Modeling Dilated Cardiomyopathies in Drosophila

Trends in Cardiovascular Medicine

Volumn 22, Issue 3, 2012, Pages 55-61

  Wolf, Matthew J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACTILE PROTEIN; DELTA SARCOGLYCAN; DYSTROPHIN; STRUCTURAL PROTEIN; TROPONIN I; VALINE;

CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CELL DIFFERENTIATION; CONGESTIVE CARDIOMYOPATHY; CORONARY ARTERY BLOOD FLOW; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE IDENTIFICATION; GENE PRODUCT; GENETIC ASSOCIATION; GENOME SIZE; HAPLOINSUFFICIENCY; HEART FAILURE; HEART FUNCTION; HEART VENTRICLE HYPERTROPHY; IN SITU HYBRIDIZATION; MECHANICAL STRESS; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHENOTYPE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE; UNITED STATES; YEAST; ZYGOTE;

ANIMALS; CARDIOMYOPATHY, DILATED; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; HUMANS; MUTATION; MYOCYTES, CARDIAC;

EID: 84866515978     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2012.06.012     Document Type: Review

References (51)

1. Allikian M.J., Bhabha G., Dospoy P., et al. Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants. Hum Mol Genet 2007, 16:2933-2943.
2. Artavanis-Tsakonas S., Muskavitch M.A. Notch: The past, the present, and the future. Curr Top Dev Biol 2010, 92:1-29.
3. Ashburner M., Golic K.G., Hawley R.S. Drosophila: A laboratory handbook 2005, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
4. Beall C.J., Fyrberg E. Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms. J Cell Biol 1991, 114:941-951.
5. Bodmer R., Venkatesh T.V. Heart development in Drosophila and vertebrates: Conservation of molecular mechanisms. Dev Genet 1998, 22:181-186.
6. Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
7. Braunwald E., Bonow R.O. Braunwald's heart disease: A textbook of cardiovascular medicine 2012, Elsevier/Saunders, Philadelphia.
8. Bray S.J., Takada S., Harrison E., et al. The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol 2008, 8:11.
9. Crone S.A., Zhao Y.Y., Fan L., et al. ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 2002, 8:459-465.
10. de la Pompa J.L., Epstein J.A. Coordinating tissue interactions: Notch signaling in cardiac development and disease. Dev Cell 2012, 22:244-254.
11. Dietzl G., Chen D., Schnorrer F., et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007, 448:151-156.
12. Dulcis D., Levine R.B. Innervation of the heart of the adult fruit fly, Drosophila melanogaster. J Comp Neurol 2003, 465:560-578.
13. Dulcis D., Levine R.B. Glutamatergic innervation of the heart initiates retrograde contractions in adult Drosophila melanogaster. J Neurosci 2005, 25:271-280.
14. Dulcis D., Levine R.B., Ewer J. Role of the neuropeptide CCAP in Drosophila cardiac function. J Neurobiol 2005, 64:259-274.
15. Evans P.D., Maqueira B. Insect octopamine receptors: A new classification scheme based on studies of cloned Drosophila G-protein coupled receptors. Invert Neurosci 2005, 5:111-118.
16. Felker G.M., Pang P.S., Adams K.F., et al. Clinical trials of pharmacological therapies in acute heart failure syndromes: Lessons learned and directions forward. Circ Heart Fail 2010, 3:314-325.
17. Friedman A., Perrimon N. A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature 2006, 444:230-234.
18. Goldstein J.A., Kelly S.M., LoPresti P.P., et al. SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy. Hum Mol Genet 2011, 20:894-904.
19. Greenspan R.J. Fly pushing: The theory and practice of Drosophila genetics 1997, Cold Spring Harbor Laboratory Press, Plainview, NY.
20. Haley B., Hendrix D., Trang V., Levine M. A simplified miRNA-based gene silencing method for Drosophila melanogaster. Dev Biol 2008, 321:482-490.
21. Heineke J., Molkentin J.D. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 2006, 7:589-600.
22. Heydemann A., McNally E.M. Consequences of disrupting the dystrophin-sarcoglycan complex in cardiac and skeletal myopathy. Trends Cardiovasc Med 2007, 17:55-59.
23. Hunt S.A., Abraham W.T., Chin M.H., et al. 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009, 119:e391-e479.
24. Karlik C.C., Fyrberg E.A. An insertion within a variably spliced Drosophila tropomyosin gene blocks accumulation of only one encoded isoform. Cell 1985, 41:57-66.
25. Kim I.M., Wolf M.J. Serial examination of an inducible and reversible dilated cardiomyopathy in individual adult Drosophila. PLoS ONE 2009, 4:e7132.
26. Kim I.M., Wolf M.J., Rockman H.A. Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res 2010, 106:1233-1243.
27. Lemberg M.K., Freeman M. Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases. Genome Res 2007, 17:1634-1646.
28. Lin N., Badie N., Yu L., et al. A method to measure myocardial calcium handling in adult Drosophila. Circ Res 2011, 108:1306-1315.
29. Roy S., Ernst J., Kharchenko P.V., et al. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science 2010, 330:1787-1797. modENCODE Consortium.
30. Monier B., Astier M., Sémériva M., Perrin L. Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart. Development 2005, 132:5283-5293.
31. Neely G.G., Kuba K., Cammarato A., et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell 2010, 141:142-153.
32. Olson E.N. Gene regulatory networks in the evolution and development of the heart. Science 2006, 313:1922-1927.
33. Qian L., Wythe J.D., Liu J., et al. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol 2011, 193:1181-1196.
34. Reiter L.T., Potocki L., Chien S., et al. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res 2001, 11:1114-1125.
35. Roger V.L., Go A.S., Lloyd-Jones D.M., et al. Heart disease and stroke statistics-2011 update: A report from the American Heart Association. Circulation 2011, 123:e18-e209.
36. Romfh A., McNally E.M. Cardiac assessment in Duchenne and Becker muscular dystrophies. Curr Heart Fail Rep 2010, 7:212-218.
37. Rubin G.M., Yandell M.D., Wortman J.R., et al. Comparative genomics of the eukaryotes. Science 2000, 287:2204-2215.
38. Stebbings L.A., Todman M.G., Phelan P., et al. Two Drosophila innexins are expressed in overlapping domains and cooperate to form gap-junction channels. Mol Biol Cell 2000, 11:2459-2470.
39. Suter T.M., Procter M., van Veldhuisen D.J., et al. Trastuzumab-associated cardiac adverse effects in the Herceptin adjuvant trial. J Clin Oncol 2007, 25:3859-3865.
40. Taghli-Lamallem O., Akasaka T., Hogg G., et al. Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Aging Cell 2008, 7:237-249.
41. Tao Y., Schulz R.A. Heart development in Drosophila. Semin Cell Dev Biol 2007, 18:3-15.
42. Tsubata S., Bowles K.R., Vatta M., et al. Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy. J Clin Invest 2000, 106:655-662.
43. Urban S., Dickey S.W. The rhomboid protease family: A decade of progress on function and mechanism. Genome Biol 2011, 12:231.
44. Vigoreaux J.O. Genetics of the Drosophila flight muscle myofibril: A window into the biology of complex systems. Bioessays 2001, 23:1047-1063.
45. Vikhorev P.G., Vikhoreva N.N., Cammarato A., Sparrow J.C. In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation. J Muscle Res Cell Motil 2010, 31:171-179.
46. Wasserthal L.T. Drosophila flies combine periodic heartbeat reversal with a circulation in the anterior body mediated by a newly discovered anterior pair of ostial valves and "venous" channels. J Exp Biol 2007, 210:3707-3719.
47. Willmann R., Possekel S., Dubach-Powell J., et al. Mammalian animal models for Duchenne muscular dystrophy. Neuromuscul Disord 2009, 19:241-249.
48. Wolf M.J., Amrein H., Izatt J.A., et al. Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A 2006, 103:1394-1399.
49. Wolf M.J., Rockman H.A. Drosophila, genetic screens, and cardiac function. Circ Res 2011, 109:794-806.
50. Yu L., Lee T., Lin N., Wolf M.J. Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet 2010, 6:e1000969.
51. Zaffran S., Frasch M. Early signals in cardiac development. Circ Res 2002, 91:457-469.