The usefulness of non-human primates in central nervous system safety pharmacology

Journal of Pharmacological and Toxicological Methods

Volumn 68, Issue 1, 2013, Pages 23-29

  Porsolt, Roger D ^a  

^a Porsolt SAS   (France)

Author keywords

Biting; Cognition; Delayed matching non matching to sample; Dystonia; Executive function; Extrapyramidal symptoms (EPS); Frustration aggression; Methods; Non human primates (NHP); Object retrieval

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CHLORPROMAZINE; CLOZAPINE; FLUPHENAZINE; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; REMOXIPRIDE; RISPERIDONE; ROLIPRAM; SCOPOLAMINE; THIORIDAZINE; ZIPRASIDONE;

AGGRESSION; ANIMAL BEHAVIOR; ARTICLE; BITE; BRAIN FUNCTION; CENTRAL NERVOUS SYSTEM; COGNITION; DRUG EFFECT; DRUG SAFETY; DYSTONIA; EXECUTIVE FUNCTION; EXPERIMENTAL ANIMAL; EXPERIMENTAL TEST; EXTRAPYRAMIDAL SYMPTOM; FRUSTRATION; IRRITABILITY; NONHUMAN; PRIMATE; RODENT; SHOCK; SPECIES DIFFERENCE; SQUIRREL MONKEY;

BITING; COGNITION; DELAYED MATCHING/NON-MATCHING-TO-SAMPLE; DYSTONIA; EXECUTIVE FUNCTION; EXTRAPYRAMIDAL SYMPTOMS (EPS); FRUSTRATION-AGGRESSION; METHODS; NON-HUMAN PRIMATES (NHP); OBJECT RETRIEVAL;

ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM; COGNITION; DISEASE MODELS, ANIMAL; HUMANS; MODELS, ANIMAL; PRIMATES; RODENTIA; SPECIES SPECIFICITY;

ANIMALIA; PRIMATES; RODENTIA; SAIMIRI;

EID: 84880046152     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2013.03.004     Document Type: Article

References (37)

1. Anon Guideline on the non-clinical investigation of the dependence potential of medicinal products 2006, European Medicines Agency, London, (23 March 2006).
2. Auclair A.L., Kleven M.S., Barret-Grévoza C., Barretoa M., Newman-Tancredi A., Depoortère R. Differences among conventional, atypical and novel putative D2/5-HT1A antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys. Behavioural Brain Research 2009, 203:288-295.
3. Balls M., Goldberg A.M., Fentem J.H., Broadhead C.L., Burch R.L., Festing M.F., et al. The three Rs: The way forward: The report and recommendations of ECVAM Workshop 11. Alternatives to laboratory animals 1995, 23:838-866.
4. Bartus R.T., Dean R.L. Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurodegenerative conditions: Exploring new territory using traditional tools and established maps. Psychopharmacology 2009, 202:15-36.
5. Bartus R.T., Flicker C., Dean R.L. Logical principles for the development of animal models of age-related memory impairments. Assessment in geriatric psychopharmacology 1983, 263-299. Mark Powley Associates, New Canaan (CT). T. Crook, S. Ferris, R.T. Bartus (Eds.).
6. Berkowitz L. The frustration-aggression hypothesis revisited 1969, Atherton Press, New York.
7. Buccafusco J.J., Terry A.V. Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys. Journal of Molecular Neuroscience 2004, 24:85-91.
8. Casey D.E. Neuroleptic-induced acute extrapyramidal syndromes and tardive dyskinesia. Psychiatric Clinics of North America 1993, 16:589-610.
9. Casselli L., Chelazzi L. Does the macaque monkey provide a good model for studying human executive control? A comparative behavioral study of task switching. PLoS One 2011, 6:e21489. (Epub 2011 Jun 24). 10.1371/journal.pone.0021489.
10. Chudasama Y. Animal models of prefrontal-executive function. Behavioral Neuroscience 2011, 125:327-343.
11. Davis K.L., Thal L.J., Gamzu E.R., Davis C.S., Woolson R.F., Gracon S.I., et al. A double-blind placebo-controlled multicenter study of tacrine for Alzheimer's disease. New England Journal of Medicine 1992, 327:1253-1259.
12. Deniker P., Ginestet D., Loo H. Le maniement des médicaments psychotropes 1980, Doin Editeurs, Paris.
13. Diamond A., Zola-Morgan S., Squire L.R. Successful performance by monkeys with lesions of the hippocampal formation on AB and object retrieval, two tasks that mark developmental changes in human infants. Behavioral Neuroscience 1989, 103(3):526-537.
14. Emley G.S., Hutchinson R.R. Unique influences of ten drugs upon post-shock biting attack and pre-shock manual responding. Pharmacology Biochemistry and Behavior 1983, 19:5-12.
15. Haase H.J. Neuroleptics and the extrapyramidal system. Arzneimittel-Forschung 1978, 28:1536-1537.
16. Hayes E., Hubert I., Oktarina R., Budiarsa N., Iskandriati D., Pushett D., et al. EPS Liability in the Cynomolgus Monkey: Effects of acute haloperidol and olanzapine administration in drug naïve animals. Poster N° 017 presented at the Safety Pharmacology Society Meeting in Phoenix (Arizona), October 2012 2012.
17. Hutchinson R.R., Azrin N.H., Hake D.F. An automatic method for the study of aggression in squirrel monkeys. Journal of Experimental Analysis of Behavior 1966, 9:233-237.
18. Hutchinson R.R., Azrin N.H., Hunt G.M. Attack produced by intermittent reinforcement of a concurrent operant response. Journal of Experimental Analysis of Behavior 1968, 11:489-495.
19. Janssen P.A., Jagenau A.H., Niemegeers C.J. Effects of various drugs on isolation-induced fighting behavior of male mice. Journal of Pharmacology and Experimental Therapeutics 1960, 129:471-475.
20. Jentsch J.D., Roth R.H., Taylor J.R. Object retrieval/detour deficits in monkeys produced by prior subchronic phencyclidine administration: Evidence for cognitive impulsivity. Biological Psychiatry 2000, 48:415-424.
21. Levin E.D., Bushnell P.J., Rezvani A.H. Attention-modulating effects of cognitive enhancers. Pharmacology Biochemistry and Behavior 2011, 99:146-154.
22. Meltzer H.Y. Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 1989, 99:S18-S27. (Suppl.).
23. O'Connor E.C., Chapman K., Butler P., Mead A.N. The predictive validity of the rat self-administration model for abuse liability. Neuroscience and Biobehavioral Reviews 2011, 35:912-938.
24. Olivier B., Mos J., Rasmussen D. Behavioural pharmacology of the serenic, eltoprazine. Drug Metabolism and Drug Interactions 1990, 8:31-83.
25. Porsolt R.D., Dürmüller N., Castagné V., Moser P. CNS Safety Pharmacology. Nonclinical drug safety assessment: Practical considerations for successful registrations 2007, 141-162. FDANews, Washington DC. W.K. Sietsema, R. Schwen (Eds.).
26. Porsolt R.D., Jalfre M. Neuroleptic-induced acute dyskinesias in rhesus monkeys. Psychopharmacology 1981, 75:16-21.
27. Porsolt R.D., Moser P.C., Castagné V. Behavioral indices in antipsychotic drug discovery. Journal of Pharmacology and Experimental Therapeutics 2010, 333:632-638.
28. Porsolt R.D., Roux S., Wettstein J.G. Animal models of dementia. Drug Development Research 1995, 35:214-229.
29. Roux S., Hubert I., Porsolt R.D. Delayed alternation in rats. Current protocols in pharmacology 1999, 5.13.1-5.13.9. Wiley, New York. S.J. Enna, M. Williams (Eds.).
30. Rutten K., Basile J.L., Prickaerts J., Blokland A., Vivian J.A. Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques. Psychopharmacology 2008, 196:643-648.
31. Stoet G., Snyder L.H. Neural correlates of executive control functions in the monkey. Trends in Cognitive Science 2009, 13:228-234.
32. Ward K.W., Smith B.R. A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance. Drug Metabolism and Disposition 2004, 32:603-611.
33. Ward K.W., Smith B.R. A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time. Drug Metabolism and Disposition 2004, 32:612-619.
34. Weatherall D. The use of non-human primates in research. Medical Research Council Report. London, December 2006 2006.
35. Weerts E.M., Fantegrossi W.E., Goodwin A.K. The value of nonhuman primates in drug abuse research. Experimental and Clinical Psychopharmacology 2007, 15:309-327.
36. Wolinsky T., Cruz C., Hubert I., Lemaire M., Virley D. The object retrieval test in the non-human primate: Effects of rolipram and scopolamine on cognitive performance. Poster N°: 916.14/DDD2, presented at the Society for Neuroscience Meeting, New Orleans (Louisiana), October 2012 2012.
37. Zwirner P.P., Porsolt R.D., Loew D.M. Inter-group aggression in mice: A new method for testing the effects of centrally active drugs. Psychopharmacologia 1975, 45:133-138.