Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy

Epilepsy Research

Volumn 105, Issue 3, 2013, Pages 272-279

  Harty, Rosemary C ^a   Kim, Tae Hwan ^a   Thomas, Evan A ^a   Cardamone, Lisa ^b   Jones, Nigel C ^b   Petrou, Steven ^a,c   Wimmer, Verena C ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Amygdala kindling; Axon initial segment; Childhood absence epilepsy; Epilepsy; Seizure; Structural neuronal plasticity

Indexed keywords

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SIZE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPILEPSY; IMMUNOHISTOCHEMISTRY; NERVE CELL PLASTICITY; NERVE CELL STIMULATION; NERVE CONDUCTION; NERVE FIBER; NERVE FUNCTION; NERVE POTENTIAL; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SOMATOSENSORY CORTEX;

AMYGDALA KINDLING; AXON INITIAL SEGMENT; CHILDHOOD ABSENCE EPILEPSY; EPILEPSY; SEIZURE; STRUCTURAL NEURONAL PLASTICITY;

ANIMALS; AXONS; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; EPILEPSY; KINDLING, NEUROLOGIC; MALE; MICE; MICE, TRANSGENIC; MODELS, NEUROLOGICAL; MUTATION; NEURONAL PLASTICITY; PHOSPHATE TRANSPORT PROTEINS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SODIUM CHANNELS; SOMATOSENSORY CORTEX;

EID: 84880041743     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2013.03.004     Document Type: Article

References (32)

1. Akerman C.J., Cline H.T. Refining the roles of GABAergic signaling during neural circuit formation. Trends Neurosci. 2007, 30:382-389.
2. Berghs S., Aggujaro D., Dirkx R., Maksimova E., Stabach P., Hermel J.-M., Zhang J.-P., Philbrick W., Slepnev V., Ort T., Solimena M. βIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system. J. Cell Biol. 2000, 151:985-1002.
3. Boiko T., Van Wart A., Caldwell J.H., Levinson S.R., Trimmer J.S., Matthews G. Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J. Neurosci. 2003, 23:2306-2313.
4. Carnevale N.T., Hines M.L. The NEURON Book 2006, Cambridge University Press, Cambridge, UK.
5. Chiu C., Reid C.A., Tan H.O., Davies P.J., Single F.N., Koukoulas I., Berkovic S.F., Tan S.-S., Sprengel R., Jones M.V., Petrou S. Developmental impact of a familial GABAA receptor epilepsy mutation. Ann. Neurol. 2008, 64:284-293.
6. Dodge F.A., Cooley J.W. Action potential of the motoneuron. IBM J. Res. Dev. 1973, 17:219-229.
7. Grubb M.S., Burrone J. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature 2010, 465:1070-1074.
8. Grubb M.S., Burrone J. Building and maintaining the axon initial segment. Curr. Opin. Neurobiol. 2010, 20:481-488.
9. Kole M.H.P., Ilschner S.U., Kampa B.M., Williams S.R., Ruben P.C., Stuart G.J. Action potential generation requires a high sodium channel density in the axon initial segment. Nat. Neurosci. 2008, 11:178-186.
10. Kole M.H.P., Letzkus J.J., Stuart G.J. Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron 2007, 55:633-647.
11. Komada M., Soriano P. βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J. Cell Biol. 2002, 156:337-348.
12. Krieger P., Kuner T., Sakmann B. Synaptic connections between layer 5B pyramidal neurons in mouse somatosensory cortex are independent of apical dendrite bundling. J. Neurosci. 2007, 27:11473-11482.
13. Kuba H., Oichi Y., Ohmori H. Presynaptic activity regulates Na+ channel distribution at the axon initial segment. Nature 2010, 465:1075-1078.
14. Lorincz A., Nusser Z. Molecular identity of dendritic voltage-gated sodium channels. Science 2010, 328:906-909.
15. McNamara J.O., Constant Byrne M., Dasheiff R.M., Gregory Fitz J. The kindling model of epilepsy: a review. Prog. Neurobiol. 1980, 15:139-159.
16. Meeren H., van Luijtelaar G., Lopes da Silva F., Coenen A. Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory. Arch. Neurol. 2005, 62:371-376.
17. Morimoto K., Fahnestock M., Racine R.J. Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog. Neurobiol. 2004, 73:1-60.
18. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2005, Elsevier Academic Press, San Diego.
19. Post R.M. Neurobiology of seizures and behavioral abnormalities. Epilepsia (Series 4) 2004, 45:5-14.
20. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972, 32:281-294.
21. Salzberg M., Kumar G., Supit L., Jones N.C., Morris M.J., Rees S., O'Brien T.J. Early postnatal stress confers enduring vulnerability to limbic epileptogenesis. Epilepsia 2007, 48:2079-2085.
22. Schafer D.P., Jha S., Liu F., Akella T., McCullough L.D., Rasband M.N. Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury. J. Neurosci. 2009, 29:13242-13254.
23. Song A.-H., Wang D., Chen G., Li Y., Luo J., Duan S., Poo M.-M. A selective filter for cytoplasmic transport at the axon initial segment. Cell 2009, 136:1148-1160.
24. Susuki K., Yuki N., Schafer D.P., Hirata K., Zhang G., Funakoshi K., Rasband M.N. Dysfunction of nodes of Ranvier: a mechanism for anti-ganglioside antibody-mediated neuropathies. Exp. Neurol. 2012, 233:534-542.
25. Tan H.O., Reid C.A., Chiu C., Jones M.V., Petrou S. Increased thalamic inhibition in the absence seizure prone DBA/2J mouse. Epilepsia 2008, 49:921-925.
26. Tan H.O., Reid C.A., Single F.N., Davies P.J., Chiu C., Murphy S., Clarke A.L., Dibbens L., Krestel H., Mulley J.C., Jones M.V., Seeburg P.H., Sakmann B., Berkovic S.F., Sprengel R., Petrou S. Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:17536-17541.
27. Wallace R.H., Marini C., Petrou S., Harkin L.A., Bowser D.N., Panchal R.G., Williams D.A., Sutherland G.R., Mulley J.C., Scheffer I.E., Berkovic S.F. Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat. Genet. 2001, 28:49-52.
28. Wang D.D., Kriegstein A.R. Defining the role of GABA in cortical development. J. Physiol. 2009, 597:1873-1879.
29. Wimmer V.C., Bruno R.M., de Kock C.P.J., Kuner T., Sakmann B. Dimensions of a projection column and architecture of VPM and POm axons in rat vibrissal cortex. Cereb. Cortex 2010, 20:2265-2276.
30. Wimmer V.C., Reid C.A., Mitchell S., Richards K.L., Scaf B.B., Leaw B.T., Hill E.L., Royeck M., Horstmann M.-T., Cromer B.A., Davies P.J., Xu R., Lerche H., Berkovic S.F., Beck H., Petrou S. Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J. Clin. Invest. 2010, 120:2661-2671.
31. Wimmer V.C., Reid C.A., So E.Y.-W., Berkovic S.F., Petrou S. Axon initial segment dysfunction in epilepsy. J. Physiol. 2010, 588:1829-1840.
32. Yang Y., Ogawa Y., Hedstrom K.L., Rasband M.N. βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG. J. Cell Biol. 2007, 176:509-519.