Deconvolution-based assessment of pituitary GH secretion stimulated with GHRH+arginine in Prader-Willi adults and obese controls

Clinical Endocrinology

Volumn 79, Issue 2, 2013, Pages 224-231

  Grugni, Graziano ^a   Marostica, Eleonora ^b   Crinò, Antonino ^c   Marzullo, Paolo ^a   De Nicolao, Giuseppe ^b   Sartorio, Alessandro ^a  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CLINICAL ASSESSMENT; CONTROLLED STUDY; EVOLUTION; FEMALE; GENOTYPE; GROWTH HORMONE RELEASE; HORMONE RESPONSE; HUMAN; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; OBESITY; PRADER WILLI SYNDROME; PRIORITY JOURNAL; SECRETION RATE; STANDARD; STIMULATION; STIMULUS;

ADOLESCENT; ADULT; AREA UNDER CURVE; ARGININE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 15; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; MALE; MOSAICISM; OBESITY; PITUITARY GLAND; PRADER-WILLI SYNDROME; TRISOMY; UNIPARENTAL DISOMY;

EID: 84880060536     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.12142     Document Type: Article

References (25)

1. Bittel, D.C., &, Butler, M.G., (2005) Prader-Willi syndrome. Clinical genetics, cytogenetics, and molecular biology. Expert Reviews in Molecular Medicine, 7, 1-20.
2. Whittington, J.E., Holland, A.J., Webb, T., et al,. (2001) Population prevalence and estimated birth incidence and mortality rate for people with Prader-Willi syndrome in one UK Health Region. Journal of Medical Genetics, 38, 792-798.
3. Cassidy, S.B., &, Driscoll, D.J., (2009) Prader-Willi syndrome. European Journal of Human Genetics, 17, 3-13.
4. Goldstone, A.P., (2004) Prader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends in Endocrinology and Metabolism, 15, 12-20.
5. Burman, P., Ritzen, E.M., &, Lindgren, A.C., (2001) Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH. Endocrine Reviews, 22, 787-799.
6. Hoybye, C., Hilding, A., Jacobsson, H., et al,. (2002) Metabolic profile and body composition in adults with Prader-Willi syndrome and severe obesity. Journal of Clinical Endocrinology and Metabolism, 87, 3590-3597.
7. Grugni, G., Marzullo, P., Ragusa, L., et al,. (2006) Impairment of GH responsiveness to combined GH-releasing hormone and arginine administration in adult patients with Prader-Willi syndrome. Clinical Endocrinology, 65, 492-499.
8. van Nieuwpoort, I.C., Sinnema, M., Castelijns, J.A., et al,. (2011) The GH/IGF-I axis and pituitary function and size in adults with Prader-Willi syndrome. Hormone Research in Paediatrics, 75, 403-11.
9. Grugni, G., Giardino, G., Crinò, A., et al,. (2011) Growth hormone secretion among adult patients with Prader-Willi syndrome due to different genetic subtypes. Journal of Endocrinological Investigation, 34, 493-497.
10. Kreitschmann-Andermahr, I., Suarez, P., Jennings, R., et al,. (2010) GH/IGF-I regulation in obesity-mechanisms and practical consequences in children and adults. Hormone Research in Paediatrics, 73, 153-60.
11. Veldhuis, J.D., Carlson, M.L., &, Johnson, M.L., (1987) The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proceedings of the National Academy of Sciences, 4, 7686-7690.
12. Sartorio, A., De Nicolao, G., Pizzini, G., et al,. (1997) Non-parametric deconvolution provides an objective assessment of GH responsiveness to GH-releasing stimuli in normal subjects. Clinical Endocrinology, 46, 387-395.
13. De Nicolao, G., Liberati, D., &, Sartorio, A., (2000) Stimulated secretion of pituitary hormones in normal humans: a novel direct assessment from blood concentrations. Annals of Biomedical Engineering, 28, 1136-1145.
14. Cacciari, E., Milani, S., Balsamo, A., et al,. (2006) Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). Journal of Endocrinological Investigation, 29, 581-93.
15. De Nicolao, G., Liberati, D., Veldhuis, J.D., et al,. (1999) LH and FSH secretory responses to GnRH in normal individuals: a non-parametric deconvolution approach. European Journal of Endocrinology, 141, 246-256.
16. Sartorio, A., De Nicolao, G., &, Liberati, D., (2002) An improved computational method to assess pituitary responsiveness to secretagogue stimuli. European Journal of Endocrinology, 147, 323-332.
17. Marzullo, P., Marcassa, C., Campini, R., et al,. (2005) The impact of growth hormone/insulin-like growth factor-1 and nocturnal breathing disorders on cardiovascular features of adult patients with Prader-Willi syndrome. Journal of Clinical Endocrinology and Metabolism, 90, 5639-5646.
18. Zipf, W.B., (2004) Prader-Willi syndrome: the care and treatment of infants, children, and adults. Advances in Pediatrics, 51, 409-434.
19. Grugni, G., Crinò, A., Bertocco, P., et al,. (2009) Body fat excess and stimulated growth hormone levels in adult patients with Prader-Willi syndrome. American Journal of Medical Genetics. Part A, 149A, 726-731.
20. Goldstone, A.P., (2006) The hypothalamus, hormones, and hunger: alterations in human obesity and illness. Progress in Brain Research, 153, 57-73.
21. Iughetti, L., Bosio, L., Corrias, A., et al,. (2008) Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome. European Journal of Pediatrics, 167, 701-702.
22. Corrias, A., Grugni, G., Crinò, A., et al,. (2012) Assessment of central adrenal insufficiency in children and adolescents with Prader-Willi syndrome. Clinical Endocrinology, 76, 843-50.
23. Radicioni, A., Di Giorgio, G., Grugni, G., et al,. (2012) Multiple forms of hypogonadism of central, peripheral or combined origin in males with Prader-Willi syndrome. Clinical Endocrinology, 76, 72-7.
24. Miller, J.L., Couch, J.A., Schmalfuss, I., et al,. (2007) Intracranial abnormalities detected by three-dimensional magnetic resonance imaging in Prader-Willi syndrome. American Journal of Medical Genetics. Part A, 143A, 476-483.
25. Swaab, D.F., Purba, J.S., &, Hofman, M.A., (1995) Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. Journal of Clinical Endocrinology and Metabolism, 80, 573-579.