Evidence for exposure-induced DNA repair abnormality is indicative of health and genetic risk

International Journal of Hygiene and Environmental Health

Volumn 216, Issue 5, 2013, Pages 566-573

  Ruchirawat, Mathuros ^a   Cebulska Wasilewska, Antonina ^b   Au, William W ^c  

^a CHULABHORN RESEARCH INSTITUTE   (Thailand)

^b INSTITUTE OF NUCLEAR PHYSICS   (Poland)

^c SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Challenge assay; DNA repair; Environmental toxicology; Genetic toxicology; Health risk; Population monitoring

Indexed keywords

BIOLOGICAL MARKER; MUTAGENIC AGENT;

ARTICLE; CHALLENGE ASSAY; CHEMICALLY INDUCED DISORDER; DISORDERS OF DNA SYNTHESIS AND REPAIR; DNA REPAIR; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL TOXICOLOGY; GENETIC TOXICOLOGY; HEALTH HAZARD; HUMAN; NEOPLASM; POPULATION MONITORING; RISK ASSESSMENT;

CHALLENGE ASSAY; DNA REPAIR; ENVIRONMENTAL TOXICOLOGY; GENETIC TOXICOLOGY; HEALTH RISK; POPULATION MONITORING;

BIOLOGICAL MARKERS; DNA REPAIR-DEFICIENCY DISORDERS; ENVIRONMENTAL EXPOSURE; HUMANS; MUTAGENS; NEOPLASMS; RISK ASSESSMENT;

EID: 84880041763     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2013.03.003     Document Type: Article

References (74)

1. Abdel-Rahman S., El-Zein R. Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches. Biomarkers 2011, 16:393-404.
2. Ahsan H., Chen Y., Wang Q., Slavkovich V., Graziano J.H., Santella R.M. DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis. Toxicol. Lett. 2003, 143:123-131.
3. Alain G., Tousignant J., Rozenfarb E. Chronic arsenic toxicity. Int. J. Dermatol. 1993, 32:899-901.
4. Arayasiri M., Mahidol C., Navasumrit P., Autrup H., Ruchirawat M. Biomonitoring of benzene and 1,3-butadiene exposure and early biological effects in traffic policemen. Sci. Total Environ. 2010, 408:4855-4862.
5. Athas W.F., Hedayati M.A., Matanoski G.M., Farmer E.R., Grossman L. Development and field-test validation of an assay for DNA repair in circulating human lymphocytes. Cancer Res. 1991, 51:5786-5793.
6. Au W.W., Walker D.M., Ward J.B., Whorton E., Legator M.S., Singh V. Factors contributing to chromosome damage in lymphocytes of cigarette smokers. Mutat. Res. 1991, 260:137-144.
7. Au W.W. Abnormal chromosome repair and risk to develop cancer. Environ. Health Persp. 1993, 101(S3):303-308.
8. Au W.W., Bechtold W.E., Whorton E.B.J., Legator M.S. Chromosome aberrations and response to gamma-ray challenge in lymphocytes of workers exposed to 1,3 butadiene. Mutat. Res. 1995, 334:125-130.
9. Au W.W., Lane R.G., Legator M.S., Whorton E.B., Wilkinson G.S., Gabehart G.J. Biomarker monitoring of a population residing near uranium mining activities. Environ. Health Persp. 1995, 103:466-470.
10. Au W.W., Rodriguez G., Rocco C., Legator M.S., Wilkinson G.S. Chromosomal damage and DNA repair response in lymphocytes of women who had children with neural tube defects. Mutat. Res. 1996, 361:17-21.
11. Au W.W., Sierra-Torres C.H., Cajas-Salazar N., Shipp B.K., Legator M.S. Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibility. Environ. Health Perspect. 1999, 107:501-505.
12. Au W.W., Salama S.A., Sierra-Torres C.H. Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays. Environ. Health Perspect. 2003, 111:1843-1850.
13. Au W.W., Salama S.A. Cytogenetic challenge assays for assessment of DNA repair capacities. Methods in Molecular Biology: DNA Repair Protocols: Mammalian Systems 2005, vol. 3:25-42. Humana Press, Totowa, New Jersey, Chapter 3. second ed.
14. Au W.W., Salama S.A. Use of Biomarkers to elucidate genetic susceptibility to environmental cancer. Environ. Mol. Mutag. 2005, 45:222-228.
15. Au W.W., Giri A., Ruchirawat M. Challenge assay: a functional biomarker for exposure-induced DNA repair deficiency and for risk of cancer. Int. J. Hyg. Env. Health 2010, 213:329-338.
16. Banerjee M., Sarma N., Biswas R., Roy J., Mukherjee A., Giri A.K. DNA repair deficiency leads to susceptibility to develop arsenic-induced premalignant skin lesions. Int. J. Cancer 2008, 123:283-287.
17. Basten G., Duthie S.J., Pirie L., Vaughan N., Hill M.H., Powers H.J. Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Br. J. Cancer. 2006, 94:1942-1947.
18. Beckman R.A., Loeb L.A. Efficiency of carcinogenesis with and without a mutator mutation. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:14140-14145.
19. Bickham J.W., Sandhu S., Hebert P.D.N., Chikhi L., Athwal R. Effects of chemical contaminants on genetic diversity in natural populations: implications for biomonitoring and ecotoxicology. Mutat. Res. 2000, 463:33-51.
20. Bolengenova N.K., Bekmanov B.O., Djansugurava L.B., Bersimbaev R.I., Salama S.A., Au W.W. Genetic polymorphisms and expression of minisatellite mutations in a 3-generation population around the Semipalatinsk nuclear explosion test site, Kazakhstan. Int. J. Hyg. Env. Health 2009, 212:654-660.
21. Borresen-Dale A.L. TP53 and breast cancer. Hum. Mutat. 2003, 21:292-300.
22. Buttitta F., Felicionim L., Barassim F. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. J. Pathol. 2006, 208:350-355.
23. Cebulska-Wasilewska A., Nowak D., Niedźwiedź W., Anderson D. Correlations between DNA and cytogenetic damage induced after chemical treatment and radiation. Mutat. Res. 1998, 421:83-91.
24. Cebulska-Wasilewska A., Wierzewska A., Dyga W., Drag Z., Siffel C., Horvath M., Au W. Induction of DNA and cytogenetic damage in lymphocytes of Polish workers exposed to pesticides. Central Eur. J. Occup. Environ. Med. 2000, 6:272-287.
25. Cebulska-Wasilewska A. Response to challenging dose of X-rays as a predictive assay for molecular epidemiology. Mutat. Res. Rev. 2003, 544:289-297.
26. Cebulska-Wasilewska A., Panek A., Zabinski Z., Moszczynski P., Au W.W. Occupational exposure to mercury vapour on genotoxicity and DNA repair. Mutat. Res. 2005, 586:102-114.
27. Cebulska-Wasilewska A., Binkova B., Sram R.J., Kalina I., Popov T., Farmer P.B. Repair competence assay in studies of the influence of environmental exposure to c-PAHs on individual susceptibility to induction of DNA damage. Mutat. Res. 2007, 620:155-164.
28. Chanvaivit S., Navasumrit P., Hunsonti P., Autrup H., Ruchirawat M. Exposure assessment of benzene in Thai workers, DNA-repair capacity and influence of genetic polymorphisms. Mutat. Res. 2007, 626:79-87.
29. Chen S., Parmigiani G. Meta-analysis of BRCA1 and BRCA2 penetrance. J. Clin. Oncol. 2007, 25:1329-1333.
30. Collins A.R., Gaivao I. DNA based excision repair as a biomarker in molecular epidemiology studies. Mol. Aspect Med. 2007, 28:307-322.
31. DeCaprio J.A., Ludlow J.W., Lynch D., Furukawa Y., Griffin J., Piwnica-Worms H., Huang C.M., Livingston D.M. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell 1989, 58:1085-1095.
32. De Chaudhuri S., Jundu M., Banerjee M., Das J.K., Majumdar P., Basu S., Roychoudhury S., Singh K.K., Giri A.K. Arsenic-induced health effects and genetic damage in karatotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility. Mutat. Res. 2008, 659:118-125.
33. Decordier I., Loock K.V., Kirsch-Volders M. Pheotyping for DNA repair capacity. Mutat. Res. 2010, 705:107-129.
34. Dubrova Y.E., Bersimbaev R.I., Djansugurova L.B., Tankimanova M., Mamyrbaeva Z., Mustonen R., Lindholm C., Mustonen R., Salomaa S. Nuclear weapons tests and human germline mutation rate. Science 2002, 295:1307.
35. Duker N.J. Chromosome breakage syndromes and cancer. Am. J. Med. Genet. 2002, 115:125-129.
36. Duthie S.J., McMillan P. Uracil misincorporation in human DNA detected using single gel electrophoresis. Carcinogenesis 1997, 18:1709-1714.
37. Dyga W., Drag Z., Cebulska-Wasilewska A. The influence of the occupational exposure to pesticides on the kevel of DNA damage induced in human lymphocytes (Polish group) by UV-C and X-rays. NATO Science Series, Series I: Life and Behavioural Sciences 2003, vol. 351:198-213. IOS Press, New York, NY, USA. 1566-7693. A. Cebulska-Wasilewska, W.W. Au, R.J. Sram (Eds.).
38. Guha D.N., Haque R., Ghosh N., De B.K., Santra A., Chakroborty D., Smith A.H. Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal. India. Int. J. Epidemiol. 1998, 27:871-877.
39. Hallberg L.M., El Zein R., Grossman L., Au W.W. Measurement of DNA repair deficiency in workers exposed to benzene. Environ. Health Persp. 1996, 104(Suppl. 3):529-534.
40. Hallberg L.M., Bechtold W.E., Grady J., Legator M.S., Au W.W. Abnormal DNA repair activities in lymphocytes of workers exposed to 1,3-butadiene. Mutat. Res. 1997, 383:213-221.
41. IARC IARC monographs on the evaluation of carcinogenic risk of chemicals to humans: some drinking water disinfectants and contaminants, including arsenic. IARC Sci. Publ. 2004, 84:1-477.
42. Jalal S., Earley J.N., Turchi J.J. DNA repair: from genome maintenance to biomarker and therapeutic target. Clin. Cancer Res. 2011, 17:6973-6984.
43. Jóhannsson O.T., Idvall I., Anderson C., Borg A., Barkardóttir R.B., Egilsson V., Olsson H. Tumour biological features of BRCA1-induced breast and ovarian cancer. Eur. J. Cancer 1997, 33:362-371.
44. Knudsen A.G. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. U.S.A. 1971, 68:820-823.
45. Kohler M.F., Marks J.R., Wiseman R.W. Sepctrum of mutation and frequency of allelic deletion of the P53 gene in ovarian cancer. J. Natl. Cancer Inst. 1993, 85:1513-1519.
46. Kumari A., Lim Y.X., Newell A.H., Olson S.B., McCullough A.K. Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway. DNA Repair 2012, 11:236-246.
47. Kuo K.T., Mao T.L., Jones S. Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am. J. Pathol. 2009, 174:1597-1601.
48. Kyrtopoulos S.A., Sarrif A., Elliott B.M., Schoket B., Demopoulos N.A. Biomarkers and molecular epidemiology - present state and future trends: concluding remarks. Mutat. Res. 2006, 600:77-78.
49. Lee E.Y., To H., Shew J.Y., Bookstein P., Scully P., Lee W.H. Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 1988, 241:218-221.
50. Loeb L.A. A mutator phenotype in cancer. Can. Res. 2001, 61:3230-3236.
51. López-Abente G., Aragonés N., Pollán M., Ruiz M., Gandarillas A. Leukemia, lymphomas, and myeloma mortality in the vicinity of nuclear power plants and nuclear fuel facilities in Spain. Cancer Epidemiol. Biomarkers Prev. 1999, 8:925-934.
52. López-Abente G., Aragonés N., Pollán M. Solid-tumor mortality in the vicinity of uranium cycle facilities and nuclear power plants in Spain. Environ. Health Perspect. 2001, 109:721-729.
53. Lord C.J., Ashworth A. The DNA damage response and cancer therapy. Nature 2012, 481:287-294.
54. Martínez-Cruz A.B., Santos M., Lara M.F., Segrelles C., Ruiz S., Moral M., Lorz C., García-Escudero R., Paramio J.M. Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors. Cancer Res. 2008, 68:683-689.
55. McConnell M.A., Sadagopa Ramanujam V.M., Alcock N., Au W.W. Distribution of uranium-238 and thorium-232 in environmental samples around uranium mining and milling activities. Environ. Chem. Toxicol. 1998, 17:841-850.
56. Navasumrit P., Arayasiri M., Hiang O.M., Leechawengwongs M., Promvijit J., Choonvisase S., Chantchaemsai S., Nakngam N., Mahidol C., Ruchirawat M. Potential health effects of exposure to carcinogenic compounds in incense smoke in temple workers. Chem. Biol. Interact. 2008, 173:19-31.
57. NRC Arsenic in Drinking Water 1999, National Academy Press, Washington, D.C., Subcommittee on Arsenic in Drinking Water.
58. Oberheitmann B., Frentzel-Beyme R., Hoffmann W. An application of the challenge assay in boat builders exposed to low levels of styrene - a feasibility study of a possible biomarker for acquired susceptibility. Int. J. Hyg. Environ. Health 2001, 204:54-60.
59. Orlow I., Park B.J., Mujumdar U., Patel H., Siu-Lau P., Clas B.A. DNA damage and repair capacity in patients with lung cancer: prediction of multiple primary tumors. J. Clin. Oncol. 2008, 26:3560-3566.
60. Roy R., Chun J., Powell S.N. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat. Rev. 2012, 12:68-78.
61. Pruthi S., Gostout B.S., Lindor N.M. Identification and management of women with BRCA mutations or hereditary predisposition for breast and ovarian cancer. Mayo Clin. Proc. 2010, 85:1111-1120.
62. Ruchirawat M., Mahidol C., Tangjarukij C., Pui-ock S., Jensen O., Kampeerawi-pakorn O., Tuntaviroon J., Aramphongphan A., Autrup H. Exposure to genotoxins present in ambient air in Bangkok, Thailand-particle associated polycyclic aromatic hydrocarbons and biomarkers. Sci. Total Environ. 2002, 287:121-132.
63. Ruchirawat M., Navasumrit P., Settachan D. Exposure to benzene in various susceptible populations: co-exposures to 1,3-butadiene and PAHs and implications for carcinogenic risk. Chem. Biol. Interact. 2010, 184:67-76.
64. Schmezer P., Rajaee-Behbahani N., Risch A., Thiel S., Rittgen W., Drings P. Rapid screening assay for mutagen sensitivity an dDNA repair capacity in human peripheral blood lymphocytes. Mutagenesis 2001, 16:25-30.
65. Spitz M.R., Fueger J.J., Halabi S., Schantz S.P., Sampe D., Hsu T.C. Mutagen sensitivity in upper aerodigestive tract cancer: a case-control analysis. Cancer Epidemiol. Biomarkers Prev. 1993, 2:329-333.
66. Thompson L.H., Schild D. Recombinational DNA repair and human disease. Mutat. Res. 2002, 509:49-78.
67. Tuntawiroon J., Mahidol C., Navasumrit P., Autrup H., Ruchirawat M. Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources. Carcinogenesis 2007, 28:816-822.
68. Turner N., Tutt A., Ashworth A. Hallmarks of "BRACness" in sporadic cancers. Nat. Rev. Cancer 2004, 4:814-819.
69. Tutt A., Ashworth A. The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. Trends Mol. Med. 2002, 8:571-576.
70. Venkitaraman A.R. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002, 108:171-182.
71. Vollebergh M.A., Jonkers J., Linn S.C. Genomic instability in breaste and ovarian cancers: translation inot clinical predictive biomarkers. Cell. Mol. Life Sci. 2012, 69:223-245.
72. Wei Q., Cheng L., Amos C.I., Wang L.E., Guo Z., Hong W.K. Repair of tobacco carcinogen-induced DAN adducts and lung cancer risk: a molecular epidemiologic study. J. Natl. Cancer Inst. 2000, 92:1764-1772.
73. Wu X., Gu J., Spitz M.R. Mutagen sensitivity: a genetic predisposition factor for cancer. Cancer Res. 2007, 67:3493-3495.
74. Zheng Y.L., Loffredo C.A., Zhipeng Y., Jones R.T., Krasna M.J., Alberg A.J., Yung R., Perlmutter D., Enewold L., Harris C.C., Shields P.G. Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls. Carcinogenesis 2003, 24:269-274.