The evolution of malignant and reactive γδ + T cell clones in a relapse T-ALL case after allogeneic stem cell transplantation

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Chen, Shaohua ^a,b   Huang, Xin ^c   Zheng, Haitao ^b   Geng, Suxia ^c   Wu, Xiuli ^a,b   Yang, Lijian ^b   Weng, Jianyu ^c   Du, Xin ^c   Li, Yangqiu ^a,b  

^a JINAN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^c GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

T cell clone; Allo HSCT; FT CGH; T ALL; TCR

Indexed keywords

T LYMPHOCYTE RECEPTOR; COMPLEMENTARITY DETERMINING REGION; LYMPHOCYTE ANTIGEN RECEPTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLONAL VARIATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TREATMENT RESPONSE; ADULT; ALLOTRANSPLANTATION; CASE REPORT; CELL CLONE; CLONAL EVOLUTION; COMPLEMENTARITY DETERMINING REGION; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; MALE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECURRENT DISEASE;

ADULT; BASE SEQUENCE; CLONAL EVOLUTION; CLONE CELLS; COMPARATIVE GENOMIC HYBRIDIZATION; COMPLEMENTARITY DETERMINING REGIONS; GENE EXPRESSION REGULATION, LEUKEMIC; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECURRENCE; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 84880026522     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-73     Document Type: Article

References (32)

1. Kraszeska MD, Dawidowska M, Szczepański T, Witt M. T-cell acute lymphoblastic leukemia: recent molecular biology findings. Br J Haematol 2012, 15:303-315.
2. Cleaver AL, Beesley AH, Firth MJ, Sturges NC, O'Leary RA, Hunger SP, Baker DL, Kees UR. Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study. Mol Cancer 2010, 9:105. 10.1186/1476-4598-9-105, 2879253, 20459861.
3. Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 2008, 8:380-390. 10.1038/nri2304, 18421304.
4. Wang Y, Liu DH, Xu LP, Liu KY, Chen H, Chen YH, Han W, Zhang XH, Huang XJ. Haploidentical/mismatched hematopoietic stem cell transplantation without in vitro T cell depletion for T cell acute lymphoblastic leukemia. Biol Blood Marrow Transplant 2012, 18:716-721. 10.1016/j.bbmt.2011.08.024, 21924223.
5. Lv M, Huang X. Allogeneic hematopoietic stem cell transplantation in China: where we are and where to go. J Hematol Oncol 2012, 5:10. 10.1186/1756-8722-5-10, 3353833, 22424172.
6. Rezvany MR, Jeddi-Tehrani M, Wigzell H, Osterborg A, Mellstedt H. Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia. Blood 2003, 101:1063-1070. 10.1182/blood-2002-03-0746, 12393705.
7. De Rijke B, Fredrix H, Zoetbrood A, Scherpen F, Witteveen H, De Witte T, van de Wiel-Van Kemenade E, Dolstra H. Generation of autologous cytotoxic and helper T-cell responses against the B-cell leukemia-associated antigen HB-1: relevance for precursor B-ALL-specific immunotherapy. Blood 2003, 102:2885-2891. 10.1182/blood-2002-11-3584, 12842998.
8. Zheng H, Chen Y, Chen S, Niu Y, Yang L, Li B, Lu Y, Geng S, Du X, Li Y. Expression and distribution of the PPP2R5C gene in leukemia. J Hematol Oncol 2011, 4:21. 10.1186/1756-8722-4-21, 3117819, 21548944.
9. Huang X, Du X, Li Y. The role of BCL11B in hematological malignancy. Exp Hematol Oncol 2012, 1:22. 10.1186/2162-3619-1-22, 3514087, 23211040.
10. Bellone M, Svensson AM, Zaslav AL, Spitzer S, Golightly M, Celiker M, Hu Y, Ma Y, Ahmed T. Pediatric T-cell prolymphocytic leukemia with an isolated 12(p13) deletion and aberrant CD117 expression. Exp Hematol Oncol 2012, 1:7. 10.1186/2162-3619-1-7, 3514102, 23211022.
11. Langerak AW, van Den Beemd R, Wolvers-Tettero IL, Boor PP, Van Lochem EG, Hooijkaas H, Van Dongen JJ. Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβT-cell proliferations. Blood 2001, 98:165-173. 10.1182/blood.V98.1.165, 11418476.
12. Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, Siebert R, Dölken G, Ludwig WD, Verhaaf B, Van Dongen JJ, Schmidt CA, Langerak AW. Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. Leukemia 2005, 19:201-208. 10.1038/sj.leu.2403619, 15668700.
13. Tanaka-Harada Y, Kawakami M, Oka Y, Tsuboi A, Katagiri T, Elisseeva OA, Nishida S, Shirakata T, Hosen N, Fujiki F, Murao A, Nakajima H, Oji Y, Kanda Y, Kawase I, Sugiyama H. Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies. Cancer Sci 2010, 101:594-600. 10.1111/j.1349-7006.2009.01453.x, 20132220.
14. Wang Q, Liu H, Zhang X, Liu Q, Xing Y, Zhou X, Tong C, Zhu P. High doses of mother's lymphocyte infusion to treat EBV-positive T-cell lymphoproliferative disorders in childhood. Blood 2010, 116:5941-5947. 10.1182/blood-2010-01-262311, 20926772.
15. Przybylski GK, Dittmann K, Grabarczyk P, Dölken G, Gesk S, Harder L, Landmann E, Siebert R, Schmidt CA. Molecular characterization of a novel chromosomal translocation t(12;14)(q23;q11.2) in T-lymphoblastic lymphoma between the T-cell receptor delta-deleting elements (TRDREC and TRAJ61) and the hypothetical gene C12orf42. Eur J Haematol 2010, 85:452-456. 10.1111/j.1600-0609.2010.01508.x, 20659153.
16. Li Y, Chen S, Yang L, Li B, Chan JYH, Cai D. TRGV and TRDV repertoire distribution and clonality of T cells from umbilical cord blood. Transpl Immunol 2009, 20:155-162. 10.1016/j.trim.2008.10.010, 19013241.
17. Puisieux I, Even J, Pannetier C, Jotereau F, Favrot M, Kourilsky P. Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J Immunol 1994, 153:2807-2818.
18. Weng JY, Du X, Geng SX, Peng YW, Wang Z, Lu ZS, Wu SJ, Luo CW, Guo R, Ling W, Deng CX, Liao PJ, Xiang AP. Mesenchymal stem cell as salvage treatment for refractory chronic GVHD. Bone Marrow Transplant 2010, 45:1732-1740. 10.1038/bmt.2010.195, 3035976, 20818445.
19. Vanura K, Vrsalovic MM, Le T, Marculescu R, Kusec R, Jäger U, Nadel B. V(D)J targeting mistakes occur at low frequency in acute lymphoblastic leukemia. Genes Chromosomes Cancer 2009, 48:725-736. 10.1002/gcc.20677, 19455608.
20. Thulien KJ, Belch AR, Reiman T, Pilarski LM. In non-transplant patients with multiple myeloma, the pre-treatment level of clonotypic cells predicts event-free survival. Mol Cancer 2012, 11:78. 10.1186/1476-4598-11-78, 3522007, 23083101.
21. Kode J, Advani S, Chiplunkar S. T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia in Indian patients. Leuk Lymphoma 2000, 36:331-338. 10.3109/10428190009148854, 10674905.
22. Langerak AW, Wolvers-Tettero IL, van den Beemd MW, Van Wering ER, Ludwig WD, Hählen K, Necker A, Dongen JJ. Immunophenotypic and immunogenotypic characteristics of TCRγδ + T cell acute lymphoblastic leukemia. Leukemia 1999, 13:206-214. 10.1038/sj.leu.2401276, 10025894.
23. Stams WAG, Den Boer ML, Beverloo HB, Meijerink JPP, Stigter RL, Van Wering ER, Janka-Schaub GE, Slater R, Pieters R. Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL. Blood 2003, 101:2743-2747. 10.1182/blood-2002-08-2446, 12433682.
24. Chen S, Zha X, Yang L, Li B, Zhong L, Li Y. Deficiency of CD3γ, δ, ε{lunate} and ζ expression in T-cells from AML patients. Hematology 2011, 16:31-36. 10.1179/102453311X12902908411832, 21269565.
25. Warren RL, Freeman JD, Zeng T, Choe G, Munro S, Moore R, Webb JR, Holt RA. Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes. Genome Res 2011, 21:790-797. 10.1101/gr.115428.110, 3083096, 21349924.
26. Zha X, Chen S, Yang L, Li B, Chen Y, Yan X, Li Y. Characterization of the CDR3 structure of Vβ21 T cell clone in patients with P210BCR-ABL-positive CML and B-ALL. Hum Immunol 2011, 72:798-804. 10.1016/j.humimm.2011.06.015, 21820025.
27. Yin Q, Zha X, Yang L, Chen S, Zhou Y, Wu X, Li Y. Generation of diffuse large B cell lymphoma-associated antigen-specific Vα6/Vβ13 + T cells by TCR gene transfer. J Hematol Oncol 2011, 4:2. 10.1186/1756-8722-4-2, 3024308, 21223579.
28. Meeh PF, King M, O'Brien RL, Muga S, Buchhalts P, Meuberg R, Lamb LS. Characterization of the γδ T cell response to acute leukemia. Cancer Immunol Immunother 2006, 55:1072-1080. 10.1007/s00262-005-0094-6, 16328383.
29. Wang Y, Liu DH, Fan ZP, Sun J, Wu XJ, Ma X, Xu LP, Liu KY, Liu QF, Wu DP, Huang XJ. Prevention of relapse using DLI can increase survival following HLA-identical transplantation in patients with advanced-stage acute leukemia: a multi-center study. Clin Transplant 2012, 26:635-643. 10.1111/j.1399-0012.2012.01626.x, 22515260.
30. Cabillic F, Toutirais O, Lavoué V, de La Pintière CT, Daniel P, Rioux-Leclerc N, Turlin B, Mönkkönen H, Mönkkönen J, Boudjema K, Catros V, Bouet-Toussaint F. Aminobisphosphonate-pretreated dendritic cells trigger successful Vgamma9Vdelta2 T cell amplification for immunotherapy in advanced cancer patients. Cancer Immunol Immunother 2010, 59:1611-1619. 10.1007/s00262-010-0887-0, 20582413.
31. Li Y, Lin C, Schmidt CA. New insights into antigen specific immunotherapy for chronic myeloid leukemia. Cancer Cell Int 2012, 12:52. 10.1186/1475-2867-12-52, 3538626, 23241263.
32. Kessels HW, Wolkers MC, van den Boom MD, van der Valk MA, Schumacher TN. Immunotherapy through TCR gene transfer. Nat Immunol 2001, 2:957-961. 10.1038/ni1001-957, 11577349.