The GH/IGF-I axis and pituitary function and size in adults with Prader-Willi syndrome

Hormone Research in Paediatrics

Volumn 75, Issue 6, 2011, Pages 403-411

  Van Nieuwpoort, I C ^a   Sinnema, M ^b   Castelijns, J A ^a   Twisk, J W R ^c   Curfs, L M G ^b   Drent, M L ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Endocrine function; Growth hormone; Insulin like growth factor I; Magnetic resonance imaging; Pituitary gland; Prader Willi syndrome

Indexed keywords

ARGININE; GROWTH HORMONE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADRENAL INSUFFICIENCY; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HUMAN; HYPOGONADISM; HYPOPHYSIS FUNCTION; HYPOTHYROIDISM; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRADER WILLI SYNDROME; PRIORITY JOURNAL;

ADIPOSITY; ADOLESCENT; ADULT; ARGININE; CASE-CONTROL STUDIES; ENDOCRINE GLANDS; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; ORGAN SIZE; PITUITARY GLAND; PITUITARY HORMONES; PRADER-WILLI SYNDROME; YOUNG ADULT;

EID: 79957956132     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000323442     Document Type: Article

References (41)

1. Prader A, Labhart A, Willi H: Ein Syndrom von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach myatonieartigem Zustand im Neugeborenenalter. Schweiz Med Wochenschr 1956; 86: 1260-1261.
2. Burman P, Ritzen EM, Lindgren AC: Endocrine dysfunction in Prader-Willi syndrome: A review with special reference to GH. Endocr Rev 2001; 22: 787-799. (Pubitemid 34214295)
3. Holm VA, Cassidy SB, Butler MG, Hanchett JM, Greenswag LR, Whitman BY, Greenberg F: Prader-Willi syndrome: Consensus diagnostic criteria. Pediatrics 1993; 91: 398-402. (Pubitemid 23042323)
4. Cassidy SB: Prader-Willi syndrome. J Med Genet 1997; 34: 917-923. (Pubitemid 27480947)
5. Swaab DF: Prader-Willi syndrome and the hypothalamus. Acta Paediatr Suppl 1997; 423: 50-54. (Pubitemid 27511888)
6. Miller L, Angulo M, Price D, Taneja S: MR of the pituitary in patients with Prader-Willi syndrome: Size determination and imaging findings. Pediatr Radiol 1996; 26: 43-47. (Pubitemid 26030742)
7. Iughetti L, Bosio L, Corrias A, Gargantini L, Ragusa L, Livieri C, Predieri B, Bruzzi P, Caselli G, Grugni G: Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome. Eur J Pediatr 2008; 167: 701-702. (Pubitemid 351503494)
8. Tauber M, Barbeau C, Jouret B, Pienkowski C, Malzac P, Moncla A, Rochiccioli P: Auxological and endocrine evolution of 28 children with Prader-Willi syndrome: Effect of GH therapy in 14 children. Horm Res 2000; 53: 279-287. (Pubitemid 32037593)
9. Beccaria L, Bosio L, Sanzari A, Aimaretti G, Ghigo E, Chiumello G: GH secretion in Prader-Labhart-Willi syndrome: Somatotrope responsiveness to GHRH is enhanced by arginine but not by pyridostigmine. J Pediatr Endocrinol Metab 1996; 9: 577-583. (Pubitemid 27023618)
10. Bray GA, Dahms WT, Swerdloff RS, Fiser RH, Atkinson RL, Carrel RE: The Prader-Willi syndrome: A study of 40 patients and a review of the literature. Medicine (Baltimore) 1983; 62: 59-80. (Pubitemid 13113779)
11. Corrias A, Bellone J, Beccaria L, Bosio L, Trifiro G, Livieri C, Ragusa L, Salvatoni A, Andreo M, Ciampalini P, Tonini G, Crino A: GH/IGF-I axis in Prader-Willi syndrome: Evaluation of IGF-I levels and of the somatotroph responsiveness to various provocative stimuli. Genetic Obesity Study Group of Italian Society of Pediatric Endocrinology and Diabetology. J Endocrinol Invest 2000; 23: 84-89. (Pubitemid 30189267)
12. Grugni G, Marzullo P, Ragusa L, Sartorio A, Trifiro G, Liuzzi A, Crino A: Impairment of GH responsiveness to combined GH-releasing hormone and arginine administration in adult patients with Prader-Willi syndrome. Clin Endocrinol (Oxf) 2006; 65: 492-499. (Pubitemid 44414273)
13. Hoybye C: Endocrine and metabolic aspects of adult Prader-Willi syndrome with special emphasis on the effect of growth hormone treatment. Growth Horm IGF Res 2004; 14: 1-15. (Pubitemid 38094239)
14. Partsch CJ, Lammer C, Gillessen-Kaesbach G, Pankau R: Adult patients with Prader-Willi syndrome: Clinical characteristics, life circumstances and growth hormone secretion. Growth Horm IGF Res 2000; 10(suppl B):S81-S85. (Pubitemid 30637221)
15. Davies PS: Growth hormone therapy in Prader-Willi syndrome. Int J Obes Relat Metab Disord 2001; 25: 2-7. (Pubitemid 32142377)
16. Eiholzer U, Stutz K, Weinmann C, Torresani T, Molinari L, Prader A: Low insulin, IGF-I and IGFBP-3 levels in children with Prader-Labhart-Willi syndrome. Eur J Pediatr 1998; 157: 890-893. (Pubitemid 28506547)
17. Eiholzer U, Bachmann S, l'Allemand D: Is there growth hormone deficiency in Prader-Willi syndrome? Six arguments to support the presence of hypothalamic growth hormone deficiency in Prader-Willi syndrome. Horm Res 2000; 53(suppl 3):44-52.
18. Goldstone AP: Prader-Willi syndrome: Advances in genetics, pathophysiology and treatment. Trends Endocrinol Metab 2004; 15: 12-20. (Pubitemid 38198094)
19. Hoybye C, Frystyk J, Thoren M: The growth hormone-insulin-like growth factor axis in adult patients with Prader-Willi syndrome. Growth Horm IGF Res 2003; 13: 269-274. (Pubitemid 37161681)
20. Eiholzer U, l'Allemand D, Rousson V, Schlumpf M, Gasser T, Girard J, Gruters A, Simoni M: Hypothalamic and gonadal components of hypogonadism in boys with Prader-Labhart-Willi syndrome. J Clin Endocrinol Metab 2006; 91: 892-898. (Pubitemid 43357755)
21. Hirsch HJ, Eldar-Geva T, Benarroch F, Rubinstein O, Gross-Tsur V: Primary testicular dysfunction is a major contributor to abnormal pubertal development in males with Prader-Willi syndrome. J Clin Endocrinol Metab 2009; 94: 2262-2268.
22. Jeffcoate WJ, Laurance BM, Edwards CR, Besser GM: Endocrine function in the Prader-Willi syndrome. Clin Endocrinol (Oxf) 1980; 12: 81-89. (Pubitemid 10174986)
23. Lee PD: Disease management of Prader-Willi syndrome. Expert Opin Pharmacother 2002; 3: 1451-459. (Pubitemid 35174877)
24. Muller J: Hypogonadism and endocrine metabolic disorders in Prader-Willi syndrome. Acta Paediatr Suppl 1997; 423: 58-59. (Pubitemid 27511890)
25. Butler MG, Theodoro M, Skouse JD: Thyroid function studies in Prader-Willi syndrome. Am J Med Genet A 2007; 143: 488-492. (Pubitemid 46348921)
26. Cassidy SB, Driscoll DJ: Prader-Willi syndrome. Eur J Hum Genet 2009; 17: 3-13.
27. Festen DA, Visser TJ, Otten BJ, Wit JM, Duivenvoorden HJ, Hokken-Koelega AC: Thyroid hormone levels in children with Prader-Willi syndrome before and during growth hormone treatment. Clin Endocrinol (Oxf) 2007; 67: 449-456. (Pubitemid 47283846)
28. Zipf WB: Prader-Willi syndrome: The care and treatment of infants, children, and adults. Adv Pediatr 2004; 51: 409-434. (Pubitemid 39303487)
29. De Lind van Wijngaarden RF, Otten BJ, Festen DA, Joosten KF, de Jong FH, Sweep FC, Hokken-Koelega AC: High prevalence of central adrenal insufficiency in patients with Prader-Willi syndrome. J Clin Endocrinol Metab 2008; 93: 1649-1654. (Pubitemid 351656500)
30. Lukaski HC, Johnson PE, Bolonchuk WW, Lykken GI: Assessment of fat-free mass using bioelectrical impedance measurements of the human body. Am J Clin Nutr 1985; 41: 810-817. (Pubitemid 15092891)
31. Aimaretti G, Corneli G, Razzore P, Bellone S, Baffoni C, Arvat E, Camanni F, Ghigo E: Comparison between insulin-induced hypoglycemia and growth hormone-releasing hormone plus arginine as provocative tests for the diagnosis of growth hormone deficiency in adults. J Clin Endocrinol Metab 1998; 83: 1615-1618. (Pubitemid 28501031)
32. Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G: The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 2005; 153: 257-264. (Pubitemid 41174451)
33. Brambilla P, Bosio L, Manzoni P, Pietrobelli A, Beccaria L, Chiumello G: Peculiar body composition in patients with Prader-Labhart-Willi syndrome. Am J Clin Nutr 1997; 65: 1369-1374. (Pubitemid 27187745)
34. Miller JL, Goldstone AP, Couch JA, Shuster J, He G, Driscoll DJ, Liu Y, Schmalfuss IM: Pituitary abnormalities in Prader-Willi syndrome and early onset morbid obesity. Am J Med Genet A 2008; 146A:570-577.
35. Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M: Recommendations for the diagnosis and management of Prader-Willi syndrome. J Clin Endocrinol Metab 2008; 93: 4183-4197. (Pubitemid 352789509)
36. Aimaretti G, Bellone S, Baffoni C, Cornel G, Origlia C, Di VL, Rovere S, Arvat E, Camanni F, Ghigo E: Short procedure of GHRH plus arginine test in clinical practice. Pituitary 2001; 4: 129-134. (Pubitemid 34679328)
37. Grugni G, Crino A, Bertocco P, Marzullo P: Body fat excess and stimulated growth hormone levels in adult patients with Prader-Willi syndrome. Am J Med Genet A 2009; 149A:726-731.
38. Sode-Carlsen R, Farholt S, Rabben KF, Bollerslev J, Schreiner T, Jurik AG, Christiansen JS, Hoybye C: Body composition, endocrine and metabolic profiles in adults with Prader-Willi syndrome. Growth Horm IGF Res 2010; 20: 179-184.
39. Grugni G, Giardino D, Crino A, Malvestiti F, Ballarati L, Di GG, Marzullo P: Growth hormone secretion among adult patients with Prader-Willi syndrome due to different genetic subtypes. J Endocrinol Invest 2010 (in press).
40. Makimura H, Stanley T, Mun D, You SM, Grinspoon S: The effects of central adiposity on growth hormone response to growth hormone-releasing hormone-arginine stimulation testing in men. J Clin Endocrinol Metab 2008; 93: 4254-4260. (Pubitemid 352789519)
41. Mogul HR, Lee PD, Whitman BY, Zipf WB, Frey M, Myers S, Cahan M, Pinyerd B, Southren AL: Growth hormone treatment of adults with Prader-Willi syndrome and growth hormone deficiency improves lean body mass, fractional body fat, and serum triiodothyronine without glucose impairment: Results from the United States multicenter trial. J Clin Endocrinol Metab 2008; 93: 1238-1245. (Pubitemid 351519716)