characterization of aromaticand purine dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice. Infect Immun 1988; 56:419-23. PMID:3276625
23. rd. Virulence and vaccine potential of phoP mutants of Salmonella typhimurium. Microb Pathog 1989; 6:433-43. PMID:2671582. http://dx.doi.org/10.1016/0882-4010(89)90085-5
24. Hohmann EL, Oletta CA, Miller SI. Evaluation of a phoP/phoQ-deleted, aroA-deleted live oral Salmonella typhi vaccine strain in human volunteers. Vaccine 1996; 14:19-24. PMID:8821644. http://dx.doi.org/10.1016/0264-410X(95)00173-X
25. Garmory HS, Brown KA, Titball RW. Salmonella vaccines for use in humans: present and future perspectives. FEMS Microbiol Rev 2002; 26:339-53. PMID:12413664
26. Hohmann EL, Oletta CA, Killeen KP, Miller SI. phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers. J Infect Dis 1996; 173:1408-14. PMID:8648213. http://dx.doi.org/10.1093/infdis/173.6.1408
27. Bowe F, O'Gaora P, Maskell D, Cafferkey M, Dougan G. Virulence, persistence, and immunogenicity of Yersinia enterocolitica O:8 aroA mutants. Infect Immun 1989; 57:3234-6. PMID:2777382
28. Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, et al. The response regulator PhoP is important for survival under conditions of macro-phage-induced stress and virulence in Yersinia pestis. Infect Immun 2000; 68:3419-25. PMID:10816493. http://dx.doi.org/10.1128/IAI.68.6.3419-3425.2000
29. Foulongne V, Walravens K, Bourg G, Boschiroli ML, Godfroid J, Ramuz M, et al. Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models. Infect Immun 2001; 69:547-50. PMID:11119550. http://dx.doi.org/10.1128/IAI.69.1.547-550.2001
30. Kato A, Groisman EA; Howard Hughes Medical Institute. The PhoQ/PhoP regulatory network of Salmonella enterica. Adv Exp Med Biol 2008; 631:7-21. PMID:18792679. http://dx.doi.org/10.1007/978-0-387-78885-2_2
31. Curtiss III R, Wanda SY, Gunn BM, Zhang X, Tinge SA, Ananthnarayan V, et al. Salmonella enteric serovar typhimurium strains with regulated delayed attenuation in vivo. Infect Immun 2009; 77:1071-82. PMID:19103774. http://dx.doi.org/10.1128/IAI.00693-08
32. Sun W, Roland KL, Kuang X, Branger CG, Curtiss R 3rd. Yersinia pestis with regulated delayed attenuation as a vaccine candidate to induce protective immunity against plague. Infect Immun 2010; 78:1304-13. PMID:20086087. http://dx.doi.org/10.1128/IAI.01122-09
33. rd, Xin W, Li Y, Kong W, Wanda SY, Gunn B, et al. New technologies in using recombinant attenuated Salmonella vaccine vectors. Crit Rev Immunol 2010; 30:255-70. PMID:20370633. http://dx.doi.org/10.1615/CritRevImmunol.v30.i3.30
34. Yang X, Suo Z, Thornburg T, Holderness K, Cao L, Lim T, et al. Expression of Escherichia coli virulence usher protein attenuates wild-type Salmonella. Virulence 2012; 3:29-42. PMID:22286706. http://dx.doi.org/10.4161/viru.3.1.18447
35. Cao L, Suo Z, Lim T, Jun S, Deliorman M, Riccardi C, et al. Role of overexpressed CFA/I fimbriae in bacterial swimming. Phys Biol 2012; 9:036005. PMID:22562964. http://dx.doi.org/10.1088/1478-3975/9/3/036005
36. Yang X, Thornburg T, Holderness K, Suo Z, Cao L, Lim T, et al. Serum antibodies protect against intraperitoneal challenge with enterotoxigenic Escherichia coli. J Biomed Biotechnol 2011; 2011:632396. PMID:22007145. http://dx.doi.org/10.1155/2011/632396
37. Suo Z, Avci R, Deliorman M, Yang X, Pascual DW. Bacteria survive multiple puncturings of their cell walls. Langmuir 2009; 25:4588-94. PMID:19260649. http://dx.doi.org/10.1021/la8033319
38. Evans DG, Satterwhite TK, Evans DJ Jr., DuPont HL. Differences in serological responses and excretion patterns of volunteers challenged with enterotoxigenic Escherichia coli with and without the colonization factor antigen. Infect Immun 1978; 19:883-8. PMID:346488
39. Cao L, Lim T, Jun S, Thornburg T, Avci R, Yang X. Vulnerabilities in Yersinia pestis caf operon are unveiled by a Salmonella vector. PLoS One 2012; 7:e36283. PMID:22558420. http://dx.doi.org/10.1371/journal.pone.0036283
40. Yang X, Thornburg T, Suo Z, Jun S, Robison A, Li J, et al. Flagella overexpression attenuates Salmonella pathogenesis. PLoS One 2012; 7:e46828. PMID:23056473. http://dx.doi.org/10.1371/journal.pone.0046828
41. Yang X, Hinnebusch BJ, Trunkle T, Bosio CM, Suo Z, Tighe M, et al. Oral vaccination with Salmonella simultaneously expressing Yersinia pestis F1 and V antigens protects against bubonic and pneumonic plague. J Immunol 2007; 178:1059-67. PMID:17202369
42. Yang X, Thornburg T, Walters N, Pascual DW. DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate. Vaccine 2010; 28:1069-74. PMID:19914192. http://dx.doi.org/10.1016/j.vaccine.2009.10.113
43. Yang X, Skyberg JA, Cao L, Clapp B, Thornburg T, Pascual DW. Progress in Brucella vaccine development. Front Biol 2013; 8:60-77. http://dx.doi.org/10.1007/s11515-012-1196-0
44. Yang X, Becker T, Walters N, Pascual DW. Deletion of znuA virulence factor attenuates Brucella abortus and confers protection against wild-type challenge. Infect Immun 2006; 74:3874-9. PMID:16790759. http://dx.doi.org/10.1128/IAI.01957-05
45. Mizel SB, Bates JT. Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol 2010; 185:5677-82. PMID:21048152. http://dx.doi.org/10.4049/jimmunol.1002156
46. Mizel SB, Graff AH, Sriranganathan N, Ervin S, Lees CJ, Lively MO, et al. Flagellin-F1-V fusion protein is an effective plague vaccine in mice and two species of nonhuman primates. Clin Vaccine Immunol 2009; 16:21-8. PMID:18987167. http://dx.doi.org/10.1128/CVI.00333-08
47. Pecota DC, Kim CS, Wu K, Gerdes K, Wood TK. Combining the hok/sok, parDE, and pnd postsegregational killer loci to enhance plasmid stability. Appl Environ Microbiol 1997; 63:1917-24. PMID:9143123
48. Gerdes K, Thisted T, Martinussen J. Mechanism of post-segregational killing by the hok/sok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells. Mol Microbiol 1990; 4:1807-18. PMID:1707122. http://dx.doi.org/10.1111/j.1365-2958.1990.tb02029.x
49. Mellies J, Wise A, Villarejo M. Two different Escherichia coli proP promoters respond to osmotic and growth phase signals. J Bacteriol 1995; 177:144-51. PMID:8002611