Raf-mediated cardiac hypertrophy in adult Drosophila

DMM Disease Models and Mechanisms

Volumn 6, Issue 4, 2013, Pages 964-976

  Yu, Lin ^a   Daniels, Joseph ^a   Glaser, Alex E ^a   Wolf, Matthew J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; RAF PROTEIN;

ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; CELL COUNT; CONTROLLED STUDY; DROSOPHILA; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HYPERPLASIA; HYPERTROPHIC CARDIOMYOPATHY; MUSCLE CELL; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSGENE;

AGING; ANIMALS; CARDIOMEGALY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; MUTANT PROTEINS; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; PLOIDIES; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84880019664     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.011361     Document Type: Article

References (52)

1. Adler, C. P. and Friedburg, H. (1986). Myocardial DNA content, ploidy level and cell number in geriatric hearts: post-mortem examinations of human myocardium in old age. J. Mol. Cell. Cardiol. 18, 39-53. (Pubitemid 16174714)
2. Adler, C. P., Friedburg, H., Herget, G. W., Neuburger, M. and Schwalb, H. (1996). Variability of cardiomyocyte DNA content, ploidy level and nuclear number in mammalian hearts. Virchows Arch. 429, 159-164. (Pubitemid 26378968)
3. Ahuja, P., Sdek, P. and MacLellan, W. R. (2007). Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol. Rev. 87, 521-544. (Pubitemid 47086282)
4. Alayari, N. N., Vogler, G., Taghli-Lamallem, O., Ocorr, K., Bodmer, R. and Cammarato, A. (2009). Fluorescent labeling of Drosophila heart structures. J. Vis. Exp. 32, e1423.
5. Ashburner, M., Golic, K. G. and Hawley, R. S. (2005). Drosophila: a Laboratory Handbook. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
6. Bainbridge, S. P. and Bownes, M. (1981). Staging the metamorphosis of Drosophila melanogaster. J. Embryol. Exp. Morphol. 66, 57-80. (Pubitemid 12247854)
7. Baker, N. E. and Rubin, G. M. (1989). Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor. Nature 340, 150-153. (Pubitemid 19175367)
8. Baylies, M. K., Bate, M. and Ruiz Gomez, M. (1998). Myogenesis: a view from Drosophila. Cell 93, 921-927. (Pubitemid 28280786)
9. Bergmann, A., Agapite, J., McCall, K. and Steller, H. (1998). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341. (Pubitemid 28507322)
10. Bodmer, R. and Venkatesh, T. V. (1998). Heart development in Drosophila and vertebrates: conservation of molecular mechanisms. Dev. Genet. 22, 181-186. (Pubitemid 28257595)
11. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415. (Pubitemid 23214028)
12. Brand, A. H. and Perrimon, N. (1994). Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev. 8, 629-639. (Pubitemid 24086131)
13. Braunwald, E. and Bonow, R. O. (2012). Braunwald's Heart Disease: a Textbook of Cardiovascular Medicine. Philadelphia, PA: Elsevier/Saunders.
14. Brunner, D., Oellers, N., Szabad, J., Biggs, W. H., III, Zipursky, S. L. and Hafen, E. (1994). A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76, 875-888. (Pubitemid 24085325)
15. Bueno, O. F., De Windt, L. J., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C. F. et al. (2000). The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. EMBO J. 19, 6341-6350.
16. Buff, E., Carmena, A., Gisselbrecht, S., Jiménez, F. and Michelson, A. M. (1998). Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors. Development 125, 2075-2086. (Pubitemid 28297794)
17. Carmena, A., Bate, M. and Jiménez, F. (1995). Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis. Genes Dev. 9, 2373-2383.
18. Carmena, A., Murugasu-Oei, B., Menon, D., Jiménez, F. and Chia, W. (1998). Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. Genes Dev. 12, 304-315. (Pubitemid 28084260)
19. Chen, M. H., Kerkelä, R. and Force, T. (2008). Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation 118, 84-95.
20. Chu, T. F., Rupnick, M. A., Kerkela, R., Dallabrida, S. M., Zurakowski, D., Nguyen, L., Woulfe, K., Pravda, E., Cassiola, F., Desai, J. et al. (2007). Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 370, 2011-2019. (Pubitemid 350236338)
21. Crone, S. A., Zhao, Y. Y., Fan, L., Gu, Y., Minamisawa, S., Liu, Y., Peterson, K. L., Chen, J., Kahn, R., Condorelli, G. et al. (2002). ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat. Med. 8, 459-465. (Pubitemid 34546747)
22. Edgar, B. A. and Orr-Weaver, T. L. (2001). Endoreplication cell cycles: more for less. Cell 105, 297-306. (Pubitemid 32455339)
23. Fink, M., Callol-Massot, C., Chu, A., Ruiz-Lozano, P., Izpisua Belmonte, J. C., Giles, W., Bodmer, R. and Ocorr, K. (2009). A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 46, 101-113.
24. Fox, D. T., Gall, J. G. and Spradling, A. C. (2010). Error-prone polyploid mitosis during normal Drosophila development. Genes Dev. 24, 2294-2302.
25. Gelb, B. D. and Tartaglia, M. (2011). RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it. J. Clin. Invest. 121, 844-847.
26. Halfon, M. S., Carmena, A., Gisselbrecht, S., Sackerson, C. M., Jiménez, F., Baylies, M. K. and Michelson, A. M. (2000). Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell 103, 63-74.
27. Heineke, J. and Molkentin, J. D. (2006). Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat. Rev. Mol. Cell Biol. 7, 589-600. (Pubitemid 44325350)
28. Hesse, M., Raulf, A., Pilz, G. A., Haberlandt, C., Klein, A. M., Jabs, R., Zaehres, H., Fügemann, C. J., Zimmermann, K., Trebicka, J. et al. (2012). Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle. Nat. Commun. 3, 1076.
29. Karim, F. D. and Rubin, G. M. (1998). Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development 125, 1-9. (Pubitemid 28048448)
30. Kehat, I., Davis, J., Tiburcy, M., Accornero, F., Saba-El-Leil, M. K., Maillet, M., York, A. J., Lorenz, J. N., Zimmermann, W. H., Meloche, S. et al. (2011). Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circ. Res. 108, 176-183.
31. Krenz, M., Gulick, J., Osinska, H. E., Colbert, M. C., Molkentin, J. D. and Robbins, J. (2008). Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc. Natl. Acad. Sci. USA 105, 18930-18935.
32. Lee, H. O., Davidson, J. M. and Duronio, R. J. (2009). Endoreplication: polyploidy with purpose. Genes Dev. 23, 2461-2477.
33. Lo, P. C. and Frasch, M. (2001). A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech. Dev. 104, 49-60. (Pubitemid 32549763)
34. Lu, X., Melnick, M. B., Hsu, J. C. and Perrimon, N. (1994). Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. EMBO J. 13, 2592-2599. (Pubitemid 24188392)
35. Oellers, N. and Hafen, E. (1996). Biochemical characterization of rolledSem, an activated form of Drosophila mitogen-activated protein kinase. J. Biol. Chem. 271, 24939-24944. (Pubitemid 26333250)
36. Pandit, B., Sarkozy, A., Pennacchio, L. A., Carta, C., Oishi, K., Martinelli, S., Pogna, E. A., Schackwitz, W., Ustaszewska, A., Landstrom, A. et al. (2007). Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat. Genet. 39, 1007-1012. (Pubitemid 47185177)
37. Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S. et al. (2011). Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 123, e18-e209.
38. Rushton, E., Drysdale, R., Abmayr, S. M., Michelson, A. M. and Bate, M. (1995). Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development. Development 121, 1979-1988.
39. Sandritter, W. and Scomazzoni, G. (1964). DNA content (feulgen photometry) and dry weight (interference microscopy) of normal and hypertrophic heart muscle fibers. Nature 202, 100-101.
40. Sigrist, S. J. and Lehner, C. F. (1997). Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90, 671-681. (Pubitemid 27357959)
41. Suter, T. M., Procter, M., van Veldhuisen, D. J., Muscholl, M., Bergh, J., Carlomagno, C., Perren, T., Passalacqua, R., Bighin, C., Klijn, J. G. et al. (2007). Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J. Clin. Oncol. 25, 3859-3865. (Pubitemid 47477261)
42. Vasan, R. S., Larson, M. G., Benjamin, E. J., Evans, J. C. and Levy, D. (1997). Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N. Engl. J. Med. 336, 1350-1355. (Pubitemid 27208618)
43. Ward, E. J. and Skeath, J. B. (2000). Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo. Development 127, 4959-4969.
44. White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M. H. (1995). Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541.
45. Wolf, M. J. (2012). Modeling dilated cardiomyopathies in Drosophila. Trends Cardiovasc. Med. 22, 55-61.
46. Wolf, M. J. and Rockman, H. A. (2011). Drosophila, genetic screens, and cardiac function. Circ. Res. 109, 794-806.
47. Wolf, M. J., Amrein, H., Izatt, J. A., Choma, M. A., Reedy, M. C. and Rockman, H. A. (2006). Drosophila as a model for the identification of genes causing adult human heart disease. Proc. Natl. Acad. Sci. USA 103, 1394-1399. (Pubitemid 43191176)
48. Wu, X., Simpson, J., Hong, J. H., Kim, K. H., Thavarajah, N. K., Backx, P. H., Neel, B. G. and Araki, T. (2011). MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. J. Clin. Invest. 121, 1009-1025.
49. Yu, L., Lee, T., Lin, N. and Wolf, M. J. (2010). Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet. 6, e1000969.
50. Zaffran, S. and Frasch, M. (2002). Early signals in cardiac development. Circ. Res. 91, 457-469.
51. Zaffran, S., Reim, I., Qian, L., Lo, P. C., Bodmer, R. and Frasch, M. (2006). Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila. Development 133, 4073-4083. (Pubitemid 44756200)
52. Zielke, N., Querings, S., Rottig, C., Lehner, C. and Sprenger, F. (2008). The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles. Genes Dev. 22, 1690-1703. (Pubitemid 351846847)