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Volumn 12, Issue 7, 2013, Pages 1332-1342

Antiproliferative effects of continued mitogen-activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CYCLIN D1; DABRAFENIB; FLUORODEOXYGLUCOSE F 18; MITOGEN ACTIVATED PROTEIN KINASE; RETINOBLASTOMA PROTEIN; TRAMETINIB; VEMURAFENIB;

EID: 84880057441     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0011     Document Type: Article
Times cited : (62)

References (49)
  • 3
    • 84861083983 scopus 로고    scopus 로고
    • Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
    • Falchook GS, Long GV, Kurzrock R, Kim KB, Arkenau TH, Brown MP, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet 2012;379:1893-901.
    • (2012) Lancet , vol.379 , pp. 1893-1901
    • Falchook, G.S.1    Long, G.V.2    Kurzrock, R.3    Kim, K.B.4    Arkenau, T.H.5    Brown, M.P.6
  • 4
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob J-J, Demidov LV, Jouary T, Gutzmer R, Millward M, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012;380:358-65.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.-J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5    Millward, M.6
  • 6
    • 84864371119 scopus 로고    scopus 로고
    • Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial
    • Falchook GS, Lewis KD, Infante JR, Gordon MS, Vogelzang NJ, DeMarini DJ, et al. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol 2012;13:782-9.
    • (2012) Lancet Oncol , vol.13 , pp. 782-789
    • Falchook, G.S.1    Lewis, K.D.2    Infante, J.R.3    Gordon, M.S.4    Vogelzang, N.J.5    DeMarini, D.J.6
  • 8
    • 84862908097 scopus 로고    scopus 로고
    • RAS Mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
    • Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, et al. RAS Mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med 2012;366:207-15.
    • (2012) N Engl J Med , vol.366 , pp. 207-215
    • Su, F.1    Viros, A.2    Milagre, C.3    Trunzer, K.4    Bollag, G.5    Spleiss, O.6
  • 10
    • 49649118852 scopus 로고    scopus 로고
    • Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
    • Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res 2008;68:4853-61.
    • (2008) Cancer Res , vol.68 , pp. 4853-4861
    • Montagut, C.1    Sharma, S.V.2    Shioda, T.3    McDermott, U.4    Ulman, M.5    Ulkus, L.E.6
  • 12
    • 84859183431 scopus 로고    scopus 로고
    • Melanoma whole-exome sequencing identi fies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance
    • Shi H, Moriceau G, Kong X, Lee M-K, Lee H, Koya RC, et al. Melanoma whole-exome sequencing identi fies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance. Nat Commun 2012;3:724.
    • (2012) Nat Commun , vol.3 , pp. 724
    • Shi, H.1    Moriceau, G.2    Kong, X.3    Lee, M.-K.4    Lee, H.5    Koya, R.C.6
  • 13
    • 78649436372 scopus 로고    scopus 로고
    • BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation
    • Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci Signal 2010;3:ra84.
    • (2010) Sci Signal , vol.3
    • Corcoran, R.B.1    Dias-Santagata, D.2    Bergethon, K.3    Iafrate, A.J.4    Settleman, J.5    Engelman, J.A.6
  • 14
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 2010;468:973-7.
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3    Kong, X.4    Koya, R.C.5    Lee, H.6
  • 15
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol 2011;29:3085-96.
    • (2011) J Clin Oncol , vol.29 , pp. 3085-3096
    • Wagle, N.1    Emery, C.2    Berger, M.F.3    Davis, M.J.4    Sawyer, A.5    Pochanard, P.6
  • 16
    • 85081775978 scopus 로고    scopus 로고
    • BRAF inhibitor resistance in melanoma
    • Los Angeles, CA: Pigment Cell Melanoma Res
    • Lo RS. BRAF inhibitor resistance in melanoma. Society for Melanoma Research 2012 Congress. Los Angeles, CA: Pigment Cell Melanoma Res 2012. p. 836-903.
    • (2012) Society for Melanoma Research 2012 Congress , pp. 836-903
    • Lo, R.S.1
  • 17
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    • Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 2011;480:387-90.
    • (2011) Nature , vol.480 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2    Janakiraman, M.3    Kong, X.4    Ng, C.5    Moriceau, G.6
  • 18
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 2010;18:683-95.
    • (2010) Cancer Cell , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3    Somasundaram, R.4    Fukunaga-Kalabis, M.5    Cipolla, A.K.6
  • 19
    • 79953325104 scopus 로고    scopus 로고
    • PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    • Paraiso KHT, Xiang Y, Rebecca VW, Abel EV, Chen YA, Munko AC, et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res 2011;71:2750-60.
    • (2011) Cancer Res , vol.71 , pp. 2750-2760
    • Paraiso, K.H.T.1    Xiang, Y.2    Rebecca, V.W.3    Abel, E.V.4    Chen, Y.A.5    Munko, A.C.6
  • 20
    • 54049158957 scopus 로고    scopus 로고
    • Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas
    • Smalley KSM, Lioni M, Palma MD, Xiao M, Desai B, Egyhazi S, et al. Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas. Mol Cancer Ther 2008;7:2876-83.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2876-2883
    • Smalley, K.S.M.1    Lioni, M.2    Palma, M.D.3    Xiao, M.4    Desai, B.5    Egyhazi, S.6
  • 21
    • 84864285794 scopus 로고    scopus 로고
    • Tumour microenvironment elicits innate resistance to RAF inhibitors through HGF secretion
    • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, et al. Tumour microenvironment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012;487:500-4.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3    Barzily-Rokni, M.4    Qian, Z.R.5    Du, J.6
  • 22
    • 84864994126 scopus 로고    scopus 로고
    • Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma
    • Yadav V, Zhang X, Liu J, Estrem S, Li S, Gong X-Q, et al. Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma. J Biol Chem 2012;287:28087-98.
    • (2012) J Biol Chem , vol.287 , pp. 28087-28098
    • Yadav, V.1    Zhang, X.2    Liu, J.3    Estrem, S.4    Li, S.5    Gong, X.-Q.6
  • 23
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012;483:100-3.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3    Di Nicolantonio, F.4    Salazar, R.5    Zecchin, D.6
  • 24
    • 65349110371 scopus 로고    scopus 로고
    • Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 Study
    • von Minckwitz G, du Bois A, Schmidt M, Maass N, Cufer T, de Jongh FE, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a German Breast Group 26/Breast International Group 03-05 Study. J Clin Oncol 2009;27:1999-2006.
    • (2009) J Clin Oncol , vol.27 , pp. 1999-2006
    • Von Minckwitz, G.1    Du Bois, A.2    Schmidt, M.3    Maass, N.4    Cufer, T.5    De Jongh, F.E.6
  • 25
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM, Rugo H, Sledge G, Koehler M, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 2010;28:1124-30.
    • (2010) J Clin Oncol , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3    Rugo, H.4    Sledge, G.5    Koehler, M.6
  • 29
    • 59349116914 scopus 로고    scopus 로고
    • Dose escalation of imatinib after failure of standard dose in Korean patients with metastatic or unresectable gastrointestinal stromal tumor
    • Park I, Ryu MH, Sym SJ, Lee SS, Jang G, Kim TW, et al. Dose escalation of imatinib after failure of standard dose in Korean patients with metastatic or unresectable gastrointestinal stromal tumor. Jpn J Clin Oncol 2008;39:105-10.
    • (2008) Jpn J Clin Oncol , vol.39 , pp. 105-110
    • Park, I.1    Ryu, M.H.2    Sym, S.J.3    Lee, S.S.4    Jang, G.5    Kim, T.W.6
  • 30
    • 84870478924 scopus 로고    scopus 로고
    • Patterns of progression in patients (pts) with V600 BRAF-mutated melanoma metastatic to the brain treated with dabrafenib (GSK2118436)
    • abstr 8558
    • Azer MWF, Menzies AM, Haydu L, Kefford R, Long GV. Patterns of progression in patients (pts) with V600 BRAF-mutated melanoma metastatic to the brain treated with dabrafenib (GSK2118436). J Clin Oncol 30, 2012 (suppl; abstr 8558).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Azer, M.W.F.1    Menzies, A.M.2    Haydu, L.3    Kefford, R.4    Long, G.V.5
  • 31
    • 84864278914 scopus 로고    scopus 로고
    • Updated safety and ef ficacy results from a phase I/II study of the oral BRAF inhibitor dabrafenib (GSK2118436) combined with the oral MEK 1/2 inhibitor trametinib (GSK1120212) in patients with BRAFi-naive metastatic melanoma
    • abstr 8510
    • Weber JS, Flaherty KT, Infante JR, Falchook GS, Kefford R, Daud A, et al. Updated safety and ef ficacy results from a phase I/II study of the oral BRAF inhibitor dabrafenib (GSK2118436) combined with the oral MEK 1/2 inhibitor trametinib (GSK1120212) in patients with BRAFi-naive metastatic melanoma. J Clin Oncol 30, 2012 (suppl; abstr 8510).
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Weber, J.S.1    Flaherty, K.T.2    Infante, J.R.3    Falchook, G.S.4    Kefford, R.5    Daud, A.6
  • 32
    • 0000827344 scopus 로고    scopus 로고
    • Tumor treatment response based on visual and quantitative changes in global tumor glycolysis using PET-FDG imaging. The visual response score and the change in total lesion glycolysis
    • Larson SM, Erdi Y, Akhurst T, Mazumdar M, Macapinlac HA, Finn RD, et al. Tumor treatment response based on visual and quantitative changes in global tumor glycolysis using PET-FDG imaging. The visual response score and the change in total lesion glycolysis. Clin Positron Imaging 1999;2:159-71.
    • (1999) Clin Positron Imaging , vol.2 , pp. 159-171
    • Larson, S.M.1    Erdi, Y.2    Akhurst, T.3    Mazumdar, M.4    Macapinlac, H.A.5    Finn, R.D.6
  • 33
    • 0035291880 scopus 로고    scopus 로고
    • Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis
    • Nguyen T, Zhang XD, Hersey P. Relative resistance of fresh isolates of melanoma to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Clin Cancer Res 2001;7:966s-73s. (Pubitemid 33600952)
    • (2001) Clinical Cancer Research , vol.7 , Issue.11 SUPPL.
    • Nguyen, T.1    Zhang, X.D.2    Hersey, P.3
  • 34
  • 36
    • 25144503764 scopus 로고    scopus 로고
    • Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis
    • Gallagher S, Kefford RF, Rizos H. Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis. Cell Cycle 2005;4:465-72. (Pubitemid 41359735)
    • (2005) Cell Cycle , vol.4 , Issue.3 , pp. 465-472
    • Gallagher, S.1    Kefford, R.F.2    Rizos, H.3
  • 39
    • 79951818749 scopus 로고    scopus 로고
    • MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720
    • Jiang CC, Lai F, Thorne RF, Yang F, Liu H, Hersey P, et al. MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720. Clin Cancer Res 2010;17:721-30.
    • (2010) Clin Cancer Res , vol.17 , pp. 721-730
    • Jiang, C.C.1    Lai, F.2    Thorne, R.F.3    Yang, F.4    Liu, H.5    Hersey, P.6
  • 40
    • 79951834644 scopus 로고    scopus 로고
    • website. Available from: Wellcome Trust Sanger Institute
    • Catalogue of Somatic Mutations in Cancer (COSMIC) website. Available from: http://www.sangeracuk/genetics/CGP/cosmic/. Wellcome Trust Sanger Institute.
    • Catalogue of Somatic Mutations in Cancer (COSMIC)
  • 41
    • 84862305656 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition
    • Gowrishankar K, Snoyman S, Pupo GM, Becker TM, Kefford RF, Rizos H. Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition. J Invest Dermatol 2012;132:1850-9.
    • (2012) J Invest Dermatol , vol.132 , pp. 1850-1859
    • Gowrishankar, K.1    Snoyman, S.2    Pupo, G.M.3    Becker, T.M.4    Kefford, R.F.5    Rizos, H.6
  • 42
    • 84891923377 scopus 로고    scopus 로고
    • The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma
    • Dec 17. [Epub ahead of print]
    • Todd JR, Scurr LL, Becker TM, Kefford RF, Rizos H. The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Oncogene 2012 Dec 17. [Epub ahead of print].
    • (2012) Oncogene
    • Todd, J.R.1    Scurr, L.L.2    Becker, T.M.3    Kefford, R.F.4    Rizos, H.5
  • 43
    • 84873728334 scopus 로고    scopus 로고
    • Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
    • Das Thakur M, Salangsang F, Landman AS, Sellers WR, Pryer NK, Levesque MP, et al. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature 2013;494:251-5.
    • (2013) Nature , vol.494 , pp. 251-255
    • Das Thakur, M.1    Salangsang, F.2    Landman, A.S.3    Sellers, W.R.4    Pryer, N.K.5    Levesque, M.P.6
  • 44
    • 80053531654 scopus 로고    scopus 로고
    • Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefi tinib: Implications for clinical trial design
    • Chaft JE, Oxnard GR, Sima CS, Kris MG, Miller VA, Riely GJ. Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefi tinib: implications for clinical trial design. Clin Cancer Res 2011;17:6298-303.
    • (2011) Clin Cancer Res , vol.17 , pp. 6298-6303
    • Chaft, J.E.1    Oxnard, G.R.2    Sima, C.S.3    Kris, M.G.4    Miller, V.A.5    Riely, G.J.6
  • 45
    • 34548853993 scopus 로고    scopus 로고
    • Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus
    • DOI 10.1158/1078-0432.CCR-07-0560
    • Riely GJ, Kris MG, Zhao B, Akhurst T, Milton DT, Moore E, et al. Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus. Clin Cancer Res 2007;13:5150-5. (Pubitemid 47502083)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 5150-5155
    • Riely, G.J.1    Kris, M.G.2    Zhao, B.3    Akhurst, T.4    Milton, D.T.5    Moore, E.6    Tyson, L.7    Pao, W.8    Rizvi, N.A.9    Schwartz, L.H.10    Miller, V.A.11
  • 46
    • 28244448020 scopus 로고    scopus 로고
    • Effects of cessation of imatinib mesylate (IM) therapy in patients (pts) with IM-refractory gastrointestinal stromal tumors (GIST) as visualized by FDG-PET scanning
    • abstr 3012
    • Van Den Abbeele AD, Badawi RD, Manola J, Morgan JA, Desai J, Kazanovicz A, et al. Effects of cessation of imatinib mesylate (IM) therapy in patients (pts) with IM-refractory gastrointestinal stromal tumors (GIST) as visualized by FDG-PET scanning. J Clin Oncol 22, 2004 (suppl; abstr 3012).
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL.
    • Van Den Abbeele, A.D.1    Badawi, R.D.2    Manola, J.3    Morgan, J.A.4    Desai, J.5    Kazanovicz, A.6
  • 47
    • 18844457915 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate
    • DOI 10.1148/radiol.2353040332
    • Shankar S, vanSonnenberg E, Desai J, DiPiro PJ, Van Den Abbeele A, Demetri GD. Gastrointestinal stromal tumor: new nodule-within-amass pattern of recurrence after partial response to imatinib mesylate1. Radiology 2005;235:892-8. (Pubitemid 40695886)
    • (2005) Radiology , vol.235 , Issue.3 , pp. 892-898
    • Shankar, S.1    VanSonnenberg, E.2    Desai, J.3    DiPiro, P.J.4    Van Den, A.A.5    Demetri, G.D.6
  • 48
    • 84855440693 scopus 로고    scopus 로고
    • Pattern and outcome of disease progression in phase I study of vemurafenib in patients with metastatic melanoma (MM)
    • abstr 8519
    • Kim KB, Flaherty KT, Chapman PB, Sosman JA, Ribas A, McArthur GA, et al. Pattern and outcome of disease progression in phase I study of vemurafenib in patients with metastatic melanoma (MM). J Clin Oncol 29, 2011 (suppl; abstr 8519).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kim, K.B.1    Flaherty, K.T.2    Chapman, P.B.3    Sosman, J.A.4    Ribas, A.5    McArthur, G.A.6
  • 49
    • 84861450830 scopus 로고    scopus 로고
    • Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: A possible algorithm for clinical use
    • Ascierto PA, Simeone E, Giannarelli D, Grimaldi AM, Romano A, Mozzillo N. Sequencing of BRAF inhibitors and ipilimumab in patients with metastatic melanoma: a possible algorithm for clinical use. J Transl Med 2012;10:107.
    • (2012) J Transl Med , vol.10 , pp. 107
    • Ascierto, P.A.1    Simeone, E.2    Giannarelli, D.3    Grimaldi, A.M.4    Romano, A.5    Mozzillo, N.6


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