Human aflatoxin exposure in Kenya, 2007: A cross-sectional study

Food Additives and Contaminants - Part A

Volumn 30, Issue 7, 2013, Pages 1322-1331

  Yard, Ellen E ^a   Daniel, Johnni H ^a   Lewis, Lauren S ^a   Rybak, Michael E ^a   Paliakov, Ekaterina M ^a   Kim, Andrea A ^b   Montgomery, Joel M ^b   Bunnell, Rebecca ^b   Abudo, Mamo Umuro ^c   Akhwale, Willis ^c   Breiman, Robert F ^b   Sharif, Shahnaaz K ^c  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c Kenya Ministry of Public Health and Sanitation   (Kenya)

Author keywords

aflatoxin; epidemiology; Kenya; liver cancer; maize; serosurvey

Indexed keywords

AGRICULTURAL PRODUCTS; AGRICULTURAL ROBOTS; AMINO ACIDS; DISEASES; EPIDEMIOLOGY; VIRUSES;

CROSS-SECTIONAL STUDY; GEOGRAPHIC CHARACTERISTICS; HUMAN IMMUNODEFICIENCY VIRUS; KENYA; LIVER CANCERS; MAIZE; SEROSURVEY; SOCIOECONOMIC CHARACTERISTICS;

AFLATOXINS;

AFLATOXIN B1; ALBUMIN; LYSINE DERIVATIVE;

ADOLESCENT; ADULT; AFLATOXICOSIS; ALBUMIN BLOOD LEVEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; EPIDEMIC; EXPOSURE; FEMALE; GEOGRAPHIC AND GEOLOGICAL PHENOMENA; HEALTH STATUS; HUMAN; INTERVIEW; ISOTOPE DILUTION ASSAY; KENYA; MALE; MARRIAGE; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RANDOMIZED CONTROLLED TRIAL; RELIGION; SOCIOECONOMICS; STRATIFIED SAMPLE;

HUMAN IMMUNODEFICIENCY VIRUS; ZEA MAYS;

EID: 84880035225     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2013.789558     Document Type: Article

References (35)

1. Allen SJ, Wild CP, Wheeler JG, Riley EM, Montesano R, Bennett S, Whittle HC, Hall AJ, Greenwood BM. 1992. Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Trans R Soc Trop Med Hyg. 86:426-430.
2. Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers HS, Kieszak S, Njapau H, Schleicher R, McCoy LF, Misore A, DeCock K, et al. 2005. Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environ Health Perspect. 113:1779-1783.
3. Basappa SC. 2009. Aflatoxins: formations, analysis, and control. Oxford: Alpha Science International, Ltd.
4. Centers for Disease Control and Prevention. 2004. Outbreak of aflatoxin poisoning - eastern and central provinces, Kenya, January-July 2004. MMWR Morb Mortal Wkly Rep. 53:790-793.
5. Centers for Disease Control and Prevention. 2012. National Health and Nutrition Examination Survey: aflatoxin B1-lysine concentration in serum (SSAFB_A). [Internet]. [cited 2012 Oct 17]. Available from: http://www.cdc.gov/nchs/nhanes/nhanes1999-2000/SSAFB_A.htm.
6. Cotty PJ, Antilla L, Wakelyn PJ. 2007. Competitive exclusion of aflatoxin producers: farmer driven research and development. In: C. Vincent, N. Goettel, and G. Lazarovitis, editors, Biological control: a global perspective. Wallingford: CAB International; p. 241-253.
7. Daniel JH, Lewis LW, Redwood YA, Kieszak S, Breiman RF, Flanders WD, Bell C, Mwihia J, Ogana G, Likimani S, et al. 2011. Comprehensive assessment of maize aflatoxin levels in Eastern Kenya, 2005-2007. Environ Health Perspect. 119:1794-1799.
8. Egal S, Hounsa A, Gong YY, Turner PC, Wild CP, Hall AJ, Hell K, Cardwell KF. 2005. Dietary exposure to aflatoxin from maize and groundnut in young children from Benin and Togo, West Africa. Int J Food Microbiol. 104:215-224.
9. Export Processing Zones Authority. 2005. Grain Production in Kenya: 2005. [Internet]. [cited 2012 Oct 25]. Available from: http://www.epzakenya.com/UserFiles/files/GrainReport.pdf
10. Gan LS, Skipper PL, Peng XC, Groopman JD, Chen JS, Wogan GN, Tannenbaum SR. 1988. Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B1 intake and urinary excretion of aflatoxin M1. Carcinogenesis. 9:1323-1325.
11. Gong YY, Cardwell K, Hounsa A, Egal S, Turner PC, Hall AJ, Wild CP. 2002. Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. BMJ. 325:20-21.
12. Gong YY, Egal S, Hounsa A, Turner PC, Hall AJ, Cardwell KF, Wild CP. 2003. Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning. Int J Epidemiol. 32:556-562.
13. Gong Y, Hounsa A, Egal S, Turner PC, Sutcliffe AE, Hall AJ, Cardwell K, Wild CP. 2004. Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environ Health Perspect. 112:1334-1338.
14. Hell K, Fandohan P, Bandyopadhyay R, Kiewnick S, Sikora R, Cotty P. 2008. Pre- and post-harvest management of aflatoxin in maize: an African perspective. In: J. Leslie, R. Bandyopadhyay and A. Visconti, editors, Mycotoxins: detection methods, management, public health, and agricultural trade. Wallingford: CAB International; p. 219-229.
15. Jiang Y, Jolly PE, Ellis WO, Wang JS, Phillips TD, Williams JH. 2005. Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. Int Immunol. 17:807-814.
16. Jolly P, Jiang Y, Ellis W, Awuah R, Nnedu O, Phillips T, Wang JS, Afriyie-Gyawu E, Tang L, Person S, et al. 2006. Determinants of aflatoxin levels in Ghanaians: sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. Int J Hyg Environ Health. 209:345-358.
17. Kaiser R, Bunnell R, Hightower A, Kim AA, Cherutich P, Mwangi M, Oluoch T, Dadabhai S, Mureithi P, Mugo N, et al. 2011. Factors associated with HIV infection in married or cohabitating couples in Kenya: results from a nationally representative study. PLoS One. 6:e17842.
18. Khlangwiset P, Shephard GS, Wu F. 2011. Aflatoxins and growth impairment: a review. Crit Rev Toxicol. 41:740-755.
19. Lewis L, Onsongo M, Njapau H, Schurz-Rogers H, Luber G, Kieszak S, Nyamongo J, Backer L, Dahiye AM, Misore A, et al. 2005. Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya. Environ Health Perspect. 113:1763-1767.
20. McCoy LF, Scholl PF, Schleicher RL, Groopman JD, Powers CD, Pfeiffer CM. 2005. Analysis of aflatoxin B1-lysine adduct in serum using isotope-dilution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 19:2203-2210.
21. McCoy LF, Scholl PF, Sutcliffe AE, Kieszak SM, Powers CD, Rogers HS, Gong YY, Groopman JD, Wild CP, Schleicher RL. 2008. Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry. Cancer Epidemiol Biomarkers Prev. 17:1653-1657.
22. Mwanda OW, Otieno CF, Omonge E. 2005. Acute aflatoxicosis: case report. East Afr Med J. 82:320-324.
23. Ngindu A, Johnson BK, Kenya PR, Ngira JA, Ocheng DM, Nandwa H, Omondi TN, Jansen AJ, Ngare W, Kaviti JN, et al. 1982. Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet. 1:1346-1348.
24. Obuseh FA, Jolly PE, Kulczycki A, Ehiri J, Waterbor J, Desmond RA, Preko PO, Jiang Y, Piyathilake CJ. 2011. Aflatoxin levels, plasma vitamins A and E concentrations, and their association with HIV and hepatitis B virus infections in Ghanaians: a cross-sectional study. J Int AIDS Soc. 14:53.
25. Ross RK, Yuan JM, Yu MC, Wogan GN, Qian GS, Tu JT, Groopman JD, Gao YT, Henderson BE. 1992. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet. 339:943-946.
26. Skipper PL, Tannenbaum SR. 1990. Protein adducts in the molecular dosimetry of chemical carcinogens. Carcinogenesis. 11:507-518.
27. Turner PC, Collinson AC, Cheung YB, Gong Y, Hall AJ, Prentice AM, Wild CP. 2007. Aflatoxin exposure in utero causes growth faltering in Gambian infants. Int J Epidemiol. 36:1119-1125.
28. Turner PC, Mendy M, Whittle H, Fortuin M, Hall AJ, Wild CP. 2000. Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Trop Med Int Health. 5:837-841.
29. Turner PC, Sylla A, Gong YY, Diallo MS, Sutcliffe AE, Hall AJ, Wild CP. 2005. Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in west Africa: a community-based intervention study. Lancet. 365:1950-1956.
30. Turner PC, Sylla A, Kuang SY, Marchant CL, Diallo MS, Hall AJ, Groopman JD, Wild CP. 2005. Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. Cancer Epidemiol Biomarkers Prev. 14:2053-2055.
31. Wang LY, Hatch M, Chen CJ, Levin B, You SL, Lu SN, Wu MH, Wu WP, Wang LW, Wang Q, et al. 1996. Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. Int J Cancer. 67:620-625.
32. Wild CP, Gong YY. 2010. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis. 31:71-82.
33. Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D. 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr. 80:1106-1122.
34. Wu HC, Wang Q, Yang HI, Ahsan H, Tsai WY, Wang LY, Chen SY, Chen CJ, Santella RM. 2009. Aflatoxin B1 exposure, hepatitis B virus infection, and hepatocellular carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev. 18:846-853.
35. Yin YN, Yan LY, Jiang JH, Ma ZH. 2008. Biological control of aflatoxin contamination of crops. J Zhejiang Univ Sci B. 9:787-792.