Erectile dysfunction precedes other systemic vascular diseases due to incompetent cavernous endothelial cell-cell junctions

Journal of Urology

Volumn 190, Issue 2, 2013, Pages 779-789

  Ryu, Ji Kan ^a   Jin, Hai Rong ^a,c   Yin, Guo Nan ^a   Kwon, Mi Hye ^a   Song, Kang Moon ^a   Choi, Min Ji ^a   Park, Jin Mi ^a   Das, Nando Dulal ^a   Kwon, Ki Dong ^a   Batbold, Dulguun ^a   Lee, Tack ^a   Gao, Zhen Li ^c   Kim, Kyu Won ^b   Kim, Woo Jean ^a   Suh, Jun Kyu ^a  

^a Inha University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c YANTAI YUHUANGDING HOSPITAL   (China)

Author keywords

cardiovascular diseases; diabetes mellitus; erectile dysfunction; intracellular junctions; penis

Indexed keywords

ENDOTHELIAL CELL CELL JUNCTION PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL PERMEABILITY; CARDIOVASCULAR DISEASE; CELL JUNCTION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; HEART; LIMB; MOUSE; NONHUMAN; PENIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANG1; ANGIOPOIETIN-1; CARDIOVASCULAR DISEASE; CARDIOVASCULAR DISEASES; CVD; DIABETES MELLITUS; EC; ED; ENDOTHELIAL CELL-CELL; ERECTILE DYSFUNCTION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELL; HUVEC; ICP; INTRACAVERNOUS PRESSURE; INTRACELLULAR JUNCTIONS; LDL; LOW DENSITY LIPOPROTEIN; MCEC; MOUSE CAVERNOUS ENDOTHELIAL CELL; NITRIC OXIDE; NO; PECAM-1; PENIS; PLATELET/ENDOTHELIAL CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL; VE; ZO-1; ZONULAR OCCLUDENS-1;

ANALYSIS OF VARIANCE; ANGIOPOIETIN-1; ANIMALS; BLOTTING, WESTERN; CARDIOVASCULAR DISEASES; CORONARY CIRCULATION; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; ERECTILE DYSFUNCTION; HINDLIMB; INTERCELLULAR JUNCTIONS; MALE; MICE; MICE, INBRED C57BL; PENIS; STATISTICS, NONPARAMETRIC;

EID: 84880039819     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.02.100     Document Type: Article

References (30)

1. T.J. Bivalacqua, M.F. Usta, H.C. Champion Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease J Androl 24 suppl. 2003 S17
2. H.A. Feldman, I. Goldstein, D.G. Hatzichristou Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study J Urol 151 1994 54
3. F. Montorsi, A. Briganti, A. Salonia Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease Eur Urol 44 2003 360
4. I.M. Thompson, C.M. Tangen, P.J. Goodman Erectile dysfunction and subsequent cardiovascular disease JAMA 294 2005 2996
5. P. Montorsi, P.M. Ravagnani, S. Galli Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial Eur Heart J 27 2006 2632
6. P. Montorsi, P.M. Ravagnani, S. Galli The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease Am J Cardiol 96 2005 19M
7. K.M. Azadzoi, I. Goldstein Erectile dysfunction due to atherosclerotic vascular disease: the development of an animal model J Urol 147 1992 1675
8. K.M. Azadzoi, I.S. deTeiada Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle J Urol 146 1991 238
9. H. Solomon, J.W. Man, G. Jackson Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator Heart 89 2003 179
10. E. Dejana Endothelial cell-cell junctions: happy together Nat Rev Mol Cell Biol 5 2004 261
11. S. Liebner, U. Cavallaro, E. Dejana The multiple languages of endothelial cell-to-cell communication Arterioscler Thromb Vasc Biol 26 2006 1431
12. H. Wessells, S.H. King, M. Schmelz Immunohistochemical comparison of vascular and sinusoidal adherens junctions in cavernosal endothelium Urology 63 2004 201
13. J.K. Ryu, L.W. Zhang, H.R. Jin Derangements in endothelial cell-to-cell junctions involved in the pathogenesis of hypercholesterolemia-induced erectile dysfunction J Sex Med 6 2009 1893
14. C. Gazzaruso, S.B. Solerte, A. Pujia Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors J Am Coll Cardiol 51 2008 2040
15. H.R. Jin, W.J. Kim, J.S. Song Functional and morphologic characterizations of the diabetic mouse corpus cavernosum: comparison of a multiple low-dose and a single high-dose streptozotocin protocols J Sex Med 6 2009 3289
16. G.N. Yin, J.K. Ryu, M.H. Kwon Matrigel-based sprouting endothelial cell culture system from mouse corpus cavernosum is potentially useful for the study of endothelial and erectile dysfunction related to high-glucose exposure J Sex Med 9 2012 1760
17. D. Behrendt, P. Ganz Endothelial function: from vascular biology to clinical applications J Am Coll Cardiol 90 2002 40
18. C. Napoli Oxidation of LDL, atherogenesis, and apoptosis Ann N Y Acad Sci 1010 2003 698
19. M. Artwohl, W.F. Graier, M. Roden Diabetic LDL triggers apoptosis in vascular endothelial cells Diabetes 52 2003 1240
20. M. Wu, Y. Chen, K. Wilson Intraretinal leakage and oxidation of LDL in diabetic retinopathy Invest Ophthalmol Vis Sci 49 2008 2679
21. D.A. Antonetti, A.J. Barber, S. Khin Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells Penn State Retina Research Group Diabetes 47 1998 1953
22. E.C. Leal, A. Manivannan, K. Hosoya Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy Invest Ophthalmol Vis Sci 48 2007 5257
23. A.B. El-Remessy, M.A. Behzadian, G. Abou-Mohamed Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor Am J Pathol 162 2003 1995
24. S. Gory-Fauré, M.H. Prandini, H. Pointu Role of vascular endothelial- cadherin in vascular morphogenesis Development 126 1999 2093
25. M. Corada, L. Zanetta, F. Orsenigo A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability Blood 100 2002 905
26. Y. Rikitake, J.K. Liao Rho GTPases, statins, and nitric oxide Circ Res 97 2005 1232
27. B. Musicki, A.L. Burnett Endothelial dysfunction in diabetic erectile dysfunction Int J Impot Res 19 2007 129
28. H.G. Augustin, G.Y. Koh, G. Thurston Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system Nat Rev Mol Cell Biol 10 2009 165
29. H.R. Jin, W.J. Kim, J.S. Song Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse Diabetes 60 2011 969
30. H.R. Jin, W.J. Kim, J.S. Song Intracavernous delivery of synthetic angiopoietin-1 protein as a novel therapeutic strategy for erectile dysfunction in the type II diabetic db/db mouse J Sex Med 7 2010 3635