In vivo detection of developing vessel occlusion in photothrombotic ischemic brain lesions in the rat by iron particle enhanced MRI

Journal of Cerebral Blood Flow and Metabolism

Volumn 25, Issue 11, 2005, Pages 1548-1555

  Kleinschnitz, Christoph ^a   Schütz, Ansgar ^a   Nölte, Ingo ^a   Horn, Tanja ^a   Frank, Marco ^a   Solymosi, Laszlo ^a   Stoll, Guido ^a   Bendszus, Martin ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Magnetic resonance imaging; Penumbra; SPIO; Stroke; Vessel occlusion

Indexed keywords

IRON; IRON OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; HISTOPATHOLOGY; ILLUMINATION; IN VIVO STUDY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RAT; TISSUE SECTION;

ANIMALS; BRAIN ISCHEMIA; CONTRAST MEDIA; INTRACRANIAL THROMBOSIS; IRON; MAGNETIC RESONANCE IMAGING; MALE; NANOSTRUCTURES; OXIDES; RATS; RATS, WISTAR;

EID: 27544515520     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600151     Document Type: Article

References (30)

1. Arbab AS, Bashaw LA, Miller BR, Jordan EK, Bulte JW, Frank JA (2003) Intracytoplasmic tagging of cells with ferumoxides and transfection agent for cellular magnetic resonance imaging after cell transplantation: methods and techniques. Transplantation 76:1123-30
2. Bendszus M, Stoll G (2003) Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging. J Neurosci 23:10892-6
3. Botnar RM, Perez AS, Witte S, Wiethoff AJ, Laredo J, Hamilton J et al (2004) In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation 109:2023-9
4. Busto R, Dietrich WD, Globus M, Valdes I, Scheinberg P, Ginsberg MD (1987) Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metabol 7:729-38
5. Chen F, Ward J, Robinson PJ (1999) MR imaging of the liver and spleen: a comparison of the effects on signal intensity of two superparamagnetic iron oxide agents. Magn Reson Imaging 17:549-56
6. Dietrich WD, Busto R, Watson BD, Scheinberg P, Ginsberg MD (1987a) Photochemically induced cerebral infarction. II. Edema and blood-brain barrier disruption. Acta Neuropathol (Berl) 72:326-34
7. Dietrich WD, Myron D, Ginsberg MD, Busto R, Watson BD (1986) Photochemically induced cortical infarction in the rat. 1. Time course of hemodynamic consequences. J Cereb Blood Flow Metabol 6:184-94
8. Dietrich WD, Watson BD, Busto R, Ginsberg MD, Bethea JR (1987b) Photochemically induced cerebral infarction. I. Early microvascular alterations. Acta Neuropathol (Berl) 72:315-25
9. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-7
10. Furlan M, Marchal G, Viader F, Derlon JM, Baron JC (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 40:216-26
11. Garcia JH, Yoshida Y, Chen H, Li Y, Zhang ZG, Lian J et al (1993) Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol 142:623-35
12. Grome JJ, Gojowczyk G, Hofmann W, Graham DI (1988) Quantitation of photochemically induced focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 8:89-95
13. Gustafsson O, Rossitti S, Ericsson A, Raininko R (1999) MR imaging of experimentally induced intracranial hemorrhage in rabbits during the first 6 h. Acta Radiol 40:360-8
14. Hoehn M, Kustermann E, Blunk J, Wiedermann D, Trapp T, Wecker S et al (2002) Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci USA 99:16267-72
15. Jander S, Kraemer M, Schroeter M, Witte OW, Stoll G (1995) Lymphocytic infiltration and expression of the intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J Cereb Blood Flow Metabol 15:42-51
16. Jiang JY, Lyeth BG, Clifton GL, Jenkins LW, Hamm RJ, Hayes RL (1991) Relationship between body and brain temperature in traumatically brain-injured rodents. J Neurosurg 74:492-6
17. Kleinschnitz C, Bendszus M, Frank M, Solymosi L, Toyka KV, Stoll G (2003) In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging. J Cereb Blood Flow Metabol 23:1356-61
18. Lee VM, Burdett NG, Carpenter A, Hall LD, Pambakian PS, Patel S et al (1996) Evolution of photochemically induced focal cerebral ischemia in the rat. Magnetic resonance imaging and histology. Stroke 27:2110-8
19. Marchal G, Beaudouin V, Rioux P, de la Sayette V, Le Doze F, Viader F et al (1996) Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis. Stroke 27:599-606
20. Moseley ME, Kucharczyk J, Mintorovitch J, Cohen Y, Kurhanewicz J, Derugin N et al (1990) Diffusion weighted MR-imaging of acute stroke: correlation with T2-w and magnetic susceptibility-enhanced MR-imaging in cats. Am J Neuroradiol 11:432-9
21. Neumann-Haefelin T, Moseley ME, Albers GW (2000) New magnetic resonance imaging methods for cerebrovascular disease: emerging clinical applications. Ann Neurol 47:559-70
22. Pratt J, Boudeau P, Uzan A, Imperato A, Stutzmann JM (1998) Enoxaparin reduces cerebral edema after photothrombotic injury in the rat. Haemostasis 28:78-85
23. Schlaug G, Benfield A, Baird AE, Siewert B, Lovblad KO, Parker RA et al (1999) The ischemic penumbra: operationally defined by diffusion and perfusion MRI. Neurology 53:1528-37
24. Schroeter M, Franke C, Stoll G, Hoehn M (2001) Dynamic changes of magnetic resonance imaging abnormalities in relation to inflammation and glial responses after photothrombotic cerebral infarction in the rat brain. Acta Neuropathol (Berl) 101:114-22
25. Schroeter M, Jander S, Huitinga I, Witte OW, Stoll G (1997) Phagocytic response in photochemically induced infarction of rat cerebral cortex. The role of resident microglia. Stroke 28:382-6
26. Schroeter M, Jander S, Stoll G (2002) Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responses. J Neurosci Methods 117:39-43
27. Stoll G, Wesemeier C, Gold R, Solymosi L, Toyka KV, Bendszus M (2004) In vivo monitoring of macrophage infiltration in experimental autoimmune neuritis by magnetic resonance imaging. J Neuroimmunol 149:142-6
28. Verlooy J, Van Reempts J, Peersman G, Van de Vyver F, Van Deuren B, Borgers M, Selosse P (1993) Photochemically-induced cerebral infarction in the rat: comparison of NMR imaging and histologic changes. Acta Neurochir (Wien) 122:250-6
29. Warach S, Gaa J, Siewert B, Wielopolski P, Edelmann RR (1995) Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging. Ann Neurol 37:231-41
30. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD (1985) Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol 17:497-504