A practical application of quantitative vascular image analysis in breast pathology

Pathology Research and Practice

Volumn 209, Issue 7, 2013, Pages 455-458

  Ozerdem, Ugur ^a   Wojcik, Eva M ^a   Barkan, Güliz A ^a   Duan, Xiuzhen ^a   Erşahin, Çaǧatay ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Breast cancer; Endothelium; Image analysis; ImageJ; Lymphangiogenesis

Indexed keywords

CD34 ANTIGEN; PHENYLENEDIAMINE;

ARTICLE; BREAST CANCER; CAMERA; CANCER STAGING; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIGITAL IMAGING; ENDOTHELIUM CELL; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMAGING SOFTWARE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; MICROSCOPE; QUANTITATIVE ANALYSIS; QUANTITATIVE VASCULAR IMAGE ANALYSIS; TISSUE MICROARRAY; TRANSLATIONAL RESEARCH; VASCULAR ENDOTHELIUM;

ANGIOGENESIS; BREAST CANCER; ENDOTHELIUM; IMAGE ANALYSIS; IMAGEJ; LYMPHANGIOGENESIS;

ANTIGENS, CD34; BREAST NEOPLASMS; ENDOTHELIUM, LYMPHATIC; ENDOTHELIUM, VASCULAR; FEASIBILITY STUDIES; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LYMPHANGIOGENESIS; NEOVASCULARIZATION, PATHOLOGIC; PREDICTIVE VALUE OF TESTS; SOFTWARE; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84880038577     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2013.03.004     Document Type: Article

References (19)

1. ACS, American Cancer Society Cancer Facts and Figures. Estimated new cancer cases for selected cancer sites by State, US, 2012.
2. Folkman J., Browder T., Palmblad J. Angiogenesis research: guidelines for translation to clinical application. Thromb. Haemost. 2001, 86:23-33.
3. Alitalo K. The lymphatic vasculature in disease. Nat. Med. 2011, 17:1371-1380.
4. Miller K.D., Sweeney C.J., Sledge G.W. Redefining the target: chemotherapeutics as antiangiogenics. J. Clin. Oncol. 2001, 19:1195-1206.
5. Hayes D.F., Miller K., Sledge G. Angiogenesis as targeted breast cancer therapy. Breast 2007, 16(Suppl. 2):S17-S19.
6. Tammela T., Zarkada G., Wallgard E., Murtomaki A., Suchting S., Wirzenius M., Waltari M., Hellstrom M., Schomber T., Peltonen R., Freitas C., Duarte A., Isoniemi H., Laakkonen P., Christofori G., Yla-Herttuala S., Shibuya M., Pytowski B., Eichmann A., Betsholtz C., Alitalo K. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008, 454:656-660.
7. Ozerdem U. Targeting neovascular pericytes in neurofibromatosis type 1. Angiogenesis 2004, 7:307-311.
8. Ozerdem U. Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse. Ophthalmic Res. 2006, 38:251-254.
9. Ozerdem U. Targeting of pericytes diminishes neovascularization and lymphangiogenesis in prostate cancer. Prostate 2006, 66:294-304.
10. Ozerdem U., Alitalo K., Salven P., Li A. Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis. Invest. Ophthalmol. Vis. Sci. 2005, 46:3502-3506.
11. Rajantie I., Ilmonen M., Alminaite A., Ozerdem U., Alitalo K., Salven P. Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood 2004, 104:2084-2086.
12. Cattaruzza S., Ozerdem U., Denzel M., Ranscht B., Bulian P., Cavallaro U., Zanocco D., Colombatti A., Stallcup W.B., Perris R. Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells. Angiogenesis 2012.
13. Fiedler U., Christian S., Koidl S., Kerjaschki D., Emmett M.S., Bates D.O., Christofori G., Augustin H.G. The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors. Am. J. Pathol. 2006, 168:1045-1053.
14. AJCC Breast. Cancer Staging Manual 2010, 349. Springer, New York, NY. AJCC (Ed.).
15. W.S. Rasband, ImageJ, U.S. National Institutes of Health, Bethesda, Maryland, USA, 1997-2012. http://imagej.nih.gov/ij/.
16. Abramoff M.D., Magalhaes P.J., Ram S.J. Image processing with ImageJ. Biophoton. Int. 2004, 11:36-42.
17. Schneider C.A., Rasband W.S., Eliceiri K.W. NIH Image to ImageJ: 25 years of image analysis. Nat. Methods 2012, 9:671-675.
18. Hansen S., Grabau D.A., Sorensen F.B., Bak M., Vach W., Rose C. The prognostic value of angiogenesis by Chalkley counting in a confirmatory study design on 836 breast cancer patients. Clin. Cancer Res. 2000, 6:139-146.
19. Dhakal H.P., Bassarova A., Naume B., Synnestvedt M., Borgen E., Kaaresen R., Schlichting E., Wiedswang G., Giercksky K.E., Nesland J.M. Breast carcinoma vascularity: a comparison of manual microvessel count and Chalkley count. Histol. Histopathol. 2009, 24:1049-1059.