Targeting pericytes diminishes neovascularization in orthotopic uveal melanoma in nerve/glial antigen 2 proteoglycan knockout mouse

Ophthalmic Research

Volumn 38, Issue 5, 2006, Pages 251-254

  Ozerdem, Ugur ^a  

^a LA JOLLA INSTITUTE FOR MOLECULAR MEDICINE   (United States)

Author keywords

Angiogenesis; Microcirculation; Neovascularization; Pericyte; Uveal melanoma

Indexed keywords

CYCLOSPORIN A; NERVE GLIAL ANTIGEN 2; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONFOCAL LASER MICROSCOPY; EYE DISEASE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOSUPPRESSIVE TREATMENT; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; UVEA MELANOMA;

ANIMALS; ANTIGENS; ANTIGENS, CD; ANTIGENS, CD31; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; MELANOMA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NEOVASCULARIZATION, PATHOLOGIC; PERICYTES; PROTEOGLYCANS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTORS, CELL SURFACE; UVEAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33749341541     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094833     Document Type: Article

References (9)

1. Hu LK, Huh K, Gragoudas ES, Young LH: Establishment of pigmented choroidal melanomas in a rabbit model. Retina 1994;14:264-269.
2. Ozerdem U, Alitalo K, Salven P, Li A: Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis. Invest Ophthalmol Vis Sci 2005;46:3502-3506.
3. Hernandez GL, Volpert OV, Iniguez MA, Lorenzo E, Martinez-Martinez S, Grau R, Fresno M, Redondo JM: Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med 2001;193:607-620.
4. Makitie T, Summanen P, Tarkkanen A, Kivela T: Microvascular density in predicting survival of patients with choroidal and ciliary body melanoma. Invest Ophthalmol Vis Sci 1999;40:2471-2480.
5. Clarijs R, van Dijk M, Ruiter DJ, de Waal RM: Functional and morphologic analysis of the fluid-conducting meshwork in xenografted cutaneous and primary uveal melanoma. Invest Ophthalmol Vis Sci 2005;46:3013-3020.
6. Balabanov R, Dore-Duffy P: Role of the CNS microvascular pericyte in the blood-brain barrier. J Neurosci Res 1998;53:637-644.
7. Ozerdem U: Targeting neovascular pericytes in neurofibromatosis type 1. Angiogenesis 2004;7:307-311.
8. Ozerdem U, Stallcup WB: Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan. Angiogenesis 2004;7:269-276.
9. Goretzki L, Burg MA, Grako KA, Stallcup WB: High-affinity binding of basic fibroblast growth factor and platelet- derived growth factor-AA to the core protein of the NG2 proteoglycan. J Biol Chem 1999;274:16831-16837.